الصفحة 1
الصفحة 1
Tissue Engineering in Oral and Maxillofacial Surgery
This book provides a thorough, up-to-date description of the scientific basis and concepts of tissue engineering in the oral and maxillofacial region. Tissue Engineering in Oral and Maxillofacial Surgery will be of interest to all researchers and practitioners who wish to learn more about the potential of tissue engineering to revolutionize practice in oral and maxillofacial surgery.
The regeneration in dentistry with scaffolds application
Examines recent developments and new ideas influencing dental treatment, from scaffold-mediated tissue regeneration to individualized dentistry. Learn how cutting-edge methods, biomaterials, and minimally invasive approaches are transforming patient outcomes and the restoration of dental health.
The Cancer Degradome : Proteases and Cancer Biology
Proteolysis is now known to be integral to many aspects of cancer biology,including angiogenesis, regulation of the bioavailability of growth factors, cellular adhesion, cytokine/chemokine signalling, inflammatory cell recruitment, and the mobilization of normal cells from their tissue compartments to act as accomplicesin metastasis. The last decade has witnessed a revolution in our thinking concerning the role of extracellular proteolysis in cancer biology: this is the primary focus of this book.
Targeted interference with signal transduction events
Lay out the state of development of tomorrow's cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities.
Regulation of carcinogenesis, angiogenesis and metastasis by the proprotein convertases (PCs) : A new potential strategy in cancer therapy
The purpose of this book is to provide detailed and updated information on the role of these molecules in cancer. This book is the first to summarize current knowledge about the importance of protein precursors maturation by the convertases in tumor progression, angiogenesis and metastasis. In each chapter, the importance of the convertases in the activation of various cancer-related molecules including growth factors, adhesion molecules and proteases is discussed. Also this book covers the role of some convertases in the clinical setting.
Platelet-Rich Plasma (PRP): Therapy and Applications
Platelet-Rich Plasma (PRP) is a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline with the full complement of growth factors and other plasma proteins, the purpose of this research is to evaluate and summarize literature, with particular focus on rejuvenation process, these include regeneration of soft tissue, skin aging mechanisms, as well as wound healing and a study reported in burns. Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds.
Pharmacological applications of hematopoietic growth factors
Hematopoietic growth factors constitute an important group of proteins that predominantly regulate the process of hematopoiesis. Several factors are approved for clinical use in various indications while others are under investigation in the clinic either alone or as combination therapy. The aim of this paper is to review hematopoietic stem cell main growth factors such as erythropoietin, G-CSF, Thrombopoietin, and their medical applications that are approved for human use and intended to treat many diseases.
Periodontology and dental implantology
Addresses the role of the oral healthcare provider in interprofessional communication in the systemic management of autoimmune bullous disease-associated conditions. A study involving chemically modified tetracyclines and host modulation with nonsurgical and surgical periodontal therapy, including postoperative pain management, is presented here. Therapeutic strategies of stem cell application in bone tissue engineering and the potential of platelet-rich fibrin-sourced growth factors in periodontal procedures to enhance wound healing and regeneration are also proposed. Supportive implant maintenance and regenerative processes are explored. Management of the endoperiodontal lesion is also discussed (note: the recent periodontal classification has not been referenced here). The book explores the best transdisciplinary practices for the management of special healthcare needs patients.
Percutaneous Collagen Induction With Microneedling : A Step-by-Step Clinical Guide
Percutaneous Collagen Induction with Microneedling is a minimally invasive technique widely used to treat numerous dermatologic conditions such as facial and body scars, melasma, wrinkles, skin laxity, stretch marks, alopecies, vitiligo and scleroderma. Microneedling can also be used to optimize transdermal drug delivery for many substances. This technique uses modern microneedling devices containing multiple fine needles, typically 0.5 to 2.5 mm in length, which are mounted on a barrel and rolled onto the skin to create numerous perforations into the stratum corneum and the papillary dermis. These micro-wounds initiate the release of growth factors, triggering collagen and elastin formation, which results in dermal remodeling and skin resurfacing. This book provides a step-by-step approach to microneedling, based on the authors’ more than ten years of experience with the technique.
Oral Implantology Review : A Study Guide ; 2nd ed. [Team-IRA]
Features over 800 practical questions on oral implantology, including over 100 new questions on medical evaluation of the patient, bone grafting, growth factors and platelet concentrates, and zygomatic and pterygoid implants. These new topics supplement the robust contents from the first edition, covering medical problems, biomedical sciences, radiology and computer-assisted technology, anatomy, biomechanics, patient data, treatment planning, principles of implantology, bone and soft tissue grafting, implant prosthodontics and occlusion , esthetics, maintenance, pharmacology, and complications. This book is perfect for board review or simply to sharpen your mind for all things implantology.
Obesity and Cancer
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development.
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
This book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies
Molecular advances in dental pulp tissue engineering
Recent advances in regenerative medicine and tissue engineering aim to restore the dentin–pulp complex using stem cells, growth factors and tailored scaffolds to achieve biological regeneration within the root canal. This Special Issue highlights scientific advances in pulp regeneration, bridging the gap between research and clinical application.
Metastasis of Breast Cancer
The book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies.
Immunogenetics of Autoimmune Disease
Utoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage ment approaches
Hormones and the brain
Peripheral hormones have a major impact on the brain: they are able to interfere with its development, to affect release of neurotransmitters and concentrations of receptors, to trigger growth factors involved in lesion repair. These multiple actions account for their capacity to modulate a number of physiological parameters, from reproductive functions to memory, behaviour and aging. Depending upon intensity and duration of exposure, they can be either neuroprotective or neurotoxic, for instance by affecting production of free radicals. This book, based on contributions of pioneer investigators in the field, outlines the ambiguous actions of gonadal steroids (estradiol, progesterone, testosterone, inhibin and activin) and of neurosteroids, related moieties produced in the brain itself. After summarizing their multiple mechanisms of action, which involve both direct effects on neuronal membranes and activation of genes coding for specific proteins in neurons or glial cells, the book outlines the role of hormones in pathogenic processes such as mental disturbances or neurodegenerative diseases.
Facilitative glucose transporters in articular chondrocytes : Expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory Cytokines
In this multidisciplinary article we review the molecular and morphological aspects of GLUT expression and function in chondrocytes and their mesenchymal and embryonic stem cell precursors and propose key roles for these proteins in glucose sensing and metabolic regulation in cartilage.
Etiology and Morphogenesis of Congenital Heart Disease : From Gene Function and Cellular Interaction to Morphology
This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration
Breast cancer chemosensitivity
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
Bone augmentation in implant dentistry : A step-by-step guide to predictable alveolar ridge and sinus grafting
Implant dentistry has evolved tremendously over the past three decades and is rapidly progressing as new materials and protocols become available each year. With the number of advancements made in digitally based media and marketing, it is imperative that the clinician is able to separate new trends from evidence-based protocols to make sound and predictable choices for the ultimate benefit of patients. This textbook presents cases from the author's 35-year practice to show the successes and failures of various treatment approaches and protocols. Early chapters discuss the relevant biomaterials and instruments utilized for bone augmentation protocols, including barrier membranes, bone grafting materials, and growth factors. Surgical chapters dedicated to extraction socket management, alveolar ridge augmentation, and sinus grafting follow, each chapter detailing specific indications and patient selection criteria as well as step-by-step surgical procedures, aspects of postoperative treatment, and complications. The final chapter focuses on full-arch reconstruction using fully guided immediate reconstruction protocols. The author's teaching institute is credited with preparing some of the world's best clinicians, and this book will pave the way for countless more.
