الصفحة 4
الصفحة 4
Epigenetics in oncology
Covers the most recent advances in RNA/histone/DNA epigenetics in Oncology. RNA/histone/DNA epigenetics have been shown to play pivotal roles in cancer initiation, progression, maintenance and drug response/resistance, tumor microenvironment, cancer stem cell self-renewal, cancer metabolism, and tumor immune evasion. In particular, research in RNA cancer epigenetics has made impressive progress in the last few years. Individual chapters in Part I (focusing on RNA epigenetics) are devoted to RNA modifications in Cancer Metabolism and Microenvironment, Cancer Stem Cell Biology, Immune Surveillance, Solid Tumors and Tumor Immunity, and Hematopoietic Malignancies, as well as to RNA editing in Cancer. Chapters in Part II and III of the book focus on histone epigenetics and DNA epigenetics, respectively.
Epigenetics and chromatin
This book provides a state-of-the-art account of a few selected hot spots by scientists at the edge in this extremely active field. It puts special emphasis on two main streams of research. One is the role of post-translational modifications of proteins, mostly histones, on chromatin structure and accessibility.
Entry Inhibitors in HIV Therapy
The introductory chapters of this book present an overview of entry inhibitors, review current knowledge of how Env mediates entry, and discuss the challenge of genetic diversity in this region of the viral genome. Subsequent chapters feature current information on individual classes of entry inhibitors that target each step of the virus entry pathway, from attachment to membrane fusion. There is an emphasis on the complex determinants of entry inhibitor susceptibility, resistance mechanisms, the need for clinical phenotyping, and how these issues create new challenges for antiretroviral therapy. Encouraging pre-clinical studies of entry inhibitors as microbicidesare also discussed. The final chapters highlight the current status of entry inhibitors in clinical studies, the major milestone achieved with FDA approval of enfuvirtide, and review drug development, past and present.
Endoscopic Surgery of the Potential Anatomical Spaces
Potential anatomical spaces" have attracted surgeons in the past and in recent years. Due to the development of modern imaging techniques and the advent of minimally invasive surgery, access to these spaces has become a real surgical option. The purpose of this book is to document the challenges related to "potential anatomical spaces", traditionally described as "hidden" spaces. The spread of video-assisted surgery and its application in the management of diseases involving organs or anatomical structures placed in the "potential spaces" (neck, mediastinum, pro-peritoneum and retro-peritoneum, subfacial space of the leg, and axilla), has rendered their surgical anatomy less abstract.
Endoscopic Extraperitoneal Radical Prostatectomy : Laparoscopic and Robot-Assisted Surgery
This book is an atlas, not a conventional textbook. Its main goal is to guide the urologist step by step through EERPE, aiming to make this highly standardized technique reproducible. Every stage of the procedure is presented with numerous endoscopic images and diagrams so that the reader can fully comprehend the different surgical steps. Complications and their management are described in detail. Special chapters are devoted to the anatomy of the prostate, anesthesiological considerations, and postoperative management and training.
Emergency Vascular Surgery : A Practical Guide
The book provides detailed guidelines to any physician treating patients with emergency vascular disorders, such as ruptured abdominal aortic aneurysms, acute limb ischemia, vascular trauma, iatrogenic vascular injuries and complications to vascular surgery. It provides an introduction to vascular surgical operations and focuses on how to manage patients from the emergency ward through the urgent operation and all the way to the immediate postoperative period. Numerous figures illustrate the particular points in vascular techniques and diagnostic problems in the emergency situation.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Distant Worlds : Milestones in Planetary Exploration
Peter Bond provides an overview of key, unmanned missions, chapter by chapter, to planets in the twentieth century. He tells the story of the mission planners and engineers who, working mostly in the background, made these unprecedented achievements in scientific exploration possible.
Dissemination of information in communication networks : Broadcasting, gossiping, leader election, and fault-tolerance
Preface Due to the development of hardware technologies (such as VLSI) in the early 1980s, the interest in parallel and distributive computing has been rapidly growingandinthelate1980sthestudyofparallelalgorithmsandarchitectures became one of the main topics in computer science. To bring the topic to educatorsandstudents,severalbooksonparallelcomputingwerewritten. The involvedtextbook“IntroductiontoParallelAlgorithmsandArchitectures”by F. Thomson Leighton in 1992 was one of the milestones in the development of parallel architectures and parallel algorithms. But in the last decade or so the main interest in parallel and distributive computing moved from the design of parallel algorithms and expensive parallel computers to the new distributive reality – the world of interconnected computers that cooperate (often asynchronously) in order to solve di?erent tasks.
Digital watermarking ; 6th International Workshop, IWDW 2007 Guangzhou, China, December 3-5, 2007 Proceedings
This book constitutes the refereed proceedings of the 6th International Workshop, IWDW 2007, held in Guangzhou, China, in December 2007.
Digital Libraries : The Era of Big Data and Data Science; 16th Italian Research Conference on Digital Libraries, IRCDL 2020, Bari, Italy, January 30–31, 2020, Proceedings
The chapter "Identifying, Classifying and Searching Graphic Symbols in the NOTAE System" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Dictionary of gems and gemology
The rapid growth of gemological sciences and mineralogy requires a comprehensive dictionary for gemologists, mineralogists, geologists, jewel dealers, industry, and hobbyists. The revised and expanded second edition of this dictionary contains about 25,000 entries - some 9,000 more than the first edition.
