الصفحة 4
الصفحة 4
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Messages security application
The rapid development of communication technology, is bringing many technological conveniences with it and simplifying our lives. On the other hand, it has disadvantages such as hiding the information that is continuously roaming through various communication media resources between senders and receivers and avoid sharing them with third parties. Eliminating these disadvantages via specific security methods and algorithms is related to the discipline called cryptography, which includes information security. Encryption is the process of turning a plaintext to jargon or the method of changing a confidential file to jargon in order to prevent unauthorized persons from gaining access to confidential message. A Message is the transfer of information from the sender to the receiver through a particular medium. Encryption is the most effective process for achieving data security.
Memory B-cells : Methods and protocols
Details in methods to assess memory B cell formation and function in mice and humans. Chapters guide readers through tetramer-based methods to assess antigen-specific memory B cell dynamics in humans and mice in different vaccine, next-generation deep-sequencing, single-cell techniques to assess epigenomic, VDJ landscapes, lymph node aspirates from humans, advanced imaging, murine models to determine memory B cells formation, and bioinformatic techniques and in silico modelling of memory b cell formation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.
Membrane Trafficking in Viral Replication
The ability of viruses to exploit cellular functions for their own ends makes them highly effective pathogens and exquisite experimental tools. Work with viruses underpins much of our current understanding of molecular cell biology and related fields. Each of the eight chapters in this volume deals with a specific aspect of viral interactions with cellular membranes. These include chapters on viral entry, viral membrane fusion, viral membrane protein synthesis and transport, viral replication, viral interactions with cytoskeletal systems and the nucleus, the trafficking of viral membrane proteins and viral perturbation of host cell protein trafficking. These chapters should provide both an overview of cellular membrane trafficking mechanisms and viral interactions with these systems, as well as reviews of the current state of each of the fields.
Medicinal plants and antimicrobial therapies
Serves as an excellent comprehensive material covering the current understandings and updates on antimicrobial resistance (AMR) and the use of medicinal plant resources for tackling it. Chapters cover important aspects of AMR and strategies to address this threatening issue with medicinal plants and their resources. One health perspectives for addressing AMR have been presented for the readers. Antimicrobial medicinal plant therapeutic resources including crude extracts, active fractions, pure molecules and essential oils, besides using them as functionalizing agents for nano-antimicrobials have been covered. Further, plant endophytes as a source of antimicrobial compounds have been discussed. Chapters cover both the bactericidal as well as resistance-reversal (or potentiating/ combinatorial therapies) potencies of medicinal plant resources. The book also focuses on how medicinal plant resources effectively target major determinants of AMR.
Medical data processing and analysis
Medical data can be defined as obtaining information from patients (such as signals, images, sounds, chemical components and their concentration, body temperature, respiratory rate, blood pressure, and different treatment measurements) to quantify the patient’s status and disease stage. Computer-aided diagnostic (CAD) systems use classical image processing, computer vision, machine learning, and deep learning methods for image analysis. Using image classification or segmentation algorithms, they find a region of interest (ROI) pointing to a specific location within the given image or an outcome of interest in the form of a label pointing to a diagnosis or prognosis. Computer science, with the evolution of artificial intelligence and machine learning techniques, facilitates the modeling and interpretation of results—from carrying out measurements to experiments and observations.
Mechanisms, Symbols, and Models Underlying Cognition ; 1st International Work-Conference on the Interplay Between Natural and Artificial Computation, IWINAC 2005, Las Palmas, Canary Islands, Spain, June 15-18, 2005, Proceedings, Part I
Constitute the refereed proceedings of the First International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2005. This two-volume set contains papers that are related with the conceptual developments in the fields of Neurophysiology and cognitive science, and also to bioinspired programming strategies.
Mechanical Ventilation
This book represents a state-of-the-art review by the leading experts in this field and covers a number of important topics including epidemiology, underlying physiological concepts, and approaches to monitoring. The pros and cons of various modes of ventilation are reviewed, as are novel forms of ventilation that may play a role in the future management of patients with respiratory failure. The importance of patient-ventilator synchrony and ventilator-induced lung injury are reviewed, with a focus on recent clinical trials and the challenges of implementing the results into clinical practice.
Measuring Methane Production from Ruminants
The world’s livestock sector is amidst a major transformation, fuelled by high demand for meat and milk, which is likely to double over the next two decades in developing countries. The challenge is to enhance animal productivity without adversely affecting the environment. A key to this is reducing methane emissions from ruminants. The major limitation to ruminant production in many tropical regions of Africa, Asia and Latin America, where a large proportion of the global ruminant population is located, is poor nutrition. The productivity of animals is restricted by the low nitrogen and high fibre content of the native grasses and crop residues, which form the basis of the diets in these regions. Animals on these types of diets emit more methane than animals fed better quality temperate forages. These methane emissions represent a loss of digestible energy to the animal (up to 15%) as well as a threat to the environment.The challenge is to devise nutritional strategies and identify dietary components, particularly from locally available plant resources, that reduce methane emissions.
Matrix-Based Multigrid : Theory and Applications
Multigrid methods are often used for solving partial differential equations. This book introduces and analyzes the multigrid approach. The approach used here applies to both test problems on rectangular grids and to more realistic applications with complicated grids and domains.
