الصفحة 50
الصفحة 50
Dynamical Systems, Graphs, and Algorithms
Provides a taster for using symbolic analysis, graph theory, and set-oriented methods in a quest to understand the global structure of the dynamics in a continuous- or discrete-time system. In many ways, the techniques discussed here are complementary to more traditional ways of analysing a dynamical system and as such, this book can be viewed as a valuable entry into the theory and computational methods
Dynamical Systems : Examples of Complex Behaviour
Our aim is to introduce, explain, and discuss the fundamental problems, ideas, concepts, results, and methods of the theory of dynamical systems and to show how they can be used in specific examples. Itis also important to find out when a certain dynamic behavior is stable under small perturbations, as well as to understand the various scenarios of instability. Finally, an essential aspect of a dynamic evolution is the transformation of some given initial state into some final or asymptotic state as time proceeds. The temporal evolution of a dynamical system maybe continuous or discrete, but it turns out that many of the concepts to be introduced a reuseful in either case.
Dynamical Oceanography
This textbook provides a mathematical introduction to the theory of large-scale ocean circulation and is accessible for readers with an elementary knowledge of mathematics and physics, including continuum mechanics and solution methods for ordinary differential equations. The book consists of four parts. Part I (chapters 1 - 4) is a very brief introduction to ocean circulation and the mathematical formulation of the governing equations of ocean flows. In addition, concepts are introduced that are necessary to describe and understand large-scale ocean currents. In part II (chapters 5 - 10), the theory of mid-latitude wind-driven ocean circulation is presented. Part III (chapters 11 - 12) focuses on the understanding of equatorial currents and El Nino. In the last part IV, chapters 13 - 16, the theory of planetary scale flows is presented, covering topics such as the thermocline problem, the Antarctic Circumpolar Current, the stability of the thermohaline circulation and the Arctic Ocean circulation.
Dynamical Contact Problems with Friction : Models, Methods, Experiments and Applications
The aim of this book is to describe an efficient procedure to model dynamical contact problems with friction. This procedure is applied to different practical problems and verified by experiments. Friction contacts are used to transmit forces or to dissipate energy. Examples for dynamical engineering systems with friction are brakes, machine tools, motors, turbines, bearings or wheel-rail systems. A better understanding of friction phenomena result in improvements like the reduction of noise and maintenance costs, increased life time of machines and improved energy efficiency. Dependent on the features of the dynamic system with friction contacts, different contact models and solution methods like multi-scaling methods are developed and applied.
Dynamic pricing and automated resource allocation for complex information services : Reinforcement learning and combinatorial auctions
This book develops allocation mechanisms that aim to ensure an efficient resource allocation in modern IT-services. The author presents two methods, both of which using the users’ willingness-to-pay to control the allocation process. The author generates a method to calculate dynamic resource prices.
Dynamic Methods for Damage Detection in Structures
Presents an overview of dynamic methods for structural health monitoring and damage detection in structures. This book explains both theoretical and experimental aspects of dynamic non-destructive methods and their connection with inverse and identification problems in structural dynamics.
Dynamic General Equilibrium Modelling : Computational Methods and Applications
Modern business cycle theory and growth theory uses stochastic dynamic general equilibrium models. Many mathematical tools are needed to solve these models. The book presents various methods for computing the dynamics of general equilibrium models. In part I, the representative-agent stochastic growth model is solved with the help of value function iteration, linear and linear quadratic approximation methods, parameterised expectations and projection methods. In order to apply these methods, fundamentals from numerical analysis are reviewed in detail. Part II discusses methods for solving heterogeneous-agent economies. In such economies, the distribution of the individual state variables is endogenous. This part of the book also serves as an introduction to the modern theory of distribution economics. Applications include the dynamics of the income distribution over the business cycle or the overlapping-generations model.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Oncology
Dynamic contrast-enhanced MRI is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. This is assisting clinical practitioners in the management of patients with solid tumors and is finding prominence in the assessment of tumor treatments, including anti-angiogenics, chemotherapy, and radiotherapy. In this book, targeted at both clinical practitioners and basic scientists, the principles of the methods, their practical implementation, and their application to specific tumor types are discussed by the leading authorities in the field today. The book will serve as an invaluable single-volume reference covering all the latest developments in contrast-enhanced oncological MRI.
