الصفحة 8
الصفحة 8
Methods of Celestial Mechanics: Vol. I: Physical, Mathematical, and Numerical Principles
G. Beutler's Methods of Celestial Mechanics is a coherent textbook for students in physics, mathematics and engineering as well as an excellent reference for practitioners. This Volume I gives a thorough treatment of celestial mechanics and presents all the necessary mathematical details that a professional would need. After a brief review of the history of celestial mechanics, the equations of motion (Newtonian and relativistic versions) are developed for planetary systems (N-body-problem), for artificial Earth satellites, and for extended bodies (which includes the problem of Earth and lunar rotation). Perturbation theory is outlined in an elementary way from generally known mathematical principles without making use of the advanced tools of analytical mechanics. The variational equations associated with orbital motion - of fundamental importance for parameter estimation (e.g., orbit determination), numerical error propagation, and stability considerations - are introduced and their properties discussed in considerable detail. Numerical methods, especially for orbit determination and orbit improvement, are discussed in considerable depth. The algorithms may be easily applied to objects of the planetary system and to Earth satellites and space debris.
Methods of Celestial Mechanics ; Vol. II : Application to Planetary System, Geodynamics and Satellite Geodesy
G. Beutler's Methods of Celestial Mechanics is a coherent textbook for students as well as an excellent reference for practitioners. Volume II is devoted to the applications and to the presentation of the program system CelestialMechanics. Three major areas of applications are covered: (1) Orbital and rotational motion of extended celestial bodies. The properties of the Earth-Moon system are developed from the simplest case (rigid bodies) to more general cases, including the rotation of an elastic Earth, the rotation of an Earth partly covered by oceans and surrounded by an atmosphere, and the rotation of an Earth composed of a liquid core and a rigid shell (Poincaré model). (2) Artificial Earth Satellites. The oblateness perturbation acting on a satellite and the exploitation of its properties in practice is discussed using simulation methods (CelestialMechanics) and (simplified) first order perturbation methods. The perturbations due to the higher-order terms of the Earth's gravitational potential and resonant perturbations are considered thereafter. Special attention is paid to satellites of the Global Navigation Satellite Systems and to geostationary satellites. The characteristics of and models for the two most important non-gravitational forces, atmospheric drag and radiation pressure, are presented as well as the most relevant forces acting on high- and low-orbiting satellites. (3) Evolution of the Planetary System. The outer planetary system consisting of the planets Jupiter to Pluto is studied over long time intervals using simulation methods and spectral analysis (CelestialMechanics). The properties of the inner systems, in particular of the Earth's orbit, are made visible by integrating the entire system over long time intervals relevant for climate change. The distribution of minor planets and their orbital properties, regular orbits, and chaotic orbits are easily generated and analyzed using CelestialMechanics. The volume concludes with the discussion of important mathematical tools of the program system and of the principles of spectral analysis.
Method validation in pharmaceutical analysis
Provides hands-on information for readers involved in development, validation, and continued maintenance and evaluation of analytical procedures in pharmaceutical analysis. This newly revised and updated Third Edition includes much-needed interpretation of the most recent ICH guidelines for validation and method development, as well as recent publications of the USP on Analytical Procedure Lifecycle Management and the activities of the British Pharmacopeia AQbD Working Party. It also addresses hot topics in the field such as data integrity and continuous monitoring of analytical performance.
Métastases vertébrales = Vertebral metastases
Updating the technical progress made by each of the players, both diagnostic and therapeutic, was necessary and confirms the quality of the result of a joint venture serving a patient in a particularly delicate situation. It is intended to be practical for each of the care providers and didactic for those who are less specialized in one or another area. This has led us to make choices, of course debatable, leading to explanations that are sometimes a little too "obvious" for connoisseurs, a little too technical for neophytes, repetitions for everyone to find in "their" chapter what makes it so. interested.
