الصفحة 1
الصفحة 1
Molecular recognition in pharmacology
Traces the behavior of the drug substance, starting from the initial pre-contact stage, and ending with the formation of the complex. Molecular recognition lies in the foundation of every life form and includes many mysteries. Currently, studies on this topic in pharmacology are limited to determining the properties of complexes of medicinal substances (drugs) with specific (complementary) biomolecules: receptors, enzymes, ion channels etc. The results present the mechanisms preventing drugs from such non-specific binding. This direction is very fruitful, although the phenomenon of molecular recognition is far wider.
Molecular analysis of B lymphocyte development and activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
IPv6 in Practice: A Unixer's Guide to the Next Generation Internet
This book is a practical guide to IPv6 addressing Unix and network administrators with experience in TCP/IP(v4) but not necessarily any IPv6 knowledge. It focuses on reliable and efficient operation of IPv6 implementations available today rather than on protocol specifications. Consequently, it covers the essential concepts - using instructive and thoroughly tested examples - on how to configure, to administrate, and to debug IPv6 setups.
Introduction to Central Banking
This book gives a concise introduction to the practical implementation of monetary policy by modern central banks. It describes the conventional instruments used in advanced economies and the unconventional instruments that have been widely adopted since the financial crisis of 2007–2008. Illuminating the role of central banks in ensuring financial stability and as last resort lenders, it also offers an overview of the international monetary framework. A flow-of-funds framework is used throughout to capture this essential dimension in a consistent and unifying manner, providing a unique and accessible resource on central banking and monetary policy, and its integration with financial stability.
Insecticides Design Using Advanced Technologies
Among the highlights of this book are the use of nanotechnology to increase potency of available insecticides, the use of genetic engineering techniques for controlling insect pests, the development of novel insecticides that bind to unique biochemical receptors, the exploration of natural products as a source for environmentally acceptable insecticides, and the use of insect genomics and cell lines for determining biological and biochemical modes of action of new insecticides.
Immune receptors : Methods and protocols
Explores immune cell receptors that are used in the detection of microbes, either by binding directly to non-self molecules or through indirectly sensing microbe-associated cellular disturbances. The covers methods for studying receptor-ligand interactions at both molecular and cellular levels; methods to create and characterize novel antibody reagents; and methods to characterize the molecular processes that lead to adaptive receptor maturation. This book also contains chapters that look at high-throughput strategies that describe the diversity of immune receptors and cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Hydrogen bonded polymers
Control of polymeric structure is among the most important endeavours of modern macromolecular science. In particular, tailoring the positioning and strength of intermolecular forces within macromolecules by synthetic me- odsandthusgaining structuralcontrolover the'nalpolymeric materials has become feasible, resulting in the ?eld of supramolecular polymer science. - sides other intermolecular forces, hydrogen bonds are unique intermolecular forces enabling the tuning of material properties via self-assembly processes, The important contribution of hydrogen bondstotheareaofsupramole- lar polymer chemistry is de'nitely outstanding, most of all since the potency of hydrogen-bonding systems has been found to be unique in relation to other supramolecular interactions.
Guide to Biomolecular Simulations
Molecular dynamics simulations have become instrumental in replacing our view of proteins as relatively rigid structures with the realization that they were dynamic systems, whose internal motions play a functional role. Over the years, such simulations have become a central part of biophysics. Applications of molecular dynamics in biophysics range over many areas. They are used in the structure determination of macromolecules with x-ray and NMR data, the modelling of unknown structures from their sequence, the study of enzyme mechanisms, the estimation of ligand-binding free energies, the evaluation of the role of conformational change in protein function, and drug design for targets of known structures.
Governing knowledge : A study of continuity and change in higher education : A Festschrift in Honour of Maurice Kogan
In this book, an international group of leading higher education researchers draw on a wealth of social theory and comparative, empirical research to analyse current developments and their implications. Different contributions focus on different levels of higher education, the system, the institution and the academic practitioner, in different national and international contexts. However, strong common themes bind these contributions together. They include not only the significance of massification, globalisation, neo-liberalism and managerialism for the governance of higher education, its knowledge and values, but also the complexities of change processes, the importance of context and history and the strength of the stabilities that remain.