Design Drawing
Covers the basics of drawing, including line, shape, tone, and space. Guiding the reader step-by-step through the entire drawing process, this Third Edition also examines different types of drawing techniques such as multiview, paraline, and perspective drawings—and reveals how the application of these techniques creates remarkable results. • Features over 1,500 hand drawings—stunning illustrations in the author's signature style that reinforce the concepts and lessons of each chapter • Offers new exercises and illustrative examples that range in complexity • Presents all-new digital drawing topics, such as hybrid floor plans, digital models and fabrication, and hand-to-digital fluency • Includes access to a new website featuring videos of the author demonstrating freehand techniques in a step-by-step manner in the studio and on location
Deepfake
The technology used to create such digital content has quickly become accessible to the masses, such as “DEEPFAKE.” Deep fakes refer to manipulated videos, or other digital representations produced by sophisticated artificial intelligence, that yields to synthesize a sequence of face images and voices of characters corresponding to their identities, such as voice tone, facial expression, with a good lip synchronization. Therefore, this study is about developing real-time video generation software, which generates a target video from a single input image. Several methods and algorithms have been applied to detect, analyze personalize facial expression, voice and natural head poses to present a life-like image instead of a low quality one.
Deconstructing Olduvai : A taphonomic study of the bed I sites
Plio-Pleistocene sites are a rare occurrence in same sites. This combination of factors is the archaeological record. When they are unique in East African Plio-Pleistocene uncovered, the faunal materials so crucial to archaeology and has stimulated much debate unlocking their behavioral meaning are often over the socioeconomic function of early sites. poorly preserved. For example, at Koobi Fora, Influential models of early hominid behavior Kenya, a prolific region that preserves several in the late 1960s and early 1970s were based classic Plio-Pleistocene sites, many bones are exclusively on information from Olduvai affected by poor cortical surface preservation Gorge (Leakey, 1971).
Data envelopment analysis : A comprehensive text with models, applications, references and DEA-Solver software
Data Envelopment Analysis: A Comprehensive Text with Models, Applications, References, And DEA-Solver Software, 2nd Edition is designed to provide a systematic introduction to DEA and its uses as a multifaceted tool for evaluating problems in a variety of contexts.
Current Themes in Theoretical Biology : A Dutch Perspective
The present volume originated in 2001 when we, together with our publishing editors at (then) Kluwer Academic Publishers, realized that the th following year the 50 volume of our journal Acta Biotheoretica would see the light. We felt that this milestone should not pass unnoticed and that the appropriate way to mark it would be the publication of a special volume of papers on theoretical biology. While editing this book during 2003 and early 2004, we realized that another milestone was not far off: in 2005 it will be 70 years ago that the journal was founded. We hope that the book lying before you will serve well to mark both events. The papers collected here have been written on invitation by representatives of the theoretical biology community in The Netherlands. They are intended to reflect the entire spectrum of topics on which Acta Biotheoretica publishes, ranging from philosophy of biology on one end to mathematical biology on the other. All chapters (except our own introductory one) have been peer reviewed according to the standards that are maintained with respect to regular submissions to Acta Biotheoretica.
Current techniques and materials in dentistry
Dental implants are one of the most interesting dental treatments. PEEK (polyetheretherketone) has recently been reported as a further innovation in polymer implant materials, although it has not yet met the requirements to be a biomechanical requirement. In the placement of mini-screws used in orthodontic treatments, micro-cracks caused by overtorquing in thick and hard bone, and the consequent heat production, can reduce the success rate. Computer-aided design/computer-aided manufacturing (CAD/CAM) techniques are becoming increasingly popular. Since complete dentures can be produced using an additive (3D printing) or subtractive (milling) process, CAD/CAM techniques for denture fabrication have many clinical and laboratory advantages.
Curcumin : clinical uses, health effects and potential complications
Curcumin is a natural product with polyphenolic structure. It is used in therapeutic remedies alone or in combination with other natural substances. Many researchers are investigating it because of its biological activities such as: anti-inflammatory, anti-cancer, anti-protozoal, anti-viral, anti-bacterial and has been found to be effective for treatment of Alzheimer, depression, headaches, fibromyalgia, leprosy, fever, menstrual problems, water retention, worms and kidney problems etc. It is an active ingredient in dietary spice, turmeric. It has reactive functional groups: a diketone moiety and two phenolic groups. Despite its unique biological activities, it suffers from some shortcomings which include: gastrointestinal problems, poor bioavailability due to its poor absorption, short half-life, poor solubility in aqueous solutions, rapid systemic elimination and antithrombotic activity which can interfere with blood clotting. The first chapter of this book reviews the different delivery systems used for incorporation of curcumin and its derivatives, release kinetics and up to date in vivo results. Chapter two discusses curcumin nano and microencapsulation and its implications on clinical uses.
Cultural heritage in a changing world
The central purpose of this collection of essays is to make a creative addition to the debates surrounding the cultural heritage domain. In the 21st century the world faces epochal changes which affect every part of society, including the arenas in which cultural heritage is made, held, collected, curated, exhibited, or simply exists. The book is about these changes; about the decentring of culture and cultural heritage away from institutional structures towards the individual; about the questions which the advent of digital technologies is demanding that we ask and answer in relation to how we understand, collect and make available Europe’s cultural heritage.
