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Antibiotic pharmacokinetic : Pharmacodynamic considerations in the critically Ill
Provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.
.NET 2.0 Interoperability Recipes : A Problem-Solution Approach
.NET represents a new and improved way of developing software for the Windows platform. Given the chance, you'd probably rewrite all of your existing code in the newer managed code environment that .NET provides. But it is difficult or impossible to throw out all existing legacy code and start over when a new technology arrives. Instead, you need to find a way to move forward with new .NET development while reusing existing pieces of tested, working code. You need a way to interoperate with the existing code until you have a chance to finally rewrite all of it in .NET.
Managing Development and Application of Digital Technologies : Research Insights in the Munich Center for Digital Technology & Management (CDTM)
Digital technology determines today’s world and will be one of the key technologies of the future. Successful technology development, introduction and management are not only a question of technical issues; due to their complexity a close cooperation between different scientific disciplines is required to discuss various consequences, chances and risks from manifold points of view as a starting point for the design of adequate solutions. The ability to integrate business and technology decisions will become a crucial core competence.
Challenges for Central Banks in an Enlarged EMU
In this book, a set of internationally renowned economists from both sides of the Atlantic analyse the challenges that lie in front of the EU as it used to be, the hurdles that have to be cleared by possible candidates, and the impact of these developments on important economic sectors like the financial markets, etc. The scientists are supported by Central Bankers from current and future Euro-zone members who give their views on the problems and chances of Euro-accession. The book is thus providing an overall view of the major developments regarding the Euro in the years to come.
A Contingency-Based View of Chief Executive Officers' Early Warning Behaviour : An Empirical Analysis of German Medium-Sized Companies
Organizations need to identify risks and chances of environmental changes in order to adapt to or possibly even to influence them. Early warning which comprises scanning and interpretation plays an important role in this process. Whereas the traditional contingency approach considers early warning as a part of the organizational structure, the extended contingency theory assumes the additional influence of an individual’s personality on early warning. Andreas Kirschkamp empirically analyses the early warning behavior of Chief Executive Officers in German medium-sized companies. First, he presents the design variables of early warning, then the influencing contingency variables. On the basis of the scholarly research on psychological and contingency theory, the author deduces hypotheses and tests them. The results show that early warning behavior is not only influenced by traditional contingency variables but also by personal attitudes.
La musica del Big Bang : Come la radiazione cosmica di fondo ci ha svelato i segreti dell’Universo = The music of the Big Bang : How the cosmic background radiation revealed the secrets of the Universe to us
Cosmic microwave background radiation is the residue of the great heat following the Big Bang. A tenuous sign, over 13 billion years old, in which the answers to many of the questions about the nature of our Universe are hidden. Discovered by chance in 1964, in the last forty years this fossil trace of the origins of the Cosmos has been explored with every available means. Two Nobel Prizes in physics have already been awarded for research involving it, the last in 2006 for the results of the COBE satellite. Much of the information encoded in the cosmic background radiation was impressed by the superimposition of acoustic waves present in the early Universe: a "music" of the Big Bang, which cosmologists have tried for years to reconstruct, using techniques similar to those that allow to distinguish the sound of different musical instruments. Only recently have the first notes of this extraordinary cosmic symphony finally been revealed, but the investigation is not over yet. This book illustrates, with a language suitable even for non-specialists, the theories, observations and discoveries that have brought cosmology into a new era.
La correspondance entre Henri Poincaré et les physiciens, chimistes et ingénieurs = The correspondence between Henri Poincaré and physicists, chemists and engineers
Cosmic microwave background radiation is the residue of the great heat following the Big Bang. A tenuous sign, over 13 billion years old, in which the answers to many of the questions about the nature of our Universe are hidden. Discovered by chance in 1964, in the last forty years this fossil trace of the origins of the Cosmos has been explored with every available means. Two Nobel Prizes in physics have already been awarded for research involving it, the last in 2006 for the results of the COBE satellite. Much of the information encoded in the cosmic background radiation was impressed by the superimposition of acoustic waves present in the early Universe: a "music" of the Big Bang, which cosmologists have tried for years to reconstruct, using techniques similar to those that allow to distinguish the sound of different musical instruments. Only recently have the first notes of this extraordinary cosmic symphony finally been revealed, but the investigation is not over yet. This book illustrates, with a language suitable even for non-specialists, the theories, observations and discoveries that have brought cosmology into a new era.