Foundation Flex for Developers : Data-Driven Applications with PHP, ASP.NET, ColdFusion, and LCDS
Flex is a very powerful and versatile technology for creating web application front-ends. But what every good web application needs is a robust data source, be it XML, or a database. Flex is very adaptable in terms of connecting to data sources, and that is the main focus of this book. In Foundation Flex for Developers, author Sas Jacobs assumes that you've got the basics of Flex down already, and explores in detail how to create professional data-centric Flex 2 and Flex 3 applications. In the first half of the book, she starts off with a brief exploration of Flex and ActionScript 3.0, before looking at application essentials in detail—creating custom components, user and web browser interactions, binding, formatting, and validating data, debugging, and more. In the second half of the book, the focus is on connecting Flex to data sources, and covers XML, LiveCycle Data Services, PHP, ASP.NET, and ColdFusion in detail, via a series of step-by-step case studies.
Fixed orthodontic appliances : A practical guide
This guide to fixed appliance-based orthodontics is designed to serve as a comprehensive ‘how to’ manual. It will offer detailed support on the use of fixed orthodontic appliances with practical orthodontic treatments, while providing a valuable refresher and reference for more experienced clinicians.
Financial market imperfections and corporate decisions : Lessons from the transition process in Hungary
The book presents the results of an empirical investigation of the behaviour of Hungarian firms during the transition process focusing in particular on the role of financial market imperfections for corporate capital structure and investment decisions. The results suggest that financial market reforms have succeeded, albeit partially, in hardening firms's budget constraints and improving the efficiency of the credit allocation process. In particular, following the introduction of the banking sector reform and of the new bankruptcy law, budget constraints became more binding for small private firms, while informational costs became less relevant for foreign-owned firms.
Ferro- and Antiferroelectricity : Order/Disorder versus Displacive
Solid-state systems are frequently classi?ed according to their physical, str- tural or chemical properties. Such schemes are extremely helpful since pr- erties related to any such classi?cation are typically known and facilitate id- tifying solids with special material classes. The best-known examples of these schemes are conductivity or resistivity measurements by means of which m- als are easily distinguishable from insulators. However, frequently clear-cut decisions between material classes are not possible, since anisotropy, chemical composition, binding forces and local effects wash out distinct properties and lead to competition or coexistence. Such unresolved situations are especially typical for transition metal oxides that exhibit a variety of ground-state properties in a fascinating way.
Epigenome editing : Methods and protocols
This second volume details new and updated methods covering applications of epigenome editing. Chapters guide readers through general and topical reviews, DNA-binding devices, optimization of the effector domains, readout of epigenome marks, and approaches for delivery at the cellular and organismal level. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Encyclopedia of Genetics, Genomics, Proteomics and Informatics
It includes about 56% more words than the 1,392-page 2nd edition of 2003. The number of illustrations increased to almost 2,000 and their quality has improved by design and four colors. Cross-references among entries are expanded. The statements are supported by references; more than 14,000 journal papers and more than 3,000 books are listed. The book includes ~1,800 current databases and web servers. Retractions and corrigenda are pointed out.It covers the basics and the latest in genomics, proteomics, genetic engineering, small RNAs, transcription factories, chromosome territories, stem cells, genetic networks, epigenetics, prions, hereditary diseases, patents, etc. Similar integrated information is not available in textbooks or on the Internet. The journal reviews called it the best, high-quality resource for researchers, instructors and students of basic and applied biology, as well as for physicians and lawyers or even for interested laymen because of the clarity of presentation.
Electromagnetic Aquametry : Electromagnetic wave interaction with water and moist substances
This book covers all aspects of Electromagnetic Aquametry. It summarizes the wide area of metrology and its applications in electromagnetic sensing of moist materials. The physical properties of water in various degrees of binding interacting with electromagnetic fields is presented by model systems. The book describes measurement methods and sensors in the frequency domain, TDR-techniques for environmental problems, methods and sensors for quality assessment of biological substances, and nuclear magnetic resonance techniques
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
Distributed computing – IWDC 2005 ; 7th International Workshop, Kharagpur, India, December 27-30, 2005, Proceedings
This book constitutes the refereed proceedings of the 7th International Workshop on Distributed Computing, IWDC 2004, held in Kharagpur, India in December 2005. The 28 revised full papers and 33 revised short papers presented together with 5 invited keynote talks were carefully reviewed and selected from 253 submissions. The papers are organized in topical sections on theory of distributed computing, sensor networks, fault tolerance, optical networks, peer-to-peer networks, wireless networks, network security, grid and networks, middleware and data management, mobility management, and distributed artificial intelligence.
Dioxygen Binding and Sensing Proteins : A Tribute to Beatrice and Jonathan Wittenberg
Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments.This book is dedicated to Jonathan’s and Bea’s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
Data Mining in Bioinformatics
8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biological research has shifted from genome sequences to protein functionality. Withwhole-genomedraftsofmouseandhumaninhand,scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erent tissues, its3Dstructure and activesites,its functionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support.
