الصفحة 1
الصفحة 1
Multiple pregnancy
Multiple pregnancy affects 0.9-3.1% of births worldwide. Prevalence rates vary significantly due to differences in dizygotic twinning rates and use of assisted reproduction. Both maternal and fetal/neonatal complications are more common in multiple compared to singleton pregnancies, and there are specific problems for the fetuses related to monochorionicity. Multiple pregnancies require specialised and individualised care. Complicated multiple pregnancies should be managed in a tertiary care centre where there is additional expertise, such as the laser ablation needed to treat monochorionic monozygotic pregnancies with conjoined circulations. Cornerstones of management in pregnancy are the need for accurate fetal measurement to optimise dating of gestational age, and documentation of chorionicity. High-level ultrasound expertise is needed. The mothers need frequent assessment to detect hypertension and anemia, and early identification and management of preterm labour.
Fetus abnormalities relating drug
Drugs use in pregnancy remains a major public health problem. Fetal teratogenicity results from the effect of these substances during fetal development, particularly when used in combination. Approximately 3-5% of live births are complicated by a birth defect each year totaling around 120,000 babies. Additionally, more women taking any kind of medication has more than doubled in the last 30 years. Current evidence suggests that between 65%-94 % of women take at least one prescription drug during pregnancy. Nearly 70% of women are taking a medication in the first trimester during organogenesis. On average, women are taking 3 medications in pregnancy with over 50% of women using four or more. This includes over the counter medications and herbal supplements. During pregnancy, drugs are often required to treat certain disorders.
