الصفحة 31
الصفحة 31
Checkpoint Responses in Cancer Therapy
This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.
Charged Particle Traps : Physics and Techniques of Charged Particle Field Confinement
This book provides an introduction and guide to modern advances in charged particle (and antiparticle) confinement by electromagnetic fields. Confinement in different trap geometries, the influence of trap imperfections, classical and quantum mechanical description of the trapped particle motion, different methods of ion cooling to low temperatures, and non-neutral plasma properties (including Coulomb crystals) are the main subjects. They form the basis of such applications of charged particle traps as high-resolution optical and microwave spectroscopy, mass spectrometry, atomic clocks, and, potentially, quantum computing.
Characterization of Pharmaceutical Nano- and Microsystems
Offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker.
Characteristic based planning with mySAP SCM™ : Scenarios, processes, and functions
Characteristics are used in SAP as attributes, e.g. to specify the configuration of products or the properties of batches. In many industries – engineering, automotive, mill, pharmaceutical and foods to name the most typical – supply chain planning has to consider these characteristics. APO offers many different functionalities for planning with characteristics, where each of the functionalities has some prerequisites and incompatibilities. This book offers help and advice for the basic design of the implementation by explaining the processes and scenarios (process chains) for planning with characteristics, the functionalities for planning with characteristics in APO including their prerequisites and incompatibilities and the entities, dependencies and system configuration determinants for planning with characteristics in R/3 and APO. This book is based on the releases R/3 4.7 and mySAP SCM 4.1.
Chamomile & insulin nasal spray in the treatment of Alzheimer's disease
Chamomile is one of the most widely used herbs in Western countries, in the present study, we assessed the effect of chamomile combined with insulin on the learning and memory impairments (Alzheimer's disease) induced by scopolamine. The cognition-enhancing effect of chamomile & insulin was investigated using the Y-maze test. Drug-induced amnesia was induced by treating animals with scopolamine. Mix solution administration intranasally reversed scopolamine induced cognitive impairments in mice by the Y-maze test. Moreover, results suggest that the combination of both chamomile and insulin may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via inhibitory effects in vivo on the release of several pro-inflammatory mediators and as a co-absorbent.
Challenge In biologic drug delivery
Biologics are currently one of the most promising avenues for therapeutic interventions in conditions such as metabolic disease, ageing and inflammatory disorders, and for chronic ailments, oral delivery of such medicines has for years been recognised as an important goal. Despite decades of intensive research, oral delivery of biologics is only just starting to prove feasible. There has been much talk about the barriers to uptake of biologics, and indeed, one function of the intestine is to prevent, in one way or another, passage of unwanted materials across the gut, and yet, grams of biological agents both large and small pass across the intestinal cell wall every day. This review first describes the functioning of the gut under normal circumstances, then identifies the principle biological mechanisms, which have been harnessed successfully, to date, to achieve oral uptake, outlining the pros and cons of each approach.
Cerebral monitoring in the OR and ICU
This comprehensive volume will serve as a complete guide to the clinical application of computer assisted systems in monitoring central nervous functions both in the OR and ICU. It presents practical guidelines and therapeutic indications for computerized EEG and Somatosensory Evoked Potential (SSEP) monitoring for the experienced user and the novice. The book also describes what cerebral monitoring can do and what its limitations are.
Cellular Automaton Modeling of Biological Pattern Formation: Characterization, Applications, and Analysis
This book focuses on a challenging application field of cellular automata: pattern formation in biological systems, such as the growth of microorganisms, dynamics of cellular tissue and tumors, and formation of pigment cell patterns. These phenomena, resulting from complex cellular interactions, cannot be deduced solely from experimental analysis, but can be more easily examined using mathematical models, in particular, cellular automaton models.
Cell-secreted vesicles : Methods and protocols
Pesents hands-on technological protocols used to target an array of cell-secreted extracellular vesicles (EVs) in a variety of biological systems. Beginning with methods for EV purification and analysis, the book continues with sections on the study of EV functions as well as specific systems and models allowing for the study of EVs of different origin. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cell-Cycle Mechanisms and Neuronal Cell Death
This book serves to gain new insights into the molecular determinants of neuronal death and to establish new targets for therapeutic intervention.
Cell Therapy, Stem Cells and Brain Repair
As our world continues to evolve, the field of regenerative medicine f- lows suit. Although many modern day therapies focus on synthetic and na- ral medicinal treatments for brain repair, many of these treatments and prescriptions lack adequate results or only have the ability to slow the p- gression of neurological disease or injury. Cell therapy, however, remains the most compelling treatment for neurodegenerative diseases, disorders, and injuries, including Parkinson’s disease, Huntington’s disease, traumatic brain injury, and stroke, which is expanded upon in more detail in Chapter 1 by Snyder and colleagues. Cell therapy is also unique in that it is the only therapeutic strategy that strives to replace lost, damaged, or dysfunctional cells with healthy ones.
