الصفحة 49
الصفحة 49
Data Mining in Bioinformatics
8. 1. 1 Protein Subcellular Location The life sciences have entered the post-genome era where the focus of biological research has shifted from genome sequences to protein functionality. Withwhole-genomedraftsofmouseandhumaninhand,scientistsareputting more and more e?ort into obtaining information about the entire proteome in a given cell type. The properties of a protein include its amino acid sequences, its expression levels under various developmental stages and in di?erent tissues, its3Dstructure and activesites,its functionalandstructural binding partners, and its subcellular location. Protein subcellular location is important for understanding protein function inside the cell. For example, the observation that the product of a gene is localized in mitochondria will support the hypothesis that this protein or gene is involved in energy metabolism. Proteins localized in the cytoskeleton are probably involved in intracellular tra?cking and support.
Data Mining and Knowledge Discovery Approaches Based on Rule Induction Techniques
This book will give the reader a perspective into the core theory and practice of data mining and knowledge discovery (DM&KD). Its chapters combine many theoretical foundations for various DM&KD methods, and they present a rich array of examples—many of which are drawn from real-life applications. Most of the theoretical developments discussed are accompanied by an extensive empirical analysis, which should give the reader both a deep theoretical and practical insight into the subjects covered.
Data mining : Concepts, models, methods, and algorithms ; 3rd ed.
Presents the latest techniques for analyzing and extracting information from large amounts of data in high-dimensional data spaces. Explores big data and cloud computing Examines deep learning Includes information on convolutional neural networks (CNN) Offers reinforcement learning Contains semi-supervised learning and S3VM Reviews model evaluation for unbalanced data
Data feminism
We have seen through many examples that data science and artificial intelligence can reinforce structural inequalities like sexism and racism. Data is power, and that power is distributed unequally. This book offers a vision for a feminist data science that can challenge power and work towards justice. This book takes a stand against a world that benefits some (including the authors, two white women) at the expense of others. It seeks to provide concrete steps for data scientists seeking to learn how feminism can help them work towards justice, and for feminists seeking to learn how their own work can carry over to the growing field of data science.
Data Assimilation : The Ensemble Kalman Filter
Data Assimilation comprehensively covers data assimilation and inverse methods, including both traditional state estimation and parameter estimation. This text and reference focuses on various popular data assimilation methods, such as weak and strong constraint variational methods and ensemble filters and smoothers. It is demonstrated how the different methods can be derived from a common theoretical basis, as well as how they differ and/or are related to each other, and which properties characterize them, using several examples.It presents the mathematical framework and derivations in a way which is common for any discipline where dynamics is merged with measurements. The mathematics level is modest, although it requires knowledge of basic spatial statistics, Bayesian statistics, and calculus of variations. Readers will also appreciate the introduction to the mathematical methods used and detailed derivations, which should be easy to follow, are given throughout the book. The codes used in several of the data assimilation experiments are available on a web page.The focus on ensemble methods, such as the ensemble Kalman filter and smoother, also makes it a solid reference to the derivation, implementation and application of such techniques. Much new material, in particular related to the formulation and solution of combined parameter and state estimation problems and the general properties of the ensemble algorithms, is available here for the first time.
Data and Text Processing for Health and Life Sciences
This book is a step-by-step introduction on how shell scripting can help solve many of the data processing tasks that Health and Life specialists face everyday with minimal software dependencies. The examples presented in the book show how simple command line tools can be used and combined to retrieve data and text from web resources, to filter and mine literature, and to explore the semantics encoded in biomedical ontologies. To store data this book relies on open standard text file formats, such as TSV, CSV, XML, and OWL, that can be open by any text editor or spreadsheet application.
