الصفحة 3
الصفحة 3
Drug interactions in infectious diseases : Mechanisms and models of drug interactions
Provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development
Drug disposition and pharmacokinetics : Principles and applications for medicine, toxicology and biotechnology
Delivers an authoritative and comprehensive discussion of the fate of drug molecules in the body, as well as its implications for pharmacological and clinical effects. The text offers a unique and balanced approach that combines discussion of the specific physical and biological factors affecting the absorption, distribution, metabolism, and excretion of drugs, with mathematical assessments of plasma and body fluid concentrations. The book assumes little prior knowledge and is an ideal reference for practicing professionals in industry as well as researchers and academics.
Drug delivery technology : Herbal bioenhancers in pharmaceuticals
Bioenhancers have been used in Ayurveda historically and are now being investigated for their pharmacological effi cacy. Herbal bioenhancers work on the gastrointestinal tract to improve absorption and drug bioavailability by acting on the drug metabolic process. Many herbal drugs show low activity due to their poor lipid solubility or improper molecular size. Piperine, gingerol, naringin, quercetin, niaziridin, glycyrrhizin, allicin, curcumin, genistein and others are able to enhance the bioavailability of active pharmaceuticals. This book details various facets of herbal bio-enhancers in a single comprehensive text.
Drug delivery systems using quantum computing
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells, and subcellular organs for drug release and absorption through a variety of drug carriers. By controlling the precise level and/or location of a given drug in the body, side effects are reduced, doses are lowered, and new therapies are possible. Nevertheless, there are still significant obstacles to delivering certain medications to particular cells. Drug delivery methods change pharmacokinetic, pharmacodynamic, and drug release patterns to enhance product efficacy and safety, as well as patient convenience and compliance.
Drug Delivery Approaches : Perspectives from Pharmacokinetics and Pharmacodynamics
Delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes.
Drug Absorption Studies : In Situ, In Vitro and In Silico Models
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found very useful in not only characterising the permeability behaviour of drugs molecules in epithelial and endothelial tissues, but also studying drug delivery systems for improved delivery and enhanced absorption. Compared to the complex in vivo situation, in vitro models offer a fast, convenient approach with cost advantages most of times. Most importantly, they can be standardised and automatised to be applicable to the high-throughput screening. Starting at the molecular level of studies, continuing with cell monolayer models (both primary and cell lines) and in situ techniques as a final testing format, the book provides a practical approach to contemporary in vitro techniques for drug absorption studies. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix comprised with a number of practical protocols is available online, updated as needed, should prove very helpful to apply the techniques directly to the benchside.
Dissipative Solitons
This volume is devoted to the exciting topic of dissipative solitons, i.e. pulses or spatially localised waves in systems exhibiting gain and loss. Examples are laser systems, nonlinear resonators and optical transmission lines. The physical principles and mathematical concepts are explained in a clear and concise way, suitable for students and young researchers. The similarities and differences in the notion of a soliton between dissipative systems and Hamiltonian and integrable systems are discussed, and many examples are given. The contributions are written by the world's leading experts in the field, making it a unique exposition of this emerging topic.
Differential Optical Absorption Spectroscopy : Principles and Applications
This book reviews the basics of atmospheric chemistry, radiation transport, and optical spectroscopy before detailing the principles underlying DOAS. The second part of the book describes the design and application of DOAS instruments as well as the evaluation and interpretation of spectra. The recent expansion of DOAS application to the imaging of trace gas distributions by ground, aircraft, and satellite-based instruments is also covered.
Diagnosing and managing temporomandibular joint conditions
Aims to contribute to current knowledge in diagnosing and managing temporomandibular joint (TMJ) disease. Individual chapters cover imaging techniques, myofascial pain, minimally invasive techniques, and operative arthroscopy. The book includes two chapters on condylar head changes regarding condylar resorption and condylar hyperplasia. The book concludes with the issues of TMJ reconstruction with total joint replacement. This book is intended for dentists, oral surgeons, maxillofacial surgeons, ENT physicians, students, and anyone interested in TMJ disease.
Developing Organogel of CoEnzyme Q10
Coenzyme Q10 is a small lipophilic molecule composed of a benzoquinone ring and a hydrophobic isoprenoid tail and is present in all cell membranes. It is also an antioxidant. It plays a substantial role in energy production by acting as a mobile electron carrier in the electron transport chain. It has poor intestinal absorption and is prepared in topical forms. Organogel is a non-crystalline, non-glassy thermoreversible (thermoplastic) solid material and viscoelastic system can be regarded as a semi-solid preparation which has an immobilized external apolar phase, it is compatible with high molecular weight ingredients. The objective of present work is to prepare new dosage form with studying of different factors and conditions affecting preparation. Materials and methods: stearic acid and Flaxseed oil organogel was prepared by three methods and confirmed by quality assessment methods including: transparency, structure analysis, inverted tube test, kinetic of organogalation and stability test.
Deep eutectic polvents : Synthesis, properties, and applications
Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic solvents (DESs) as an environmentally benign alternative reaction media for chemical transformations and processes. The contributors cover a range of topics including synthesis, structure, properties, toxicity and biodegradability of DESs. The book also explores myriad applications in various disciplines, such as organic synthesis and (bio)catalysis, electrochemistry, extraction, analytical chemistry, polymerizations, (nano)materials preparation, biomass processing, and gas adsorption.
