الصفحة 54
الصفحة 54
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BioMEMS and biomedical nanotechnology ; Vol. II : Micro/Nano Technologies for Genomics and Proteomics

Numerous miniaturized DNA microarray, DNA chip, Lab on a Chip and biosensor devices have been developed and commercialized. Such devices are improving the way many impor-tant genomic and proteomic analyses are performed in both research and clinical diagnostic laboratories. The development of these technologies was enabled by a synergistic combina-tion of disciplines that include microfabrication, microfluidics, MEMS, organic chemistry and molecular biology. Some of these new devices and technologies utilize sophisticated mi-crofabrication processes developed by the semiconductor industry.

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Biological Membrane Ion Channels : Dynamics, Structure, and Applications

Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts.

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Bio-informatique moléculaire : Une approche algorithmique = Molecular bioinformatics : An algorithmic approach

Deals with genetic maps, from the problem of sequence comparison and alignment, including DNA chips and genomic rearrangement. It thus covers a wide variety of topics relating to algorithmic and combinatorial processing of questions arising from molecular bioinformatics and biotechnology.

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Bioinformatics Using Computational Intelligence Paradigms

Bioinformatics as well as Computational Intelligence are undoubtedly remarkably fast growing fields of research and real-world applications with enormous potential for current and future developments. "Bioinformatics using Computational Intelligence Paradigms" contains recent theoretical approaches and guiding applications of biologically inspired information processing systems(Computational Intelligence) against the background of bioinformatics. This carefully edited monograph combines the latest results of Bioinformatics and Computational Intelligence and offers a promising cross-fertilisation and interdisciplinary work between these growing fields.

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Bioinformatics and Computational Biology Solutions Using R and Bioconductor

Bioconductor is a widely used open source and open development software project for the analysis and comprehension of data arising from high-throughput experimentation in genomics and molecular biology. Bioconductor is rooted in the open source statistical computing environment R. This volume's coverage is broad and ranges across most of the key capabilities of the Bioconductor project, including: Importation and preprocessing of high-throughput data from microarray, proteomic, and flow cytometry platforms / Curation and delivery of biological metadata for use in statistical modeling and interpretation. / Statistical analysis of high-throughput data, including machine learning and visualization,modeling and visualization of graphs and networks. This book is a dynamic document. Code underlying all of the computations that are shown is made available on a companion website, and readers can reproduce every number, figure, and table on their own computers.

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Biogeochemical cycles in globalization and sustainable development

This valuable study of environmental subsystems functioning under various climatic and anthropogenic conditions provides a unique insight into the social context of global changes in biogeochemical cycles and demonstrates current understanding of globalization and sustainable development.

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Bioarrays : From Basics to Diagnostics

Bioarrays: From Basics to Diagnostics provides an integrated and comprehensive collection of timely articles on the use of bioarray techniques in the fields of biotechnology and molecular medicine. The entire volume is broken into four sections – Bioarray Technology Platforms, Biomarkers and Clinical Genomics, Biomarker Identification Using Clinical Proteomics and Glycomics, and Emerging Technologies in Diagnostics – that create one well-integrated work. Particular emphasis is placed on DNA, protein, and carbohydrate biochips. The volume also looks extensively at oligonucleotides, cDNA, proteins, antibodies, and carbohydrate arrays.

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Bioactive Heterocycles III

Bioactive Heterocycles III provides readers with a comprehensive overview of the most recent breakthroughs in the ?eld of heterocycles. This volume contains 8 chapters written by experts in their respective ?elds from all over the world. The chapters summarize years of extensive research in each area, and providein sight in the new themesofnaturalproduct research.Manyofthe contributors illustrate their laboratory experiences. It's obvious that readers will gain exciting and essential information fromthe volume. In the ?rst chapter, Kayser et al. describe the chemistry, biosynthesis and biological activities of artemisinin, one of the most promising antimalarial molecules, and its related natural peroxides.

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Bioactive Conformation I

This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts – it is still valid and useful after 5 or 10 years. More information as well as the electronic version of the whole content available at: springerlink.com. The book will appeal to scientists and practitioners in the mentioned fields and in industry.

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Bioactive Confirmation II

Specific binding of a ligand to a receptor is a key step in a variety of biol- ical processes, such as immune reactions, enzyme cascades, or intracellular transport processes. The ligand-receptor terminology implies that the rec- tor molecule is signi?cantly larger than the ligand, and the term "bioactive conformation" usually characterizes the conformation of a ligand when it is bound to a receptor. In a more general sense, bioactive conformation applies toanymoleculeinabiologicallyrelevantboundstateregardlessofsizecons- erations. Mostofthecontributions tothisbookaddressligandsthat aremuch smaller than their receptors. X-ray crystallography and high resolution NMR spectroscopy are the two main experimental techniques used to study bioactive conformations. The- fore, the twovolumes ofthisbookcover approachesthat use either ofthetwo techniques, or a combination thereof.

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Binary Rare Earth Oxides

The book begins with a brief introduction to binary rare earth oxides, their physical and chemical stabilities, polymorphism, crystal structures and phase transformation and the association with current applications. The book goes on to present the band structure of the oxides using several quantum chemical calculations, which belong to a newly developed area in the binary rare earth oxides. Central to this chapter are the characterizations of electrical, magnetic and optical properties, as well as details of single crystal growth and particle preparation methods that have progressed in recent years. Later chapters concentrate on thermo-chemical properties and trace determination techniques. The final chapter contains a variety of useful applications in various fields such as phosphors, glass abrasives, automotive catalysts, fuel cells, solid electrolytes, sunscreens, iron steels, and biological materials.

