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الصفحة 1
الصفحة 1
Animal Models of T Cell-Mediated Skin Diseases
Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
Aesthetic Surgery of the Abdominal Wall
We have come a long way since the days when abdominal wall contouring was p- formed by simple dermolipectomies, with no attention to diastasis correction and muscular reinforcement, and little regard for the final aesthetic result. Nowadays, an abdominoplasty may be indicated for even the most demanding of patients. Details such as placement of the incision and umbilicoplasty are meticulously planned so as to conceal undesirable scars. Since the advent of suction-assisted lipectomy, in as- ciation with a classical operation or as an isolated procedure, the plastic surgeon has become capable of remodeling the entire trunk, assuring removal of considerable amounts of adipose tissue.
Artificial intelligence in the financial services industry
Today, the financial services sector is facing a period of rapid disruption and innovation, and artificial intelligence (AI) is at the heart of these changes. Artificial intelligence can be used to gather enormous amounts of data, detect abnormalities, and solve complex problems. Financial institutions are already experimenting extensively with AI strategies to enhance and streamline financial institutions, BSA and AML compliance, CRA requirements, fraud detection, and real estate valuations, all while reducing cost levels. This book looks at how artificial intelligence is affecting the financial services industry.
Iterating Infusion : Clearer Views of Objects, Classes, and Systems
Iterating Infusion presents comprehensive tools for you to best manage and work with object orientation. These include simplified fundamental concepts, popular language comparisons, advanced designing strategies, a broad usage progression, thorough design notations (interaction algebra), and data-oriented (fundamentally-OO) languages. The title, Iterating Infusion, alludes to the fact that any system has multiple, coexisting functional levels and that new levels—both lower and higher—are continually added to the same functional area. The practical effect is to bring processes into focus, always clarifying the vague. The extreme form of this is when separate but compatible technologies are brought together to create advancements; these can be baby-steps or great leaps, with varying amounts of effort. In more general terms, the same thing in a different context can take on much more power. And actually, this phenomenon is at the heart of object-oriented software.
Big data and artificial intelligence in digital finance : Increasing personalization and trust in digital finance using big data and AI
This book presents how cutting-edge digital technologies like Machine Learning, Artificial Intelligence (AI), and Blockchain are set to disrupt the financial sector. The book illustrates how recent advances in these technologies facilitate banks, FinTechs, and financial institutions to collect, process, analyze, and fully leverage the very large amounts of data that are nowadays produced and exchanged in the sector. To this end, the book also introduces some of the most popular Big Data, AI and Blockchain applications in the sector, including novel applications in the areas of Know Your Customer (KYC), Personalized Wealth Management and Asset Management, Portfolio Risk Assessment, as well as variety of novel Usage-based Insurance applications based on Internet-of-Things data.
Algorithms and data structures for massive datasets
Learn: Probabilistic sketching data structures for practical problems Choosing the right database engine for your application Evaluating and designing efficient on-disk data structures and algorithms Understanding the algorithmic trade-offs involved in massive-scale systems Deriving basic statistics from streaming data Correctly sampling streaming data Computing percentiles with limited space resources Algorithms and Data Structures for Massive Datasets reveals a toolbox of new methods that are perfect for handling modern big data applications. You'll explore the novel data structures and algorithms that underpin Google, Facebook, and other enterprise applications that work with truly massive amounts of data. These effective techniques can be applied to any discipline, from finance to text analysis. Graphics, illustrations, and hands-on industry examples make complex ideas practical to implement in your projects--and there's no mathematical proofs to puzzle over. Work through this one-of-a-kind guide, and you'll find the sweet spot of saving space without sacrificing your data's accuracy. About the Technology Standard algorithms and data structures may become slow--or fail altogether--when applied to large distributed datasets. Choosing algorithms designed for big data saves time, increases accuracy, and reduces processing cost.
Advanced machine learning and deep learning approaches for remote sensing
Provides research on how technologies such as artificial intelligence-based machine learning and deep learning can be applied to remote sensing. Through this, we can see the process of solving the existing problems of image and image signal processing for remote sensing. These techniques are computationally intensive and require the help of high-performance computing devices. With the development of devices such as GPUs, remote sensing technology, and aerial sensing technology, it is possible to monitor the Earth with high-resolution images and to obtain vast amounts of Earth observation data. The papers published in this reprint describe recent advances in big data processing and artificial intelligence-based technologies for remote sensing technology.
Civil engineering materials
Concentrates on demonstrating methods to obtain, analyse and use information rather than focusing on presenting large amounts of data. Beginning with basic properties of materials, it moves on to more complex areas such as the theory of concrete durability and corrosion of steel.
Land Use and Soil Resources
Land-use change is one of the main drivers of many environmental change processes. It influences the basic resources of land use, including the soil. Its impact on soil often occurs so creepingly that land managers hardly contemplate initiating ameliorative or counterbalance measures. Poor land management has degraded vast amounts of land, reduced our ability to produce enough food, and is a major threat to rural livelihoods in many developing countries. To date, there has been no single unifying volume that addresses the multifaceted impacts of land use on soils. This book has responded to this challenge by bringing together renowned academics and policy experts to analyze the patterns, driving factors and proximate causes, and the socioeconomic impacts of soil degradation. Policy measures to prevent irreversible degradation and rehabilitate degraded soils are also identified.
Care of Astronomical Telescopes and Accessories : A Manual for the Astronomical Observer and Amateur Telescope Maker
guide for anyone who wants to understand more than just the basics of astronomical telescopes and accessories, and how to maintain them in the peak of condition. The latest on safely adjusting, cleaning, and maintaining your equipment is combined with thoroughly updated methods from the old masters. Here, too, are details of choosing new and used optics and accessories, along with enhancements you can make to extend their versatility and useful lifetime. This book is for you. Really. Looking after an astronomical telescope isn’t only for the experts - although there are some things that only an expert should attempt - and every serious amateur astronomer will find invaluable information here, gleaned from Barlow Pepin's many years’ experience working with optical instruments.
Calcium in Human Health
Calcium performs diverse biological functions in the human body and is a micronutrient essential to human health and well-being. It serves as a second messenger for nearly every biological process, stabilizes many proteins, and in deficient amounts is associated with a large number diseases and disorders. In Calcium in Human Health, a panel of highly respected researchers and clinical practitioners comprehensively reviews the state of our knowledge concerning this ubiquitous micronutrient, not only demonstrating its importance to human health, but also defining its many complex roles.
Bioactive Molecules and Medicinal Plants
Use of medicinal plants is as old as human civilization and continuous efforts are being made to improve medicinal plants or produce their products in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identifed from higher plants and microorganisms. Some plant-based drugs have been used for centuries and there is no alternative medicine for many drugs, such as cardiac glycosides. However, natural products research was sidelined to pave the way for com- natorial chemistry, which was expected to produce large numbers of synthetic compounds for high-throughput screening (HTS). This line of work has failed to deliver desirable results. Moreover, it is not possible for all pharmaceutical companies and institutions to adopt costly HTS technology. Therefore, medi- nal plants and their bioactive molecules are always in demand and are a central point of research. While planning this book, we endeavored to incorporate - ticles that cover the entire gamut of current medicinal plants research.