Chance Rules : An informal guide to probability, risk and statistics
This second edition of Chance Rules again recounts the story of chance through history and the various ways it impacts on our lives. Here you can read about the earliest gamblers who thought that the fall of the dice was controlled by the gods, as well as the modern geneticist and quantum theory researcher trying to integrate aspects of probability into their chosen speciality. Example included in the first addition such as the infamous Monty Hall problem, tossing coins, coincidences, horse racing, birthdays and babies remain, often with an expanded discussion, in this edition. Additional material in the second edition includes, a probabilistic explanation of why things were better when you were younger, consideration of whether you can use probability to prove the existence of God, how long you may have to wait to win the lottery, some court room dramas, predicting the future, and how evolution scores over creationism. Chance Rules lets you learn about probability without complex mathematics.
Chance Discoveries in Real World Decision Making : Data-based Interaction of Human intelligence and Artificial Intelligence
For this book, the editors invited and called for contributions from indispensable research areas relevant to "chance discovery," which has been defined as the discovery of events significant for making a decision, and studied since 2000. From respective research areas as artificial intelligence, mathematics, cognitive science, medical science, risk management, methodologies for design and communication, the invited and selected authors in this book present their particular approaches to chance discovery. The chapters here show contributions to identifying rare or hidden events and explaining their significance, predicting future trends, communications for scenario development in marketing and design, identification effects and side-effects of medicines, etc.
Chance : The life of games and the game of life
With its many easy-to-follow mathematical examples, this book takes the reader on an almost chronological trip through the fascinating and amazing laws of chance, omnipresent in the natural world and in our daily lives. Along the route many fascinating topics are discussed, such as: challenging probability paradoxes; "paranormal" coincidences; game odds; causes and effects; interpretation of opinion polls; winning chances as a game proceeds; the nature of randomness; entropy and randomness; randomness in life; algorithmic complexity and the undecidability of randomness; possibilities and limitations of learning the laws of a Universe immersed in chance events. This charming book will inform and entertain the scientist and non-scientist alike.
Basic principles and applications of probability theory
This introductory chapter discusses such notions as determinism, chaos and randomness, p- dictibility and unpredictibility, some initial approaches to formalizing r- domness and it surveys certain problems that can be solved by probability theory. This will perhaps give one an idea to what extent the theory can - swer questions arising in speci?c random occurrences and the character of the answers provided by the theory. 1. 1 The Nature of Randomness The phrase “by chance” has no single meaning in ordinary language. For instance, it may mean unpremeditated, nonobligatory, unexpected, and so on. Its opposite sense is simpler: “not by chance” signi?es obliged to or bound to (happen). In philosophy, necessity counteracts randomness. Necessity signi?es conforming to law – it can be expressed by an exact law. The basic laws of mechanics, physics and astronomy can be formulated in terms of precise quantitativerelationswhichmustholdwithironcladnecessity.
At the crossroads : The world trading system and the Doha Round
Since its foundation in 1995 the legitimacy of the WTO – and herewith the notion of organising global trade on the basis of herewith the notion of organising global trade on the basis of concepts like trade-liberalisation, treaty-based rule of law and concepts like trade-liberalisation, treaty-based rule of law and enforceability – is challenged for very different reasons this volume not only documents the proceedings of this conference but, against the backdrop of the ongoing efforts to revive the Doha Round wants to be understood as some sort of stocktaking: What did really go wrong in Cancún? Where does the WTO stand today? Has there been any progress made since? And, finally: Is there any chance left to reach the ambitions goals postulated by the Doha Development Agenda? These and other, related questions are being discussed in the volume at hand.
Astroparticle physics
The book describes the branch of astrophysics in which processes in the universe are investigated with experimental methods known from particle physics experiments. After a historical introduction to the basics of elementary particles, their interactions and the relevant detection techniques are described. The main body of the book concerns cosmic rays. The modern aspects of astroparticle physics are described in a chapter on cosmology. The book provides an orientation in the field of astroparticle physics that many beginners might look for. The physics issues are presented with little mathematics, and the results are illustrated by many diagrams. The reader has a chance to enter this field of astrophysics with a book that closes the gap between expert and popular level.
A History of Chinese Mathematics
It includes many new recent insights and illustrations, a new appendix on Chinese primary sources and a guide to the to the bibliography. From the reviews: "This book ranks with the most erudite Asian publications, and is the most informative and most broadly informed on its topic in any language.this book apart from the usual histories of mathemathics (in any language, Chinese or Western, of any period or country) is its emphasis first on context, then on content, in describing the long history of Chinese mathematics. It is primarily the question of context that Martzloff approaches directly. Perhaps the greatest contribution his book makes is the chance it offers to consider issues of cultural context as significant, determining factors in the history of mathematics.