Metals in Society and in the Environment : A Critical Review of Current Knowledge on Fluxes, Speciation, Bioavailability and Risk for Adverse Effects of Copper, Chromium, Nickel and Zinc
In 2002, the Swedish Metal Information Task Force (MITF) engaged the Environmental Research Group (MFG) to update previous monographs on copper, zinc and major alloying metals (such as chromium, nickel and molybdenum) in society and in the environment. This book presents new results on metal fluxes from society to the environment, on metal speciation in water, soil and sediment, and its interpretation in terms of mobility, biological uptake and toxicity. The scientific fundamentals of new approaches, like the Acid Volatile Sulphide (AVS) concept to predict metal bioavailability in sediments, and the Biotic Ligand Model (BLM) to calculate the toxicity of metals to aquatic organisms, are critically evaluated, with a focus on copper, nickel, zinc, and, in part, chromium.
Metal-containing molecules and nanomaterials : from diagnosis to therapy
Since the discovery and successful deployment of salvarsan to treat syphilis, as well as cisplatin as a cancer drug, the field of metallodrugs has been flourishing. In addition to therapeutic applications, metals and metal-containing molecules have properties, such as an electrochemical or an optical signal, used to diagnose biologically relevant molecules or unravel cellular metabolism. Metals are part of the essential elements for life, and of increased attention in nutraceuticals. Most of the current diagnosis processes, therapeutics and nutraceuticals are based on organic molecules. MILS-26 reviews the most recent metal-containing molecules and nanomaterials for diagnosis and therapy
Metabolomics : The frontier of systems biology
Metabolism is the sum of the chemical reactions in cells that produce life-sustaining chemical energy and metabolites. In the post-genome era, metabolism has taken on new significance for biological scientists: metabolites are the chemical basis of phenotypes that are final expressions of genomic information. This book covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. The authors have been directly involved in the development of all the subject areas, including capillary electrophoresis, liquid chromatography, mass spectrometry, metabolic databases, and metabolic simulation. Breakthrough achievements and the future of metabolome studies are described, making this book a valuable source for researchers in metabolomics in diverse fields, such as plant, animal, cellular, microbial, pharmaceutical, medical, and genetic sciences.
Metabolome Analyses : Strategies for Systems Biology
Metabolome Analyses is intended as a follow-up to Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Kluwer, 2003). That text offered guidelines to currently available technology, bioinformatics and databases. Evidence was presented showing metabolic profiling as a valuable addition to genomics and proteomics strategies devoted to drug discovery and development. This book focuses on how metabolic profiling is being more comprehensively integrated with the other "omics" technologies. It provides more practical applications of such "panomics" or "Systems Biology" approaches. The expanding use of mass spectrometry as a measurement technology in metabolic profiling is addressed through demonstrated applications. The integration of metabolic profiling and proteomics is probably most developed for plant-based studies, which was not addressed in Volume 1. Other areas related to metabolic profiling continue to show significant development. These include database strategies and an increased acceptance by the pharmaceutical industry of metabolic profiling. Also covered is the use of in silico metabolic networks. Again the focus is primarily on the pharmaceutical industry but the importance of metabolic profiling to studies on human nutrition (a burgeoning area) is discussed.
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Memories : Molecules and Circuits
This volume surveys the recent advances and provides an integrative view of molecular, cellular, and systems level mechanisms underlying cognitive processes in both animals and humans. Current state of the art and future avenues are discussed by distinguished scientists who provide not only an overview of the underlying neurobiology of cognitive processes from a basic science standpoint, but who also focus on clinical and therapeutic aspects surrounding impairments associated with disorders that affect cognition.
Mémento de la recherche biomédicale portant sur un médicament à usage humain = Summary of biomedical research on a medicinal product for human use
Presents the reference texts, structures and authorities that govern clinical research in France, as well as its practical aspects. It is aimed at all of its stakeholders, both caregivers and patients. It will allow the most novices to familiarize themselves with the specific vocabulary of this discipline, to answer the questions raised during the conduct or participation in a therapeutic trial, and the most experienced to consider setting up a research structure. clinic in the rules of art.
Medicinal spice and condiment crops
Spices are used in small quantities to add flavor, aroma, color, and texture in food preparation. However, spices and condiments have also been recognized as having medicinal value. They have been used traditionally as curative and preventive agents, the bioactive compounds obtained from these plants are used in herbal drug formulations in modern times.
