الصفحة 92
الصفحة 92
Ion channels as targets in drug discovery
Built around ion channel research and, more specifically, ion channels as important therapeutic drug targets. Under the editorial leadership of Gary Stephens in academic research and Edward Stevens from industry, the aim is to bring these strands together to provide a cutting-edge translational reference on ion channel drug discovery. Exploiting our knowledge of ion channel structure and function has clear current and future potential to intervene and correct the pathophysiology associated with debilitating conditions, including cardiovascular disease, diabetes, cystic fibrosis, pain, epilepsy, and neurodegenerative disorders. Individual chapters have a disease focus, also providing a “case study story” that will also appeal to a clinical audience
Ion Channels
Ion channels play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases. Following an overview chapter summarizing the current state of ion channel screening technologies, five topics covering areas such as cancer, cardiac arrhythmias, cystic fibrosis, and pain have been selected, and the current state of knowledge is presented by leading experts in their field.
Io After Galileo : A New View of Jupiter’s Volcanic Moon
A New View of Jupiter’s Volcanic Moon is the first book dedicated to this unique satellite, and it does justice to Io’s dubious charms.a thoughtful collection of articles ranging from the history of Io exploration through the satellite’s remarkable and hostile surface geology to its interaction with the harsh Jovian environment.
Invited Lectures from the 13th International Congress on Mathematical Education
The book presents the Invited Lectures given at 13th International Congress on Mathematical Education (ICME-13). The papers present the work of prominent mathematics educators from all over the globe and give insight into the current discussion in mathematics education. The Invited Lectures cover a wide spectrum of topics, themes and issues and aim to give direction to future research towards educational improvement in the teaching and learning of mathematics education. This book is of particular interest to researchers, teachers and curriculum developers in mathematics education.
Invexity and Optimization
Invexity and Optimization presents results on invex function and their properties in smooth and nonsmooth cases, pseudolinearity and eta-pseudolinearity. Results on optimality and duality for a nonlinear scalar programming problem are presented, second and higher order duality results are given for a nonlinear scalar programming problem, and saddle point results are also presented. Invexity in multiobjective programming problems and Kuhn-Tucker optimality conditions are given for a multiobjecive programming problem, Wolfe and Mond-Weir type dual models are given for a multiobjective programming problem and usual duality results are presented in presence of invex functions. Continuous-time multiobjective problems are also discussed. Quadratic and fractional programming problems are given for invex functions. Symmetric duality results are also given for scalar and vector cases.
Investor-State Dispute Settlement and National Courts : Current Framework and Reform Options
This book examines the multiple intersections between national and international courts in the field of investment protection, and suggests possible modes for regulating future jurisdictional interactions between domestic courts and international tribunals.
Investment valuation and asset pricing : Models and methods
Offers an overview of original works on foundational asset pricing studies that follows their historical publication chronologically throughout the text. Each chapter stays close to the original works of these major authors, including quotations, examples, graphical exhibits, and empirical results. Additionally, it includes statistical concepts and methods as applied to finance. These statistical materials are crucial to learning asset pricing, which often applies statistical tests to evaluate different asset pricing models.
Investment Management and Mismanagement : History, Findings, and Analysis
These issues include performance, anomalies, market timing, suitability, and churning, among others. The construct of mismanagement is presented in light of the impact of various costs on investment returns.
Investment Banking : Valuation, LBOs, M&A, and IPOs
This book fulfills an important need as a valuable training material and reliable handbook for finance professionals in these markets. This book also provides essential tools for professionals at corporations, including members of business development, M&A, finance, and treasury departments. These specialists are responsible for corporate finance, valuation, and transaction-related deliverables on a daily basis. They also work with investment bankers on various M&A transactions (including leveraged buyouts (LBOs) and related financings), as well as IPOs, restructurings, and other capital markets transactions.
Investment Appraisal : Methods and Models
Investment decisions are of vital importance to all companies. Getting these decisions right is crucial but, due to a complex and dynamic business environment, this remains a challenging management task. Effective appraisal methods are valuable tools in supporting investment decision-making. As organisations continue to seek a competitive edge, it is increasingly important that management accountants and strategic decision-makers have a sound knowledge of these tools. This book presents a range of investment appraisal methods and models, some of which are not widely known, or at least not well covered in other books. Each approach is thoroughly described, evaluated and illustrated using examples, with its assumptions and limitations analysed in terms of their implications for investment decision-making practice.
