الصفحة 6
الصفحة 6
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural Product Synthesis II : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural Product Synthesis I : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural product experiments in drug discovery
Explores a wide range of evidence-based complementary medicine and various bio-analytical techniques used to define botanical products. Collecting recent work and current developments in the field of contemporary phytomedicine as well as their future possibilities in human health care, the book includes unique contributions in the form of chapters on phytomedicine and screening biological activities explained with diverse hyphenated techniques, as well as issues related to herbal medications, such as efficacy, adulteration, safety, toxicity, regulations, and drug delivery. Written for the Springer Protocols Handbooks series, chapters feature advice from experts on how to best conduct future experiments. Extensive and practical, Natural Product Experiments in Drug Discovery serves as an ideal reference for students, professors, and researchers in universities, R&D institutes, pharmaceutical and herbal enterprises, and health organizations.
Natural Language Processing and Information Systems ; Vol. 3999 ; 11th International Conference on Applications of Natural Language to Information Systems, NLDB 2006, Klagenfurt, Austria, May 31 - June 2, 2006, Proceedings
This book constitutes the refereed proceedings of the 11th International Conference on Applications of Natural Language to Information Systems, NLDB 2006, held in Klagenfurt, Austria in May/June 2006 as part of UNISCON 2006. The book presents 17 revised full papers and 5 revised short papers, organized in topical sections on concepts extraction and ontology, ontologies and task repository utilization, query processing, information retrieval and dialog processing, and NLP techniques.
Natural Language Processing and Chinese Computing ; 9th CCF International Conference, NLPCC 2020, Zhengzhou, China, October 14–18, 2020, Proceedings, Part II
This two-volume set of LNAI 12340 and LNAI 12341 constitutes the refereed proceedings of the 9th CCF Conference on Natural Language Processing and Chinese Computing, NLPCC 2020, held in Zhengzhou, China, in October 2020. The 70 full papers, 30 poster papers and 14 workshop papers presented were carefully reviewed and selected from 320 submissions. They are organized in the following areas: Conversational Bot/QA; Fundamentals of NLP; Knowledge Base, Graphs and Semantic Web; Machine Learning for NLP; Machine Translation and Multilinguality; NLP Applications; Social Media and Network; Text Mining; and Trending Topics.
Natural language processing and chinese computing ; 9th CCF International conference, NLPCC 2020, Zhengzhou, China, October 14–18, 2020, Proceedings, Part I
This two-volume set of LNAI 12340 and LNAI 12341 constitutes the refereed proceedings of the 9th CCF Conference on Natural Language Processing and Chinese Computing, NLPCC 2020, held in Zhengzhou, China, in October 2020. The 70 full papers, 30 poster papers and 14 workshop papers presented were carefully reviewed and selected from 320 submissions. They are organized in the following areas: Conversational Bot/QA; Fundamentals of NLP; Knowledge Base, Graphs and Semantic Web; Machine Learning for NLP; Machine Translation and Multilinguality; NLP Applications; Social Media and Network; Text Mining; and Trending Topics.
Natural Language Processing – IJCNLP 2004 ; 1st International Joint Conference, Hainan Island, China, March 22-24, 2004, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the First International Joint Conference on Natural Language Processing, IJCNLP 2004, held in Hainan Island, China in March 2004. The 84 revised full papers presented in this volume were carefully selected during two rounds of reviewing and improvement from 211 papers submitted. The papers are organized in topical sections on dialogue and discourse; FSA and parsing algorithms; information extractions and question answering; information retrieval; lexical semantics, ontologies, and linguistic resources; machine translation and multilinguality; NLP software and applications, semantic disambiguities; statistical models and machine learning; taggers, chunkers, and shallow parsers; text and sentence generation; text mining; theories and formalisms for morphology, syntax, and semantics; word segmentation; NLP in mobile information retrieval and user interfaces; and text mining in bioinformatics.
Natural Disasters and Extreme Events in Agriculture : Impacts and Mitigation
Agricultural production is highly dependent on weather, climate and water availability and is adversely affected by the weather and climate-related disasters. Droughts and natural disasters such as floods can result in crop failures, food insecurity, famine, loss of property and life, mass migration and negative national economic growth. It may not be possible to prevent the occurrence of these natural disasters, but the resultant disastrous effects can be reduced considerably through proper planning and effective preparation. Vulnerability associated with the hazards of natural disasters can be controlled to some extent by accurate and timely prediction and by taking counter-measures to reduce their impacts on agriculture. This book based on an expert meeting held in Beijing, China should be of interest to all organizations involved in disasters reduction and mitigation of extreme events.
NATO and terrorism catastrophic terrorism and first responders : Threats and mitigation
In this important new book a group of experts represents the current knowledge on the various terrorism threats to first responders resulting from the novel use of conventional weapons, as well radiological, nuclear, biological and chemical weapons. Also, the current situation in selected countries of different sizes and practical experience with terrorism countermeasures (Austria, Israel, Slovenia, Russia, U.S.) is reviewed, focusing on the national operational logistics and the individual needs for improving the present situation. Finally, this book offers innovative solutions to strengthen the level of protection of the first responders, culminating in fifty-one practically applicable recommendations
National security exceptions in international trade and investment agreements : Justiciability and standards of review
provides a comprehensive analysis of national security exceptions in international trade and investment agreements. The subject has gained particular relevance in the past few years, as both the United States and the Russian Federation have invoked national security as justification for trade-restrictive measures in the context of WTO dispute settlement proceedings. describes the evolution of security exceptions in international economic law, from the GATT 1947 to the most recent economic treaties, such as the 2017 Buenos Aires Protocol for Intra-Mercosur Investment and the 2018 USMCA.
