الصفحة 5
الصفحة 5
Drug and Biological Development : From Molecule to Product and Beyond
Drug and Biological Development: From Molecule to Product and Beyond offers a complete discussion of product development in the pharmaceutical and biotechnology industries from discovery to product launch, continuing through life cycle management. The book is organized for optimal usefulness in the education and training of health care professionals. The text's narrative descriptions are enhanced by real-life examples, illustrations, controversies in industry, and references. Dr. Ronald Evens and his contributors are industry and research experts in a variety of disciplines.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Digital watermarking ; Vol. 3304 ; 3rd International Workshop, IWDW 2004, Seoul, Korea, October 30 - November 1, 2004, revised selected papers
We are happy to present to you the proceedings of the 3rd International Workshop on Digital Watermarking, IWDW 2004. Since its modern reappearance in the academic community in the early 1990s, great progress has been made in understanding both the capabilities and the weaknesses of digital watermarking. On the theoretical side, we all are now well aware of the fact that digital watermarking is best viewed as a form of communication using side information. In the case of digital watermarking the side information in question is the document to be watermarked. This insight has led to a better understanding of the limits of the capacity and robustness of digital watermarking algorithms. It has also led to new and improved watermarking algorithms, both in terms of capacity and imperceptibility. Similarly, the role of human perception, and models thereof, has been greatly enhanced in the study and design of digital watermarking algorithms and systems. On the practical side, applications of watermarking are not yet abundant. The original euphoria on the role of digital watermarking in copy protection and copyright protection has not resulted in widespread use in practical systems. With hindsight, a number of reasons can be given for this lack of practical applications.
Device Applications of Nonlinear Dynamics
This edited book is devoted specifically to the applications of complex nonlinear dynamic phenomena to real systems and device applications. While in the past decades there has been significant progress in the theory of nonlinear phenomena under an assortment of system boundary conditions and preparations, there exist comparatively few devices that actually take this rich behavior into account. "Device Applications of Nonlinear Dynamics" applies and exploits this knowledge to make devices which operate more efficiently and cheaply, while affording the promise of much better performance. Given the current explosion of ideas in areas as diverse as molecular motors, nonlinear filtering theory, noise-enhanced propagation, stochastic resonance and networked systems, the time is right to integrate the progress of complex systems research into real devices.
Development of geopolymer from pond ash-thermal power plant waste : Novel constructional materials for civil engineers
Demonstrates how to utilize fly ash/pond ash (waste materials from thermal power plants) to produce a novel material called 'Geopolymer' (GP). Red mud, slags, etc., are mixed with fly ash to produce GP with enhanced strength. As shown in a few European countries, GP can replace cement, and some permanent structures constructed with GP are now appearing in a few advanced countries. GP, and geopolymer concrete, is considered suitable for the construction of roads, buildings, etc., and will eventually, fully or partially, replace cement.
Dental caries: the disease and its clinical management ; 4th ed.
Maintains the same focus on high-level coverage of the disease etiology and process, clinical assessment and prognosis and wider public health issues connected with dental caries management, including an enhanced focus on caries control. Fully updated throughout, the chapters that discuss theory emphasize how the knowledge can be applied in both the clinic and in the public health domain to improve oral health. The new edition also includes up-to-date and validated diagnostic and management options for caries whilst ensuring that the tools provided allow practitioners to serve the needs of different socio-economic populations. All sections are complimented by high-quality color photographs, clear line drawings and references for further study.
