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الصفحة 43
High performance computing for drug discovery and biomedicine
Explores the application of high-performance computing (HPC) technologies to computational drug discovery (CDD) and biomedicine. Collects CDD approaches that, together with HPC, can revolutionize and automate drug discovery process, such as knowledge graphs, natural language processing (NLP), Bayesian optimization, automated virtual screening platforms, alchemical free energy workflows, fragment-molecular orbitals (FMO), HPC-adapted molecular dynamic simulation (MD-HPC), and the potential of cloud computing for drug discovery. And delves into computational algorithms and workflows for biomedicine, featuring an HPC framework to assess drug-induced arrhythmic risk, digital patient applications relevant to the clinic, virtual human simulations, cellular and whole-body blood flow modeling for stroke treatments, prediction of the femoral bone strength from CT data, and many more subjects.
High performance computing for computational science - VECPAR 2006 ; 7th International Conference, Rio de Janeiro, Brazil, June 10-13, 2006, Revised Selected and Invited Papers
This book constitutes the thoroughly refereed post-proceedings of the 7th International Conference on High Performance Computing for Computational Science, VECPAR 2006, held in Rio de Janeiro, Brazil, in June 2006.
High performance computing for computational science - VECPAR 2004 ; 6th International conference, Valencia, Spain, June 28-30, 2004, Revised Selected and Invited Papers
VECPAR is a series of international conferences dedicated to the promotion and advancement of all aspects of high-performance computing for computational science, as an industrial technique and academic discipline, extending the fr- tier of both the state of the art and the state of practice. The audience for and participants in VECPAR are seen as researchers in academic departments, g- ernment laboratories and industrial organizations. There is now a permanent website for the series, http://vecpar.fe.up.pt, where the history of the conf- ences is described. ThesixtheditionofVECPARwasthe?rsttimetheconferencewascelebrated outside Porto – at the Universitad Politecnica de Valencia (Spain), June 28–30, 2004.
High performance computing - HiPC 2007 ; 14th International Conference, Goa, India, December 18-21, 2007, Proceedings
This book constitutes the refereed proceedings of the 14th International Conference on High-Performance Computing, HiPC 2007, held in Goa, India, in December 2007. The 53 revised full papers presented together with the abstracts of five keynote talks were carefully reviewed and selected from 253 submissions.
High performance computational science and engineering : IFIP TC5 Workshop on High Performance Computational Science and Engineering (HPCSE), World Computer Congress, August 22-27, 2004, Toulouse, France
The IFIP series publishes state-of-the-art results in the sciences and technologies of information and communication. The scope of the series includes: foundations of computer science; software theory and practice; education; computer applications in technology; communication systems; systems modeling and optimization; information systems; computers and society; computer systems technology; security and protection in information processing systems; artificial intelligence; and human-computer interaction. Proceedings and post-proceedings of referred international conferences in computer science and interdisciplinary fields are featured. These results often precede journal publication and represent the most current research. The principal aim of the IFIP series is to encourage education and the dissemination and exchange of information about all aspects of computing.
High Frequency Financial Econometrics : Recent Developments
This exciting volume presents cutting-edge developments in high frequency financial econometrics, spanning a diverse range of topics: market microstructure, tick-by-tick data, bond and foreign exchange markets and large dimensional volatility modelling. The chapters on market microstructure deal with liquidity, asymmetries of information, and limit order aggressiveness in pure limit order book markets. The chapters on tick-by-tick data present statistical techniques for the analysis of the discrete nature of price movements, the intraday seasonal patterns of financial durations, and the joint probability law of prices, volume and durations. Bond markets are brought into focus through the analysis of macroeconomic announcements in the future bond market as a function of the business cycle.
High Energy Density Materials
The series Structure and Bonding publishes critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table. It focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures. Physical and spectroscopic techniques used to determine, examine and model structures fall within the purview of Structure and Bonding to the extent that the focus is on the scientific results obtained and not on specialist information concerning the techniques themselves.
High Density Lipoproteins : From Biological Understanding to Clinical Exploitation
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation.
High Confidence Software Reuse in Large Systems ; 10th International Conference on Software Reuse, ICSR 2008, Beijing, China, May 25-29, 2008 Proceedings
This book constitutes the refereed proceedings of the 10th International Conference on Software Reuse, ICSR 2008, held in Beijing, China, in May 2008.The 40 revised full papers presented together with 5 workshop summaries and 5 tutorials were carefully reviewed and selected from numerous submissions. The papers are organized in topical sections on architecture and reuse approaches, high confidence and reuse, component selection and reuse repository, product line, domain models and analysis, service oriented environment, components and services, reuse approaches and frameworks, as well as reuse approaches and methods.
Hierarchy in Natural and Social Sciences
This book reviews ancient and modern representations and explanations of hierarchies, and compares their relevance in a variety of fields, such as language, societies, cities, and living species. It throws light on concepts and models such as scaling laws, fractals and self-organisation that are fundamental in the dynamics and morphology of complex systems.This book addresses a wide audience of biologists and social scientists, as well as managers and executives in a variety of institutions.
