الصفحة 57
الصفحة 57
Drug and Biological Development : From Molecule to Product and Beyond
Drug and Biological Development: From Molecule to Product and Beyond offers a complete discussion of product development in the pharmaceutical and biotechnology industries from discovery to product launch, continuing through life cycle management. The book is organized for optimal usefulness in the education and training of health care professionals. The text's narrative descriptions are enhanced by real-life examples, illustrations, controversies in industry, and references. Dr. Ronald Evens and his contributors are industry and research experts in a variety of disciplines.
Drug Addiction : From Basic Research to Therapy
Drug Addiction: From Basic Research to Therapy provides a comprehensive overview of physiological, biochemical, genetic and behavioral pathways underlying drug addiction. Focusing on fundamental neurophysiological processes that overlap between drug addiction and other CNS disorders, this volume covers the translation of basic research into novel therapies, not only of drug addiction but a spectrum of related CNS disorders, including pain. Chapters are written by leading scientists with widely ranging expertise in synthetic and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and development, drug targeting, and quantitative therapeutics, providing an unprecedented overview of a complex field of high societal signficance.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Driving digital transformation through data and AI : A practical guide to delivering data science and machine learning products
Explains how to build the organizational capability to deliver Data and AI products and drive immediate business results as new digital technologies significantly disrupt business Provides best practices, tools and templates for managing the organizational and technological change process to become an AI-driven enterprise Includes a variety of international case studies across several industries such as insurance, fashion, consumer goods, finance, technology and automotive Outlines how to develop a product strategy, build teams and design the platform and architecture Provides key principles for sharing knowledge, educating staff on data and AI, and effectively engaging top executives
Dream catcher
Dream Catcher is a video generation application that helps in many fields as science fiction, imagine event’s scenarios, education, animation and montage. By applying artificial algorithms implemented and trained on a dataset containing video samples and there descriptions to generate videos from any given text. The idea of generating videos from text is a new idea that was first presented at 2017, even that international companies like Google and OpenAi In the last year, was working on developing models to generate images from text. To make it easier to use the application, there are many ways to enter the text either by an image, voice or Typing from the keyboard.
Drawing the Ground - Landscape Urbanism Today : The Work of Palmbout Urban Landscapes
Documents some fifteen projects organized into six thematic blocks, including such extensive projects as Amsterdam Ijburg, a design for an urban extension to Amsterdam with a total area of 450 hectares, 18,000 residences, 100,000 square meters of office space, 30,000 square meters of stores, and other facilities, and Maastricht Belvedere, a restructuring of 280 hectares of a former industrial site with 4,000 residences, 100,000 square meters of office space, parking lots, and a vehicle bridge.
Double-stranded RNA : Methods and protocols
Examines classical and cutting-edge methods involving double-stranded RNA (dsRNA), specifically regarding isolation, visualization, characterization, production, and application. Many protocols, such as co-immunoprecipitation-based isolation of double-stranded RNA-associated protein complexes, identification of mycoviruses by dsRNA extraction, application of dsRNA for fungi disease management (Sclerotinia sclerotiorum and Botrytis cin), and production of double-stranded RNA in plants by plant viral vectors for gene silencing, can also be easily adapted for identification of viruses from other organisms, control of other pathogens, and fundamental research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips for troubleshooting and avoiding known pitfalls.
Double Balloon Endoscopy : Theory and Practice
The chapters of this book describe the principles, insertion technique, and clinical applications of double-balloon endoscopy, which will become the gold standard of enteroscopy and may well eliminate the need for intraoperative enteroscopy in many patients.
Domain-driven design with Java, a practitioner's guide : create simple, elegant, and valuable software solutions for complex business problems
Helps you as a developer and architect to put your knowledge to work in order to create elegant software designs that are enjoyable to work with and easy to reason about. You'll begin with an introduction to the concepts of domain-driven design and discover various ways to apply them in real-world scenarios. You'll also appreciate how DDD is extremely relevant when creating cloud native solutions that employ modern techniques such as event-driven microservices and fine-grained architectures. As you advance through the chapters, you'll get acquainted with core DDD's strategic design concepts such as the ubiquitous language, context maps, bounded contexts, and tactical design elements like aggregates and domain models and events. You'll understand how to apply modern, lightweight modeling techniques such as business value canvas, Wardley mapping, domain storytelling, and event storming, while also learning how to test-drive the system to create solutions that exhibit high degrees of internal quality.
Domain Decomposition Methods in Science and Engineering XVII
This volume contains a selection of papers presented at the 17th International Conference on Domain Decomposition Methods in Science and Engineering held at St. Wolfgang / Strobl, Austria, July 3 - 7, 2006. Domain decomposition is an active, interdisciplinary research area concerned with the development, analysis, and implementation of coupling and decoupling strategies in mathematical and computational models. Domain decomposition techniques provide efficient tools for treating problems in all Computational Sciences. The reader will become familiar with the newest domain decomposition technologies and their use for modeling and simulating of complex problems from different fields of applications.
