الصفحة 44
الصفحة 44
Biophysical characterization of functional peptides
Presents reproducible and step-by-step procedures for the peptide synthesis, their characterization and applications. The volume includes an introductory section on in silico modelling of new peptide molecules, Molecular Dynamics Simulations, Docking, Electrostatic fingerprinting of peptides, and other modelling tools for peptide designing and optimization. Further, it covers protocols for the solid phase peptide synthesis, chromatographic and mass spectrometric characterization of peptides. Importantly, it covers methods for biophysical characterizations of peptides for their potential applications as drug delivery vehicles, peptide nano-assembly, bionanocatalysis, protein aggregation diseases, and peptide-based anti-bacterial.
Biophysical Aspects of Transmembrane Signaling
Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally build up the creation of an "excited" cell that will respond to particular signals from the outer or inner world.
Biophotonics and Coherent Systems in Biology
Biophotonics and Coherent Systems in Biology offers a timely research volume derived from papers submitted at the 3rd International Alexander Gurwitsch Conference. Biophotonics and Coherent Systems in Biology covers the major aspects of modern biophotonics and related biological and biophysical problems of interest to researchers today.Key topics include: Coherency of biophoton emission and its related physical and biological properties , Biological effects of microwaves, Photon emission from living samples, starting from human bodies up to cell cultures, Fundamental role of water in bioenergetics and the influence of electromagnetic fields upon hydrophobic-hydrophilic balance
Biophotonics ; Optical science and engineering for the 21st century
Biophotonics: Optical Science and Engineering in the 21st Century serves as an ideal aid to the research and development of these areas integrating light, photonics, and biological systems.Key topics include: Fluctuation Correlation Spectroscopy in Cells: Determination of Molecular Aggregation ,Using GFP and FRET Technologies for Studying Signaling Mechanisms of Apoptosis in a Single Living Cell, Study on Protein-Protein Interaction in Single Living Cells, Functional Optical Coherence Tomography: Simultaneous In Vivo Imaging of Tissue Structure and Physiology, Imaging –Photo- and Sonodynamic Diagnosis of Cancer Mediated by Chemiluminescence Probes, Biophotonic Analysis of Spontaneous Self-Organizing Oxidative Processes in Aqueous Systems, Biophoton Emission and Defense Systems in Plants
Biophotonics
More profound understanding of the nature of light and light-matter interactions in biology has enabled many applications in the biology and medical fields. So a new discipline is born, namely biophotonics. The aim of this book is to review the current state-of-the-art of the field by means of authoritative chapters written by the world leaders of the respective fields. Biosensors, biochips, optical tomography, optical microsurgery, photodynamics therapy, bioactivation of gene, photobiology of skin, and nanobiophotonics are each introduced and recent advances presented. This book will be useful not only to physicians, biologists, physicists, chemists, materials scientists, and engineers but also to graduate students who are interested in these rapidly developing fields.
Biopharmaceutics : From fundamentals to industrial practice
Beginning with an expansive introduction to the basics of biopharmaceutics and the context that underpins the field, the included resources go on to discuss how biopharmaceutics are integrated into product development within the pharmaceutical industry. Explorations of how the regulatory aspects of biopharmaceutics function, as well as the impact of physiology and anatomy on the rate and extent of drug absorption, follow.
Biopharmaceutical manufacturing progress, trends and challenges
Source of the latest innovative research and technical development in biomanufacturing systems. It is organised into 2 parts: 1) Manufacturing of recombinant therapeutic proteins (e.g. therapeutic antibodies, biosimilars/biogenerics) and 2) Manufacturing aspects of cell and gene therapy. Each with selected chapters on the following topics for both up- and downstream, such as: Advanced process strategies, especially continuous manufacturing, Advanced culture techniques, especially single-use systems, Process transfer, scale-up/scale-down models, Processing advances/Manufacturing productivity/efficiency, Model-assisted process understanding and development/Digital Twins, Process controls and analytics, Quality control, Quality by design, Facility design and full-scale commercial systems, manufacturing technology innovation.
