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الصفحة 3
الصفحة 3
Left-right asymmetry in vertebrate development
A host of studies has unravelled the involvement of many genes in the left right patterning pathway. Based on this knowledge the genetic basis of human laterality defects are beginning to be revealed. It is a major challenge now to understand how all these genes control left right development as well as the complex set of interactions established between them.
Lectins
In the intervening years well over 10,000 articles have appeared with lectins as the main subject, and more than twice as many in which they were touched upon, as well as around 20 books. In particular, great strides have been made in several areas of lectin research, about which little was known until the late 1980s. One prominent example is animal lectins, many of which have been discovered only during the last decade and the functions of several of which have been clarified, especially as to their key role in innate immunity.
Latency Strategies of Herpesviruses
This is the first book dealing with the intricate epigenetic mechanisms (DNA methylation, histone modification, alteration of chromatin structure) that regulate latency-associated transcription. Special attention is given to immune evasion "tricks" blocking immune responses to herpesvirus infected cells and viral RNAs and proteins involved in malignant transformation.
Landscapes, Genomics and Transgenic Conifers
What is the future of genetically modified (or transgenic) conifer plantations? The content of this edited volume Landscapes, Genomics and Transgenic Conifers addresses this question directly - and indirectly - using language drawn from policy, forest history, genomics, metabolism, pollen dispersal and gene flow, landscape ecology, evolution, economics, technology transfer and regulatory oversight. Although the book takes its title from a Nicholas School Leadership forum held November 17-19, 2004 at Duke University, its de novo contents move past the forum’s deliberations. The result is a trans-disciplinary book composed of 14 chapters written by a total of 31 authors working in North America, South America, Europe and Africa.
Landscapes of a New Cultural Economy of Space
Aims to tie together various perspectives, insights and constructions pertaining to landscapes and landscape representations from different theoretical and methodological positions as well as from diverse geographical and historical contexts in order to elucidate and illustrate processes of cultural transformation inscribed in space.
Landscape Pattern Analysis for Assessing Ecosystem Condition
Landscape Pattern Analysis for Assessing Ecosystem Condition presents a new method for assessing spatial pattern in raster land cover maps based on satellite imagery in a way that incorporates multiple pixel resolutions. This is combined with more conventional single-resolution measurements of spatial pattern and simple non-spatial land cover proportions to assess predictability of both surface water quality and ecological integrity within watersheds of the state of Pennsylvania (USA).
Landscape Ecological Applications in Man-Influenced Areas : Linking Man and Nature Systems
This book also includes several case studies concerning landscape analysis and evaluation using spatial analysis and landscape modelling for establishing sustainable management strategy in urban and agricultural landscapes. The subtitle of the book suggests the integrative and ubiquitous landscape planning considering harmony of man and nature systems in the socio-economic and cultural background.
Landscape Amenities : Economic Assessment of Agricultural Landscapes
The book mainly tries to formulate an answer to following questions: What is the economic value for society of the farmers' role as stewards of the countryside; and under which conditions are farmers willing to provide these landscape amenities? The challenge of this research is to value the agricultural landscape, as a non-commodity output from agriculture, both from a supply and demand perspective.
Lamto : Structure, Functioning, and Dynamics of a Savanna Ecosystem
Known as "a dream place for scientists," the Lamto savannas, located on the edge of the Cote d'Ivoire rain forests, are one of the only savannas in the world where ongoing ecological research has endured for more than forty years. Drawing from and synthesizing this abundance of research, the book examines the structure, functioning, and dynamics of the Lamto humid savanna. Beginning with the history of the Lamto ecology station and an overview of the major environmental conditions of the site, this exacting work specifically examines the integrative view of energy and nutrient fluxes relative to the dynamics of the savanna's vegetation.
Lake Verevi, Estonia : A highly stratified hypertrophic lake
The present book summarises investigations on Lake Verevi (surface 12.6 ha, mean depth 3.6 m). The seventeen articles in this issue deal with a wide range of questions, starting with a holistic overview of the ecological status, over assessments of long-term changes in biotic and abiotic conditions and finishing with proposed restoration plans. Abiotic chapters provide calculations on water and mass balance, distribution and fractions of phosphorus in the sediment, optical properties and penetration of radiation in the water column, sedimentation rate during the formation of stratification, and nitrogen circulation characteristics.