Dental caries : The disease and its clinical management
In this highly anticipated new edition, the editors maintain the same focus on high-level coverage of the disease etiology and process, clinical management best-practice, and wider public health issues connected with dental caries management, including an enhanced focus on the ‘caries control concept’. The aim is to link theory with clinical performance, making prevention, diagnosis and restorative procedures evidence based. The structure of the book has been completely overhauled, with the same coverage streamlined in order to distil information effectively. The book is divided into six main sections: An overview of the disease and its prevalence / The caries lesion and its biological determinants / Diagnosis / Controlling dental caries / Operative intervention / Caries control in special populations
CyberParks – The Interface Between People, Places and Technology: New Approaches and Perspectives
This book is about public open spaces, about people, and about the relationship between them and the role of technology in this relationship. It is about different approaches, methods, empirical studies, and concerns about a phenomenon that is increasingly being in the centre of sciences and strategies – the penetration of digital technologies in the urban space. As the main outcome of the CyberParks Project, this book aims at fostering the understanding about the current and future interactions of the nexus people, public spaces and technology. It addresses a wide range of challenges and multidisciplinary perspectives on emerging phenomena related to the penetration of technology in people’s lifestyles - affecting therefore the whole society, and with this, the production and use of public spaces. Cyberparks coined the term cyberpark to describe the mediated public space, that emerging type of urban spaces where nature and cybertechnologies blend together to generate hybrid experiences and enhance quality of life.
Creating New Learning Experiences on a Global Scale ; 2nd European Conference on Technology Enhanced Learning, EC-TEL 2007, Crete, Greece, September 17-20, 2007, Proceedings
It is holding more than 500 pages of combined wisdom on Technology Enhanced Learning (TEL) in your hands! With the advance of metadata, standards, learning objects, Web 2. 0 approaches to rip, mix and burn learning, wikis, blogs, syndication, user-generated content, W- based video, games and the ubiquitous availability of computing devices we can and have to offer more flexible learning services on a global scale.It provided a unique forum for all research related to technology enhanced learning, including its interactions with knowledge management, business processes and work environments.
Contrast-Enhanced Ultrasound in Clinical Practice : Liver, Prostate, Pancreas, Kidney and Lymph Nodes
Concomitant with the improvement of contrast agents, different contrast-specific imaging modalities have been developed which, used in combination with USCA and a low mechanical index, allow continuous real-time grey-scale imaging. These recent technical improvements have opened new possibilities in the use of USCA in a variety of indications. Written by internationally renowned experts, the contributions gathered in this book give an overview of current and possible future new applications of USCA in routine and clinical practice.
Computer organization and design, enhanced : The hardware / software interface ; 5th ed.
Contains new examples and material highlighting the emergence of mobile computing and the cloud. It explores this generational change with updated content featuring tablet computers, cloud infrastructure, and the ARM (mobile computing devices) and x86 (cloud computing) architectures. The book uses a MIPS processor core to present the fundamentals of hardware technologies, assembly language, computer arithmetic, pipelining, memory hierarchies and I/O.Because an understanding of modern hardware is essential to achieving good performance and energy efficiency, this edition adds a new concrete example, Going Faster, used throughout the text to demonstrate extremely effective optimization techniques. There is also a new discussion of the Eight Great Ideas of computer architecture.
Computational Discovery of Scientific Knowledge : Introduction, Techniques, and Applications in Environmental and Life Sciences
Advances in technology have enabled the collection of data from scientific observations, simulations, and experiments at an ever-increasing pace. For the scientist and engineer to benefit from these enhanced data collecting capabilities, it is becoming clear that semi-automated data analysis techniques must be applied to find the useful information in the data. Computational scientific discovery methods can be used to this end: they focus on applying computational methods to automate scientific activities, such as finding laws from observational data. In contrast to mining scientific data, which focuses on building highly predictive models, computational scientific discovery puts a strong emphasis on discovering knowledge represented in formalisms used by scientists and engineers, such as numeric equations and reaction pathways. This state-of-the-art survey provides an introduction to computational approaches to the discovery of scientific knowledge and gives an overview of recent advances in this area, including techniques and applications in environmental and life sciences.
Managing the Complexity of Critical Infrastructures : A Modelling and Simulation Approach
This book summarizes work being pursued in the context of the CIPRNet (Critical Infrastructure Preparedness and Resilience Research Network) research project, co-funded by the European Union under the Seventh Framework Programme (FP7). The project is intended to provide concrete and on-going support to the Critical Infrastructure Protection (CIP) research communities, enhancing their preparedness for CI-related emergencies, while also providing expertise and technologies for other stakeholders to promote their understanding and mitigation of the consequences of CI disruptions, leading to enhanced resilience.
