الصفحة 1
الصفحة 1
Neuropsychiatric Disorders : An Integrative Approach
This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.
Molecular Neurosurgery with Targeted Toxins
Focuses on the highly successful use of the immunotoxins, 192 IgG-saporin and ME20.4-saporin, to lesion the cholinergic basal forebrain in order to model the behavior, anatomy, physiology, and pharmacology of Alzheimer's disease in animals. Also discussed are the uses of anti-DBH-saporin immunotoxin to make remarkably selective lesions of catecholaminergic neurons, hypocretin-saporin that can produce narcoleptic animals, and other saporin conjugates, such as neuropeptide-saporin conjugates for pain research and cholera toxin B chain-saporin to produce a model of central nervous system demyelination. Overview perspectives and, in some cases, more practical details are provided that allow the reader to appreciate exactly what is involved in using these agents. Both practical and theoretical, Molecular Neurosurgery With Targeted Toxins provides readers with not only the background to understand these techniques, but also numerous real-life examples that can be readily adapted to new purposes and an ever-increasing number of new targeted toxins.
Intramembrane-Cleaving Proteases (I-CLiPs)
The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.
Inflammation in the Pathogenesis of Chronic Diseases : The COX-2 Controversy
In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors.
Fullerene and Alzheimer disease
Patients have suffered for a long time from Alzheimer's disease. The presence of some obstacles in treatment, which prompted us to talk in this research on one of the modern treatments for this disease, which is fullerene. The focus was in some detail on its structure and characteristics, in addition to its applications. We especially mention its application in the treatment of Alzheimer's. This was a new step in the world of medicine and pharmacy.
Exploring the Vertebrate Central Cholinergic Nervous System
The volume’s eleven chapters cover a wide variety of topics including the complexity of synthesis of acetylcholine, cholinesterases, cholinergic teratology, anticholinesterase agents, clinical use of cholinergic drugs, central cholinergic pathways and behaviors with cholinergic correlates. The figures and diagrams help illustrate various subjects and its photographs of "cholinergikes" of the past and present bring a personal note to the book. The book illustrates the peaks that have been reached in the course of the history of cholinergic research and challenges the perennial frontier of human science: the understanding of ourselves.
Evidence-Based Imaging : Optimizing Imaging in Patient Care
Evidence-Based Imaging: Optimizing Imaging for Patient Care presents the radiologist and clinician with a user-friendly guide to the evidence-based science and the merit behind the diagnostic imaging studies performed in medicine. The book provides a systematic framework for understanding the best imaging choices for patient care.
Estrogen Effects in Psychiatric Disorders
A number of studies, mostly focusing on estrogen replacement therapy in women, have reported beneficial actions of these hormones on various neurobiological and neuropathological parameters in health and disease. Recent research has focused on gender differences and there is increasing evidence that estrogens exert protective effects in schizophrenia. Hormonal fluctuations or lack of estrogen may increase the risk of depression among vulnerable women. Treatment of depression with estrogen may stabilize and restore disrupted homeostasis – as during post-partum, premenstrual, or perimenopausal conditions – and act as a psychomodulator to offset vulnerability to dysphoric mood when estrogen levels are significantly decreased, as in the case of postmenopausal women. Studies on the effect of estrogens on Alzheimer’s Disease are still rather controversial, they do, however, facilitate the hypothesis that estrogens may have a modifying effect on the onset and course of AD, at least in subgroups of patients.
DNA Repair and Human Disease
DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.
Diffusion-Weighted MR Imaging of the Brain
Diffusion-weighted MR imaging is widely accepted as a means to identify stroke, thus enabling rapid and effective treatment. Over the past four years, these expert authors have presented over 30 exhibits and scientific reports on diffusion-weighted imaging at the RSNA and the American Society of Neuroradiology (ASNR), and more than 10 of these presentations have been recognized by specific awards. Diffusion-Weighted MR Imaging of the Brain’s chapters range from basic principles to interpretation of diffusion-weighted MR imaging and specific disease.
Clinical Pharmacology of Sleep
This volume covers the clinical and pharmacological treatment of several important sleep disorders such as insomnia, sleep apnea, narcolepsy, restless legs syndrome, and periodic limb movement syndrome. It further addresses the use of sleep medications in children, adolescents, and in the elderly. It offers a comprehensive overview of the currently available hypnotic medications and covers aspects of chronopharmacology and its implications for the pharmacology of sleep. It also reviews the basic science of sleep and sleep disorders, and thus the potential development of new pharmacological approaches. The book will be useful for physicians, psychopharmacologists, psychiatrists, sleep disorder specialists and other healthcare professionals such as nurses, social workers and graduate medical students.
Alzheimers disease : Cellular and molecular aspects of Amyloid beta
This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy)
Alzheimers Disease : Advances in genetics, molecular and cellular biology
Alzheimer’s Disease: Advances in Genetics, Cellular and Molecular Biology provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. The studies and advances described in this volume will help to accelerate the process of rational drug discovery and soon serve to extend and enhance the mental health and lifespan of our burgeoning elderly population.
Alzheimers Disease
Alzheimer’s disease (AD) is a neurodegenerative disease that robs the minds of our elderly population. Approximately one in every eight adults over the age of 65 and nearly half of those over 85 are afflicted with this disease. The aging population in developed societies will impose an ever increasing socioeconomic threat in the future. Current medicines for AD patients are mainly symptomatic treatments and a huge unmet medical need exists to slow the progression of this disease. A great deal of research has been dedicated to understanding the pathogenesis of AD from which comes many ideas for intervening with its progression. Some of these ideas have been fast-tracked to clinical trials due to the availability of medicines with proven clinical efficacies for other diseases (e.g. atorvastatin, simvastatin, rosiglitazone and clioquinol) while others represent novel chemical entities (e.g. glycogen synthase kinase-3 inhibitors).
Alzheimer : 100 Years and Beyond
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4th, 1906 in Tübingen. The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiative of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, at the very site of the original lecture, namely the Institute of Psychiatry at the University of Tübingen in Germany from November 2nd to 5th, 2006, was the highlight of the Alzheimer Year. Over the last century of Alzheimer research (1906-2006), remarkable progress has been achieved. Most of the authors of the major discoveries and the people involved in research in this field will present, during the meeting and in this volume, the pioneering research explaining the conditions under which they were conducted. The goal of this book is to honor the work accomplished, to summarize the most important knowledge and to provide material for the history of science.
Abeta Peptide and Alzheimers Disease : Celebrating a Century of Research
Abeta Peptide and Alzheimer’s Disease summarizes current knowledge of beta-amyloid peptide (Aß) and its role as the major culprit in Alzheimer’s Disease (AD), shown by recent advances in genetics and brain biochemistry.the book covers fundamental biochemical studies on the Aß peptide, the genetic impact on Aß expression and processing, and various AD therapeutic strategies that target Aß. Although specifically focusing on Aß and AD, there is also some discussion on the similarity and differences of this peptide and AD with other amyloidogenic diseases.
