تحسين النتائح
ترتيب حسب
من
الى
الصفحة 1
الصفحة 1
La scuola dell’atopia = The school of atopy
The need to clarify the current concepts of atopy, which for too long have oscillated between a primitive purely clinical vision and a subsequent purely immunological one, had been ripe for some time. Understanding that the role of immunoglobulins E is not exhaustive and accepting the Solomonic division between intrinsic and extrinsic atopy were the first two fundamental steps. Recent discoveries of the role of innate immunity, and therefore of antimicrobial peptides, have opened fundamental spaces for understanding in atopy and beyond. What now appears clear is that atopy is not the disease of an organ but rather a defect in the membranes that delimit our "self". The fact that these membranes are called skin, intestines, conjunctiva, bronchi or whatever has artificially fragmented the understanding and treatment of a unitary phenomenon. This book seeks to summarize the different experiences but above all to be a stimulus to ensure that medicine focuses constructively on the same target. If this is the case, we will no longer see "religious wars" between scientists and practicing doctors or, even worse, between the different specialists vying for the patient. If atopy, as we believe, is a global problem, it can only be adequately addressed in a multidisciplinary context and in a collaborative atmosphere, not only between doctor and doctor but also between doctor and patient.
Cell Division Control in Plants
The molecular mechanisms controlling cell cycle progression are highly conserved in eukaryotes. In addition to the basic protein machinery involved in cell cycle regulation, higher plants have also evolved unique molecular mechanisms that allow integration of environmental, physiological, and developmental signals into networks to control proper cell division and expansion. Rapid and exciting research progress in these fields has been achieved from experimental observations on plants over the past decade. The scope of this volume is focused on the molecular basis of all aspects of cell division and cytokinesis in plants. It is an essential reference book for instructors and scientists working in the areas of molecular, cell, and developmental biology of plants. The editors of this book are veterans in the field of plant molecular biology and highly respected worldwide.
Cell cycle control : Methods and protocols
Collects techniques to study the highly regulated cell cycle process. Beginning with chapters investigating these processes and assessing how cells respond when these complicated pathways are simplified by using synthetic biology and in vitro reconstitutions, the book continues by exploring how cells sense and respond to environmental conditions, different model systems and cellular types used to visualize cellular architecture during cell division, as well as innovative single cell microscopy techniques to highlight the heterogeneity of the cell population with respect to cell cycle progression. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cell and Molecular Biology of Plastids
The present book provides a comprehensive overview of our current knowledge on plastid biogenesis, plastid-nuclear communication, the regulation of plastid gene expression at all levels, and also assesses the state of the art in key technologies, such as proteomics and chloroplast transformation. Written by recognized experts in the field, it covers plastid differentiation and division, genome structure and function, plastid inheritance, recombination, DNA replication and repair, transcription, RNA processing and translation as well as crucial posttranslational processes in plastid biogenesis and function, including protein processing, the assembly of multiprotein complexes, protein stability and degradation, protein import and sorting.
Asymmetric Cell Division
Cell biologists have recently become aware that the asymmetry of cell division is an important regulatory phenomenon in the fate of a cell. During development, cell diversity originates through asymmetry; in the adult organism asymmetric divisions regulate the stem cell reservoir and are a source of the drift that contributes to the aging of organisms with renewable cell compartments. Because of the concept of semi-conservative DNA synthesis, it was thought that the distribution of DNA between daughter cells was symmetric. The analysis of the phenomenon in cells during mitosis, however, revealed the asymmetry in the distribution of the genetic material that creates the drift contributing to aging of mammals. On the other hand, cancer cells can originate from a deregulation of asymmetry during mitosis in particular during stem cell expansion. The book describes the phenomenon in different organisms from plants to animals and addresses its implications for the development of the organism, cell differentiation, human aging and the biology of cancers.
Apoptosis, cell signaling, and human diseases : Molecular mechanisms ; Vol.1
Volume 1 is divided into two sections: “Malignant Transformation and Metastasis” and “Molecular Basis of Disease Therapy.” Volume 2 follows a similar structure and is divided into sections entitled “Kinases and Phosphate” and “Molecular Basis of Cell Death.” All of the contributors are at the forefront of scientific discovery, and the reviews they present systemically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.
Actin-Binding Proteins and Disease
This volume, written by experts in the field, is the first to deal with the relationship between human disease and the actin cytoskeleton. It provides overviews of actin and selected actin-binding proteins, and then focuses on diseases that involve these proteins. Specific chapters deal with actin, cofilin, profilin, gelsolin and thymosin ¾4. Other chapters discuss the roles of multiple actin-binding proteins in cancer and metastasis, leukocyte disorders, and heart failure, and there is a chapter that describes how intracellular pathogens use the host actin cytoskeleton. This seminal volume is intended for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Classifications and lists in oral and maxillofacial surgery
Contains a concise collection of the most important oral and maxillofacial surgery classifications and lists. Such classifications help to describe diseases in a comprehensible, measurable, validated and reproducible manner and are the first step towards a systematic approach for treating specific conditions. Elsewhere in this book, lists provide clinical guidance on key subspecialty topics. Using subdivisions such as trauma, head and neck cancer, and orthognathic surgery, this is a succinct and easy-to-use guide for the head and neck clinician.