Management of Data Center Networks
Delivers a rigorous and insightful exploration of the network management challenges that present within intra- and inter-data center networks, including reliability, routing, and security. The book also discusses new architectures found in data center networks that aim to minimize the complexity of network management while maximizing Quality of Service, like Wireless/Wired DCNs, server-only DCNs, and more. offers: A thorough overview of the architectures of data center networks, including the classification of switch-centric, server-centric, enhanced, optical, and wireless DCN architectures An exploration of resource management in wired and wireless data center networks, including routing and wireless channel allocation and assignment challenges and criteria Practical discussions of inter-data center networks, including an overview of basic virtual network embedding Examinations of energy and security management in data center networks
Making Beautiful Deep-Sky Images : Astrophotography with Affordable Equipment and Software
Professor Greg Parker's astronomical photographs are widely known for their excellence, and a selection of them has recently been shown as a public exhibition in the UK. In Making Beautiful Deep-Sky Images, he provides a detailed account of how spectacular deep-sky images can be taken by amateur astronomers using CCD cameras, and how they can subsequently be processed and enhanced in the "electronic darkroom" for maximum beauty and impact. Quite simply, this is a "how to do it" book for people who want to make stunning astronomical pictures.
Magnetic resonance angiography : techniques, indications and practical applications
The advent of contrast-enhanced MRA in the early to mid 1990s revolutionized the clinical approach to vascular imaging: an accurate non-invasive imaging modality, not requiring ionizing radiation or potentially nephrotoxic iodinated contrast media, was able to compete with the more hazardous and invasive catheter angiography. Today, MRA is a safe, easy-to-perform procedure routinely used in most imaging centers, and the continued development of faster, more powerful magnets and more effective contrast agents is increasingly helping to overcome many of the early limitations of the technique.
Machine Learning for Cyber Agents : Attack and Defence
The cyber world has been both enhanced and endangered by AI. On the one hand, the performance of many existing security services has been improved, and new tools created. On the other, it entails new cyber threats both through evolved attacking capacities and through its own imperfections and vulnerabilities. Moreover, quantum computers are further pushing the boundaries of what is possible, by making machine learning cyber agents faster and smarter.
Lippincott illustrated reviews : Pharmacology
Presents up-to-date drug information in an accessible format ideal for a fast, effective refresher. Part of the popular Lippincott® Illustrated Reviews series, this concise resource features clear, effective writing and hundreds of illustrations that break down complex information for rapid review. Sequential images present mechanisms of action and focus on showing rather than telling students how drugs work, and review questions with answers deliver powerful, practical exam preparation. Updated drug information reflects the most current, clinically relevant pharmacology material. Approachable outline format distills complex information for easier review. High-quality illustrations reinforce understanding in vibrant detail. Enhanced review questions with answers test students' understanding and identify areas for further study.
Light Scattering from Polymer Solutions and Nanoparticle Dispersions
Light scattering is a very powerful method to characterize the structure of polymers and nanoparticles in solution. Recent technical developments have strongly enhanced the possible applications of this technique, overcoming previous limitations like sample turbidity or insufficient experimental time scales. However, despite their importance, these new developments have not yet been presented in a comprehensive form. In addition, and maybe even more important to the broad audience, there lacks a simple-to-read textbook for students and non-experts interested in the basic principles and fundamental techniques of light scattering. As part of the Springer Laboratory series, this book tries not only to provide such a simple-to-read and illustrative textbook about the seemingly very complicated topic of light scattering from polymers and nanoparticles in dilute solution, but also intends to cover some of the newest technical developments in experimental light scattering.
Learning and Teaching for the Twenty-first Century : Festschrift for Professor Phillip Hughes
This book stresses learning and teaching, rather than teaching and learning. The contention of the contributors is that the focus in all educational endeavours should not be primarily on teachers and teaching, but on learners; how to best facilitate learning, in the most effective, enjoyable, relevant and cost-effective ways for learners, whether they be children, youth or adults. The focus is therefore on how learning can be enhanced, through effective teaching; and how individuals can be best prepared to be excellent teachers.
