الصفحة 5
الصفحة 5
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lifetime Spectroscopy : A Method of Defect Characterization in Silicon for Photovoltaic Applications
Lifetime spectroscopy is one of the most sensitive diagnostic tools for the identification and analysis of impurities in semiconductors. Since it is based on the recombination process, it provides insight into precisely those defects that are relevant to semiconductor devices such as solar cells. This book introduces a transparent modeling procedure that allows a detailed theoretical evaluation of the spectroscopic potential of the different lifetime spectroscopic techniques. The various theoretical predictions are verified experimentally with the context of a comprehensive study on different metal impurities. The quality and consistency of the spectroscopic results, as explained here, confirms the excellent performance of lifetime spectroscopy.
Left-right asymmetry in vertebrate development
A host of studies has unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.
Le forme spastiche della paralisi cerebrale infantile : Guida all'esplorazione delle funzioni adattive = Spastic forms of cerebral palsy : A guide to exploring adaptive functions
Offers "travel notes" on the topics covered, to spark reflection and comparisons with the readers' experience. The authors address the topics from a pathophysiological perspective that guides their interpretation of the nature of the defect (functional diagnosis), the problems related to prognosis (as a natural history hypothesis), and rehabilitation (as a modification of the architecture of the function in an adaptive sense).The text is accompanied by an extensive glossary of terms used and a DVD with clinical cases, organized according to the authors' classification. This material also highlights the volume's great educational value, both for those already working in this field (physicians, child neuropsychiatrists and physiatrists, rehabilitation therapists) and for students completing their first and second level degrees in rehabilitation and attending postgraduate schools.
Laser additive manufacturing: design, materials, processes and applications
Laser-based additive manufacturing (LAM) is a revolutionary advanced digital manufacturing technology developed in recent decades, which is also a key strategic technology for technological innovation and industrial sustainability. This technology unlocks the design and constraints of traditional manufacturing and meets the needs of complex geometry fabrication and high-performance part fabrication. A deeper understanding of the design, materials, processes, structures, properties and applications is desired to produce novel functional devices, as well as defect-free structurally sound and reliable LAM parts.The topics in this Special Issue reprint include macro- and micro-scale additive manufacturing with lasers, such as structure/material design, fabrication, modeling and simulation, in situ characterization of additive manufacturing processes and ex situ materials characterization and performance, with an overview that covers various applications in aerospace, biomedicine, optics and energy.
La scuola dell’atopia = The school of atopy
The need to clarify the current concepts of atopy, which for too long have oscillated between a primitive purely clinical vision and a subsequent purely immunological one, had been ripe for some time. Understanding that the role of immunoglobulins E is not exhaustive and accepting the Solomonic division between intrinsic and extrinsic atopy were the first two fundamental steps. Recent discoveries of the role of innate immunity, and therefore of antimicrobial peptides, have opened fundamental spaces for understanding in atopy and beyond. What now appears clear is that atopy is not the disease of an organ but rather a defect in the membranes that delimit our "self". The fact that these membranes are called skin, intestines, conjunctiva, bronchi or whatever has artificially fragmented the understanding and treatment of a unitary phenomenon. This book seeks to summarize the different experiences but above all to be a stimulus to ensure that medicine focuses constructively on the same target. If this is the case, we will no longer see "religious wars" between scientists and practicing doctors or, even worse, between the different specialists vying for the patient. If atopy, as we believe, is a global problem, it can only be adequately addressed in a multidisciplinary context and in a collaborative atmosphere, not only between doctor and doctor but also between doctor and patient.
Knee Arthroplasty Handbook : Techniques in Total Knee and Revision Arthroplasty
This text is designed to be a concise guide to the essentials of total knee arthroplasty and revision total knee arthroplasty. World-renowned experts cover basic principles and instrumentation, ligament releases, and bone defects.
Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Cleft Maxillary Reconstruction
Aims to teach the reader about all aspects of maxillary cleft reconstruction, with emphasis on management of the patient born with a congenital anomaly, cleft lip and palate, which will usually have been managed by several different providers during earlier childhood.
Chiral Soliton Models for Baryons
This concise research monograph introduces and reviews the concept of chiral soliton models for baryons. In these models, baryons emerge as (topological) defects of the chiral field. The many applications shed light on a number of bayron properties, ranging from static properties via nucleon resonances and deep inelastic scattering to even heavy ion collisions. As far as possible, the theoretical investigations are confronted with experiment. Conceived to bridge the gap between advanced graduate textbooks and the research literature, this volume also features a number of appendices to help nonspecialist readers to follow in more detail some of the calculations in the main text.
Ceramic materials : Science and engineering
Ceramic Materials: Science and Engineering is an up-to-date treatment of ceramic science, engineering, and applications in a single, integrated text. Building on a foundation of crystal structures, phase equilibria, defects and the mechanical properties of ceramic materials, students are shown how these materials are processed for a broad diversity of applications in today's society. Concepts such as how and why ions move, how ceramics interact with light and magnetic fields, and how they respond to temperature changes are discussed in the context of their applications. References to the art and history of ceramics are included throughout the text. The text concludes with discussions of ceramics in biology and medicine, ceramics as gemstones and the role of ceramics in the interplay between industry and the environment. The text is extensively illustrated and includes references and questions for the student.
