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الصفحة 1
الصفحة 1
Alternative Splicing and Disease
Splicing of primary RNA transcript, i.e. removal of introns and joining of exons to produce mature mRNAs competent for translation into proteins, is a quasi-systematic step of gene expression in higher organisms. However, this process is not unequivocal but can follow alternate pathways. Alternative splicing of a given transcript can therefore yield several distinct mRNAs encoding as many different proteins. Its full biological significance has not been appreciated until it was recognized that alternative splicing is so general as to affect about 75% of all human genes. Therefore, alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences.
List decoding of error-correcting codes : Winning thesis of the 2002 ACM doctoral dissertation competition
Presents some spectacular new results in the area of decoding algorithms for error-correcting codes. Specifically, it shows how the notion of “list-decoding” can be applied to recover from far more errors, for a wide variety of err- correcting codes, than achievable before. A brief bit of background : error-correcting codes are combinatorial str- tures that show how to represent (or “encode”) information so that it is - silient to a moderate number of errors. Speci?cally, an error-correcting code takes a short binary string, called the message, and shows how to transform it into a longer binary string, called the codeword, so that if a small number of bits of the codewordare ?ipped, the resulting string does not look like any other codeword. The maximum number of errorsthat the code is guaranteed to detect, denoted d, is a central parameter in its design. A basic property of such a code is that if the number of errors that occur is known to be smaller than d/2, the message is determined uniquely. This poses a computational problem, called the decoding problem : compute the message from a corrupted codeword, when the number of errors is less than d/2.
An Introduction to Language Processing with Perl and Prolog : An Outline of Theories, Implementation, and Application with Special Consideration of English, French, and German
This book teaches the principles of natural language processing, first covering linguistics issues such as encoding, entropy, and annotation schemes; defining words, tokens and parts of speech; and morphology. It then details the language-processing functions involved, including part-of-speech tagging using rules and stochastic techniques; using Prolog to write phase-structure grammars; parsing techniques and syntactic formalisms; semantics, predicate logic and lexical semantics; and analysis of discourse, and applications in dialog systems. The key feature of the book is the author's hands-on approach throughout, with extensive exercises, sample code in Prolog and Perl, and a detailed introduction to Prolog. The reader is supported with a companion website that contains teaching slides, programs, and additional material.