Bioorganometallic Chemistry
Bioorganometallic Chemistry has become a mature area of science and is comprehensively covered by leading experts in this book. Naturally occuring bioorganometallic complexes, such as vitamin B12 and recently discovered iron and nickel hydrogenases, including a possible role of the latter in the geochemical theory of the origin of life, are considered.
BioNanoFluidic MEMS
BioNanoFluidic MEMS explains nanofabrication and nanomaterials synthesis suitable for the development of biosensors. The fundamentals initiate an awareness for engineers and scientists who would like to develop and implement novel biosensors for various applications. In addition, the material covered includes: BioNanoFluidic MEMS connection between the interdisciplinary nature of BioNanoFluidics and MEMS BioNanoFluidics and sensor technology including Micro-Mechanical Sensors and Chemical Sensor Technologies ands-on steps for implementation of biosensor fabrication including a discussion of the clean room lithography process and etching, microsensor systems lamination, PDMS moulding, parylene deposition, and others Interconnection between the interdisciplinary nature of BioNanoFluidics and MEMS BioNanoFluidics and sensor technology including Micro-Mechanical Sensors and Chemical Sensor Technologies
Biomolecular and bioanalytical techniques : Theory, methodology and applications
Offers an introduction to, and a basic understanding of, a wide range of biophysical techniques. The text takes an interdisciplinary approach with contributions from a panel of distinguished experts. With a focus on research, the text comprehensively covers a broad selection of topics drawn from contemporary research in the fields of chemistry and biology. Each of the internationally reputed authors has contributed a single chapter on a specific technique. The chapters cover the specific technique’s background, theory, principles, technique, methodology, protocol and applications.
Biomineralization II : Mineralization Using Synthetic Polymers and Templates
In nature, biological organisms produce mineralized tissues such as bone, teeth, diatoms, and shells. Biomineralization is the sophisticated process of production of these inorganic minerals by living organisms. Construction of organic–inorganic hybrid materials with controlled mineralization analogous to those produced by nature has recently received much attention because it can aid in understanding the mechanisms of the biomineralization process and development of biomimetic materials processing. The biomineralization processes use aqueous solutions at temperatures below 100 ◦C and no toxic intermediates are produced in these systems. This series presents critical reviews of the present position and future trends in modern chemical research. The short and concise reports on chemistry are each written by world renowned experts. This series is still valid and useful after 5 or 10 years.
Biomineralization I : Crystallization and Self-Organization Process
The five chapters of Biomineralization, volume 1, provide a bridge between the mineralogy and the organic substrates that enable the mineral formation by organisms in nature and under laboratory conditions. The book is a most useful reference for all concerned with biomineralization and biogenic minerals.In nature, biological organisms produce mineralized tissues such as bone, teeth, diatoms, and shells. Biomineralization is the sophisticated process of production of these inorganic minerals by living organisms. Construction of organic–inorganic hybrid materials with controlled mineralization analogous to those produced by nature has recently received much attention because it can aid in understanding the mechanisms of the biomineralization process and development of biomimetic materials processing.
BioMEMS and biomedical nanotechnology ; Vol. II : Micro/Nano Technologies for Genomics and Proteomics
Numerous miniaturized DNA microarray, DNA chip, Lab on a Chip and biosensor devices have been developed and commercialized. Such devices are improving the way many impor-tant genomic and proteomic analyses are performed in both research and clinical diagnostic laboratories. The development of these technologies was enabled by a synergistic combina-tion of disciplines that include microfabrication, microfluidics, MEMS, organic chemistry and molecular biology. Some of these new devices and technologies utilize sophisticated mi-crofabrication processes developed by the semiconductor industry.
