الصفحة 81
الصفحة 81
Kindling 6
A broad array of themes concerned with research on epilepsy and kindling is covered in the book: Pathogenesis of kindling, including developmental patterns; electrophysiology; anatomy, morphology, and neural circuitry; genes, species, and strains; synaptic pharmacology and neurochemistry ; Behavioral consequences of kindling ; Drugs and interventions against kindling ; Clinical relevance of kindling for our understanding of epilepsy in patients
Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
KI 2008 : Advances in Artificial Intelligence ; 31st Annual German Conference on AI, KI 2008, Kaiserslautern, Germany, September 23-26, 2008. Proceedings
This book constitutes the thoroughly refereed proceedings of the 31th Annual German Conference on Artificial Intelligence, KI 2008, held in Kaiserslautern, Germany, September 2008.The 15 revised full papers presented together with 2 invited contributions and 30 posters were carefully reviewed and selected from 77 submissions. The papers cover important areas such as pattern recognition, multi-agent systems, machine learning, natural language processing, constraint reasoning, knowledge representation and management, planning, and temporal reasoning.
Kernel Methods for Machine Learning with Math and Python: 100 Exercises for Building Logic
Addresses the fundamentals of kernel methods for machine learning by considering relevant math problems and building Python programs. The book’s main features are as follows: Includes 100 exercises, which have been carefully selected and refined. As their solutions are provided in the main text, readers can solve all of the exercises by reading the book. / The mathematical premises of kernels are proven and the correct conclusions are provided, helping readers to understand the nature of kernels. / Source programs and running examples are presented to help readers acquire a deeper understanding of the mathematics used. / Once readers have a basic understanding of the functional analysis topics covered in Chapter 2, the applications are discussed in the subsequent chapters. Here, no prior knowledge of mathematics is assumed. / Considers both the kernel for reproducing kernel Hilbert space (RKHS) and the kernel for the Gaussian process; a clear distinction is made between the two.
Jurisdiction and arbitration agreements in international commercial law
This book offers a comprehensive study of the prerequisites, effectiveness, and enforcement of exclusive jurisdiction and arbitration agreements in international dispute resolution. It examines whether jurisdiction and arbitration clauses have identical effects in private international law and whether they have been or should be given the same treatment by most countries in the world. The book considers whether the Hague Convention on Choice of Court Agreements could be treated as a litigating counterpart to the New York Convention.
Jubilee Line Extension : From concept to completion
Details the story of London Underground's award winning Jubilee Line Extension (JLE), how it came to being, how it was planned, how it was designed, built and commissioned, and how the millennium deadline imposed by the Dome was met. Always in the public eye and the political spotlight, the JLE has played a significant role in the success of the Canary Wharf development, improved public transport immeasurably in the areas of southeast and east London, and set new standards for London Underground and public transport.
Journeys to a Graveyard : Perceptions of Europe in Classical Russian Travel Writing
Journeys to a Graveyard examines the descriptions provided by eight Russian writers of journeys made to western European countries between 1697 and 1880. The descriptions reveal the mentality and preoccupations of the Russian social and intellectual elites during this period. The travellers' perceptions of western European countries are treated here as an ambivalent response to a civilization with which Russia was belatedly coming into close contact as a result of the imperial ambition of the Russian state and the westernization of the Russian elites. The travellers perceived the most advanced European countries as superior to Russia in terms of material achievement and the maturity and refinement of their cultures, but they also promoted a view of Russia as in other respects superior to the western nations. Heavily influenced from the late eighteenth century by Romanticism and by the rise of nationalism in the west, they tended to depict European civilization as moribund. By this means they managed to define their own emergent nation in a contrastive way as having youth and promising futurity.
Jets from Young Stars II : Clues from High Angular Resolution Observations
This volume contains the edited lecture notes of the Second JETSET School on Jets from Young Stars: Clues from High Angular Resolution Observations organised by the Marie Curie Research Training Network JETSET: Jet Simulations, Experiments and Theory. After the opening two chapters on jet emission, readers can learn the fundamental background of modern high-spatial-resolution techniques, and how such methods have impacted on our understanding of young stars.
JDF : Process Integration, Technology, Product Description
The arrival of PDF has successfully optimized certain elements of the production workflow – the next challenge facing the print media industry is to resolve the problem of non-networked software packages that exist in isolation. Businesses today need to identify process inefficiencies to ensure the successful process integration of the entire value added chain. The PDF document format and the vendor-independent JDF (Job Definition Format) provide the technical platform for devising new, fully integrated workflow solutions. Networking decisions involve virtually every department of a print service provider and lay down the direction of the company over the long term. These decisions offer opportunities, but they also harbor risks. If businesses are to make the right investment decisions, it is vital they have extensive background information on technical and business management issues. The authors provide focused information for decision makers looking for support in implementing networking projects successfully. This book is couched in straightforward language, explains and highlights relevant terms, and provides readers with numerous practical illustrations, graphics and checklists that they can apply to real-life applications.