Cell therapy stem cells and regenerative medicine
Provides an overview of cell-based therapy for human diseases including the definition, history, and clinical applications of human stem cells and their use in regenerative medicine. It covers human pluripotent stem cells (human embryonic stem cells and human induced pluripotent stem cells), mesenchymal stem/stromal cells, and hematopoietic stem cells, bone marrow mononuclear cells. In terms of clinical applications, this book also provides an update on recent human trials using these cells to treat various diseases, including neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, frailty, and cancer treatment. In addition, it discusses the authors’ clinical trial experiences related to these conditions in a clinical setting to provide additional insight into regenerative medicine, especially cell-based therapy.
Cell Technology for Cell Products ; Proceedings of the 19th ESACT Meeting, Harrogate, UK, June 5-8, 2005
The 19th ESACT meeting was to highlight the novel capabilities of the industry to move the products towards the clinic and was attended by a wide range of workers in the industry and for many it was their first ESACT meeting. The meeting was started with a session on Transcription to Secretion with a notable set of presentations on the emerging issues. The other sessions that followed Therapeutic Cell Engineering, Gene Medicine, Cells to Tissue, Protein products and Process Technology guided the delegates through the advances made for the progression of the biotechnology towards the industrial application of the products from cells. The meeting was supported by some exceptional invited speakers from around the world whose contributions complemented the emerging technologies and the changes being made at the industrial end of the ESACT spectrum.
Cell Signaling in Vascular Inflammation
Although inflammatory disease of the vascular bed of the lung is a major cause of morbidity and mortality in both adult and pediatric age groups, the importance of vascular biology to its understanding, and in developing novel therapeutics, has been overlooked. In Cell Signaling in Vascular Inflammation, leading basic and clinical researchers review the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement.
Cell Motility in Cancer Invasion and Metastasis
Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
Cell Culture Engineering
Many patients suffering with life-threatening diseases or chronic dysfunctions, which were medically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the first generation of p- tein therapeutics was produced in recombinant Escherichia coli, most recent products use mammalian cells as production hosts. Not long after the first p- duction of recombinant proteins in E. coli, it was realized that the complex tasks of most post-translational modifications on proteins could only be efficiently carried out in mammalian cells.
Celiac disease
Celiac Disease is a chronic small intestinal immune-mediated enteropathy caused by the ingestion of dietary gluten proteins in genetically susceptible individuals. CD is one of the most common autoimmune diseases, affecting around 1.4% of the population globally . Celiac disease remains a challenging condition because of a steady increase in knowledge tackling its pathophysiology, diagnosis, management, and possible therapeutic options. Finding alternative diet and trying different lifestyle still under debates. However, complete exclusion of the gluten-containing food from the patient's diet is the only effective treatment to avoid the disease complications
Celebrating applied sciences reaches 20,000 articles milestone: invited papers in "applied dentistry and oral sciences" section
Encompasses a wide range of disciplines, covering everything from dental materials and biomaterials to preventive and therapeutic strategies, from clinical applications to regenerative dentistry.We envision this milestone as a stepping stone toward even greater accomplishments. Through the collaboration and collective efforts of researchers worldwide, we strive to push the boundaries of dental science, explore new frontiers, and improve oral health outcomes for individuals across the globe.
CD4+CD25+ Regulatory T Cells : Origin, Function and Therapeutic Potential
CD4+CD25+ regulatory T cells (Treg) and interleukin-10 producing T regulatory 1 (Tr1) cells have been studied in most detail and are the subject of most articles in this issue. Treg, also called "natural" regulatory T cells, will be traced from their intra-thymic origin to the site of their action in peripheral lymphoid organs and tissues.
CD137 Pathway : Immunology and Diseases
This comprehensive volume, written by experts in the field, covers nearly all aspects of ongoing research related to the CD137 pathway. Recent research has shown that the manipulation of CD137 pathway molecules is very promising in the treatment of cancer, viral infection, transplantation rejection and autoimmune diseases in experimental animal models. The volume includes research related to the identification and understanding of functional consequences of CD137 receptor and ligand molecules which represents a major effort in the field of immunology. CD137 Pathway: Immunology and Diseases is an ideal book for immunologists, microbiologists, cancer researchers, molecular biologists, biochemists, and pharmaceutical and biotechnology company scientists.
