الصفحة 6
الصفحة 6
Mortality and Maldevelopment : Part I : Congenital cardiovascular malformations
The most frequent of them all are the many types of malformations of the cardiovascular system, the heart and its blood vessels.Study of these conditions during the twentieth century took many forms, revolving about examination and analysis of their causes, genetic, nongenetic, and complex. To aid in unraveling the complexities of this causation, various influences on their frequency are considered, among them social conditions, maternal health, birthweight, newborn maturity. And of course the known and possible environmental bases of their occurrence are fully described.
Morphosemantic Number : From Kiowa Noun Classes To UG Number Features
This volume presents: the foundations of a unified morphosemantic theory of number; insight into the flow of information from the lexicon, via syntax, into the morphology; wide-ranging topics: nominal semantics, noun classes, DP syntax, agreement, suppletion, complex morphology.
Monoaminergic modulation of cortical excitability
Monoaminergic Modulation of Cortical Excitability serves as an integrative and comprehensive comparison of the diverse and complex modulatory action of dopamine, noradrenaline, and serotonin receptors in the cortex. The volume is organized into several sections offering a broad spectrum of opinions on how the monoamine systems affect cortical function from a cellular/sub-cellular level to a system level. The complexity of these interactions are discussed in light of recent data showing how disruption of these systems dramatically affects the memory formation and information processing in the cortex.
Molecular Wires : From Design to Properties
In the emerging field of nanoscience the desire to construct objects which in the molecular scale can resemble and act as macroscopic devices is a constant trend. Amongst the simplest but also most attractive functional component molecular wires are surely the most investigated. The reason for such interest is quite obvious since wires, in today world, are used all around us and are the most indispensable unit to assemble any type of electronic devices.In this issue the synthesis and characterization of molecular wires based on organic or metal complexes components, their properties and some theoretical background will be illustrated.
Molecular Targeting in Oncology
In Molecular Targeting in Oncology, authors present an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer and is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice. The volume is divided into five sections that cover the most important elements of drug development. The first section focuses on approaches using targeted therapies to inhibit cell growth. The second section describes how clinicians are evaluating targeted therapies in specific organ systems. The third section illustrates how various classes of pharmacologic and immunologic agents are developed for individual molecular targets. The fourth section details new drugs that have novel mechanisms of action. The final section looks to the future of targeted therapeutics and includes chapters on appropriate patient selection, use of combination therapy, dealing with tumor cell resistance, and more. Comprehensive and cutting-edge, Molecular Targeting in Oncology is an essential reference for those working in the field.
Molecular recognition in pharmacology
Traces the behavior of the drug substance, starting from the initial pre-contact stage, and ending with the formation of the complex. Molecular recognition lies in the foundation of every life form and includes many mysteries. Currently, studies on this topic in pharmacology are limited to determining the properties of complexes of medicinal substances (drugs) with specific (complementary) biomolecules: receptors, enzymes, ion channels etc. The results present the mechanisms preventing drugs from such non-specific binding. This direction is very fruitful, although the phenomenon of molecular recognition is far wider.
Molecular Paradigms of Infectious Disease : A Bacterial Perspective
This comprehensive volume, written by leading authors in the field, provides a fundamental understanding of the complex cellular and molecular processes that are important for bacterial virulence and the infectious disease process. Written in a clear and engaging manner, the book highlights key techniques and methodologies that have driven recent discoveries in bacterial pathogenesis, major structures and mechanisms in bacteria that are important for the pathogenesis of these organisms, the regulation of these virulence determinants by global regulators, and bacterial biowarfare agents. Molecular Paradigms of Infectious Disease: A Bacterial Perspective is an ideal book for students, microbiologists, immunologists and scientists and researchers of bacterial pathogenesis.
Molecular Mechanisms of Plant and Microbe Coexistence
Molecular Mechanisms of Plant and Microbe Coexistence presents studies on the complex and manifold interactions of plants and microbes at the population, genomics and proteomics level. The role of soil microbial diversity in enhancing plant health and plant microbe beneficial symbioses is discussed. Microbial communities are shown in the light of evolution. Main topics include genome coexistence and the functional genomics and proteomics of plant-associated microbes, which could form the basis for new environmentally benign strategies to combat infectious plant diseases and regulate plant growth. Further chapters focus on the role of signaling during the different stages of plant microbe coexistence, in symbiotic or pathogenic relationships, in quorum sensing and plant viral infections. Methods for studying the interactions in the root zone complement the book, which will certainly be of relevance in the practical application to agriculture, food security and for maintaining the balance of our ecosystems.
Molecular Mechanisms of Phagocytosis
Although, Phagocytosis was first described nearly 120 year ago, we are just recently beginning to understand the molecules that phagocytic cells use to bring about this complex cell function. Molecular Mechanisms of Phagocytosis was prepared as a series of up-to-date essays (chapters) that describe the present knowledge on the various steps of the phagocytic process from initial cell contact, through internalization of the foreign particle, to the final phagosome formation where the phagocytosed particle is destroyed.
Molecular Mechanisms of Neurotransmitter Release
Within the complex neuronal network of the nervous system, neuron-to-neuron communication occurs mainly through chemical synapses, where the presynaptic nerve terminal releases neurotransmitters that control the function of postsynaptic neurons by acting on postsynaptic receptors. Recent decades have brought groundbreaking new developments and a wealth of knowledge to this field. In Molecular Mechanisms of Neurotransmitter Release, leading experts provide concise, up-to-date information on all major molecular mechanisms involved, with complete background information and figures and diagrams to further elucidate key concepts or experiments.Comprehensive and cutting-edge, Molecular Mechanisms of Neurotransmitter Release is sure to provide a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for all those who have a general interest in the ever-evolving field of neuroscience.
