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الصفحة 7
Chemical Biology and Drug Discovery
Gives the reader, through the specific selection of chemical-biological techniques and concepts, the necessary tools to be able to develop new ways of thinking and thus new therapeutic options in the complex field of chemical biology and drug development. The stated aim of this book is to provide concrete solutions and inspiration to students, (post)graduate students, and experienced scientists at universities as well as in industry in their problems.
Chemical and clinical applications of tempol : A marvelous molecule
A comprehensive and authoritative exploration of Tempol (4-Hydroxy-TEMPO), an exceptional chemical compound with diverse applications in both scientific research and medical practice. This book delves into Tempol's unique properties, mechanisms of action, and its potential role in combating oxidative stress-related disorders. Includes a chapter devoted to the safe handling, storage, and disposal of Tempol in compliance with pharmaceutical regulations. The authors pay particular attention to pharmaceutical regulations in the industry.
Characterization of Pharmaceutical Nano- and Microsystems
Offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker.
Chapel and Haeneys essentials of clinical immunology
Contains the knowledge necessary to understand the diagnosis and treatment of immunological disorders. With easy-to-read text and a wealth of colour clinical images and diagrams, this well-regarded textbook introduces complex concepts using effective pedagogical tools such as bulleted lists, key point boxes, real-life case studies, practical examples, figures and tables, chapter introductions, and keywords in bold integrated in each chapter.
Changing Land Use Patterns in the Coastal Zone : Managing Environmental Quality in Rapidly Developing Regions
Coastal ecosystems make up some of the most important, yet most endangered, regions in the world. The protection of the unique processes that take place in these ecosystems requires that partnerships be formed among ecologists, resource managers, and planners. Experienced in the challenges of coastal system analysis, the contributors to this book provide multidisciplinary guidance on the assessment and management of environmental impacts caused by development. Each chapter examines an issue important to these fragile ecosystems, first presenting a non-technical summary of the issue and a review of the current state of the knowledge, then following with data and a more detailed consideration of the topic.
Changing Aspects in Stroke Surgery : Aneurysms, Dissections, Moyamoya Angiopathy and EC-IC Bypass
What is arterial dissection? What is Moyamoya angiopathy? What is the state of art of AVM treatment? Readers will find answers to these questions in this book. But they will also be informed about the state of the art treatment in the daily stroke therapy.
Cerebral monitoring in the OR and ICU
This comprehensive volume will serve as a complete guide to the clinical application of computer assisted systems in monitoring central nervous functions both in the OR and ICU. It presents practical guidelines and therapeutic indications for computerized EEG and Somatosensory Evoked Potential (SSEP) monitoring for the experienced user and the novice. The book also describes what cerebral monitoring can do and what its limitations are.
Cephalopods Present and Past : New Insights and Fresh Perspectives
Cephalopods are diverse, highly developed molluscs capable of swimming and jet propulsion. These animals are an important component of present-day marine ecos- tems throughout the world and comprise approximately 900 species. They also have an extraordinary fossil record, extending back to the Cambrian Period, with as many as 10,000 extinct species. Throughout their long history, they have experienced sp- tacular radiations and near-total extinctions. Because of their superb fossil record, they also serve as ideal index fossils to subdivide geologic time. This book touches on many of these themes, and it treats both fossil and present-day cephalopods.
Cell-secreted vesicles : Methods and protocols
Pesents hands-on technological protocols used to target an array of cell-secreted extracellular vesicles (EVs) in a variety of biological systems. Beginning with methods for EV purification and analysis, the book continues with sections on the study of EV functions as well as specific systems and models allowing for the study of EVs of different origin. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cell-Cycle Mechanisms and Neuronal Cell Death
This book serves to gain new insights into the molecular determinants of neuronal death and to establish new targets for therapeutic intervention.