Hiérarchie de modèles en optique quantique: De Maxwell-Bloch à Schrödinger non-linéaire
The book under review appears to be relevant in this respect since it cross-fertilizes such a fundamental field of research in physics in two important ways.
Hierarchical Bayesian Optimization Algorithm : Toward a New Generation of Evolutionary Algorithms
This book provides a framework for the design of competent optimization techniques by combining advanced evolutionary algorithms with state-of-the-art machine learning techniques. The book focuses on two algorithms that replace traditional variation operators of evolutionary algorithms by learning and sampling Bayesian networks: the Bayesian optimization algorithm (BOA) and the hierarchical BOA (hBOA). BOA and hBOA are theoretically and empirically shown to provide robust and scalable solution for broad classes of nearly decomposable and hierarchical problems. A theoretical model is developed that estimates the scalability and adequate parameter settings for BOA and hBOA. The performance of BOA and hBOA is analyzed on a number of artificial problems of bounded difficulty designed to test BOA and hBOA on the boundary of their design envelope.
Hidden Markov Models in Finance
A number of methodologies have been employed to provide decision making solutions to a whole assortment of financial problems in today's globalized markets. Hidden Markov Models in Finance by Mamon and Elliott will be the first systematic application of these methods to some special kinds of financial problems; namely, pricing options and variance swaps, valuation of life insurance policies, interest rate theory, credit risk modeling, risk management, analysis of future demand and inventory level, testing foreign exchange rate hypothesis, and early warning systems for currency crises.
Heterogeneous Objects Modelling and Applications : Collection of Papers on Foundations and Practice
Heterogeneous object modelling is a new and quickly developing research area. This book is one of the first attempts to systematically cover the most relevant themes and problems of this new and challenging subject area. It is a collection of invited papers and papers co-authored by the editors. Each chapter presents either new research results or a survey on the following topics:Formal models and abstractions of heterogeneous objects including geometric, topological, discrete and continuous models, operations forming special algebras and conversions between different model types.
Heterogeneity, high performance computing, self-organization and the cloud
Addresses the most recent developments in cloud computing such as HPC in the Cloud, heterogeneous cloud, self-organising and self-management, and discusses the business implications of cloud computing adoption. Establishing the need for a new architecture for cloud computing, it discusses a novel cloud management and delivery architecture based on the principles of self-organisation and self-management. This focus shifts the deployment and optimisation effort from the consumer to the software stack running on the cloud infrastructure. It also outlines validation challenges and introduces a novel generalised extensible simulation framework to illustrate the effectiveness, performance and scalability of self-organising and self-managing delivery models on hyperscale cloud infrastructures. It concludes with a number of potential use cases for self-organising, self-managing clouds and the impact on those businesses.
Heterogeneity in statistical genetics : How to assess, address, and account for mixtures in association studies
Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon.In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association.
Heritage building conservation : Sustainable and digital modelling
Covers: The technology used to digitally document heritage buildings, including LIDAR, photogrammetry, Heritage Building Information Modelling (HBIM), and Virtual Reality (VR) technologies Introducing a Maintainability Index of Heritage Buildings (MIHB) to support the decision-making and prioritization process for the maintenance of heritage buildings The adaptive reuse of heritage buildings Modelling embodied and operational energy performance Using Chatbot and Blockchain technology to support the management and preservation of heritage buildings Ultimately, this book presents a useful tool for use in heritage management and highlights how the reusability of heritage buildings is critical to the creation and survival of sustainable communities.
Hemodynamical Flows : Modeling, Analysis and Simulation
This book surveys research results on the physical and mathematical modeling, as well as the numerical simulation of complex fluid and structural mechanical processes occurring in the human blood circulation system. Topics treated include continuum mechanical description; choice of suitable liquid and wall models; mathematical analysis of coupled models; numerical methods for flow simulation; parameter identification and model calibration; fluid-solid interaction; mathematical analysis of piping systems; particle transport in channels and pipes; artificial boundary conditions, and many more.
Hedonic Methods in Housing Markets : Pricing Environmental Amenities and Segregation
Cities are growing worldwide and their sprawl is increasingly challenged for its pressure on open spaces and environmental quality. Economic arguments can help to decide about the trade-off between preserving environmental quality and developing housing and business surfaces, provided the benefits of environmental quality are adequately quantified. To this end, this book focuses on the use and advancement of the "hedonic approach", an economic valuation technique that analyses and quantifies the sources of rent and property price differentials. Starting from theoretical foundations, the hedonic approach is applied to the valuation of natural land use preservation and noise abatement measures, as well as to residential segregation and discrimination, extending the analysis to the role of the buyers' and sellers' identity on housing market prices and to the issue of environmental justice.
Hedgehog-Gli Signaling in Human Disease
Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