Kolmogorovs Heritage in Mathematics
A.N. Kolmogorov (b. Tambov 1903, d. Moscow 1987) was one of the most brilliant mathematicians that the world has ever known. Incredibly deep and creative, he was able to approach each subject with a completely new point of view: in a few magnificent pages, which are models of shrewdness and imagination, and which astounded his contemporaries, he changed drastically the landscape of the subject.Most mathematicians prove what they can, Kolmogorov was of those who prove what they want. For this book several world experts were asked to present one part of the mathematical heritage left to us by Kolmogorov.
Knowledge and Civil Society
Focuses on the role of civil society in the creation, dissemination, and interpretation of knowledge in geographical contexts. It offers original, interdisciplinary and counterintuitive perspectives on civil society. The book includes reflections on civil and uncivil society, the role of civil society as a change agent, and on civil society perspectives of undone science. Conceptual approaches go beyond the tripartite division of public, private and civic sectors to propose new frameworks of civic networks and philanthropic fields, which take an inclusive view of the connectivity of civic agency across sectors.
Comparative Perspectives on Work-Life Balance and Gender Equality : Fathers on Leave Alone
This book portrays men’s experiences of home alone leave and how it affects their lives and family gender roles in different policy contexts and explores how this unique parental leave design is implemented in these contrasting policy regimes. The book brings together three major theoretical strands: social policy, in particular the literature on comparative leave policy developments; family and gender studies, in particular the analysis of gendered divisions of work and care and recent shifts in parenting and work-family balance; critical studies of men and masculinities, with a specific focus on fathers and fathering in contemporary western societies and life-courses. Drawing on empirical data from in-depth interviews with fathers across eleven countries, the book shows that the experiences and social processes associated with fathers’ home alone leave involve a diversity of trends, revealing both innovations and absence of change, including pluralization as well as the constraining influence of policy, gender, and social context.
Bioactive Marine Natural Products
Bioactive Marine Natural Products is the first book available that covers all aspects of bioactive marine natural products. It fills the void in the literature for bioactive marine natural products. The book covers various aspects of marine natural products and it is hoped that all the major classes of bioactive compounds are included. Different classes of marine organisms and the separation and isolation techniques are discussed. The chemistry and biology of marine toxins, peptides, alkaloids, nucleosides and prostanoids are discussed in detail. Biological, toxicological and clinical evaluations are also dealt with to ensure that the book may be adopted at any stage by any practicing organic chemist or biologist, working in academia or in R&D divisions of pharmaceutical companies. Each chapter in the book includes an abstract to highlight the major points discussed in the text and concluding remarks are given. References to books, monographs, review articles and original papers are provided at the end of each chapter.
Archaeology at the millennium : A sourcebook
The sourcebook is divided into four substantive sections, each of which is introduced by a summary statement outlining the chapters in the section. Part I deals with the history of archaeology and the advance of archaeological theory. Part II ranges over the first four million years of our evolution as a cultural species and covers the first hominids to complex hunter-gatherers. Part III concerns the origins of agriculture and features discussions of such issues as craft production, the division of labor, warfare, and the rise of social inquality. Part IV analyzes the rise of states and empired in both the Old and New World; the archaeology of the classical Mediterranean states is also included in this section. A final chapter portends the future of archaeology.
Advances in solid state physics ; Vol. 46
Many topical talks given at the numerous symposia are included. Most of these were organized collaboratively by several of the divisions of the Arbeitskreis. The topis range from zero-dimensional physics in quantum dots, molecules and nanoparticles over one-dimensional physics in nanowires and 1d systems to more applied subjects like optoelectronics and materials science in thin films.
Advanced Linear Algebra
For the third edition, the author has added a new chapter on associative algebras that includes the well known characterizations of the finite-dimensional division algebras over the real field (a theorem of Frobenius) and over a finite field (Wedderburn's theorem); polished and refined some arguments (such as the discussion of reflexivity, the rational canonical form, best approximations and the definitions of tensor products); upgraded some proofs that were originally done only for finite-dimensional/rank cases; added new theorems, including the spectral mapping theorem; considerably expanded the reference section with over a hundred references to books on linear algebra.
A life cycle for clusters? : The dynamics of agglomeration, change, and adaption
The phenomenon of non-random spatial concentrations of firms in one or few related sectors (clusters) is intensively debated in economic theory and policy. The euphoria about successful clusters however neglects that historically, many thriving clusters did deteriorate into old industrial areas. This book studies the determinants of cluster survival by analyzing their adaptability to change in the economic environment. Linking theoretic knowledge with empirical observations, a simulation model (based in the N/K method) is developed, which explains when and why the cluster's architecture assists or hampers adaptability. It is found that architectures with intermediate degrees of division of labour and more collective governance forms foster adaptability. Cluster development is thus path dependent as architectures having evolved over time impact on the likelihood of future survival.
