الصفحة 5
الصفحة 5
Handbook of cell and gene therapy
Intended as a one-stop resource for availability of state-of-the-art information related to cell and gene therapy products for researchers, scientists, management and other academic and research institutions working in the field
Growth, Differentiation and Sexuality
Since publication of the first edition of Volume I in 1994, the field of fungal biology has developed tremendously, mainly through the advancement of various molecular techniques and international fungal genome projects. To accommodate these developments, the second edition has been completely updated. Six chapters have been revised by former authors, others by newly recruited experts, and also novel subjects, emerged in more recent years, have been added to the book. Leading scientists in the field have compiled comprehensive overviews as well as latest results obtained from cytological, genetic and molecular studies. Topics include: cellular and colony growth of fungi, cellular fusion and incompatibility, senescence and programmed cell death, environmental and physiological signalling in differentiation processes, asexual and sexual reproduction, mitosis and meiosis of various types of fungi. Both parallels and differences become visible between individual fungi as well as between fungal classes.
Global optimization ; Vol. 85 : Scientific and engineering case studies
Optimization models based on a nonlinear systems description often possess multiple local optima. The objective of global optimization (GO) is to find the best possible solution of multiextremal problems. Global Optimization: Selected Case Studies illustrates the applicability of GO modeling techniques and solution strategies to real-world problems.The contributed chapters cover a broad range of applications from agroecosystem management, assembly line design, bioinformatics, biophysics, black box systems optimization, cellular mobile network design, chemical process optimization, chemical product design, composite structure design, computational modeling of atomic and molecular structures, controller design for induction motors, electrical engineering design, feeding strategies in animal husbandry, the inverse position problem in kinematics, laser design, learning in neural nets, mechanical engineering design, numerical solution of equations, radiotherapy planning, robot design, and satellite data analysis. The solution strategies discussed encompass a range of practically viable methods, including both theoretically rigorous and heuristic approaches.
Geometric Group Theory ; Geneva and Barcelona Conferences
This volume assembles research papers in geometric and combinatorial group theory. This wide area may be defined as the study of those groups that are defined by their action on a combinatorial or geometric object, in the spirit of Klein’s programme.The contributions range over a wide spectrum: limit groups, groups associated with equations, with cellular automata, their structure as metric objects, their decomposition, etc. Their common denominator is the language of group theory, used to express and solve problems ranging from geometry to logic.
Genome integrity : Facets and perspectives
The volume begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. Examples of human diseases are included and the cellular responses to radiation and genotoxic stress affecting whole genomes are reviewed.
Genetic rogramming ; Vol. 3447 : 8th European conference, EuroGP 2005, Lausanne, Switzerland, March 30-April 1, 2005, Proceedings
In this volume we present the contributions for the 18th European Conference on Genetic Programming (EuroGP 2005). The conference took place from 30 March to 1 April in Lausanne, Switzerland. EuroGP is a well-established conf- ence and the only one exclusively devoted to genetic programming. All previous proceedings were published by Springer in the LNCS series. From the outset, EuroGP has been co-located with the EvoWorkshops focusing on applications of evolutionary computation. Since 2004, EvoCOP, the conference on evolutionary combinatorial optimization, has also been co-located with EuroGP, making this year’s combined events one of the largest dedicated to evolutionary computation in Europe. Genetic programming (GP) is evolutionary computation that solves complex problems or tasks by evolving and adapting a population of computer programs, using Darwinian evolution and Mendelian genetics as its sources of inspiration. Some of the 34 papers included in these proceedings address foundational and theoretical issues and there is also a wide variety of papers dealing with di?erent application areas, such as computer science, engineering, language processing, biology and computational design, demonstrating that GP is a powerful and practical problem-solving paradigm.
Genetic Engineering of Mesenchymal Stem Cells
MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.
Gene Therapy for Cancer
The possibility of treating cancer, a disease defined by genetic defects, by introducing genes targeting these very alterations has led to an immense interest in gene therapy for cancer. Although incremental successes have been realized, enthusiasm for gene therapy has declined due to an increasing number of obstacles. These obstacles include vector systems that do not reach systemic metastases, therapeutic genes with redundant mec- nisms allowing for cellular resistance, and toxicities in clinical trials leading to premature closure of these studies. Different tactics to overcome or circumvent these obstacles have catalyzed the development of a wide range of gene therapy approaches. Thus far, almost two-thirds of gene therapy trials have focused on cancer. This reflects the concept that gene therapy approaches for the treatment of cancer do not necessarily require long-term expression of the gene as is necessary for the treatment of primary genetic defects like hemophilia or juvenile diabetes.
Gastrointestinal malignancies
Details the advances in drug discovery and delivery and the present need for emerging technologies. Throughout the text new micro and nanofabrication techniques are described, including methods such as electrohydrodynamic processes, additive manufacturing, and microfluidics, which have the potential to produce drug delivery systems that were not possible a few years ago. This book is of great use to both entry-level and experienced researchers in the field of emerging technologies for the manufacturing of drug delivery devices.