Data Analysis, Classification and the Forward Search ; Proceedings of the Meeting of the Classification and Data Analysis Group (CLADAG) of the Italian Statistical Society, University of Parma, June 6-8, 2005
This book presents new developments in data analysis, classification and multivariate statistics, and in their algorithmic implementation. The volume offers contributions to the theory of clustering and discrimination, multidimensional data analysis, data mining, and robust statistics with a special emphasis on the novel Forward Search approach. Many papers provide significant insight in a wide range of fields of application. Customer satisfaction and service evaluation are two examples of such emerging fields.
Data Algorithms with Spark
Apache Spark's speed, ease of use, sophisticated analytics, and multilanguage support makes practical knowledge of this cluster-computing framework a required skill for data engineers and data scientists. With this hands-on guide, anyone looking for an introduction to Spark will learn practical algorithms and examples using PySpark. you will: Learn how to select Spark transformations for optimized solutions Explore powerful transformations and reductions including reduceByKey(), combineByKey(), and mapPartitions() Understand data partitioning for optimized queries Build and apply a model using PySpark design patterns Apply motif-finding algorithms to graph data Analyze graph data by using the GraphFrames API Apply PySpark algorithms to clinical and genomics data Learn how to use and apply feature engineering in ML algorithms Understand and use practical and pragmatic data design patterns
Cyclotomic Fields and Zeta Values
Cyclotomic fields have always occupied a central place in number theory, and the so called "main conjecture" on cyclotomic fields is arguably the deepest and most beautiful theorem known about them. It is also the simplest example of a vast array of subsequent, unproven "main conjectures'' in modern arithmetic geometry involving the arithmetic behaviour of motives over p-adic Lie extensions of number fields. These main conjectures are concerned with what one might loosely call the exact formulae of number theory which conjecturally link the special values of zeta and L-functions to purely arithmetic expressions.
Cycle Spaces of Flag Domains : A Complex Geometric Viewpoint
This monograph, divided into four parts, presents a comprehensive treatment and systematic examination of cycle spaces of flag domains. Assuming only a basic familiarity with the concepts of Lie theory and geometry, this work presents a complete structure theory for these cycle spaces, as well as their applications to harmonic analysis and algebraic geometry.
Cybersecurity of Digital Service Chains : Challenges, Methodologies, and Tools
This book presents the main scientific results from the H2020 GUARD project. The GUARD project aims at filling the current technological gap between software management paradigms and cybersecurity models, the latter still lacking orchestration and agility to effectively address the dynamicity of the former. This book provides a comprehensive review of the main concepts, architectures, algorithms, and non-technical aspects developed during three years of investigation; the description of the Smart Mobility use case developed at the end of the project gives a practical example of how the GUARD platform and related technologies can be deployed in practical scenarios.
Cybernetical Physics : From Control of Chaos to Quantum Control
This book is, perhaps, the first attempt to present a unified exposition of the subject and methodology of cybernetical physics as well as solutions to some of its problems. Emphasis of the book is on the examination of fundamental limits on energy transformation by means of control procedures in both conservative and dissipative systems.
Cyanobacterial Harmful Algal Blooms : State of the Science and Research Needs
Humans can be exposed to cyanobacterial toxins by drinking water that contains the toxins, swimming in water that contains high concentrations of cyanobacterial cells, or breathing air that contains cyanobacterial cells or toxins (while watering a lawn with contaminated water, for example). Health effects associated with exposure to high concentrations of cyanobacterial toxins include: - stomach and intestinal illness; -trouble breathing; - allergic responses; - skin irritation; - liver damage; and neurotoxic reactions, such as tingling fingers and toes. Scientists are exploring the human health effects associated with long-term exposure to low levels of cyanobacterial toxins. Some studies have suggested that such exposure could be associated with chronic illnesses, such as liver cancer and digestive-system cancer. This monograph contains the proceedings of the International Symposium on Cyanobacterial Harmful Algal Blooms held in Research Triangle Park, NC, September 6-10, 2005.
Curves and Surfaces for Computer Graphics
Computer graphics is important in many areas including engineering design, architecture, education, and computer art and animation. This book examines a wide array of current methods used in creating real-looking objects in the computer, one of the main aims of computer graphics.
