الصفحة 1
الصفحة 1
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Big data analytics and machine intelligence in biomedical and health informatics : Concepts, methodologies, tools and applications

Provides coverage of developments and state-of-the-art methods in the broad and diversified data analytics field and applicable areas such as big data analytics, data mining, and machine intelligence in biomedical and health informatics. Covers the latest advances and developments in health informatics, data mining, machine learning, and artificial intelligence. They have been organized with respect to the similarity of topics addressed, ranging from issues pertaining to the Internet of Things (IoT) for biomedical engineering and health informatics, computational intelligence for medical data processing, and Internet of Medical Things??(IoMT).

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AI in clinical practice : A guide to artificial intelligence and digital medicine

Explains how artificial intelligence is applied to medicine, illustrating not only its enormous potential but also ancillary issues and the limits and risks inherent in its use on a large scale. The book focuses on the intersection between medicine and AI and its implications on the impact of human health care delivery. Topics discussed include wearable devices, health data, Internet of Things, virtual reality, robotic assistance system, and digital intelligence in the health sector. Additionally, sections discuss diagnostics and decision-making systems and machine/deep learning in clinical setting.

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Management of Acute Pulmonary Embolism

Management of Acute Pulmonary Embolism highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel. The authors critically review and interpret available data, and provide clear recommendations for diagnosis and therapeutic concerns in clinical management of PE patients. Management of Acute Pulmonary Embolism is organized in three precise sections - diagnosis, treatment, and special topics. Each section is up-to-date and detailed, and provides clear recommendations for diagnostic and therapeutic approaches to patients with PE in clinical practice. This practical volume is an essential starting point for future study for both medical students and established investigators.

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Machine learning for neurodegenerative disorders : advancements and applications

Explores the application of machine learning to the understanding, early diagnosis, and management of neurodegenerative disorders. With a specific focus on its role in ongoing clinical trials, the book covers essential topics such as data collection, pre-processing, feature extraction, model development, and validation techniques. It delves into the applications of neuroimaging techniques like magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) in the diagnosis and understanding of neurodegenerative disorders. Additionally, the book examines various machine-learning algorithms employed for biomarker discovery in neurodegenerative disorders. It highlights the role of neuroinformatics and big data analysis in advancing the understanding and management of neurodegenerative disorders. Furthermore, the book reviews future prospects and presents the ethical considerations and regulatory challenges associated with implementing machine learning approaches in the diagnosis, treatment, and prevention of neurodegenerative disorders.

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Low-Dose Radiation Effects on Animals and Ecosystems : Long-Term Study on the Fukushima Nuclear Accident

Brings together the works of radiation biologists and ecologists to provide reliable radioecology data and gives insight into future radioprotection. The book examines the environmental pollution and radiation exposure, and contains valuable data from abandoned livestock in the ex-evacuation zone and from wild animals including invertebrates and vertebrates, aqueous and terrestrial animals, and plants that are subjected to long-term exposure in the area still affected by radiation. It also analyzes dose evaluation, and offers new perspectives gained from the accident, as well as an overview for future studies to promote radioprotection of humans and the ecosystem.

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Living Rivers : Trends and Challenges in Science and Management

All over the world, sustainable river basin management is a leading principle of policy plans and legal instruments for water management (e.g. the European Water Framework Directive). The evidence, however, to underpin the full scope of sustainability is rather scanty. In this book an integrative perspective on trends and challenges in river science and management is demonstrated. The three pillars underneath sustainable water management, ecology, economy and sociology, are elaborated by experts in their fields. A number of papers integrate the current knowledge on the structure, functioning and management of ‘living rivers’. The book includes data and experiences concerning the rivers Allier, Meuse, Rhine, Sava and Tagliamento in Europe and the river Illinois in the USA. Sustainable river basin management asks for un-orthodox rehabilitation programmes and ecosystem based and transboundary management approaches.

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Les infections intra-abdominales aiguës = Acute intra-abdominal infections

Paradoxically, serious intra-abdominal infections are the forgotten ones in the world of infectious diseases. Paradoxical, because they are very common pathologies, affecting all age groups of the population and often life-threatening; paradoxical, because they concern many medical specialties through intensive care, gastroenterology, hepatology, imaging, infectious diseases, emergencies and surgery. Hence the need, thanks to an interdisciplinary collaboration, to publish a book in French bringing together all infectious abdominal pathologies, thus offering a synthesis of recent data from the literature in this field. This document should allow the various specialties concerned to find updates integrating the latest clinical, diagnostic and therapeutic data. Specialty interns and practitioners in the field will find something to establish an effective and up-to-date strategy for the management of patients with these pathologies, the high incidence of which and the severity of which is too often overlooked, it is important to remember.

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Le cancer du sein = Breast cancer

The reader will find there both a synthetic summary of the current state of knowledge of epidemiology, risk factors and pathological aspects as well as a presentation of the surgical aspects, in particular, of the new approach that constitutes the sentinel node procedure. Radiotherapy, in a practical view, is divided into essential clinical questions. The medical treatment is then discussed according to the different situations encountered on a daily basis. Particular attention is of course paid to recent data both with the contribution of hormone therapy and targeted therapies. Finally, the symptomatic treatments and especially the psychological care of these patients are not forgotten.