Narrowing the Achievement Gap : Strategies for Educating Latino, Black, and Asian Students
This volume is an important and impressive collection of scholarship that addresses one of the more intractable education problems of our times--ensuring that ALL children receive a quality education." -- Gloria Ladson-Billings, Kellner Family Professor in Urban Education University of Wisconsin at Madison, and 2005-2006 President of AERA "A major contribution to the field, the in-depth analyses provided by the chapter authors should be of substantial appeal to a wide audience because of its interdisciplinary approach and orientation to theory, research, and practice." -- Stanley Sue, Distinguished Professor of Psychology and Asian American Studies University of California at Davis "In considering the broad problems and in recommending solutions, the book provides breadth, concision, and unique organization." -- Edmund W. Gordon, John M.
Nanoscale Assembly : Chemical Techniques
Recent advances have pushed the limits of lithography firmly into the sub-100 nm domain, with smallest feature sizes around 10 nm. However, compared to living organisms, devices fabricated using nanolithography are not nearly as complex, as they are essentially 2D and contain only a limited number of chemical elements. For centuries, Nature has been a major inspiration for science. First of all to learn how Life functions at cellular level, but increasingly, as a blueprint for designing non-natural devices where the building blocks and their assembly are inspired by biological examples. The key tool in translating these examples into the domain of engineering, has been self-assembly or self-organization. This book gathers a spectrum researchers who have not only furthered our knowledge of self-assembly using small molecules, polymers and colloidal particles as building blocks, but who have also shown it to be a practical tool in the assembly of an astonishing variety of devices, ranging from molecular electronics to biosensors.
Nanophytomedicine : An emerging platform for drug delivery
Covers recent advances in experimental and theoretical studies on various properties of nanoparticles derived from plant sources. This book assesses the recent advancements and applications of plant-based nanoparticles and also highlights emerging concepts of biomimetics. Contains 24 chapters encompassing various therapeutic applications of phytochemicals derived from plants, ferns, seaweeds, and so on, mediated through nanotechnology and its allied approaches. A fervent attempt has been made to compile every significant advancement in the field of phytonanomedicine so as to accelerate its momentum in the pharmaceutical sector.
Nanopharmaceuticals : Vol.3 : Principles and applications
Focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Nanoparticle-Based Drug Delivery in Cancer Treatment
Discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Focuses on : Recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Material platforms that establish NPs and both localized and controlled gene silencing The most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment The most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells
Nanofillers : Fabrication, characterization and applications of organic nanofillers
Explores the modifying effects of various nanofillers on mechanical and physical properties of polymer nanocomposites. Looking at the four basic aspects of processing, characterization, properties, and applications, it analyzes how their features can allow for innovative multifunction within industry. Covering design, production, and manufacture, this book focuses on meeting end-use requirements and the fabrication of materials. The importance of mindful design and the use of an appropriate synthesis method is the primary lens through which theory and practice are discussed. This volume looks at the various synthesis methods available for organic nanofillers and what characterizes them. Properties including mechanical, thermal, electrical, and tribological are thoroughly examined, along with the various computational techniques used to determine them. With important sustainable properties, nanofillers are essential to meeting the increasing demand for biodegradable and environmentally friendly materials. This book details the role nanofillers have to play in sustainability, alongside economic factors such as efficient manufacturing processes.
Nanocrystals : Synthesis, Properties and Applications
Nanocrystals and Their Mesoscopic Organization is an up-to-date monograph on an important aspect of nanoscience and technology. It opens with an elegant introduction including a brief historical account. Emphasis is then given to diverse synthetic methods, both chemical and physical, in addition to modern hybrid methods. The orientation shifts gradually to properties of nanocrystals that evolve with size; detailed discussions are to be found on mesoscalar assemblies in different dimensions, special cases of core-shell and magic nuclearity nanocrystals. The authors also address applications of nanocrystals, carefully separating out potential applications and those that have already emerged, and cite around 900 references from the literature, most from the last decade. Tables providing information at a glance and schematic diagrams at relevant places, make the monograph appealing to read.
Nanocomposites : Ionic Conducting Materials and Structural Spectroscopies
Nanocomposites have been receiving more and more attention given the improvement of synthesis techniques and the availability of powerful characterization techniques. The aim of the book is to introduce nanocomposite materials using a broad range of inorganic and organic solids. Furthermore, it is intended to present recent and not very common developments in especially spectroscopic characterization techniques, including Mössbauer, EXAFS, NMR. This should make the book attractive for a broad range of readers, including chemists and physicists.
Nano physical pharmaceutics
Nanomedicine is an emerging and rapidly evolving field, which could significantly help in early disease diagnosis, therapeutic improvement, novel therapeutic modality development, and medical expenditure reduction. The challenge remains, however, that the specially designed and carefully synthesized nanomedicines function poorly in animal verification despite great performance in vitro. A deeper understanding of the physicochemical properties of nanomedicine is the key. This book applies physical theories and models to determine the parameters for controlling the physicochemical properties of nanomedicines, including micelles, liposomes, and inorganic nanoparticles. Qualitative and quantitative relationships are established to provide guidance for nanomedicine design, characterization, and analysis. The text also compiles cutting-edge research in nanomedicine from the interdisciplinary team of the Department of Nanomedicine at Naval Medical University, China, which is currently establishing the characteristic discipline called Nano Physical Pharmaceutics. Edited by Wei Li, a prominent nanotechnology researcher, this book will appeal to anyone involved in nanotechnology, medicine, macromolecular science, biology, chemistry, and especially those with an interest in drug delivery or cancer therapy.