Investing in Your 20s & 30s For Dummies
Investing in Your 20s and 30s For Dummies provides novice investors with time-tested advice, along with strategies that reflect today’s market conditions. You’ll get no-nonsense guidance on how to invest in stocks, bonds, funds, and even real estate—complete with definitions of all the must-know lingo. You’ll also learn about the latest investment trends, including using robo-advisors to manage your portfolio, relying on apps to make fast trades, and putting your hard-earned cash in digital currencies.
Investing in Private Equity Partnerships : The Role of Monitoring and Reporting
Private equity has become an important asset class for institutional investors. As the asset class grows and investors get more experienced, the debate concerning transparency and governance of private equity funds has intensified. Fund investors demand more disclosure from private equity fund managers. Are these calls justified? What information do fund investors need? How can private equity fund investors manage their exposure to the asset class effectively? Kay Müller presents an in-depth analysis into the monitoring activities of institutional investors and explores their information requirements by interviewing leading European private equity fund investors. He contrasts these results with the actual reporting by fund managers and reveals essential information gaps based on a disclosure study of private equity fund reports. Since effective and open communication supports long-lasting and trusted partnerships, these findings provide important guidance on how to improve the relationships between investors and fund managers in the private equity industry.
Investing in Movies : Strategies for Investors and Producers
Offers a broad range of guidelines on how to source interesting projects and advice on what kinds of projects to avoid, as well as numerous ways to maximize risk-adjusted returns. While focusing primarily on investments in independent films, Cohen also provides valuable insights into the studio and independent slate deals that have been marketed to the institutional investment community.
Investing in e-Health : What it Takes to Sustain Consumer Health Informatics
Investing in eHealth: What it Takes to Sustain Consumer Health Informatics examines the evolution of the IHCS and the significant changes in organizational culture and operational systems that may be required for successful and sustained implementation. This book culminates a set of general guidelines for any health care provider striving to successfully employ the model, and suggests directions for future research on the diffusion of IHCSs and related technologies. Investing in eHealth provides a principled approach to support health care managers, clinicians, and educators interested in complementing clinical services with interactive health communication systems (IHCSs).
Investing For Dummies
Investing for your future is wise and essential. Of course, you want to make solid investment choices and minimize mistakes. This updated, best-selling guide educates you on investing concepts and lingo so you can make the best decisions in all economies and markets. Understanding how to find and make smart investments is a skill that can be learned, and this book by money-pro Eric Tyson will help you by discovering how to weigh risk vs. return, offering tips on choosing stocks and funds, getting started in real estate and small business.
Investing amid low expected returns : Making the most when markets offer the least
Investing Amid Low Expected Returns: Making the Most When Markets Offer the Least provides an evidence-based blueprint for successful investing when decades of market tailwinds are turning into headwinds.
Investigative Electrocardiography in Epidemiological Studies and Clinical Trials
It reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction and epidemiological consideration of relative risks associated with ECG abnormalities. As such it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.
Investigations Into the Phenomenology and the Ontology of the Work of Art : What are Artworks and How Do We Experience Them?
This book investigates the nature of aesthetic experience and aesthetic objects. Written by leading philosophers, psychologists, literary scholars and semioticians, the book addresses two intertwined issues. The first is related to the phenomenology of aesthetic experience: The understanding of how human beings respond to artworks, how we process linguistic or visual information, and what properties in artworks trigger aesthetic experiences. The examination of the properties of aesthetic experience reveals essential aspects of our perceptual, cognitive, and semiotic capacities. The second issue studied in this volume is related to the ontology of the work of art: Written or visual artworks are a specific type of objects, containing particular kinds of representation which elicit a particular kind of experience.
Investigation and management of soft rock cliffs
Cliff recession and coastal landsliding of soft rock cliffs present significant threats to land use and development. Investigation and management of soft rock cliffs presents state-of-the-art guidance on how eroding cliffs can best be managed, stressing the need to consider both structural and non-structural solutions to cliff recession problems. This authoritative text outlines the investigation approaches, measurement and monitoring techniques, and prediction methods available for obtaining the necessary cliff recession information.
Investigating the long-run relation between crypto-currencies and other assets
Crypto-currencies are financial assets with high volatility, which calls for an investigation of the long-run relation between crypto-currencies and other assets. The present study aims to explore the long-run relation between crypto-currencies and assets such as Gold and Oil Contracts For Differences (CFDs), the CBOE volatility index (VIX) and the Dow Jones Industrial Average Index. To this purpose, we analyze this relation using the Autoregressive Distributed Lag (ARDL) approach based on quarterly data for the period between first quarter of 2011 and first quarter of 2022, and monthly data for the period between Jan. 2018 and March 2022.
