الصفحة 1
الصفحة 1
Open access databases and datasets for drug discovery
With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process.
Ontologies for Software Engineering and Software Technology
The editors structured the contributions into three parts: first, a detailed introduction into the use of ontologies in software engineering and software technology in general; second, the use of ontologies to conceptualize different process-related domains such as software maintenance, software measurement, or SWEBOK, initiated by IEEE; third, the use of ontologies as artifacts in several software processes, like, for example, in OMG’s MOF or MDA.
One Hundred Years of Intuitionism (1907-2007) : The Cerisy Conference
With logicism and formalism, intuitionism is one of the main foundations for mathematics proposed in the twentieth century; and since the seventies, notably its views on logic have become important also outside foundational studies, with the development of theoretical computer science. The aim of the book is threefold: to review and complete the historical account of intuitionism; to present recent philosophical work on intuitionism; and to give examples of new technical advances and applications of intuitionism.
On the construction of engineering handbooks : With an Illustration from the railway safety domain
This book is the first to reflect upon the question of how to construct a desktop handbook. It is demonstrated how concept analysis can be used for identifying settled knowledge as the key ingredient by utilizing the assembled data for classification; a presentation scheme for handbook articles is developed and demonstrated to be suitable. The sketched approach is then illustrated by an example from the railway safety domain. Finally, the limitations of the presented methods are discussed.
On color
Investigates color from numerous perspectives: literary, historical, cultural, anthropological, philosophical, art historical, political, and scientific. In ten lively and wide-ranging chapters, each devoted to a different color, they examine the various ways colors have shaped and continue to shape our social and moral imaginations. Each individual color becomes the focal point for a consideration of one of the extraordinary ways in which color appears and matters in our lives. Beautifully produced in full color, this book is a remarkably smart, entertaining, and fascinating guide to this elusive topic.
olution Sets for Net Zero Energy Buildings : Feedback from 30 Buildings Worldwide
Presents a unique study of 30 NZEBs that have been constructed and have had their performance measured for at least 12 months. The study is based upon an international collaborative research initiated by the International Energy Agency. It is the first book to evaluate building strategies in houses, educational buildings and offices that have been demonstrated to work in practice. It examines how the design challenges of climate and building type have been addressed, and to what extent the various design approaches have been successful. This book presents convincing evidence that a careful re-thinking of conventional design norms can achieve a far greater performance benefit than is normally feasible. It identifies 'solution sets' that work at the whole building level and at the individual building design challenge level for each climate and building type. In doing so, the book provides guidance as to how to improve the design by learning from these cases. Unusually for a book of this type it has examples of buildings in what are conventionally labeled 'hot' and 'cold' climates.
Oil and Security : A World Beyond Petroleum
This book examines the economic impact of changes in the global demand and supply for fossil fuels both on the major producers in Middle Eastern countries around the Persian Gulf, other producers, as well as the world at large. The economic, social and political life of most countries is not only intimately linked to and influenced by the energy market but also affected by historical developments. Among other issues, it shows how the economic, social and political development of societies in Arabia, the peoples of the Arab Peninsula are influenced by their historic and cultural environment, and what the future may bring to this region when their principal economic assets, petroleum and gas, start to lose markets as alternative sources of fossil fuel, alternative, and renewable energy supply the bulk of global energy needs. It also describes how changing fossil fuel costs, access, security of supply, and environmental impacts may affect future economic, social, and political developments as well as technological advances and changes in priorities.
Occlusal splints for painful craniomandibular dysfunction
Bridges that gap, presenting a practical guide for the treatment of craniomandibular dysfunction (CMD)—a functional disorder that affects the muscles of mastication, temporomandibular joints, and/or occlusion—in patients with related pain. The first half of the book provides detailed but simple clinical instructions and examples of occlusal splint therapy, including splint fabrication and coordinative training for painful CMD, based entirely on a high level of evidence. The second half delves deeper into the etiology, advanced diagnostic techniques, neurobiology, and pathophysiology of painful CMD and splint therapy.
Obstetrics in Family Medicine : A Practical Guide
The key points for each topic are summarized in tabular form for quick reference, and diagnostic flow charts illuminate all aspects of the decision-making process. Expert advice based on years of experience is also presented concerning physical and ultrasound examinations, laboratory tests, drug toxicities, and screening techniques.
Obstetric medicine : A problem-based approach
This book is a collection of exam questions and case studies which illustrates both common and more unusual problems in obstetric medicine. Using a problem–based approach to both teach and test knowledge, it incorporates many different approaches to obstetric medicine, in Q & A format. The ‘Extended Matched Questions’ section covers the breadth of theoretical knowledge. The ‘Short Answers / Data Interpretation’ section requires a systematic approach to a clinical problem. Most of the case reports are based on real cases and all are accompanied by a brief literature review to further broaden the learning experience.
Observing justice : Digital transparency, openness and accountability in criminal courts
Examines how major but often under-scrutinised legal, social, and technological developments have affected the transparency and accountability of the criminal justice process. The book proposes a framework for open justice which prioritises public legal education and justice system accountability
Object-Oriented Programming Languages : Interpretation
This comprehensive examination of the main approaches to object-oriented language explains the key features of the languages in use today. Class-based, prototypes and Actor languages are all looked at and compared in terms of their semantic concepts. In providing such a wide-ranging comparison, this book provides a unique overview of the main approaches to object-oriented languages.