Curriculum Reform in the European Schools : Towards a 21st Century Vision
Examines the modern role of the European School system within the European Union, at a time when the global economy demands a new vision for contemporary education. The European schools are currently in a state of crisis: their 60-year-old tradition of bilingual and multilingual education is being strained by rapid EU expansion and the removal of English speaking teachers as a result of Brexit. Their tried and tested model of mathematics and science education has rapidly been overtaken by new developments in pedagogy and assessment research, while recruitment and retention of students and teachers has become increasingly fraught as European member states review what they are, and what they are not, prepared to fund. The authors draw on original and empirical research to assess the European Schools’ place in a new Europe where the entire post-war European Project is potentially at risk. This well-researched volume will be of interest to practitioners working in European schools as well as students and scholars of EU politics and international education.
Current Advances in Drug Delivery Through Fast Dissolving
Presents detailed information about FDDFs (Fast Dissolving/Disintegrating Dosage Forms) from their inception to recent developments. Readers will learn about the technical details of various FDDF manufacturing methods, formulation aspects, evaluation and methods to conduct clinical studies. The authors also give examples of marketed fast disintegrating/dissolving drug products in US, Europe, Japan, and India. This reference is ideal for pharmacology students at all levels seeking information about this specific form of drug delivery and formulation.
Cultural representations of gender vulnerability and resistance : A Mediterranean approach to the Anglosphere
This book considers the cultural representation of gender violence, vulnerability and resistance with a focus on the transnational dimension of our contemporary visual and literary cultures in English. Contributors address concepts such as vulnerability, resilience, precarity and resistance in the Anglophone world through an analysis of memoirs, films, TV series, and crime and literary fiction across India, Ireland, Canada, Australia, the US, and the UK. Chapters explore literary and media displays of precarious conditions to examine whether these are exacerbated when intersecting with gender and ethnic identities, thus resulting in structural forms of vulnerability that generate and justify oppression, as well as forms of individual or collective resistance and/or resilience. Substantial insights are drawn from Animal Studies, Critical Race Studies, Human Rights Studies, Post-Humanism and Postcolonialism.
Cultural Convergence : The Dublin Gate Theatre, 1928–1960
Based on extensive archival research, this book examines the poetics and politics of the Dublin Gate Theatre (est. 1928) over the first three decades of its existence, discussing some of its remarkable productions in the comparative contexts of avant-garde theatre, Hollywood cinema, popular culture, and the development of Irish-language theatre, respectively. The overarching objective is to consider the output of the Gate in terms of cultural convergence – the dynamics of exchange, interaction, and acculturation that reveal the workings of transnational infrastructures.
Cryptography, information theory, and error-correction : A handbook for the 21st century ; 2nd ed.
A rich examination of the technologies supporting secure digital information transfers from respected leaders in the field. Is an indispensable resource for anyone interested in the secure exchange of financial information. Identity theft, cybercrime, and other security issues have taken center stage as information becomes easier to access. Three disciplines offer solutions to these digital challenges: cryptography, information theory, and error-correction, all of which are addressed in this book. The book also: Shares vital, new research in the field of information theory / Provides quantum cryptography updates / Includes over 350 worked examples and problems for greater understanding of ideas.
Crypto-Finance, Law and Regulation : Governing an Emerging Ecosystem
Explores the emergence of a decentralised and disintermediated crypto-market and investigates the way in which it can transform the financial markets. It examines three components of the financial market – technology, finance, and the law – and shows how their interrelationship dictates the structure of a crypto-market. It focuses on regulators’ enforcement policies and their jurisdiction over crypto-finance operators and participants. The book also discusses the latest developments in crypto-finance, and the advantages and disadvantages of crypto-currency as an alternative payment product. It also investigates how such a decentralised crypto-finance system can provide access to finance, promote a shared economy, and allow access to justice.
