الصفحة 7
الصفحة 7
Targeted metallo-drugs : Design, development, and mode of action
Inspired by the clinical success of cisplatin as a leading anticancer drug but mindful of the shortcomings associated with its use including dose-limiting toxic side effects and acquired or intrinsic drug resistance, scientists across the globe have been endeavoring to identify new metallo-drugs for therapeutic exploitation. This has led to innovative metallo-drug candidates that (i) enhance cancer cell selectivity, thus reducing toxic side effects, and/or (ii) possess new modes of action to improve efficacy and also target resistance pathways. This and more are captured in MILS- 24 which consists of 12 comprehensive, well-illustrated, and up to date chapters with over 1600 citations, 100 figures, and 10 tables with key contributions from 32 international experts from Europe, Asia, and North and South America. MILS- 24 not only keeps the scientific community abreast of latest developments, it also serves as an invaluable resource to stimulate further research on targeted metallo-drug design and development.
T cell activation by CD1 and lipid antigens
This volume provides a comprehensive discussion of basic aspects of CD1 biology and summarizes the most recent research into the role of CD1 in infectious, autoimmune, allergic and neoplastic disease.
Systems Biology ; Vol. 61 : Applications and Perspectives
Systems biology has emerged as a highly interdisciplinary ?eld that has created broad enthusiasm in the scienti?c community. Systems biology is in vogue because of its potential to revolutionize not only biology but also medicine.
Symptoms in the Pharmacy : A Guide to the Management of Common Illnesses ; 8th ed.
Provides pharmacists working in the community with the treatment information they need when they need it. Each chapter incorporates a decision-making framework which distills the information necessary for treatment along with suggestions on “when to refer” set off in summary boxes. Elucidating case studies are provided throughout, in which pharmacists and doctors describe, in their own words, listening to and treating patients suffering with a range of common problems, from migraine to eczema to IBS. The indispensable guide to assessing and managing common symptoms seen in the pharmacy / Includes information about medicines recently reclassified for OTC supply such as those for malaria prophylaxis and erectile dysfunction / Now includes more highlights of “Red Flag” signs and symptoms / Covers respiratory, gastrointestinal, skin, ear and eye, cardiovascular, and pain conditions / Offers specific recommendations for women’s, men’s and children’s health problems / Provides decision making support for cases involving ethical dilemmas / Features a visual display of relevant treatment guidelines / Emphasizes the evidence base for OTC medicines
Symmetries in Science XI
This book is a collection of reviews and essays about the recent developments in the area of Symmetries and applications of Group Theory. Contributions have been written mostly at the graduate level but some are accessible to advanced undergraduates. The book is of interest to a wide audience and covers a broad range of topics with a strong degree of thematical unity.
Sustainable nation : Urban design patterns for the future
Embraces the idea that the humanitarian, population, and climate crises are three facets of one interrelated human existential challenge, one with impossibly short deadlines. The vision of Sustainable Nation is to accelerate the pace of progress of human civilization to create an equitable and sustainable world. The core strategy of Sustainable Nation is the perfection of the design and governance of all neighborhoods to make them unique exemplars of community and sustainability.
Sustainable Internet ; 3rd Asian Internet Engineering Conference, AINTEC 2007, Phuket, Thailand, November 27-29, 2007, Proceedings
The 3rd Asian Internet Engineering Conference (AINTEC) followed the first two successful editions held in Bangkok, Thailand, and focused on developing synergies between researchers in Asia and worldwide, but was also a unique chance for young, talented regional scientists to meet and interact. AINTEC2007 was therefore a major opportunity for presentations and discussions around these objectives. In particular, it aimed at addressing issues pertinent to the Asian region with vast diversities of socio-economic and networking conditions while inviting high-quality and recent research results from the global international research community to be presented. The conference is single-track to favor discussions among a diverse set of participants.