Do-All Computing in Distributed Systems : Cooperation in the Presence of Adversity
Do-All Computing in Distributed Systems: Cooperation in the Presence of Adversity is the first book that presents an in depth study of cooperation problems, abstracted in terms of the Do-All problem, where a collection of processors cooperatively perform a collection of independent tasks in the presence of adversity.
DNA Methylation and Cancer Therapy
DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.
DNA Methylation : Development, Genetic Disease and Cancer
It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.
DNA Computing ; Vol. 4287 ; 12th International Meeting on DNA Computing, DNA12, Seoul, Korea, June 5-9, 2006, Revised Selected Papers
This book constitutes the thoroughly refereed postproceedings of the 12th International Meeting on DNA Computing, DNA12, held in Seoul, Korea in June 2006. The 34 revised full papers presented are organized in topical sections on molecular and membrane computing models, complexity analysis, sequence and tile designs and their properties, DNA tile self-assembly models, simulator and software for DNA computing, DNA computing algorithms and new applications, novel experimental approaches, and experimental solutions.
DNA Binders and Related Subjects
advances in technology and the application of new methods to outstanding problems have played a major part in the development of ideas about drug-nucleic acid recognition. The field has undergone an explosive diversification as wider and wider problems became accessible to study using the new ideas and techniques. This volume reflects that diversification by offering accounts of selected areas that illustrate recent advances in the study of ligand–nucleic acid binding over disparate areas of the subject. There are chapters dealing specifically with the invention and application of new methodology, and a particularly thoughtful essay on the interpretation of X-ray diffraction data which may not be as straightforward as is often imagined. Other chapters illustrate the diversity and complexity of drug-DNA binding from several perspectives, referring to particular groups of related compounds or the potential attractions of the less-preferred DNA major groove as a target for nucleotide sequence recognition by ligands.
DNA barcoding : Methods and protocols
Covers the latest advancements and methods used to study DNA barcoding. The chapters in this book are organized into six parts: theory, DNA manipulation, specialized barcoding methods, analysis of DNA barcodes, completing a successful DNA barcode project, and barcoding as citizen science. Part One looks at several theoretical issues in DNA barcoding concerned with DNA barcodes that can and should be used. Part Two discusses protocols for processing samples into DNA barcodes, including DNA isolation, sequencing and managing samples, and the resulting DNA barcodes. Part Three explores the next generation of DNA barcoding such as FRET-based detection, dual nanopore detection, skimming, and closed-tube methods. Part Four addresses programs and websites that handle DNA barcoding data, and includes character-based approaches, barcode gap methods, integrated approaches, and Barcode of Life Database
Distributed systems and mobile computing
About Distributed Systems and Mobile Computing. This is a branch of Computer Science devoted to the study of systems whose components are in different physical locations and have limited communication capabilities. Such components may be static, often organized in a network, or may be able to move in a discrete or continuous environment. The theoretical study of such systems has applications ranging from swarms of mobile robots (e.g., drones) to sensor networks, autonomous intelligent vehicles, the Internet of Things, and crawlers on the Web. The book includes five articles. Two of them are about networks: the first one studies the formation of networks by agents that interact randomly and have the ability to form connections; the second one is a study of clustering models and algorithms. The three remaining articles are concerned with autonomous mobile robots operating in continuous space.
Distributed Services with OpenAFS : For Enterprise and Education
This book shows in detail how to build enterprise-level secure, redundant, and highly scalable services from scratch on top of the open source Linux operating system, suitable for small companies as well as big universities. The core architecture presented is based on Kerberos, LDAP, AFS, and Samba. It is shown how to integrate web, message related, data base and other services with this backbone. This architecture provides a Single-Sign-On solution for different client platforms and can also be employed for clustering. Although it is implemented with Debian GNU/Linux, the content can be applied to other UNIX flavors.
Distributed Embedded Control Systems : Improving Dependability with Coherent Design
Distributed Embedded Control Systems handles the domains encountered when designing a distributed embedded computer control system as an integrated whole. First to be discussed are some basic issues about real-time systems and their properties, specifically safety. Then, system and hardware architectures are dealt.
Distributed Cooperative Laboratories : Networking, Instrumentation, and Measurements
This is a highly interdisciplinary topic, where various aspects converge: multimedia communications and networking, sensor networks, Grid technology, Quality of Service (QoS) provisioning and control, network management, measurement instrumentation and methodology, architecture of measurement systems. The material is organized into six parts: Technologies for Real-Time Interactive Multimedia Communications; Monitoring, Management and Configuration of Networks and Networking Devices; Data Acquisition and Aggregation in Sensor Networks; Grid Structures for Distributed Cooperative Laboratories; Architectures and Techniques for Tele-Measurements; Virtual Immersive Communications and Distance Learning. Each contribution presents a self-contained treatment, within a framework that provides the reader with an up-to-date picture of the most recent state-of-the-art developments.