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Lake Taihu, China : Dynamics and Environmental Change

There are many shallow lakes in the world. Many of them play an important socio-economic role as contributors to the drinking water supply, in flood attenuation, fisheries and recreation activities. Because of the current anthropogenic changes in the environment, such lakes rapidly respond to eutrophication and swamping. It is often hard to address these issues because many changes in the ecosystems of shallow lakes are associated with little studied physical processes. This interaction between the aquatic biota and the physical and chemical environment increases the complexity of shallow lake ecosystems. Lake Taihu, located in the delta of Yangtze River, is a typical large, shallow eutrophic lake with area of 2338 km2 and maximum depth of less than 3m . This book provides basic data on various aspects of this lake and summarizes research work on the interaction between its ecology and physical limnology. It will be a reference for teachers and students of freshwater ecology and biology, the aquatic environment in general, and, most strikingly, for all those interested in physical limnology.

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La lombalgie en 2007 : Aspects pratiques = Low back pain in 2007 : Practical aspects

Low back pain is one of the main reasons for consultation, whether in general or specialized medicine. It poses a real public health problem. This "back pain", which can despair patients and doctors by its sometimes rebellious character, explains the multiplicity of examinations sometimes practiced and the treatments implemented. This work is a collection of the most recent developments in terms of physiopathological knowledge of disc involvement, clinical examination and the place of surgery and in particular disc prostheses. An update concerns the indications and contributions of additional examinations; some formidable diagnostic traps are mentioned. Medical treatments such as infiltrations, manipulations, the benefit of restraints and the provision of acupuncture are being developed. Also discussed are the latest scientific data on isokinetic evaluation and retraining, as well as the role of sports activity as a factor in the prevention or aggravation of low back pain. Finally, the medico-legal aspect is dealt with in the context of work accidents, and the assessment after trauma. This book is the result of the collaboration and experience of undisputed specialists in this field.

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L’insuffisance rénale aiguë = Acute renal failure

The aim of this book is to make current data from the experimental and clinical literature accessible to readers. More than a thousand articles are published each year on the theme and the authors aim to synthesize this information. These data relate in particular to the identification of early markers of renal dysfunction without which screening, recognition of the main pathophysiological determinants and prevention remain uncertain. This book focuses attention on clinical situations characterized by the renal impact of the main dysfunctions of vital functions, the prognosis of which is worsened by the occurrence of this renal failure. The following will be treated in particular: the renal consequences of oxidative stress, the renal consequences of respiratory dysfunction, cardiac dysfunction, hepatic dysfunction, alterations in hemostasis, septic shock and hemorrhagic shock. Finally, the physiopathological data from experimental models are gradually finding their echo in the clinical field, opening up therapeutic avenues whose recent evaluations will be analyzed.

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Computational biology in drug discovery and repurposing

Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin

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Computational and Statistical Approaches to Genomics

Computational and Statistical Approaches to Genomics, 2nd Edition, aims to help researchers deal with current genomic challenges. During the three years after the publication of the first edition of this book, the computational and statistical research in genomics have become increasingly more important and indispensable for understanding cellular behavior under a variety of environmental conditions and for tackling challenging clinical problems. In the first edition, the organizational structure was: data à analysis à synthesis à application. In the second edition, the same structure remains, but the chapters that primarily focused on applications have been deleted.

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Complement and Kidney Disease

It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.

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Comparative Placentation : Structures, Functions and Evolution

Science produces fascinating puzzles: why is there such a range of placental structures when other mammalian organs are so structurally uniform ? Why and how did the different placental structures evolve ? Comparative placental studies can facilitate the identification of the common factors in placental growth, differentiation and function and their relevance to possible evolutionary pathways. Comparative Placentation is the only book presenting up-to-date data illustrating the great variety of structure but uniform function of vertebrate placentas from fish to man. This information is essential for selection of suitable models to investigate particular practical problems of impaired or anomalous growth in human and animal placentation. The unique collection of the best light and electron micrographs from the last thirtyfive years which precisely illustrate the structural range in each taxon, make the book the most authoritative publication in this field and a vital source of information for anyone interested on reproductive physiology, anatomy and medicine.

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Community-Acquired Pneumonia

Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.

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Clinical Neuroembryology : Development and Developmental Disorders of the Human Central Nervous System

Combines data from human embryology, animal research and developmental neuropathology. This book provides an overview of the development of the human Central Nervous System (CNS) in the context of its many developmental disorders due to genetic, environmental and hypoxic causes. It highlights numerous clinical cases and contains over 400 figures.

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Clinical Management of Renal Tumors

Clinical Management of Renal Tumors provides an in-depth review of the data relating to the management of renal tumors as well as an updated description regarding pathologic and molecular classification of renal tumors.

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Clinical decision support systems : Theory and practice

Writes the editor, "If used properly, CDSS have the potential to change the way medicine has been taught and practiced." As clinical decision support systems (CDSS) gain an increasingly central role in the delivery of high quality health care, it becomes more important for the health care community to understand their use. This text is designed as a resource for practicing clinicians, informaticians, teachers and students alike, and provides the most current, comprehensive look a the development and evaluation of clinical decision support systems.

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Clinical Cardiac MRI

MRI has become the preferred noninvasive imaging modality for the heart and great vessels. The substantial technological progress achieved in recent years has provided the user with state of the art MRI systems, but their optimal use can be limited by restricted awareness of the potential patient benefit and the necessity for teaching. This extensively illustrated volume, has been specifically compiled to meet these needs. Essential theoretical background information is provided, and imaging acquisition and potential pitfalls are considered in detail. Most importantly, structured guidelines are provided on the interpretation of clinical data in the wide range of cardiac pathology that can be encountered. Throughout, the emphasis is on the implementation of cardiac MRI in clinical practice.

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