Case Studies in Building Rehabilitation
Presents recent research and practical insights relating to building pathology. As such it contributes toward the systematization and dissemination of knowledge regarding structural and hygrothermal pathologies, durability and diagnostic techniques, while at the same time, demonstrating the latest advances in this domain. It includes new developments in the field of building pathology and rehabilitation, bridging the gap between current approaches to the surveying of buildings and the detailed study of defect diagnosis, prognosis and remediation. It also features a number of case studies and a detailed list of references and suggestions for further reading. Providing an overview of the current state of the art in the field, the book will appeal to scientists, students, practitioners and lecturers. Furthermore, the topics covered are relevant to a variety of scientific and engineering disciplines, including civil, materials and mechanical engineering.
Bone and Cartilage Engineering
Bone and Cartilage Engineering presents the theory and practice of cell-based regeneration of skeletal defects. Much of the focus is on the importance of the cell biological and biomaterial aspects for engineering a clinically relevant device. The basic key techniques for optimal engineering outcomes including cell and organ culture, biomaterial development, and bioreactor use are described in detail and highlighted by multiple figures.
Atlas of genetic diagnosis and counseling
Many birth defects, although rare individually, are encountered in clinical practice and have now become treatable if properly diagnosed. In the Atlas of Genetic Diagnosis and Counseling, Harold Chen, MD, shares his almost 40 years of clinical genetics practice in a comprehensive pictorial atlas of 203 genetic disorders, malformations, and malformation syndromes. The author provides a detailed outline for each disorder, describing its genetics, basic defects, clinical features, diagnostic tests, and counseling issues, including recurrence risk, prenatal diagnosis, and management. Numerous color photographs of prenatal ultrasounds, imagings, cytogenetics, and postmortem findings illustrate the clinical features of patients at different ages, patients with varying degrees of severity, and the optimal diagnostic strategies. The disorders cited are supplemented by case histories and diagnostic confirmation by cytogenetics, biochemical, and molecular techniques, when available.
Approche pratique de la couverture des pertes de substance cutanée de la main et des doigts = Practical Approach to Covering Skin Losses from the Hand and Fingers
This book is neither a summary nor an encyclopedia devoted to the treatment of loss of skin substance in the hand. There are currently excellent books that can serve as a reference, at any time, for the treatment of any skin defect, of the hand ... or elsewhere. We wanted a completely different perspective on trauma management open by hand, while respecting the spirit of the “Practical Approach” collection directed by Christian Fontaine: a simple presentation diagram, relatively stereotypical, a rich and varied iconography, tips and tricks, in short, an anthology of technical details and answers to the most common questions about hand flap surgery.
Anomalies of the Developing Dentition : A Clinical Guide to Diagnosis and Management
This book is an up-to-date, succinct, and easily accessible reference on the diverse anomalies that may arise in the developing dentition, including those relating to crown size and shape, tooth formation, tooth eruption, tooth number, and enamel and dentin.
Advances in multiple Sclerosis and Experimental Demyelinating Diseases
Challenging Charcot’s hypothesis that inflammatory response is the primary contributor to demyelination, Dr. Rodriguez and colleagues take a fresh, bold look at the causes and possible treatments of MS.Assuming oligodendrocyte injury as a prerequisite to MS, the authors explore viruses, toxins and genetic defects as possible culprits. They present novel methods to interrupt and reverse demyelination. This book examines the correlation between axonal loss and clinical deficits, including the implied role of the CD8+ T cell and perforin. It assesses proteases, specifically, kallikrein 6, which are strongly associated with active demyelination. By directing natural autoantibodies against oligodendrocytes that demonstrate remyelination in animal models, the authors envision clinical trials for remyelination enhancement.
Advances in Electronic Testing : Challenges and Methodologies
The book is a comprehensive elaboration on important topics which capture major research and development efforts today. The motivation and inspiration behind this book is to deliver a thorough text that focuses on the evolution of test technology, provides insight about the abiding importance of discussed topics, records today’s state of the art and industrial practices and trends, reveals the challenges for emerging testing methodologies, and envisages the future of this journey. The book consists of eleven edited chapters written by experts in Defect-Oriented Testing, Nanometer Technologies Failures and Testing, Silicon Debug, Delay Testing, High-Speed Test Interfaces, DFT-Oriented Low-Cost Testers, Embedded Cores and System-on-Chip Testing, Memory Testing, Mixed-Signal Testing, RF Testing and Loaded Board Testing.
Advances in Electromagnetic Fields in Living Systems ; Vol.4
Advances in Electromagnetic Fields in Living Systems , Volume 4 begins with fetal magnetocardiography (fMCG), a noninvasive method of detecting components of the magnetic field produced by the electrical activity of the fetal heart. FMCG is experiencing steady growth, and is expected to gain influence in diagnosing certain congenital fetal heart defects while at the same time providing optimal care for patients. FMCG provides a distinct signal, free of maternal cardiac interference, which can be detected throughout the last half of pregnancy.
Advancement of Deep Learning and its Applications in Object Detection and Recognition
In just the past five years, deep learning has taken the world by surprise, driving rapid progress in fields as diverse as computer vision, natural language processing, automatic speech recognition, etc. This book presents an introduction to deep learning and various applications of deep learning such as recommendation systems, text recognition, diabetic retinopathy prediction of breast cancer, prediction of epilepsy, sentiment, fake news detection, software defect prediction and protein function prediction.
