الصفحة 1
الصفحة 1
The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis, and Cancer
Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
Plant Microtubules : Development and Flexibility
Plant microtubules are key elements of cell growth, division and morphogenesis. In addition to their role in plant development and architecture, they have emerged as regulatory elements of signalling and important targets of evolution.Since the publication of the first edition of Plant Microtubules in 2000, our understanding of microtubules and their manifold functions have advanced substantially. Consisting of the following three parts, this book highlights the morphogenetic potential of plant microtubules from three general viewpoints: Microtubules and Morphogenesis: control of cell axis during division and expansion, cross-talk with actin filaments, mechanical properties of the cell wall. Microtubules and Environment: the role of microtubules during the sensing or response of environmental factors such as pathogens or abiotic stresses. Microtubules and Evolution: complexity and specialization of plant microtubules in the context of plant evolution.
Pharmacological applications of hematopoietic growth factors
Hematopoietic growth factors constitute an important group of proteins that predominantly regulate the process of hematopoiesis. Several factors are approved for clinical use in various indications while others are under investigation in the clinic either alone or as combination therapy. The aim of this paper is to review hematopoietic stem cell main growth factors such as erythropoietin, G-CSF, Thrombopoietin, and their medical applications that are approved for human use and intended to treat many diseases.
Molecular Targeting in Oncology
In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice. The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more. Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.
Anti Cancer medicines derived from plants
Cancer is a broad term. It describes the disease that results when cellular changes cause the uncontrolled growth and division of cells. Some types of cancer cause rapid cell growth, while others cause cells to grow and divide ata slower rate. Certain forms of cancer result in visible growths called tumors, while others, such as leukemia, do not. Most of the body’s cells have specific functions and fixed lifespans. While it may sound like a bad thing, cell death is part of a natural and beneficial phenomenon called apoptosis.