Dynamic characterisation of analogue-to-digital converters
Dynamic Characterisation of Analogue-to-Digital Converters presents a state of the art overview of the methods and procedures employed for characterising ADCs’ dynamic performance behaviour using sinusoidal stimuli. The three classical methods – histogram, sine wave fitting, and spectral analysis – are thoroughly described, and new approaches are proposed to circumvent some of their limitations
Dynamic Analysis of Structures
Reflects the latest application of structural dynamics theory to produce more optimal and economical structural designs. The author includes carefully worked-out examples which are solved utilizing more recent numerical methods. These examples pave the way to more accurately simulate the behavior of various types of structures. The essential topics covered include principles of structural dynamics applied to particles, rigid and deformable bodies, thus enabling the formulation of equations for the motion of any structure.
Drugs used in murder and drugs facilitated sexual assaults
Since ancient times, the methods of committing crimes have varied and the methods of killing have varied. The killer has always sought to hide his crime. One of the methods of killing is poisoning the victim, but with the development of science also methods for detecting toxins inside the victim's body have developed. Also, in recent decades, drugs facilitating sexual assault have spread, which aim to make the victim unconscious and paralyze his resistance...
Drugs in palliative care
While palliative care has adopted a holistic approach to treatment / medication-driven symptom management ostensibly forms the critical aspect of care. Prescribing in palliative care can be extremely complex because the patient may often have comorbidity / or occasionally multimorbidity. The associated polypharmacy further complicates the pharmacological management of symptoms being caused by the palliative condition. This can be daunting for healthcare professionals and can negatively impact upon the effectiveness of care provided. Fully revised and updated / the third edition of Drugs in Palliative Care provides a detailed / yet concise overview of topics that are encountered in palliative care clinical practice. The book will appeal to a variety of healthcare professionals involved in the provision of palliative care and medicines information.
Drugs and a methodological compendium : From bench to bedside
Provides a meticulous view on methodological drug discovery and development insights from bench to bedside. Focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. Covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Drug utilization research : Methods and applications
Drug Utilization Research (DUR) is a discipline which combines aspects of pharmacotherapy, epidemiology, and health services research into an interdisciplinary set of methods for analyzing and assessing the prescribing, dispensing and consumption of medicines. It combines both qualitative and quantitative approaches to facilitate the safe and effective use of pharmaceuticals. Drug Utilization Research: Methods and Applications provides a comprehensive introduction to this discipline, prepared by an international team of authors with broad experience in numerous fields. Now reorganized and updated to reflect the latest research and global challenges, it is an indispensable resource for understanding the use of pharmaceuticals.
Drug transporters : Molecular characterization and role in drug disposition
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
Drug safety evaluation : Methods and protocols
Focuses on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls.
Drug repurposing and computational drug discovery strategies and advances
Defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates.
Drug delivery systems using quantum computing
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells, and subcellular organs for drug release and absorption through a variety of drug carriers. By controlling the precise level and/or location of a given drug in the body, side effects are reduced, doses are lowered, and new therapies are possible. Nevertheless, there are still significant obstacles to delivering certain medications to particular cells. Drug delivery methods change pharmacokinetic, pharmacodynamic, and drug release patterns to enhance product efficacy and safety, as well as patient convenience and compliance.
Drug Delivery Systems
Expands on the previous editions with a discussion of new and updated methods used to study drug delivery. Chapters cover topics such as drug delivery in cancer and intrathecal delivery of analgesics in humans. The increasing role of nanobiotechnology is reflected in eight of the sixteen chapters that include synthesis of gold nanoparticles; targeted siRNA delivery; and lipid nanocarriers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Drawn to Design : Analyzing Architecture Through Freehand Drawing
A guide for students and teachers to understand the need for, the role of and the methods and techniques of freehand analytical sketching in architecture. The presentation focuses on drawing as an approach to and phase of architectural design. The conceptual goal of this approach is to use drawing not as illustration or depiction, but as exploration. The first part of the book discusses underlying concepts of freehand sketching in design education and practice as a complement to digital technologies. The main component is a series of chapters that constitute a typology of fundamental issues in architecture and urban design; for instance, issues of "façade" are illustrated with sketch diagrams that show how façades can be explored and sketched through a series of specific questions and step-by-step procedures.
