الصفحة 1
الصفحة 1
Modern treatments for chronic blood diseases
Blood is a body fluid in humans and other animals that delivers necessary substances such as nutrients and oxygen to the cells and transports metabolic waste products away from those same cells. In vertebrates, it is composed of blood cells suspended in blood plasma. Plasma, which constitutes 55% of blood fluid, is mostly water (92% by volume), and contains proteins, glucose, mineral ions, hormones, carbon dioxide (plasma being the main medium for excretory product transportation), and blood cells themselves. Albumin is the main protein in plasma, and it functions to regulate the colloida osmotic pressure of blood. The blood cells are mainly red blood cells (also called RBCs or erythrocytes), white blood cells (also called WBCs or leukocytes) and platelets (also called thrombocytes). Thalassemias are inherited blood disorders characterized by decreased hemoglobin production Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result in feeling tired and pale skin. There may also be bone problems, an enlarged spleen, yellowish skin, and dark urine. Slow growth may occur in children.
Curcumin : clinical uses, health effects and potential complications
Curcumin is a natural product with polyphenolic structure. It is used in therapeutic remedies alone or in combination with other natural substances. Many researchers are investigating it because of its biological activities such as: anti-inflammatory, anti-cancer, anti-protozoal, anti-viral, anti-bacterial and has been found to be effective for treatment of Alzheimer, depression, headaches, fibromyalgia, leprosy, fever, menstrual problems, water retention, worms and kidney problems etc. It is an active ingredient in dietary spice, turmeric. It has reactive functional groups: a diketone moiety and two phenolic groups. Despite its unique biological activities, it suffers from some shortcomings which include: gastrointestinal problems, poor bioavailability due to its poor absorption, short half-life, poor solubility in aqueous solutions, rapid systemic elimination and antithrombotic activity which can interfere with blood clotting. The first chapter of this book reviews the different delivery systems used for incorporation of curcumin and its derivatives, release kinetics and up to date in vivo results. Chapter two discusses curcumin nano and microencapsulation and its implications on clinical uses.
Anti-phospholipid Syndrome
APS is an autoimmune disorder characterized by an increased tendency to form abnormal blood clots and Obstetrical morbidity wish cause to multi- miscarriages for women having this syndrome. Patients with Anti-Phospholipid Syndrome usually treated with multidrug regime depending mainly on Anticoagulant drugs, Anti Platelet Drugs and Immunomodulators Drugs. We aim in this project to talk about the Anti-Phospholipid Syndrome, what is patients’ symptoms, how is this disease diagnosed, and what drugs used in treatment and some information about the drug used in the treatment.
Anticoagulants and coronary artery disease
Blood thinners are medicines that help blood flow smoothly through your veins and arteries. There are two. The first is called anticoagulants (Warfarin, Heparin, Enoxaparin) and The second class of blood thinners is called antiplatelet (Aspirin, Ticagrelor , Clopidogrel). . Coronary arteries supply blood to the heart muscle. Coronary artery disorder or disease can have serious implications by reducing the flow of oxygen and nutrients to the heart muscle. This can lead to a heart attack and possibly death. Atherosclerosis. Medications to reduce the risk of blood clots, such as anticoagulants (including aspirin) and antiplatelet. , in particular aspirin, are effective in preventing platelet activation and thus thrombus formation and Clopidogrel is an inhibitor of platelet activation.
Anticoagulants
Anticoagulant are drugs that, when added to blood, prevents it from clotting. It does this by suppressing the synthesis or function of various clotting factors that are normally present in the blood. These drugs are frequently used to prevent the formation of blood clots (thrombi) in the veins or arteries or the enlargement of a clot that is circulating in the bloodstream. Anticoagulants are very effective in preventing life-threatening conditions...
