الصفحة 61
الصفحة 61
Drug residues in animal products
The use of veterinary drugs in food-producing animals has the potential to generate residues in animal derived products (meat, milk, eggs and honey) and poses a health hazard to the consumer. There are many factors influencing the occurrence of residues in animal products such as drug's properties and their pharmacokinetic characteristics, physicochemical or biological processes of animals and their products. The most likely reason for drug residues might be due to improper drug usage and failure to keep the withdrawal period...
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug-drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters.
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug discovery with privileged building Blocks : Tactics in medicinal chemistry
Drug Discovery with Privileged Building Blocks traces back PharmaBlock’s founding philosophy of designing privileged building blocks. High-quality building blocks are crucial not only to biological activities of different molecules but also to ADMET properties, which eventually will impact the success rate of drug discovery projects. A thorough study of how building blocks perform in drug molecules and a regular analysis of new building block structures in the latest researches have proven to be a fruitful strategy to generate novel building blocks. Using this strategy, PharmaBlock has supplied the drug industry with a great number of building blocks, which are increasingly being adopted by drug hunters, and these are identified in this book.
Driving digital transformation through data and AI : A practical guide to delivering data science and machine learning products
Explains how to build the organizational capability to deliver Data and AI products and drive immediate business results as new digital technologies significantly disrupt business Provides best practices, tools and templates for managing the organizational and technological change process to become an AI-driven enterprise Includes a variety of international case studies across several industries such as insurance, fashion, consumer goods, finance, technology and automotive Outlines how to develop a product strategy, build teams and design the platform and architecture Provides key principles for sharing knowledge, educating staff on data and AI, and effectively engaging top executives
Drift-Driven Design of Buildings : Mete Sozen’s Works on Earthquake Engineering
Summarizes the most essential concepts that every engineer designing a new building or evaluating an existing structure should consider in order to control the damage caused by drift (deformation) induced by earthquakes. It presents the work on earthquake engineering done by Dr. Mete Sozen and dozens of his collaborators and students over decades of experimentation, analysis, and reconnaissance. Many of the concepts produced through this work are integral part of earthquake engineering today. Nevertheless, the connection between the concepts in use today and the original sources is not always explained.
Dose Finding in Drug Development
When you go to the pharmacy and fill a prescription, have you ever wondered if the dose of the medication is right for you? Can the dose be too low so that the drug will not work? This book answers some of these questions, and introduces the drug development process, the design and analysis of clinical trials.
Domain Decomposition Methods in Science and Engineering XVII
This volume contains a selection of papers presented at the 17th International Conference on Domain Decomposition Methods in Science and Engineering held at St. Wolfgang / Strobl, Austria, July 3 - 7, 2006. Domain decomposition is an active, interdisciplinary research area concerned with the development, analysis, and implementation of coupling and decoupling strategies in mathematical and computational models. Domain decomposition techniques provide efficient tools for treating problems in all Computational Sciences. The reader will become familiar with the newest domain decomposition technologies and their use for modeling and simulating of complex problems from different fields of applications.
Domain Decomposition Methods in Science and Engineering XVI
The present volume sets forth new contributions in areas of numerical analysis, computer science, scientific and industrial applications, and software development.
Domain Decomposition Methods in Science and Engineering
Domain decomposition is an active, interdisciplinary research area that is devoted to the development, analysis and implementation of coupling and decoupling strategies in mathematics, computational science, engineering and industry.This book special focus has been on numerical analysis, computational issues,complex heterogeneous problems, industrial problems, and software development.
Domain Decomposition Methods for the Numerical Solution of Partial Differential Equations
Domain decomposition methods are divide and conquer methods for the parallel and computational solution of partial differential equations of elliptic or parabolic type. They include iterative algorithms for solving the discretized equations, techniques for non-matching grid discretizations and techniques for heterogeneous approximations. This book serves as an introduction to this subject, with emphasis on matrix formulations. The topics studied include Schwarz, substructuring, Lagrange multiplier and least squares-control hybrid formulations, multilevel methods, non-self adjoint problems, parabolic equations, saddle point problems (Stokes, porous media and optimal control), non-matching grid discretizations, heterogeneous models, fictitious domain methods, variational inequalities, maximum norm theory, eigenvalue problems, optimization problems and the Helmholtz scattering problem. Selected convergence theory is included.