IUTAM Symposium on Physicochemical and Electromechanical Interactions in Porous Media
The purpose of the IUTAM symposium from which this proceedings volume has been compiled was to dive deep into the mechanics of those porous media that involve mechanics and chemistry, mechanics and electromagnetism, mechanics and thermal fluctuations of mechanics and biology.
ITI treatment guide ; Vol.6 : Extended edentulous spaces in the esthetic zone
Provides clinical recommendations for implant-supported prosthodontic treatments in patients with multiple missing adjacent teeth in the esthetic zone. The authors review the current literature before detailing the treatment alternatives and procedures based on the scientific and clinical evidence. Special emphasis is given to preoperative evaluation, treatment planning, and assessment of risk factors for the complex indications of the esthetic zone. Descriptions of the surgical and prosthodontic procedures include step-by-step clinical case presentations. Complications of various etiologies are also highlighted with preventive measures as well as clinical cases that document their management.
ITI treatment guide ; Vol.10 : Implant therapy in the esthetic zone: Current treatment modalities and materials for single-tooth replacements
Dental implants are used routinely throughout the world to replace missing teeth. With the broadening of treatment options and an increasing number of clinicians who provide implant therapy, it is important to ensure that the treatment methods used meet the highest clinical standards. The ITI Treatment Guide series is a compendium of evidence-based implant-therapy techniques and procedures for daily practice.
Computational biology in drug discovery and repurposing
Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin
Computational and Instrumental Methods in EPR
This volume is devoted to both instrumentation and computation aspects of EPR, while addressing applications such as spin relaxation time measurements, the measurement of hyperfine interaction parameters, and the recovery of Mn(II) spin Hamiltonian parameters via spectral simulation.
Comprehensive utilization of magnesium slag by pidgeon process
This book introduces the harmless handling/recycling of magnesium slag , the process of magnesium silicothermic reduction (Pidgeon process)which the slag was produced, and . the magnesium resources, layout of the industry of the world. Examples and experimental data in this book are from the author group’s research programs, as well as the rencent researches in China. The book could provide precious reference to scientists and engineers in the field of recycling and environment friendly use of the industrial solid wastes. It could also be used for researchers and students who are interested in relevant field.
Comprehensive biochemistry for dentistry : Textbook for dental students
Combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitamins and hormones, enriched with flow charts and diagrams for easy understanding and quick reference. It includes chapters on nucleic acids, nutrition and serum enzymes and organ function tests, and offers an innovative approach to familiarize dental students with the biochemical composition of enamel, dentine, cementum and saliva, explaining the biochemical basis of dental caries, periodontal diseases, role of fluorides in caries prophylaxis, fluoride toxicity, and the role of amino acids as anti-hypersensitive agents
Composites with micro- and nano-structure : Computational modeling and experiments
The book contains atomistic and continuum numerical methods and experimental validation for composite materials reinforced with particles or fibres, porous materials, homogenization and other important topics for research in this field.
Composite Materials : Properties as Influenced by Phase Geometry
This book deals with the mechanical and physical behavior of composites as influenced by composite geometry. This monograph provides a comprehensive introduction for researchers and students to modern composite materials research with a special emphasis on the influence of geometry to materials properties. Composite Materials enables the reader to a better understanding of the behavior of natural composites, improvement of such materials, and design of new materials with prescribed properties.
Complications and quandaries in the ICT sector : Standard essential patents and competition issues
Talks about how the regulatory agencies and courts in the United States, European Union and India are dealing with the rising allegations of anti-competitive behaviour by standard essential patent (SEP) holders. It also discusses the role of standards setting organizations / standards developing organizations (SSO/SDO) and the various players involved in implementing the standards that influence practices and internal dynamics in the ICT sector. The book includes discussions on fair, reasonable and non-discriminatory (FRAND) licensing terms and the complexities that arise when both licensors and licensees of SEPs differ on what they mean by “fair”, “reasonable” and “non-discriminatory” terms. It also addresses topics such as the appropriate royalty base, calculation of FRAND rates and concerns related to FRAND commitments and the role of Federal Trade Commission (FTC) in collaborative standard setting process.
Complexity in chemistry, biology, and ecology
This book, written by an international team of experts, introduces the reader to various aspects of complexity theory and its applications. It illustrates the latest trends in science to go beyond the mechanistic Newtonian view of the world by shifting the focus to self-organization, adaptation, and emergent phenomena. The authors discuss these properties of complex systems in biology, ecology and chemistry along with the structure and interconnectedness of the "layers" of complexity. The qualitative description is complemented by a discussion of methods for complexity quantification. Networks are covered in detail as a universal language of the complex world.