Mathematics for Life Science and Medicine
Dynamical systems theory in mathematical biology has attracted much attention from many scientific directions. The purpose of this volume is to present and discuss the many rich properties of the dynamical systems that appear in life science and medicine. The main topics include cancer treatment, dynamics of paroxysmal tachycardia, vector disease models, epidemic diseases and metapopulations, immune systems, pathogen competition and coexistence and the evolution of virulence and the rapid evolution of viruses within a host. Each chapter will serve to introduce students and scholars to the state-of-the-art in an exciting area, to present new results, and to inspire future contributions to mathematical modeling in life science and medicine.
Mathematical Problems in Image Processing : Partial Differential Equations and the Calculus of Variations
The goals of this book are to present a variety of image analysis applications, the precise mathematics involved and how to discretize them. Thus, this book is intended for two audiences. The first is the mathematical community by showing the contribution of mathematics to this domain. It is also the occasion to highlight some unsolved theoretical questions. The second is the computer vision community by presenting a clear, self-contained and global overview of the mathematics involved in image processing problems. This work will serve as a useful source of reference and inspiration for fellow researchers in Applied Mathematics and Computer Vision, as well as being a basis for advanced courses within these fields.
Isodual theory of antimatter : With applications to antigravity, grand unification and cosmology
Antimatter, already conjectured by A. Schuster in 1898, was actually predicted by P.A.M. Dirac in the late 19-twenties in the negative-energy solutions of the Dirac equation. Its existence was subsequently confirmed via the Wilson chamber and became an established part of theoretical physics. Dirac soon discovered that particles with negative energy do not behave in a physically conventional manner, and he therefore developed his "hole theory". This restricted the study of antimatter to the sole level of second quantization. As a result antimatter created a scientific imbalance, because matter was treated at all levels of study, while antimatter was treated only at the level of second quantization.In search of a new mathematics for the resolution of this imbalance the author conceived what we know today as Santilli’s isodual mathematics, which permitted the construction of isodual classical mechanics, isodual quantization and isodual quantum mechanics. The scope of this monograph is to show that our classical, quantum and cosmological knowledge of antimatter is at its beginning with much yet to be discovered, and that a commitment to antimatter by experimentalists will be invaluable to antimatter science.
Island Universes : Structure and Evolution of Disk Galaxies
This book contains an up-to-date review of the structure and evolution of disk galaxies from both the observational and theoretical point of view. The book is the proceedings of the "Island Universes" conference held at the island of Terschelling, The Netherlands in July 2005.
Iridescences : The Physical Colors of Insects
Biologists will find a clear and in-depth study of the different physical phenomena generating colors. It will constitute a boundless "biomimetical" inspiration for physicists and engineers, for if physics is simple, the combinations of effects and the structures involved are extremely complex and original.
IP operations and management ; 7th IEEE International workshop, IPOM 2007 San José, USA, October 31 - November 2, 2007 Proceedings
This book constitutes the refereed proceedings of the 7th IEEE International Workshop on IP Operations and Management, IPOM 2007, held in the course of the 3rd International Week on Management of Networks and Services, Manweek 2007.
Introduction to Symplectic Dirac Operators
One of the basic ideas in differential geometry is that the study of analytic properties of certain differential operators acting on sections of vector bundles yields geometric and topological properties of the underlying base manifold. Symplectic spinor fields are sections in an L^2-Hilbert space bundle over a symplectic manifold and symplectic Dirac operators, acting on symplectic spinor fields, are associated to the symplectic manifold in a very natural way. Hence they may be expected to give interesting applications in symplectic geometry and symplectic topology. These symplectic Dirac operators are called Dirac operators, since they are defined in an analogous way as the classical Riemannian Dirac operator known from Riemannian spin geometry. They are called symplectic because they are constructed by use of the symplectic setting of the underlying symplectic manifold. This volume is the first one that gives a systematic and self-contained introduction to the theory of symplectic Dirac operators and reflects the current state of the subject. At the same time, it is intended to establish the idea that symplectic spin geometry and symplectic Dirac operators may give valuable tools in symplectic geometry and symplectic topology,
Introduction to basics of pharmacology and toxicology ; Vol.2 : Essentials of systemic pharmacology : From principles to practice
Describes the pharmacology of drugs acting on different systems in the human body Analyses various human diseases and the pharmacological agents governing them Provides a valuable reference resource for academicians, researchers, and clinical practitioners Offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics.
Interval / Probabilistic Uncertainty and Non-Classical Logics
Contains proceedings of the first international workshop that brought together researchers working on interval and probabilistic uncertainty and on non-classical logics. We hope that this workshop will lead to a boost in the much-needed collaboration between the uncertainty analysis and non-classical logic communities, and thus, to better processing of uncertainty.
Internet and Network Economics ; Vol. 4286 ; 2nd International Workshop, WINE 2006, Patras, Greece, December 15-17, 2006, Proceedings
Constitutes the refereed proceedings of the Second International Workshop on Internet and Network Economics, WINE 2006, held in Patras, Greece in December 2006. The 32 revised full papers presented together with 3 invited talks were carefully reviewed and selected from 79 submissions. The papers contain foundational and mathematical work from theories, methodologies, and applications in computer science, economics, mathematics, and management sciences for solving problems arisen in internet technologies, grid computing, network communication protocols, as well as social economic issues in virtual communities enabled through the World Wide Web.