Curcumin : clinical uses, health effects and potential complications
Curcumin is a natural product with polyphenolic structure. It is used in therapeutic remedies alone or in combination with other natural substances. Many researchers are investigating it because of its biological activities such as: anti-inflammatory, anti-cancer, anti-protozoal, anti-viral, anti-bacterial and has been found to be effective for treatment of Alzheimer, depression, headaches, fibromyalgia, leprosy, fever, menstrual problems, water retention, worms and kidney problems etc. It is an active ingredient in dietary spice, turmeric. It has reactive functional groups: a diketone moiety and two phenolic groups. Despite its unique biological activities, it suffers from some shortcomings which include: gastrointestinal problems, poor bioavailability due to its poor absorption, short half-life, poor solubility in aqueous solutions, rapid systemic elimination and antithrombotic activity which can interfere with blood clotting. The first chapter of this book reviews the different delivery systems used for incorporation of curcumin and its derivatives, release kinetics and up to date in vivo results. Chapter two discusses curcumin nano and microencapsulation and its implications on clinical uses.
Combined and Hybrid Adsorbents : Fundamentals and Applications
Adsorption is a separation process playing a fundamental role in several industrial areas, being used in both purification and bulk separations. The adsorbent used is the main parameter controlling the effectiveness of the process. Emerging new separations and the improvement of existing ones constitute the driving force for the development of new adsorbents with improved adsorbing properties.
Cloud Optics
Clouds affect the climate of the Earth, and they are an important factor in the weather. Therefore, their radiative properties must be understood in great detail. This book summarizes current knowledge on cloud optical properties, for example their ability to absorb, transmit, and reflect light, which depends on the clouds’ geometrical and microphysical characteristics such as sizes of droplets and crystals, their shapes, and structures. In addition, problems related to the image transfer through clouds and cloud remote sensing are addressed in this book in great detail. This book can be an important source of information on theoretical cloud optics for cloud physicists, meteorologists and optical engineers.
Lysosomes
This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases.
Light Absorption in Sea Water
Takes a fresh, holistic approach to the problems of light absorption and absorbers in seawaters, discussing the fundamentals of light absorption at various depths in seawaters of different trophicity by absorbers of diverse origin. The authors have drawn their information from a substantial body of contemporary research results published in the subject literature (over 700 references) as well as their own work during the last 30 years. No other book presently available examines the issues of light absorption and absorbers in seawaters in such a manner. The physical and chemical properties, as well as the optical constants, of organic and inorganic suspended particulate matter (SPM), are discussed in the context of their relationship to the light absorption properties of SPM. Special emphasis is placed on the role of the phytoplankton and the pigments it contains which are particularly strong and important absorbers of visible light in the sea.
Lidar : Range-Resolved Optical Remote Sensing of the Atmosphere
Written by leading experts in optical radar, or lidar, this book brings all the recent practices up-to-date and covers a multitude of applications, from atmospheric sciences to environmental protection. Its broad cross-disciplinary scope should appeal to both the experienced scientist and the novice in the field. The Foreword is by one of the early pioneers in the area, Herbert Walther.
Laser Spectroscopy : Vol.1 Basic Principles
Keeping abreast of the latest techniques and applications, this new edition of the standard reference and graduate text on laser spectroscopy has been completely revised and expanded. While the general concept is unchanged, the new edition features a broad array of new material, e.g., frequency doubling in external cavities, reliable cw-parametric oscillators, tunable narrow-band UV sources, more sensitive detection techniques, tunable femtosecond and sub-femtosecond lasers (X-ray region and the attosecond range), control of atomic and molecular excitations, frequency combs able to synchronize independent femtosecond lasers, coherent matter waves, and still more applications in chemical analysis, medical diagnostics, and engineering.
Kinetics of Water-Rock Interaction
Systems at the surface of the Earth are continually responding to energy inputs derived from solar radiation or from the radiogenic heat in the interior. These energy inputs drive plate movements and erosion, exposing metastable mineral phases at the Earth’s surface. In addition, these energy fluxes are harvested and transformed by living organisms. As long as these processes persist, chemical disequilibrium at the Earth’s surface will be perpetuated. Chemical disequilibrium is also driven by human activities related to production of food, extraction of water and energy resources, and burial of wastes. To understand how the surface of the Earth will change over time, we must understand the rates at which reactions occur and the chemical feedbacks that relate these reactions across extreme temporal and spatial scales. This book addresses fundamental and applied questions concerning the rates of water-rock interactions driven by tectonic, climatic, and anthropogenic forcings.
Kinetics of Catalytic Reactions--Solutions Manual
This textbook contains all the information needed for graduate students or industrial researchers to design kinetic experiments involving heterogeneous catalysts, to characterize these catalysts, to acquire valid rate data, to verify the absence of mass (and heat) transfer limitations, to propose reaction models, to derive rate expressions based on these models and, finally, to assess the consistency of these rate equations.The most recent technique to calculate heats of adsorption and activation barriers on metal surfaces, the BOC-MP approach, is discussed in detail. Methods to measure metal surface areas and crystallite sizes using x-ray diffraction, transmission electron microscopy and various chemisorption techniques are discussed. Different experimental techniques to determine the influence of mass transfer limitations, especially within the pores of a catalyst, are reviewed in detail, with a particular emphasis on liquid-phase reactions.
