Clinical applications of botulinum toxin

Botulinum toxin (BoNT) is a neurotoxin produced by the Gram-positive, rod-shaped, sporeforming anaerobic bacterium Clostridium botulinum. Although there are seven major serotypes of Botulinum Neurotoxin (BoNT/A-G), only type A and B are used clinically. For the purpose of this research paper, we will refer to this agent as BoNT. This research paper primarily serves to provide a historical review of the toxin, assess its mechanism of action, and highlight the most common clinical applications of BoNT therapy across multiple medical specialties in an organized, specialty-based manner, including their complications and recommended BoNT dosages.