الصفحة 8
الصفحة 8
Drug transporters : Molecular characterization and role in drug disposition
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
Drug design : A conceptual overview
The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as “Computer-Aided Drug Design" (CADD), which has profound application in RDD. The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide.
Drawn to Design : Analyzing Architecture Through Freehand Drawing
A guide for students and teachers to understand the need for, the role of and the methods and techniques of freehand analytical sketching in architecture. The presentation focuses on drawing as an approach to and phase of architectural design. The conceptual goal of this approach is to use drawing not as illustration or depiction, but as exploration. The first part of the book discusses underlying concepts of freehand sketching in design education and practice as a complement to digital technologies. The main component is a series of chapters that constitute a typology of fundamental issues in architecture and urban design; for instance, issues of "façade" are illustrated with sketch diagrams that show how façades can be explored and sketched through a series of specific questions and step-by-step procedures.
Drawn to Design : Analyzing Architecture Through Freehand Drawing
A guide for students and teachers to understand the need for, the role of and the methods and techniques of freehand analytical sketching in architecture. The presentation focuses on drawing as an approach to and phase of architectural design. The conceptual goal of this approach is to use drawing not as illustration or depiction, but exploration. The first part of the book discusses underlying concepts of freehand sketching in design education and practice as a compliment to digital technologies. The main component is a series of chapters that constitute a typology of fundamental issues in architecture and urban design; for instance, issues of "facade" are illustrated with sketch diagrams that show how facades can be explored and sketched through a series of specific questions and step-by-step procedures.
Doing integrated history and philosophy of science : A case study of the origin of genetics
offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice.
Disasters : Core Concepts and Ethical Theories
Examines disasters from a multidisciplinary perspective. Justification of actions in the face of disasters requires recourse both to conceptual analysis and ethical traditions. Part 1 of the book contains chapters on how disasters are conceptualized in different academic disciplines relevant to disasters. Part 2 has chapters on how ethical issues that arise in relation to disasters can be addressed from a number of fundamental normative approaches in moral and political philosophy. This book sets the stage for more focused normative debates given that no one book can be completely comprehensive. Providing analysis of core concepts, and with real-world relevance, this book should be of interest to disaster scholars and researchers, those working in ethics and political philosophy, as well as policy makers, humanitarian actors and intergovernmental organizations.
Digital transformation management : Challenges and futures in the Asian digital economy
Addresses key topics related to organization design and knowledge management in the digital economy with organizational context, particularly in Asia. the book conceptualizes organization design into three dimensions, people, information, and technology, and offers readers a unique valued insight, bringing new perspectives to understanding emerging business opportunities and challenges in Asia. it presents a valuable collection of 14 chapters with empirical studies from leading researchers. the book addresses digital transformation in companies and organizations in Asia, analysing how disruptive technologies can help them to have more efficient organization processes, create innovative products and services, be more resilient and achieve sustainable goals in post-pandemic time.
Digital Sketching : Computer-Aided Conceptual Design
Delivers a comprehensive and insightful examination of how architects and other design professionals can best use digital design technology to become better designers. Celebrated professional, professor, and author John Bacus provides readers with practical and timely information on emerging digital design technologies and their effect on professional practice.
Diagrammatic Representation and Inference ; 5th International Conference, Diagrams 2008, Herrsching, Germany, September 19-21, 2008. Proceedings
This book constitutes the refereed proceedings of the 5th International Conference on Theory and Application of Diagrams, Diagrams 2008, held in Herrsching, Germany, in September 2008.
Diagrammatic representation and inference ; 4th International conference, Diagrams 2006, Stanford, CA, USA, June 28-30, 2006, Proceedings
Proceedings of the 4th International Conference on Theory and Application of Diagrams, Stanford, CA, USA in June 2006. 13 revised full papers, 9 revised short papers, and 12 extended abstracts are presented together with 2 keynote papers and 2 tutorial papers. The papers are organized in topical sections on diagram comprehension by humans and machines, notations: history, design and formalization, diagrams and education, reasoning with diagrams by humans and machines, and psychological issues in comprehension, production and communication.
Development, Sexual Cultural Practices and HIV/AIDS in Africa
This book introduces the theoretical frameworks and academic debates concerning sexual cultural practices and HIV/AIDS in Africa. It shows how these frameworks have been applied in a practical sense in Africa to investigate sexual cultural practices and their link with HIV/AIDS. The author provides an overview of both the field of study and the methods used during fieldwork. Finally, it assesses the implications of the findings for the conceptualization and provision of current and future HIV/AIDS policies and programs in Africa. This monograph will appeal to policy makers and practitioners working in the field of HIV/AIDS in the Global South as well as academics and students.