Fundamentals of Space Biology : Research on Cells, Animals, and Plants in Space
This book is intended as an overview at the undergraduate or early university level and describes the effects of spaceflight at cellular and organism levels. Past, current, and future research on the effects of gravity--or its absence--and ionizing radiation on the evolution, development, and function of living organisms is presented in layman's terms by researchers who have been active in this field. The purpose is to enlighten science and non-science readers to the benefits of space biology research for conducting basic and applied research to support human exploration of space. Also covered are the advantages of approaching the space environment as a laboratory for scientific, technological, and commercial research.
Free Energy and Self-Interacting Particles
This book examines a system of parabolic-elliptic partial differential eq- tions proposed in mathematical biology, statistical mechanics, and chemical kinetics. In the context of biology, this system of equations describes the chemotactic feature of cellular slime molds and also the capillary formation of blood vessels in angiogenesis. There are several methods to derive this system. One is the biased random walk of the individual, and another is the reinforced random walk of one particle modelled on the cellular automaton. In the context of statistical mechanics or chemical kinetics, this system of equations describes the motion of a mean field of many particles, interacting under the gravitational inner force or the chemical reaction
Fractals in Biology and Medicine : Beyond Planting Trees
This volume it highlights the potential that fractal geometry offers for elucidating and explaining the complex make-up of cells, tissues and biological organisms either in normal or in pathological conditions, including the structural changes that occur in tumours. It helps develop the concepts, questions and methods required in research on fractal biology and natural phenomena and to evidence the pitfalls of a too simplistic application of these principles in investigating topical subjects of biology and medicine. It discusses present and future applications of fractal geometry, bringing together cellular and molecular biology, engineering, mathematics, physics, medicine and other disciplines and allowing an interdisciplinary vision.
Formal Models of Communicating Systems : Languages, Automata, and Monadic Second-Order Logic
This book studies the relationship between automata and monadic second-order logic, focusing on classes of automata that describe the concurrent behavior of distributed systems.
Foodborne Microbial Pathogens : Mechanisms and Pathogenesis
The author presents up-to-date information on molecular and cellular mechanism of several major foodborne microbial pathogens, including select agents for bioterrorism, virulence genes and their regulation in the host or the food environment, pathogenicity testing models, clinical symptoms, and prevention and control strategies. In order to understand the disease process, one must have certain understanding about the role of the immune system. Thus this book also covers the host parasite interaction to a level where the readers will have a better appreciation for the disease mechanism.
Food allergens : methods and protocols
Provides a comprehensive collection of methods and protocols in food allergy and food allergens studies. The selected protocols explore the study of food allergens, from recombinant production, purification procedures, IgE and T cell epitopes characterization, to allergen structure description, cellular responses, and tolerance induction, through a variety of techniques and animal models.
Fluid volume monitoring with glucose dilution
Decision making regarding fluid volume loading, fluid restriction, or administration of vasoactive drugs may vary among physicians, depending solely upon their clinical experience in the absence of evidence-based measurement. The initial distribution volume of glucose (IDVG) is believed to be clinically relevant as a marker of cardiovascular and fluid management in critically ill patients without a significant modification of glucose metabolism. This book covers all aspects of IDVG measurement, including the basic concept, its relationship with other fluid volumes, and the clinical application of this technique in the intensive care unit based on both the authors’ studies and their clinical experience with more than 4000 IDVG determinations. When the concept of IDVG is properly understood and its measurement is then performed routinely, daily fluid and cardiovascular management in critically ill patients can be improved based on evidence-based measurement.
Fine-Tuning of RNA Functions by Modification and Editing
This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression.
Fibrogenesis : Cellular and molecular basis
Fibrogenesis: Cellular and Molecular Basis is the first volume to provide a synopsis of the rapid progress that has been documented in fibrogenesis over last couple of years, which significantly enhanced our understanding of the pathomechanisms of fibrotic diseases. Knowledge on molecular and celluar basis of fibrotic diseases has provided opportunities to develop selective and effective gene-based therapeutic options.
Fatty acids
Fatty acid metabolism, including the de novo synthesis, uptake, oxidation, and derivation of fatty acids, plays several important roles at cellular and organ levels. Recent studies have identified characteristic changes in fatty acid metabolism in idiopathic pulmonary fibrosis (IPF) lungs, which implicates its dysregulation in the pathogenesis of this disorder. Here, we review the evidence for how fatty acid metabolism contributes to the development of pulmonary fibrosis, focusing on the profibrotic processes associated with specific types of lung cells, including epithelial cells, macrophages, and fibroblasts. We also summarize the potential therapeutics that target this metabolic pathway in treating IPF.
Facts about the most three common types of cancer in Syria
Cancer occurs when the cellular reproduction process goes out of control. In other words, cancer is a disease characterized by uncontrolled, uncoordinated and undesirable cell division. Unlike normal cells, cancer cells continue to grow and divide for their whole lives, replicating into more and more harmful cells. But death rates are falling, thanks to earlier detection of tumours and improved use of existing treatments - mainly chemotherapy biological therapy and radiotherapy. And today Our research tends to spot the light on the most common types of cancers in Syria which was found to be lung cancer, colorectal cancer, and breast cancer.
