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الصفحة 1
الصفحة 1
Macrosocial Determinants of Population Health
Macrosocial Determinants of Population Health explores social factors such as culture, mass media, political systems, and migration that influence population health while systematically considering how we may best study these factors and use our knowledge from this study to guide public health interventions.Each section ends with Galea’s integrative chapters, bringing the observations and conclusions from the chapters into clear, usable focus. Macrosocial Determinants of Population Health is a work of major theoretical, empirical, and practical interest for disciplines as varied as public health, epidemiology, health promotion, sociology, and health policy. Its systematic field-building approach makes it as valuable to the public health provider as to the scholars and students studying the health of populations.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Chemokine biology : Basic research and clinical application ; Vol.2 : Pathophysiology of chemokines
Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Chemokine biology : Basic research and clinical application ; Vol.1 : Immunobiology of chemokines
The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics.
Cell Adhesion and Cytoskeletal Molecules in Metastasis
In this volume, the expression of specific adhesion molecules within human cancer tissues are highlighted. The expression signatures from published DNA microarray and immunohistochemistry studies are detailed. The concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses is detailed in this volume; both features are essential for the survival of an invading tumor cell. Defining the minimal adhesion receptors preserved on cancer cells during tumor progression will define the metastatic adhesion signature. Understanding the metastatic adhesion signature will reveal vulnerabilities that could be exploited for the prevention and/or eradication of the invading cancer cell.
Advances in Molecular Oncology
Proceedings of the 2nd Annual IFOM-IEO Meeting on Cancer. This is a new meeting, it has about 200 attendees from Australia, Austria, Belgium, Brazil, Canada, England, France, Germany, Greece, Ireland, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, and the USA. The 2nd IFOM-IEO international meeting on cancer will provide a forum in which the world’s leading cancer researchers and young scientists will discuss the latest advances in molecular oncology. The impact of recent breakthroughs in basic research and of emerging technologies on molecular medicine in cancer will be highlighted.
Adhesion Molecules : Function and Inhibition
Inflammatory cell recruitment requires the concerted action of at least five major sets of adhesion molecules: integrins, immunoglobulin-like molecules, selectins, carbohydrate structures serving as selectin ligands, and certain ectoenzymes. This volume gives a comprehensive overview on the most relevant leukocyte and endothelial adhesion molecules. The chapters are written by leaders in the field and focus on the biology, structure, function, and regulation of adhesion molecules. Currently approved adhesion molecule-based therapies are reviewed and an outlook for future approaches is also provided. The book is of interest to clinicians and scientists from immunology, physiology, cancer research, rheumatology, allergology, infectious diseases, gastroenterology, pulmonology and cardiology.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Liberal Democracy : Prosperity through Freedom
Aims to show which factors have been decisive in the rise of successful countries. Never before have so many people been so well off. However, prosperity is not a law of nature; it has to be worked for. A liberal economy stands at the forefront of this success – not as a political system, but as a set of economic rules promoting competition, which in turn leads to innovation, research and enormous productivity.
Asylum Matters : On the Front Line of Administrative Decision-Making
This book examines everyday practices in an asylum administration. Asylum decisions are often criticised as being ‘subjective’ or ‘arbitrary’. Asylum Matters turns this claim on its head.
Asylum Determination in Europe : Ethnographic Perspectives
The book includes a legal overview of European asylum determination procedures, followed by sections on the diverse actors involved, the means by which they communicate, and the ways in which they make life and death decisions on a daily basis. It offers a contextually rich account that moves beyond doctrinal law to uncover the gaps and variances between formal policy and legislation, and law as actually practiced.
Long-Term Preservation of Digital Documents : Principles and Practices
Key to our culture is that we can disseminate information, and then maintain and access it over time. While we are rapidly advancing from vulnerable physical solutions to superior, digital media, preserving and using data over the long term involves complicated research challenges and organization efforts. Uwe Borghoff and his coauthors address the problem of storing, reading, and using digital data for periods longer than 50 years. They briefly describe several markup and document description languages like TIFF, PDF, HTML, and XML, explain the most important techniques such as migration and emulation, and present the OAIS (Open Archival Information System) Reference Model. To complement this background information on the technology issues the authors present the most relevant international preservation projects, such as the Dublin Core Metadata Initiative, and experiences from sample projects run by the Cornell University Library and the National Library of the Netherlands. A rated survey list of available systems and tools completes the book.