Lake Taihu, China : Dynamics and Environmental Change
There are many shallow lakes in the world. Many of them play an important socio-economic role as contributors to the drinking water supply, in flood attenuation, fisheries and recreation activities. Because of the current anthropogenic changes in the environment, such lakes rapidly respond to eutrophication and swamping. It is often hard to address these issues because many changes in the ecosystems of shallow lakes are associated with little studied physical processes. This interaction between the aquatic biota and the physical and chemical environment increases the complexity of shallow lake ecosystems. Lake Taihu, located in the delta of Yangtze River, is a typical large, shallow eutrophic lake with area of 2338 km2 and maximum depth of less than 3m . This book provides basic data on various aspects of this lake and summarizes research work on the interaction between its ecology and physical limnology. It will be a reference for teachers and students of freshwater ecology and biology, the aquatic environment in general, and, most strikingly, for all those interested in physical limnology.
Lagomorph Biology : Evolution, Ecology, and Conservation
Lagomorphs are a mammalian order which includes rabbits, hares and pikas. They are distributed throughout the world and are of both scientific and public interest as they are classified between endangered and pest species. In addition, some have a high economic value as important game species. In the last few decades, a huge amount of information was made available to the scientific community and resulted in remarkable advances on all aspects of Lagomorph biology. However, this information is dispersed in multiple scientific and non-scientific journals. This book provides an updated synthesis of the current knowledge on Lagomorph biology.
Lactic acid bacteria : Methods and protocols
This updated volume presents experimentation-based approaches to lactic acid bacteria (LAB) research. Split into three parts, the book explores techniques for analyzing lactic acid bacteria metabolism and characteristics, applications for food-related industries, such as yogurt production, beer, and wine making, and functions of LAB in human health. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topic, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
La riabilitazione dei disturbi cognitivi nella sclerosi multipla = The rehabilitation of cognitive disorders in multiple sclerosis
Multiple sclerosis is one of the most frequent causes of chronic disability in young adults. It mainly affects individuals between 20 and 50 years of age, with a peak of incidence around the age of 30. This disease is characterized by the presence of demyelinating lesions of an inflammatory nature disseminated in the central nervous system. The different localization of these lesions is at the basis of the variability of clinical symptoms which can be characterized by motor, sensory, neurovegetative and cognitive disorders. The latter concern about half of the patients affected by this pathology and have a significant impact on the personal, family and work situation of these patients.
La genetica nell’infertilità maschile = Genetics in male infertility
The notable recent cognitive advances in the field of cytogenetics and molecular genetics have made it possible to identify chromosomal anomalies and gene mutations responsible for numerous male infertility, which were completely ignored until recently. The fact is not without relevance, if the principle is valid that the recognition of the causes of a disease is also the first and necessary approach towards its correct therapy. With this publication, the authors wanted to offer specialists working in the field of assisted reproduction an update on this complex subject, dealing with both genetic causes in male infertility and infertility in genetic diseases.
KRAS : Methods and protocols
Details protocols ranging from high yield production metabolically labeled KRAS for NMR studies to approaches that quantify engagement of novel molecules that bind KRAS in live cells. Chapters focus on protein production and characterization, biochemical assays, cell-based assays, KRAS-membrane interactions, targeting KRAS, and cell models.
Köhlers Invention
This scientific biography commemorates the 10th anniversary of Köhler's untimely death. It describes his scientific and personal biography, based on 10 years of close personal and professional relationship between Eichmann and Köhler, as well as interviews with many colleagues and friends, including his "Doktorvater" and mentor Fritz Melchers. Köhler's scientific achievements are explained in a way to make them understandable for the general public and discussed in the historical context of the immunological research at the time.
Kindling 6
A broad array of themes concerned with research on epilepsy and kindling is covered in the book: Pathogenesis of kindling, including developmental patterns; electrophysiology; anatomy, morphology, and neural circuitry; genes, species, and strains; synaptic pharmacology and neurochemistry ; Behavioral consequences of kindling ; Drugs and interventions against kindling ; Clinical relevance of kindling for our understanding of epilepsy in patients
Kinase Drug Discovery : Modern Approaches
Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations.
Killer Lymphocytes
This extensively documented, comprehensive survey of cell-mediated cytotoxicity (CMC) traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike.
