الصفحة 32
الصفحة 32
Bridging divides : Maritime canals as invasion corridors
Maritime canals dissolve natural barriers to the dispersal of marine organisms, thus providing novel opportunities for natural dispersal, as well as for shipping-mediated transport. The introduction of alien species has proved to be one of the most profound and damaging of anthropogenic deeds - with both ecological and economic costs. This book is the first to assess the impacts of the world’s three principal maritime canals – the Kiel, the Panama, the Suez – as invasion corridors for alien biota. These three canals differ in their hydrological regimes, the types of biotas they connect, and in their permeability to invasions.
Breathing, feeding, and neuroprotection
New findings in brain research are being revealed on an almost daily basis, and the focus of this book is the fields of breathing, neuroprotection, and higher brain functions. An unresolved issue within respiration research and hence a topic of much interest is Where and how respiratory rhythm is generated in the brainstem, detailed analysis of which is presented herein. Chapters on neuroprotection examine the functional significance of the blood – brain barrier as an interface of blood and the central nervous system; other chapters look at health and disease in relation to the hypothalamic and limbic systems. In addition to animal experiments, research on the human brain is included, with a focus on the recently developed EEG/dipole tracing method. This book will be an invaluable reference for researchers in neuroscience and related fields.
Breast cancer research and treatment : innovative concepts
Focuses on innovative treatment options for breast cancer, including surgery, radiotherapy, systemic therapy and of course immunotherapy that is changing outcomes in some aggressive breast cancer histotypes. Subsequent chapters also address the ongoing emerging research in the screening, diagnostics, and management of all subtypes of breast cancers. All current landscapes and future perspectives in each molecular subtype: luminal, HER2-positive, and triple-negative breast cancers are discussed within the different chapters. Breast cancer is still the most common cancer and cause of cancer deaths among women worldwide. The improvement of breast cancer outcome appears to be strictly related to the validation of precise biomarkers that enable us to better select personalized approaches in breast cancer management. The closing chapters deal with the challenges of low income countries of conducting research in the era of precision medicine for cancer. The book is edited and authored by leading experts in this field and will be of interest for clinicians and scientists alike
Breast Cancer Management and Molecular Medicine : Towards Tailored Approaches
This book provides an overview of the most recent techniques, agents and approaches for breast cancer that contribute to the individualization of treatment. Current biomedical research focuses on facilitating the transfer of molecular biology knowledge into the clinical management of patients, leading to increased survival as well as improved quality of life. Particular attention is given in this book to organ-specific tailored approaches, specific populations, patients’ preferences and rehabilitation.
Breast cancer genetics, immunology, and immunotherapy : An interdisciplinary approach
Publishes comprehensive volumes on immune and genetic mechanisms of breast cancer diagnosis and prognosis. The role of molecular genetics, interleukins, chemokine receptor, and tumor-infiltrated lymphocytes-TILS in breast cancer are explained. Targeting myeloid determinants, SiRNA loaded in drug delivery nanosystems, nucleic acid and drug dual agent nanoplatforms, and oncolytic virotherapy are also discussed in the treatment of breast cancer, particularly in multidrug resistant and metastatic breast cancer.
Breast cancer chemosensitivity
In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem Breast Cancer Chemosensitivity moves on to focus on the latest findings of molecular mechanisms of drug resistance. These include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents. Breast Cancer Chemosensitivity provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment.
Branching Morphogenesis
Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.
Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries ; 7th International Workshop, BrainLes 2021, Held in Conjunction with MICCAI 2021, Virtual Event, September 27, 2021, Revised Selected Papers, Part I
The content of thebook covers the current state-of-the-art literature on federated learning applications for cancer research and Vclinical oncology analysis, as well as an overview of the deep learning approaches improving the current standard of care for brain lesions and current neuroimaging challenges. It is also focusing on the accepted BrainLes workshop submissions, is to provide an overview of new advances of medical image analysis in all the aforementioned brain pathologies. It brings together researchers from the medical image analysis domain, neurologists, and radiologists working on at least one of these diseases. The aim is to consider neuroimaging biomarkers used for one disease applied to the other diseases.
Brain-inspired computing ; 4th International Workshop, BrainComp 2019, Cetraro, Italy, July 15–19, 2019, Revised Selected Papers
The 11 papers presented in this volume were carefully reviewed and selected for inclusion in this book. They deal with research on brain atlasing, multi-scale models and simulation, HPC and data infra-structures for neuroscience as well as artificial and natural neural architectures.
Brain-computer interfaces : An international sssessment of research and development trends
This WTEC study gathered information on worldwide status and trends in BCI research to disseminate to government decisionmakers and the research community. The study reviewed and assessed the state of the art in sensor technology, the biotic-abiotic interface and biocompatibility, data analysis and modeling, hardware implementation, systems engineering, functional electrical stimulation, noninvasive communication systems, and cognitive and emotional neuroprostheses in academic research and industry.