Nutritional psychiatry : A primer for clinicians
There is increasing evidence that mental health problems such as schizophrenia, depression and anxiety are linked with poor nutrition. At present, very few psychiatrists provide nutritional advice for their patients, despite such advice complimenting drug and psychological therapies. This edited volume is the first book to provide a comprehensive overview of the relationship between nutrition and mental health, for mental health professionals. Featuring contributions from leading authorities in the field, the book examines the link between diet and the microbiome-gut brain axis and how this correlates with a variety of psychiatric disorders. The book explores how enhancing the beneficial bacteria in the gut, through the use of psychobiotics, prebiotics or dietary change can improve mood and reduce anxiety.
Nursing Care of the Pediatric Neurosurgery Patient
Nursing Care of the Pediatric Neurosurgery Patient serves as a detailed reference for all nurses caring for children with neurosurgical problems. Staff nurses (and student nurses) working in clinics, PICU, pediatrics, operating rooms, post-anesthesia care units, emergency department and radiology will benefit from the information presented in this book. The explanations of pathophysiology, anatomy, radiodiagnostic testing and treatment options for each neurosurgical diagnosis will help them to understand the rationale behind the nursing care. Presenting symptoms and findings on neurological examination and history will enable nurses to identify normal signs. Each chapter includes information on patient and family education and will give helpful guidelines.
Numerical Simulation in Molecular Dynamics : Numerics, Algorithms, Parallelization, Applications
Particle models play an important role in many applications in physics, chemistry and biology. They can be studied on the computer with the help of molecular dynamics simulations. This book presents in detail both the necessary numerical methods and techniques (linked-cell method, SPME-method, tree codes, multipole technique) and the theoretical background and foundations. It illustrates the aspects modelling, discretization, algorithms and their parallel implementation with MPI on computer systems with distributed memory. Furthermore, detailed explanations are given to the different steps of numerical simulation, and code examples are provided.
Numerical Methods Using Java : For Data Science, Analysis, and Engineering
Covers a wide range of topics, including chapters on linear algebra, root finding, curve fitting, differentiation and integration, solving differential equations, random numbers and simulation, a whole suite of unconstrained and constrained optimization algorithms, statistics, regression and time series analysis. The mathematical concepts behind the algorithms are clearly explained, with plenty of code examples and illustrations to help even beginners get started. You will: Program in Java using a high-performance numerical library / Learn the mathematics for a wide range of numerical computing algorithms / Convert ideas and equations into code / Put together algorithms/ and classes to build your own engineering solution / Build solvers for industrial optimization problems / Do data analysis using basic and advanced statistics
Numerical Methods for Laplace Transform Inversion
Operational methods have been used for over a century to solve many problems—for example, ordinary and partial differential equations. In many problems it is fairly easy to obtain the Laplace transform, but it can be very demanding to determine the inverse Laplace transform that is the solution of the given problem. Sometimes, after some difficult contour integration, we find that a series solution results, but even this may be quite difficult to evaluate in order to get an answer at a particular time value.
Numerical Methods for General and Structured Eigenvalue Problems
The purpose of this book is to describe recent developments in solving eig- value problems, in particular with respect to the QR and QZ algorithms as well as structured matrices. Outline Mathematically speaking, the eigenvalues of a square matrix A are the roots of its characteristic polynomial det(A??I). An invariant subspace is a linear subspace that stays invariant under the action of A. In realistic applications, it usually takes a long process of simpli?cations, linearizations and discreti- tions before one comes up with the problem of computing the eigenvalues of a matrix. In some cases, the eigenvalues have an intrinsic meaning, e.g., for the expected long-time behavior of a dynamical system; in others they are just meaningless intermediate values of a computational method. The same applies to invariant subspaces, which for example can describe sets of initial states for which a dynamical system produces exponentially decaying states. Computing eigenvalues has a long history, dating back to at least 1846 when Jacobi [172] wrote his famous paper on solving symmetric eigenvalue problems. Detailed historical accounts of this subject can be found in two papers by Golub and van der Vorst [140, 327].
Numerical Mathematics and Advanced Applications ENUMATH 2019 ; European Conference, Egmond aan Zee, The Netherlands, September 30 - October 4
It contians basic aspects and new trends in numerical mathematics and scientific and industrial applications, all examined at the highest level of international expertise.
Numerical Linear Algebra
This book brings together linear algebra, numerical methods and an easy to use programming environment under Matlab (or Scilab). One of the key features of the book are the worked out examples and exercises at the end of each chapter. The reader is asked to do some numerical experiments in Matlab and then to prove the results theoretically. The book is a combination and update of two earlier French books by the authors. It is appropriate for both undergraduate and beginning graduate courses in mathematics as well as for working scientists and engineers as a self-study tool and reference.This book is about numerical linear algebra and focuses on practical algorithms for solving computer problems of linear algebra.