Medicinal roots and tubers for pharmaceutical and commercial applications
The root and tuber are vital parts of medicinal plants providing mechanical support, producing critical growth regulators, and storing food. Bioactive compounds obtained from plant roots and tubers demonstrate health benefits presenting antioxidative, antimicrobial, hypoglycaemic, hypocholesterolaemic, and immunomodulatory properties. Roots of many medicinal plants have been used for the treatment of disease and formulation of drugs, and they are also known for their commercial value, being used as an ingredient in the pharmaceutical and cosmetic industries.
Medicinal plants of the world ; Vol.3 : Chemical constituents, traditional and modern medicinal uses
The author's exhaustive summary of available scientific data for each plant provides detailed information on how the plant is used in different countries, describing its traditional therapeutic applications and what is known from its use in clinical trials. Additional material presented includes a botanical description with a color photo of each plant for identification, the common names used for the plant throughout the world, and a listing of the plant's known chemical constituents. A comprehensive bibliography cites the literature available from a wide range of disciplines. Medicinal Plants of the World: Chemical Constituents, Traditional and Modern Medicinal Uses, Volume 3, offers a unique collection of vital scientific information for pharmacologists, herbal medicine practitioners, drug developers, phytochemists, medicinal chemists, phytologists, toxicologists, and researchers who want to explore the many uses of plant materials for medicinal and related purposes. Its wealth of significant information will reveal little-known facts about these plants and open new horizons of application for the many novel drugs and drug candidates found in them.
Medicinal Plants for Holistic Health and Well-Being
Medicinal Plants for Holistic Health and Well-Being discusses, in depth, the use of South African plants to treat a variety of ailments, including tuberculosis, cancer, periodontal diseases, acne, postmacular hypomelanosis, and more. Plants were selected on the basis of their traditional use, and the book details the scientific evidence that supports their pharmacological and therapeutic potential to safely and effectively treat each disease. Thus, this book is a valuable resource for all researchers, students and professors involved in advancing global medicinal plant research
Medicinal plants and antimicrobial therapies
Serves as an excellent comprehensive material covering the current understandings and updates on antimicrobial resistance (AMR) and the use of medicinal plant resources for tackling it. Chapters cover important aspects of AMR and strategies to address this threatening issue with medicinal plants and their resources. One health perspectives for addressing AMR have been presented for the readers. Antimicrobial medicinal plant therapeutic resources including crude extracts, active fractions, pure molecules and essential oils, besides using them as functionalizing agents for nano-antimicrobials have been covered. Further, plant endophytes as a source of antimicrobial compounds have been discussed. Chapters cover both the bactericidal as well as resistance-reversal (or potentiating/ combinatorial therapies) potencies of medicinal plant resources. The book also focuses on how medicinal plant resources effectively target major determinants of AMR.
Medicinal plants : From farm to pharmacy
Discuss current research on medicinal plants that connects traditionally accumulated botanical wisdom with current bioprospecting trends and (pre-clinical studies Provide an account of recent research activities on select medicinal plants from various phytogeographical regions all over the world Cater to the interest of a wide range of readers including lay enthusiasts, traditional practitioners as well as research and clinical professionals
Medicinal plants : Bioprospecting and pharmacognosy
Touches on a diverse selection of topics related to medicinal plants. Chapters look at the use of medicinal plants in healthcare and disease management, such as to treat inflammation, anti-hyperglycemia, and obesity and as immunity boosters. The authors also address the conservation, maintenance, and sustainable utilization of medicinal plants along with postharvest management issues. Topics include consumption, supply chain, marketing, trade, and future directions of research. Some specific plants discussed include fennel, basil, clove, ginger, lavender, turmeric, ginsing, and asparagus in connection with their various therapeutic properties, including anti-rheumatic, anti-asthmatic, anti-diabetic, carminative, diuretic, fever-reducing, and hypotensive. Medicinal Plants: Bioprospecting and Pharmacognosy will prove informative for scientists and researchers in medicinal plants as well as for faculty and students, pharmaceutical researchers, and others.
Medicinal foods as potential therapies for type-2 diabetes and associated diseases : The chemical and pharmacological basis of their action
Focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. Provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries.
Medicinal compounds in modern healthcare : From tradition to innovation
Reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.