Active Directory Field Guide
Active Directory Field Guide is ideal for Windows and Active Directory administrators and consultants. It contains valuable descriptions of higher-level skills, tasks, and tools, including migration, large-scale deployment, security, and disaster recovery, and provides bold, nontraditional solutions.
.NET 2.0 for Delphi Programmers
.NET 2.0 for Delphi Programmers explores .NET from a Delphi programmers viewpoint, and it is ideal for Delphi programmers moving to .NET. It presents the core concepts of the .NET world in terms you are familiar with. This book will help you with Delphi for .NET as well as C#. Apress publishes migration books for both Visual Basic 6 and C++ programmers moving to .NET. Consider this the Delphi installment of Apress migration books! There is ample coverage of C# as well as Delphi for .NET inside this edition.
Latinas/os in the United States : Changing the Face of América
This book also addresses important theoretical and methodological issues related to the study of Latinas/os and presents in-depth analyses (both quantitative and qualitative) of substantive issues relevant to this population, including migration, demographic patterns and processes, education, health, citizenship, political participation, religion, gender and sex roles, literary and cultural production, and the media. The authors seek to educate and increase awareness of the diversity that exists among the Latina/o population, and to carefully examine the social, economic, demographic, cultural, and political impacts and contributions that this growing population has had in the United States. The edited volume presents a holistic and multidisciplinary perspective of this group, and it critically documents how Latinas and Latinos have changed and will continue to change the face of América.
Land-Change Science in the Tropics : Changing Agricultural Landscapes
Land use and land-cover change research over the past decade has focused mainly on contemporary primary land-cover conversions in the tropics and sub-tropics, with considerable resources dedicated to the explanation and prediction of tropical deforestation and often ignoring the dynamism in the world’s agro-pastoral landscapes. This collection integrates cutting-edge research in the social, biogeophysical, and geographical information sciences to understand the human and environmental dynamics that change the type, magnitude and location of land uses and land covers in the changing countryside.This book describes the monitoring of land-cover changes, explains the processes through which land is altered, and describes the development of spatially-explicit models to predict land change. This book illustrates how practitioners have integrated knowledge from the three scientific realms - social, biophysical, and GIScience - that underpin land-change science.
Kinship and Demographic Behavior in the Past
This book examines the role of kinship and the family’s influence on the health outcomes of their children, their children’s selection of marriage partners, couples having higher order births or reduced fertility, individual migration and origins of populations. Mortality patterns are examined to determine the influence of fertility patterns on parents’ mortality, the contribution of parents’ longevity to their children’s lifespan, and the whether a family history of disease affects the risk of dying from that same disease.This volume emphasizes the importance of studies that include and compare other factors related to social organization with information on multi-generational families. The authors elucidate previous explanations and provide provocative new results. Such intergenerational research is crucial in understanding long term demographic trends and processes.
Junge Perspektiven der Türkeiforschung in Deutschland = Young perspectives of Turkey research in Germany
This volume creates an interdisciplinary forum for contemporary Turkey research in Germany. It presents research results from young scientists who are characterized by a fresh view of Turkey, methodological diversity and interdisciplinary approaches. The volume thus contributes to a better understanding of the society, politics, economy, history and culture of the country, which is playing an increasingly important role both regionally and in the European context.
Climate Change and Community Resilience : Insights from South Asia
Documents myriads of ways community-based climate change adaptation and resilience programs are being implemented in South Asian countries. The narrative style of writing in this volume makes it accessible to a diverse audience from academics and researchers to practitioners in various governmental, non-governmental and international agencies. At a time when climate change presents humanity with a gloomy future, the stories of innovation, creativity, grassroots engagement and locally applicable solutions highlighted in this book provides insights into hopeful ways of approaching climate solutions.
Cities between competitiveness and cohesion : Discourses, realities and implementation
The book shows that spatial and urban policy continues to be a key site of policy intervention and experimentation. Different national welfare systems, political cultures, and socio-economic conditions combine and recombine to address policy problems and opportunities. Collectively, the authors argue that the examined policy initiatives reflect and reproduce these broader changes and shifting ways of thinking about the appropriate relationships between citizens, businesses, and the state.