Brain, vision, and artificial intelligence ; 1st International Symposium, BVAI 2005, Naples, Italy, October 19-21, 2005, Proceedings
This book constitutes the refereed proceedings of the First International Symposium on Brain, Vision and Artificial Intelligence, BVAI 2005, held in Naples, Italy in October 2005. The 48 revised papers presented together with 6 invited lectures were carefully reviewed and selected from more than 80 submissions for inclusion in the book. The papers are addressed to the following main topics and sub-topics: brain basics - neuroanatomy and physiology, development, plasticity and learning, synaptic, neuronic and neural network modelling; natural vision - visual neurosciences, mechanisms and model systems, visual perception, visual cognition; artificial vision - shape perception, shape analysis and recognition, shape understanding; artificial inteligence - hybrid intelligent systems, agents, and cognitive models.
Brain, Mind and Medicine : Essays in Eighteenth-Century Neuroscience
Ideas we associate with the 18th century are clearly seen in work published from the latter decades of the 17th century through the first decades of the 19th century. This is the "long 18th century", a period which exhibits multiple discourses in medicine, brain science and philosophy. The editors have deliberately adopted a "presentist" subtitle, "neuroscience", to emphasize that this collection of essays reflect a range of current thought about 18th century-studies of the nervous system in isolation and in context. There are six sections, each preceded by a short introduction.
Brain tumor pathology : Current diagnostic hotspots and pitfalls
Since Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
Brain Repair
Brain Repair, addresses all relevant issues underlying the mechanisms of brain damage, brain plasticity and post-traumatic reorganisation after CNS lesions. This book is divided the three major sections that follow; cellular and molecular basis of brain repair, plasticity and reorganisation of neural networks, and experimental therapy strategies. Brain Repair is written by high profile, international experts who describe in detail the newest results from basic research and highlight new model systems, techniques and therapy approaches. Based on a careful analysis of the cellular and molecular reaction patterns of the CNS to lesions, the contributions cover possibilities for endogenous reorganisation and repair as well as exciting new therapies emerging from basic research, some of which have already been introduced into the clinics.
Brain Metastases
Brain metastases are the most dreaded complication of systemic cancer, affecting approximately 170,000 people a year, a far greater incidence than primary brain tumors. Advances in modern chemotherapy have led to an improved control of system cancers, often with agents that poorly penetrate the central nervous system, resulting in an increasing incidence of brain metastases. Traditional chemotherapy has had little impact on brain metastases. The main therapeutic option is radiation therapy, and in a small number of patients - surgery. However, refinements in all of these treatments offer some positive outcomes and an increased ability to stratify patients based on certain criteria.
Brain Dynamics : Synchronization and Activity Patterns in Pulse-Coupled Neural Nets with Delays and Noise
This book addresses a large variety of models in mathematical and computational neuroscience.He devotes the main part to the synchronization problem. He presents neural net models more realistic than the conventional ones by taking into account the detailed dynamics of axons, synapses and dendrites, allowing rather arbitrary couplings between neurons. He gives a complete stabile analysis that goes significantly beyond what has been known so far. He also derives pulse-averaged equations including those of the Wilson--Cowan and the Jirsa-Haken-Nunez types and discusses the formation of spatio-temporal neuronal activity pattems. An analysis of phase locking via sinusoidal couplings leading to various kinds of movement coordination is included.
Brain dynamics : An introduction to models and simualtions
Brain Dynamics serves to introduce graduate students and nonspecialists from various backgrounds to the field of mathematical and computational neurosciences. Some of the advanced chapters will also be of interest to the specialists. The book approaches the subject through pulse-coupled neural networks, with at their core the lighthouse and integrate-and-fire models, which allow for the highly flexible modelling of realistic synaptic activity, synchronization and spatio-temporal pattern formation. Topics also include pulse-averaged equations and their application to movement coordination. The book closes with a short analysis of models versus the real neurophysiological system.
Brain development in Drosophila melanogaster
The central nervous system (CNS) represents the organ with the highest structural and functional complexity. Accordingly, uncovering the mechanisms leading to cell diversity, patterning and connectivity in the CNS is one of the major challenges in developmental biology. The developing CNS of the fruitfly Drosophila melanogaster is an ideal model system to study these processes. Several principle questions regarding neurogenesis (like stem cell formation, cell fate specification, axonal pathfinding) have been addressed in Drosophila by focusing on the relatively simply structured truncal parts of the nervous system. This book provides an overview of some major facets of recent research on Drosophila brain development.
Brain and Human Body Modeling 2020 : Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting
This book describes modern applications of computational human modeling in an effort to advance neurology, cancer treatment, and radio-frequency studies including regulatory, safety, and wireless communication fields.
Brain and Human Body Modeling : Computational Human Modeling at EMBC 2018
This book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner.