Sustainability objectives in competition and intellectual property law
Focuses on how competition and intellectual property laws incorporate sustainability objectives. Businesses are increasingly embracing sustainability objectives, driven by the international community. Although competition and intellectual property law are certainly not the only tools for addressing sustainability issues, they can play a role in moving toward a more sustainable society.Sustainability has gained prominence in competition law in all jurisdictions covered in this volume.
Survie des patients atteints de cancer en France = Survival of cancer patients in France
The Francim network brings together all the French cancer registries. It has set up an observatory for cancerous pathologies in France, the purpose of which is to provide the community with epidemiological indicators useful for the knowledge and management of this pathology, in conjunction with various institutional partners. A first output of this observatory was to provide estimates of the incidence of cancer in France in 2000. Its second output is reported in this work, and concerns the survival of cancer patients, as it could be estimated. from all cancer cases recorded from 1989 to 1997 in 20 French departmental registers. To achieve these objectives, the network joined forces with the biostatistics service of the civil hospices of Lyon, which provided statistical analysis of the data collected by the various registers. The procedures that have been put in place for the different phases of this work can be implemented on a regular basis, for subsequent estimates. They also lend themselves to the implementation of more in-depth studies that are necessary for certain cancers. These so-called “population” data usefully complement the results of studies carried out in the field of clinical research. An additional tool for epidemiological cancer surveillance is therefore now available in France, thanks to the support of the National Cancer League.
Surface and Interfacial Organometallic Chemistry and Catalysis
Heterogeneous catalysis has been essential to the development of efficient chemical processes for more than a century, and this field has been traditionally part of the solid state chemistry and surface science communities. The design of better catalysts has raised the following questions: "what is the structure of the active sites?" and "how to control their nature?" The necessary need to develop more sustainable chemical processes and the success of homogeneous catalysis relying on molecular organometallic chemistry has led the community of molecular chemists to investigate the preparation of single-site heterogeneous catalysts. The authors discuss the molecular design, the preparation, the characterisation and the catalytic applications of well-defined oxides and metal particles. The readers will acquire a molecular understanding of heterogeneous catalysis, which will help them develop a critical view and which will attract them to study this fascinating field.
Stress and immunity
Many people have experienced the connection between stress and getting sick. Colds, influenza, herpes and allergies seem worse when we are severely stressed at work or in the home. Others are never sick until they go on vacation (that is, after the stress is over), and then they spend the whole time fighting the virus. Because of intrinsic connections like these, many researchers are today exploring whether (and how) stress and illness are actually linked. One specific focus of this research is to study the effects of stress on the immune systems; after all, if stress affects immunity, that would be one way in which stress could contribute to illness. The function of the immune system is to protect us from organisms that cause disease, and from other materials that would be harmful to the body. Cells of the immune system (i.e., white blood cells) circulate throughout the body in the blood and are also located in various organs, including the bone marrow, thymus, lymph nodes and spleen. There are a number of different kinds of white blood cells, but the most important in this context are lymphocytes.
Stochastic Optimization
The search for optimal solutions pervades our daily lives. From the scientific point of view, optimization procedures play an eminent role whenever exact solutions to a given problem are not at hand or a compromise has to be sought, e.g. to obtain a sufficiently accurate solution within a given amount of time. This book addresses stochastic optimization procedures in a broad manner, giving an overview of the most relevant optimization philosophies in the first part. The second part deals with benchmark problems in depth, by applying in sequence a selection of optimization procedures to them. While having primarily scientists and students from the physical and engineering sciences in mind, this book addresses the larger community of all those wishing to learn about stochastic optimization techniques and how to use them.
Stem Cells
Significant advances in stem cell research and their potentials for therap- tic applications have attracted the attention of the scienti?c community and captured the imagination of society as a whole. Not so long ago, the study of most stem cells, other than those that regenerated the haematopoietic system, was rather obscure and limited to a relatively small number of researchers and laboratories. The uproar over stem cells really began in 1998 with the s- cessful derivation of pluripotent human embryonic stem (ES) cells by James Thomson and co-workers.