Biomaterials and engineering for implantology: in medicine and dentistry
Biomaterials are composed of metallic materials, ceramics, polymers, composites and hybrid materials. Biomaterials used in human beings require safety regulations, toxicity, allergic reaction, etc. When used as implantable materials their biological compatibility, biomechanical compatibility, and morphological compatibility must be acessed. This book explores the design and requirements of biomaterials for the use in implantology.
Biomarkers in drug discovery and development : A handbook of practice, application, and strategy
Discusses biomarker characterization and validation and applications throughout drug discovery and development. Explains where proper use of biomarkers can substantively impact drug development timelines and costs, enable selection of better compounds and reduce late stage attrition, and facilitate personalized medicine. Helps readers get a better understanding of biomarkers and how to use them, for example which are accepted by regulators and which still non-validated and exploratory. Updates developments in genomic sequencing, and application of large data sets into pre-clinical and clinical testing; and adds new material on data mining, economics, and decision making, personal genetic tools, and wearable monitoring. Includes case studies of biomarkers that have helped and hindered decision making
Biomacromolecules : Carbohydrates, lipids, proteins and nucleic acids
The first chapter looks at the structural formulas and cyclic forms of monosaccharides, as well as their synthesis and breakdown. Cyclization, enolization, isomerization, tautomerization, mutarotation, and epimerization are all briefly described. Examples of disaccharides and polysaccharides are also presented. The second chapter covers triglycerides, steroids, vitamins, and their constituents. The third chapter examines the primary structure of proteins, including amino acid properties, peptide bond formation, and peptide synthesis. It also addresses secondary, tertiary, and quaternary structures. The book concludes with a chapter on nucleic acids, which covers the chemistry of nucleosides and oligonucleotides as well as topics such as genetic code, DNA secret code, Polymerase Chain Reaction and DNA fingerprinting.
Biology and mechanics of blood flows ; Part II : Mechanics and medical aspects
Biology and Mechanics of Blood Flows presents the basic knowledge and state-of-the-art techniques necessary to carry out investigations of the cardiovascular system using modeling and simulation. Part II of this two-volume sequence, Mechanics and Medical Aspects, refers to the extraction of input data at the macroscopic scale for modeling the cardiovascular system, and complements Part I, which focuses on nanoscopic and microscopic components and processes. This volume contains chapters on anatomy, physiology, continuum mechanics, as well as pathological changes in the vasculature walls including the heart and their treatments. Methods of numerical simulations are given and illustrated in particular by application to wall diseases. This authoritative book will appeal to any biologist, chemist, physicist, or applied mathematician interested in the functioning of the cardiovascular system.
Biologics, biosimilars, and biobetters : An introduction for pharmacists, physicians and other health practitioners
Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists
Biological nitrogen fixation, sustainable agriculture and the environment ; Proceedings of the 14th International nitrogen fixation congress
Covers aspects of fundamental and applied nitrogen-fixation research, from biochemistry and chemistry through genetics, regulation and physiology to agricultural practice and environmental impact. This work describes progress on studies of potential catalysts for nitrogen fixation; how the N2-fixing process is regulated in living cells; and more.
Biological nitrogen fixation : Towards poverty alleviation through sustainable agriculture ; Proceedings of the 15th International nitrogen fixation congress and the 12th International Conference of the African Association for Biological Nitrogen Fixation
This volume covers recent developments in both fundamental and applied research in biological nitrogen fixation. It emphasizes the application of biological nitrogen fixation for sustainable agriculture, which should lead to poverty alleviation, environmental protection, and good agricultural practices generally. The roles of, and advances in, plant breeding, plant molecular biology, nodule physiology, and symbiotic and associative interactions between plants and microbes in sustaining agricultural productivity and soil fertility are described. The evolution of symbioses and nitrogen fixation are also covered in this volume. To ensure high agricultural productivity, while protecting the environment (both soil and water resources), requires plant cultivars that also respond to beneficial microbes.