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Binary Quadratic Forms: An Algorithmic Approach

This book deals with algorithmic problems concerning binary quadratic forms 2 2 f(X,Y)= aX +bXY +cY with integer coe?cients a, b, c, the mathem- ical theories that permit the solution of these problems, and applications to cryptography.

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Bifurcations, Instabilities, Degradation in Geomechanics

Leading international researchers and practitioners of bifurcations and instabilities in geomechanics debate the developments and applications which have occurred over the last few decades. The topics covered include modeling of bifurcation, structural failure of geomaterials and geostructures, advanced analytical, numerical and experimental techniques, and application and development of generalised continuum models etc. In addition analytical solutions, numerical methods, experimental techniques, and case histories are presented. Beside fundamental research findings, applications in geotechnical, petroleum, mining, and bulk materials engineering are emphasised.

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Between Necessity and Probability : Searching for the Definition and Origin of Life

This study investigates the major theories of the origins of life in light of modern research with the aim of distinguishing between the necessary and the optional and between deterministic and random influences in the emergence of what we call ‘life.’ Life is treated as a cosmic phenomenon whose emergence and driving force should be viewed independently from its Earth-bound natural history. The author synthesizes all the fundamental life-related developments in a comprehensive scenario, and makes the argument that understanding life in its broadest context requires a material-independent perspective that identifies its essential fingerprints.

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Beauty’s Appeal : Measure and Excess

Beauty fulfils human existence. As it registers in our aesthetic experience, beauty enhances nature’s enchantment around us and our inward experience lifting our soul toward moral elevation. Carried by creative imagination (Imaginatio Creatrix), beauty participates in the moulding of the forms of the intellective constitution of the mind in tandem with praxis and seeks deeper enigmas of the real in the labyrinth of the cosmos. Yet with the evolution of human development and in technological inventions, beauty, while suffusing all modalities of experience, seems to undergo transformations and expansion. Are there perduring norms and modalities of beauty or are we carried along blindly by human development? Is there a measure intrinsic to our human ontopoietic unfolding and the growth of human life that we may follow instead of the whim of fancy and excess? The present collection of art-explorations seeks the elemental ties of Human Condition. Together, the authors aim to answer the questions posed above.

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Battery management systems : Accurate state-of-charge indication for battery-powered applications

Builds further on the contents of the first volume in the Philips Research Book Series, Battery Management Systems - Design by Modelling. Since the subject of battery SoC indication requires a number of disciplines, this book covers all important disciplines starting from (electro)chemistry to understand battery behaviour, via mathematics to enable modelling of the observed battery behaviour and measurement science to enable accurate measurement of battery variables and assessment of the overall accuracy, to electrical engineering to enable an efficient implementation of the developed SoC indication system. It will therefore serve as an important source of information for any person working in engineering and involved in battery management.

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Basic Real Analysis

Basic Real Analysis and Advanced Real Analysis (available separately or together as a Set) systematically develop those concepts and tools in real analysis that are vital to every mathematician, whether pure or applied, aspiring or established. These works present a comprehensive treatment with a global view of the subject, emphasizing the connections between real analysis and other branches of mathematics.

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Basic principles and applications of probability theory

This introductory chapter discusses such notions as determinism, chaos and randomness, p- dictibility and unpredictibility, some initial approaches to formalizing r- domness and it surveys certain problems that can be solved by probability theory. This will perhaps give one an idea to what extent the theory can - swer questions arising in speci?c random occurrences and the character of the answers provided by the theory. 1. 1 The Nature of Randomness The phrase “by chance” has no single meaning in ordinary language. For instance, it may mean unpremeditated, nonobligatory, unexpected, and so on. Its opposite sense is simpler: “not by chance” signi?es obliged to or bound to (happen). In philosophy, necessity counteracts randomness. Necessity signi?es conforming to law – it can be expressed by an exact law. The basic laws of mechanics, physics and astronomy can be formulated in terms of precise quantitativerelationswhichmustholdwithironcladnecessity.

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Basic Notions of Algebra

Aims to present a general survey of algebra, of its basic notions and main branches.Those parts of the book devoted to the systematic treatment of notions and results of algebra make very limited demands on the reader: we presuppose only that the reader knows calculus, analytic geometry and linear algebra in the form taught in many high schools and colleges. The extent of the prerequisites required in our treatment of examples is harder to state; an acquaintance with projective space, topological spaces, differentiable and complex analytic manifolds and the basic theory of functions of a complex variable is desirable, but the reader should bear in mind that difficulties arising in the treatment of some specific example are likely to be purely local in nature, and not to affect the understanding of the rest of the book.

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Barriers and Biases in Computer-Mediated Knowledge Communication : And How They May Be Overcome

This books deals with computer-mediated cooperation and communication scenarios in teaching and learning situations, leisure activities (e.g. laypersons looking for expert information on the internet), and net-based communication at work. Such scenarios will become increasingly important. But the successful use of such computer-mediated settings is not trivial. Cooperative learning and work itself requires special skills and strategies. And the technical settings with sometimes restricted, sometimes new possibilities for communication add problems on top of the cooperation itself. What are the barriers in computer-mediated communication for cooperative learning and work? Which are the most relevant biases in computer-mediated information processing? Based on empirical research the contributors from psychology, education and computer sciences offer different perspectives on the nature and causes of such barriers.

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