Steel Corrosion and Degradation of its Mechanical Properties
Presents the state-of-the-art-knowledge on corrosion of steel, cast iron and ductile iron with a focus on corrosion-induced degradation of their mechanical properties. The information presented in the book is largely derived from the most current research on the effect of corrosion on degradation of mechanical properties. The book covers the basics of steel corrosion, including that of cast iron and ductile iron, that are not well covered in most literature. Models for corrosion-induced degradation of mechanical properties are presented in the book with a view to wider applications. The knowledge presented in the book can be used to prevent corrosion-induced failures of corrosion-affected structures, offering enormous benefits to the industry, business, society and community.
Statistical Reasoning in Medicine : The Intuitive P-Value Primer
The successful Statistical Reasoning in Medicine: The Intuitive P-value Primer, with its novel emphasis on patient and community protection, illustrated the correct use of statistics in health care research for healthcare workers. Through clear explanations and examples, this book provided the non-mathematician with a foundation for understanding the underlying statistical reasoning process in clinical research, the core principles of research design, and the correct use of statistical inference and p-values.
Statistical Methods in Bioinformatics : An Introduction
Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community. This book provides an introduction to some of these new methods. The main biological topics treated include sequence analysis, BLAST, microarray analysis, gene finding, and the analysis of evolutionary processes. The main statistical techniques covered include hypothesis testing and estimation, Poisson processes, Markov models and Hidden Markov models, and multiple testing methods.
Statistical Methods for Human Rights
Human rights issues are shaping the modern world. They define the expectations by which nations are judged and affect the policy of governments, corporations, and foundations. They have set the agenda in prosecutions at the International Criminal Court at the Hague, funding decisions by the International Monetary Fund, and corporate expansion programs by multinationals. Statistics is central to the modern perspective on human rights. It allows researchers to measure the effect of health care policies, the penetration of educational opportunity, and progress towards gender equality. The new wave of entrepreneurial charities demands impact assessments and documentation of milestone achievement. Non-governmental organizations need statistics to build cases, conduct surveys, and target their efforts.
States of Consciousness : Models for Psychology and Psychotherapy
Consciousness has always been a particularly elusive concept and one vigorously argued in the scientific community. This new volume takes on the task of defining normal and altered consciousness in their most relevant clinical terms. In States of Consciousness, Andrzej Kokoszka expands on the pioneering work of J.H. Jackson, offering contemporary models for studying consciousness as it applies to both pathology and normal altered states, e.g., relaxation, sleep, meditation, and hypnosis. He makes clear distinctions between the neuroscientific and psychiatric components of consciousness; at the same time, his theories are rooted firmly in the biopsychosocial approach.
Stable isotopes to trace Migratory Birds and to identify harmful diseases : An introductory guide
Discusses the potentials of the approaches as mentioned below to monitor the AIVs in WMW. Molecular diagnostic platforms enable for accurate detection of the AIVs in the feces of infected birds. Similar technologies can be used to determine the bird species through DNA barcoding, enabling non-invasive research on the epidemiology of the disease. Wild migratory waterfowl (WMW) play significant role in the transmission of avian influenza viruses (AIVs) on large distances. Understanding bird migrations may therefore significantly contribute towards understanding of the disease epidemiology, however most conventional approaches to trace WMW migrations are based on capturing, tagging (mostly ringing or GPS devices) and their re-capturing to link the departure and arrival places.
Space, Structure and Randomness : Contributions in Honor of Georges Matheron in the Fields of Geostatistics, Random Sets and Mathematical Morphology
This volume is divided in three sections on random sets, geostatistics and mathematical morphology. They reflect his professional interests and his search for underlying unity. Some readers may be surprised to find theoretical chapters mixed with applied ones. We have done this deliberately. GM always considered that the distinction between the theory and practice was purely academic.