Molecular interactions : Concepts and methods
A modern, comprehensive text and reference describing intermolecular forces, this book begins with coverage of the concepts and methods for simpler systems, then moves on to more advanced subjects for complex systems – emphasizing concepts and methods used in calculations with realistic models and compared with empirical data.
Molecular genetics, structures, mechanisms, and functions : Principles of gene manipulation and genomics ; Vol.1
Provides an overview of the future of genetic engineering and delves into the role of biotechnology and its applications in genetic engineering. It discusses the tools of recombinant technology, which have brought about revolution in our understanding of various complex biological phenomena. Chapters cover mutagenesis, construction, and sequencing of DNA libraries along with applications of genetic engineering for improving health, preventing genetic diseases, enhancing food resources, managing environmental bioremediation, and more. Topics include genetic engineering tools for restriction enzymes and vectors, gene and cell division, mutation detection and screening in plants, population genetics, sexuality in bacteria, and more. Several chapters focus on the tools of recombinant technology, such as restriction enzymes, vectors, etc., that have paved the way for creating organisms of choice and opened new horizons in the field of medicine, agriculture, and industry for human welfare.
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Molecular advances in dental pulp tissue engineering
Recent advances in regenerative medicine and tissue engineering aim to restore the dentin–pulp complex using stem cells, growth factors and tailored scaffolds to achieve biological regeneration within the root canal. This Special Issue highlights scientific advances in pulp regeneration, bridging the gap between research and clinical application.
Modern natural product synthesis
Describes the details of the synthesis routes including unexpected reactions and syntheses. By presenting detailed stories behind the total synthesis developments, including those routes that were unsuccessful the book provides the reader with a better understanding of how other researchers devise their strategy and overcome difficulties in their studies. The contributions in the book have focused on highlighting the research from Japan however it is appealing to researchers and students worldwide. This compilation of cutting-edge natural product synthesis provides high-quality expertise, especially to graduate students and young researchers, regarding research on synthetic organic chemistry. It can be utilized as teaching material in university seminars as well as provide guidance to researchers in the area of total synthesis.
Modern Mathematical Statistics with Applications
This book tries to strike a balance between mathematical foundations and statistical practice. The book provides a clear and current exposition of statistical concepts and methodology, including many examples and exercises based on real data gleaned from publicly available sources. The main focus of the book is on presenting and illustrating methods of inferential statistics used by investigators in a wide variety of disciplines, from actuarial science all the way to zoology. It begins with a chapter on descriptive statistics that immediately exposes the reader to the analysis of real data. The next six chapters develop the probability material that facilitates the transition from simply describing data to drawing formal conclusions based on inferential methodology. Point estimation, the use of statistical intervals, and hypothesis testing are the topics of the first three inferential chapters. The remainder of the book explores the use of these methods in a variety of more complex settings.
Modern Genome Annotation : The Biosapiens Network
An accurate description of current scientific developments in the field of bioinformatics and computational implementation is presented by research of the BioSapiens Network of Excellence. Bioinformatics is essential for annotating the structure and function of genes, proteins and the analysis of complete genomes and to molecular biology and biochemistry. Included is an overview of bioinformatics, the full spectrum of genome annotation approaches including; genome analysis and gene prediction, gene regulation analysis and expression, genome variation and QTL analysis, large scale protein annotation of function and structure, annotation and prediction of protein interactions, and the organization and annotation of molecular networks and biochemical pathways. Also covered is a technical framework to organize and represent genome data using the DAS technology and work in the annotation of two large genomic sets: HIV/HCV viral genomes and splicing alternatives potentially encoded in 1% of the human genome.
Modern deep learning for tabular data : Novel approaches to common modeling problems
Synthesizes and presents novel deep learning approaches to a seemingly unlikely domain - tabular data. Whether for finance, business, security, medicine, or countless other domain, deep learning can help mine and model complex patterns in tabular data - an incredibly ubiquitous form of structured data. Part I of the book offers a rigorous overview of machine learning principles, algorithms, and implementation skills relevant to holistically modeling and manipulating tabular data. Part II studies five dominant deep learning model designs - Artificial Neural Networks, Convolutional Neural Networks, Recurrent Neural Networks, Attention and Transformers, and Tree-Rooted Networks - through both their 'default' usage and their application to tabular data. Part III compounds the power of the previously covered methods by surveying strategies and techniques to supercharge deep learning systems: autoencoders, deep data generation, meta-optimization, multi-model arrangement, and neural network interpretability.
Modern cryptography ; Vol.1 : A classical introduction to informational and mathematical principle
This book systematically explores the statistical characteristics of cryptographic systems, the computational complexity theory of cryptographic algorithms and the mathematical principles behind various encryption and decryption algorithms. The theory stems from technology. Based on Shannon's information theory, this book systematically introduces the information theory, statistical characteristics and computational complexity theory of public key cryptography, focusing on the three main algorithms of public key cryptography, RSA, discrete logarithm and elliptic curve cryptosystem.
Modern Control Systems ; 14th ed.
Written to be equally useful for all engineering disciplines, this text is organized around the concepts of control systems theory in the context of frequency and time domains. It provides coverage of both classical and modern methods of control engineering to give students a strong foundation in basic principles that they can utilize to explore advanced topics in later chapters. Emphasis is placed on real-world complex control systems and practical design applications as well as evolving design strategies like green engineering and human-centered design. Problem solving is strongly emphasized, with an abundance of problems of increasing complexity that help students learn to apply theory to computer-aided design and analysis concepts using MATLAB® and LabVIEW MathScript.