Doing integrated history and philosophy of science : A case study of the origin of genetics
offers an integrated historical and philosophical examination of the origin of genetics. The author contends that an integrated HPS analysis helps us to have a better understanding of the history of genetics, and sheds light on some general issues in the philosophy of science. consists of three parts. It begins with historical problems, revisiting the significance of the work of Mendel, de Vries, and Weldon. Then it turns to integrated HPS problems, developing an exemplar-based analysis of the development and the progress in early genetics. Finally, it discusses philosophical problems: conceptual change, evidence, and theory choice.
Document Analysis Systems VII ; 7th International Workshop, DAS 2006, Nelson, New Zealand, February 13-15, 2006, Proceedings
This book constitutes the refereed proceedings of the 7th International Conference on Document Analysis Systems, DAS 2006, held in Nelson, New Zealand, in February 2006.
Do-All Computing in Distributed Systems : Cooperation in the Presence of Adversity
Do-All Computing in Distributed Systems: Cooperation in the Presence of Adversity is the first book that presents an in depth study of cooperation problems, abstracted in terms of the Do-All problem, where a collection of processors cooperatively perform a collection of independent tasks in the presence of adversity.
DNA nanotechnology for cell research : from bioanalysis to biomedicine
Bringing together multidisciplinary aspects of chemical, material, and biological engineering, DNA Nanotechnology for Cell Research: From Bioanalysis to Biomedicine presents an overview of DNA nanotechnology with emphasis on a variety of different applications in cell research and engineering, covering a unique collection of DNA nanotechnology for fundamental research and engineering of living cells, mostly in cellulo and in vivo, for the first time. Broad coverage of this book ranges from pioneering concepts of DNA nanotechnology to cutting-edge reports regarding the use of DNA nanotechnology for fundamental cell science and related biomedical engineering applications in sensing, bioimaging, cell manipulation, gene therapy, and drug delivery.
DNA manipulation and analysis
Details technologies on recombinant DNA and nucleic acid manipulation that underpin much of the biological sciences and instructions on how to conduct them successfully. Chapters guide the reader through the basics of oligonucleotide synthesis and DNA sequencing; recombinant DNA plasmid work; cell-free experiments and the latest developments in CRISPR approaches to genome modification.
DNA damage detection : Methods and protocols
Explores techniques in DNA damage analysis, important not only for understanding cellular health after exposure to genotoxic agents but also for assessing cellular ability of genome maintenance. The book explores traditional DNA damage measurement methods, as well as modern fluorescence-based analysis and high throughput automatic analysis methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
DNA Computing ; Vol. 4287 ; 12th International Meeting on DNA Computing, DNA12, Seoul, Korea, June 5-9, 2006, Revised Selected Papers
This book constitutes the thoroughly refereed postproceedings of the 12th International Meeting on DNA Computing, DNA12, held in Seoul, Korea in June 2006. The 34 revised full papers presented are organized in topical sections on molecular and membrane computing models, complexity analysis, sequence and tile designs and their properties, DNA tile self-assembly models, simulator and software for DNA computing, DNA computing algorithms and new applications, novel experimental approaches, and experimental solutions.
DNA Computing ; 13th International Meeting on DNA Computing, DNA13, Memphis, TN, USA, June 4-8, 2007, Revised Selected Papers
This book constitutes the thoroughly refereed postproceedings of the 13th International Meeting on DNA Computing, DNA 13, held in Memphis, TN, USA, June 4-8, 2007.
DNA barcoding : Methods and protocols
Covers the latest advancements and methods used to study DNA barcoding. The chapters in this book are organized into six parts: theory, DNA manipulation, specialized barcoding methods, analysis of DNA barcodes, completing a successful DNA barcode project, and barcoding as citizen science. Part One looks at several theoretical issues in DNA barcoding concerned with DNA barcodes that can and should be used. Part Two discusses protocols for processing samples into DNA barcodes, including DNA isolation, sequencing and managing samples, and the resulting DNA barcodes. Part Three explores the next generation of DNA barcoding such as FRET-based detection, dual nanopore detection, skimming, and closed-tube methods. Part Four addresses programs and websites that handle DNA barcoding data, and includes character-based approaches, barcode gap methods, integrated approaches, and Barcode of Life Database