Cell-Cell Channels
The biological sciences are dominated by the idea that cells are the functionally autonomous, physically separated, discrete units of life. This concept was propounded in the 19th century by discoveries of the cellular structuring of both plants and animals. Moreover, the ap parent autonomy of unicellular eukaryotes, as well as the cellular basis of the mammalian brain (an organ whose anatomy for a long while defied attempts to validate the idea of the cellular nature of its neurons), seemed to provide the final conclusive evidence for the completeness of *cell theory', a theory which has persisted in an almost dogmatic form up to the present day. However, it is very obvious that there are numerous observations which indicate that it is not the cells which serve as the basic units of biological life but that this property falls to some other, subcellular assemblage. To deal with this intricate problem concerning the fundamental unit of living matter, we proposed the so-called Cell Body concept which, in fact, devel ops an exceedingly original idea proposed by Julius Sachs at the end of the 19th century. In the case of eukaryotic cells, DNA-enriched nuclei are intimately associated with a microtubular cytoskeleton. In this configuration—as a Cell Body—these two items comprise the fundamental functional and struc tural unit of eukaryotic living matter. The Cell Body seems to be inherent to all cells in all organisms.
Cell Surface Receptors : A Short Course on Theory and Methods
Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest.
Cell Stress Proteins
This comprehensive volume, written by experts in the field, provides a current understanding of the molecular properties of the heat shock proteins and their roles in health and disease. Cell Stress Proteins includes advances in several aspects of stress protein research, with chapters ranging from basic studies of the role of heat shock proteins in protein folding to reviews examining the breakdown of stress protein regulation during disease. It also provides analysis of the biochemical and molecular properties of heat shock proteins which can be utilized in evaluating their role in human physiology and pathology. Cell Stress Proteins is an ideal book for researchers, clinicians, physicians, and graduate students in the fields of biochemistry, cell biology, microbiology, immunology, and genetics.
Cell Signaling in Vascular Inflammation
Although inflammatory disease of the vascular bed of the lung is a major cause of morbidity and mortality in both adult and pediatric age groups, the importance of vascular biology to its understanding, and in developing novel therapeutics, has been overlooked. In Cell Signaling in Vascular Inflammation, leading basic and clinical researchers review the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement.
Cell Motility in Cancer Invasion and Metastasis
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
Cell Engineering : Apoptosis
A reference on the development of cellular systems for the production of recombinant glycoproteins, gene and cell therapies, drug screening and tissue engineering. It intends to review the in-depth assessments of this type of programmed cell death. It is suitable for biotechnologists and researchers in apoptosis, cell biology, and cell culture.
Cell Division Control in Plants
The molecular mechanisms controlling cell cycle progression are highly conserved in eukaryotes. In addition to the basic protein machinery involved in cell cycle regulation, higher plants have also evolved unique molecular mechanisms that allow integration of environmental, physiological, and developmental signals into networks to control proper cell division and expansion. Rapid and exciting research progress in these fields has been achieved from experimental observations on plants over the past decade. The scope of this volume is focused on the molecular basis of all aspects of cell division and cytokinesis in plants. It is an essential reference book for instructors and scientists working in the areas of molecular, cell, and developmental biology of plants. The editors of this book are veterans in the field of plant molecular biology and highly respected worldwide.
Cell cycle control : Methods and protocols
Collects techniques to study the highly regulated cell cycle process. Beginning with chapters investigating these processes and assessing how cells respond when these complicated pathways are simplified by using synthetic biology and in vitro reconstitutions, the book continues by exploring how cells sense and respond to environmental conditions, different model systems and cellular types used to visualize cellular architecture during cell division, as well as innovative single cell microscopy techniques to highlight the heterogeneity of the cell population with respect to cell cycle progression. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cell Communication in Nervous and Immune System
At first glance, the nervous and immune systems appear very different. However, both systems have developed mechanisms for memory formation – though of quite different quality and significance for the organism. One striking example is that both systems form and communicate via synapses armed with similar sets of proteins. This collection of reviews, contributed by internationally recognized immunologists and molecular and cellular neurobiologists, puts side by side cellular communication devices and signaling mechanisms in the immune and nervous systems and discusses mechanisms of interaction between the two systems, the significance of which has only recently been fully appreciated.
Cartilage Repair Strategies
Cartilage Repair Strategies is a comprehensive update of the present state of cartilage repair and regeneration. The information in this volume addresses what methods are effective, what methods are safe, and what methods will lead to an alteration in the short history of articular cartilage injury repair. Contributors present examinations of a variety of topics including the structure and function of articular cartilage, the evaluation of cartilage repair techniques, and the latest cartilage sensitive imaging techniques.