Development and Plasticity in Sensory Thalamus and Cortex
This book intends to bring together systems and molecular approaches on various fundamental issues on thalamocortical development and plasticity. Functional cortical circuits cannot be appreciated without thalamocortical circuits and cortical development cannot be considered without thalamocortical pathway development. The 16 chapters address key questions with diversity of techniques; ranging from molecular genetics, in vitro and in vivo methods to classical anatomical, electrophysiological and imaging procedures. The conceptual approaches formulated in these chapters should be a rich source for future research in this area.
Designing Urban Food Policies : Concepts and Approaches
This book is for scientists and experts who work on urban food policies. It provides a conceptual framework for understanding the urban food system sustainability and how it can be tackled by local governments. Written by a collective of researchers, this book describes the existing conceptual frameworks for an analysis of urban food policies, at the crossroads of the concepts of food system and sustainable city.
Designing tall buildings : Structure as architecture
Advises you to consider the influence of a particular site's geology, wind conditions, and seismicity. Using this contextual knowledge and analysis, you can determine what types of structural solutions are best suited for a tower on that site. You can then conceptualize and devise efficient structural systems that are not only safe, but also constructible and economical. Sarkisian also addresses the influence of nature in design, urging you to integrate structure and architecture for buildings of superior performance, sustainability, and aesthetic excellence.
Designing a school library media center for the future ; 2nd ed.
In this hands-on guidebook, school library construction and media specialists Rolf Erikson and Carolyn Markuson share their experiences of working on more than 100 media center building projects around the country, using conceptual plans from actual school libraries.Combining all aspects of design for the school library media center—floor plans, furniture, technology, bidding, and evaluation—this newly updated edition addresses
Design Science and Its Importance in the German Mathematics Educational Discussion
This ICME-13 Topical Survey reviews the state-of-the-art by first exploring the roots and scope of design science. Second, it presents two examples of current design science projects that focus on substantial learning environments including a student and a teacher perspective. Subsequently, the book elaborates on how empirical research can be conceptualised within design science. Lastly, it explores developments in design science from a national and international perspective, while also discussing current trends in design research. Within the German-language tradition, considering ‘mathematics education as a design science’ primarily draws on the works of Wittmann.
Design Graphics : Drawing Techniques for Design Professionals
Combines–in a single volume–simple techniques and skills related to sketching, design-development, and the schematic or preliminary phase of design presentation. Emphasizing drawing as a mental as well as physical exercise, the text helps students draw designs on paper faster and easier, showing them how visual communication with clients can provide better, more economical design solutions. Practical, straightforward, and reader-friendly, Design Graphics provides more complete coverage of the basics, making concepts and techniques accessible to students with highly diversified educational and technical backgrounds.
Defending Life : The Nature of Host-Parasite Relations
Defending Life discusses the relationship between hosts and parasites. A major contention of the book is that the immune system depends ontologically on the ecosystem in which it is embedded; it would not have the features it has if it was not related in one way or other to parasitic agents and to the host’s own cells and tissues. To sustain the argument, life is investigated at all layers – from molecules up through cells, organisms and ecosystems. Together with the inverse course, which goes from ecological contingencies down to gene-expression profiles, the approach facilitates an advanced understanding of immunocompetence as well as its converse, immunoincompetence. The emphasis on analytical abstractions, coherent patterns and generative mechanisms makes possible the distinction between genuine causality and coincidental associations, and thus increases the understanding of why we observe what we observe. The book contains detailed descriptions of the immune system and the microbial world as well as methodological and conceptual clarifications.
Deduction, Computation, Experiment : Exploring the Effectiveness of Proof
What is a proof for? What is the characteristic use of a proof as a computation, as opposed to its use as an experiment? What is the relationship between mathematical procedures and natural processes? The essays collected in this volume address such questions from different points of view and will interest students and scholars in several branches of scientific knowledge. Some essays deal with the logical skeleton of deduction, others examine the interplay between natural systems and models of computation, yet others use significant results from the natural sciences to illustrate the character of procedures in applied mathematics. Focusing on relevant conceptual and logical issues underlying the overall quest for proving, the volume seeks to cast light on what the effectiveness of proof rests on.
Data-driven BIM for Energy Efficient Building Design
Conceptualises the scale and spectrum of Building Information Modelling (BIM) and Artificial Intelligence (AI) approaches in energy efficient building design and to develop its functional solutions with a focus on four crucial aspects of building envelop, building layout, occupant behaviour and heating, ventilation and air-conditioning (HVAC) systems. Drawn from theoretical development on the sustainability, informatics and optimisation paradigms in built environment, the energy efficient building design will be marked through the power of data and BIM-intelligent agents during the design phase.
