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An introduction to clinical trials
An Introduction to clinical trials is a concise step-by-step guide to the principles and practices of clinical trials for those studying clinical trials or new to working on one. Clinical trials are critical to the progress of medicine and improving healthcare / as they evaluate whether new treatments and interventions work. They are also complex / multidisciplinary projects that integrate science / ethics / and legal requirements in the conduct of medical research.
Amino acid biosynthesis : Pathways, regulation and metabolic engineering
Amino Acids Biosynthesis presents the current knowledge of fundamental as well as applied microbiology of amino acids. Topics discussed are the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The characterization of the control mechanisms of amino acid biosynthesis has revealed insights into principles of genetic and biochemical regulation, such as transcriptional regulators and a new class of regulatory elements, the riboswitch. The volume further deals with the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and, particularly, as food and feed additives.
Advanced Techniques in Diagnostic Microbiology
The book is divided into two sections. The first techniques section covers the principles and characteristics of techniques ranging from rapid antigen testing, to advanced antibody detection, to in vitro nucleic acid amplification techniques, and to nucleic acid microarray and mass spectrometry. Sufficient space is assigned to cover different nucleic acid amplification formats that are currently being used widely in the diagnostic microbiology field. Within each technique, examples are given regarding its application in the diagnostic field. Commercial product information, if available, is introduced with commentary in each chapt
Actin Monomer Binding Proteins
The actin cytoskeleton plays a central role in many cellular processes including cell motility, cytokinesis, endocytosis and phagocytosis. The structure and dynamics of the actin cytoskeleton is regulated by a large number of proteins that interact with monomeric and/or filamentous actin. Actin monomer binding proteins provides a comprehensive view on actin monomer-binding proteins and the mechanisms by which they contribute to actin dynamics and various actin-dependent cellular processes. This new title contains chapters that describe the basic mechanisms of actin dynamics as well as the structural principles by which various actin-binding proteins interact with actin.
Brownlie's principles of public international law
A definitive guide to international law for over 40 years. This eighth edition, updated by James Crawford, builds on the reputation of its predecesors, providing outstanding, lucid and up-to-date treatment of all of the main issues in international law today
Machine learning in healthcare : Fundamentals and recent applications
Discusses how to build various ML algorithms and how they can be applied to improve healthcare systems. Healthcare applications of AI are innumerable: medical data analysis, early detection and diagnosis of disease, providing objective-based evidence to reduce human errors, curtailing inter- and intra-observer errors, risk identification and interventions for healthcare management, real-time health monitoring, assisting clinicians and patients for selecting appropriate medications, and evaluating drug responses. Extensive demonstrations and discussion on the various principles of machine learning and its application in healthcare is provided, along with solved examples and exercises.
Long-Term Preservation of Digital Documents : Principles and Practices
Key to our culture is that we can disseminate information, and then maintain and access it over time. While we are rapidly advancing from vulnerable physical solutions to superior, digital media, preserving and using data over the long term involves complicated research challenges and organization efforts. Uwe Borghoff and his coauthors address the problem of storing, reading, and using digital data for periods longer than 50 years. They briefly describe several markup and document description languages like TIFF, PDF, HTML, and XML, explain the most important techniques such as migration and emulation, and present the OAIS (Open Archival Information System) Reference Model. To complement this background information on the technology issues the authors present the most relevant international preservation projects, such as the Dublin Core Metadata Initiative, and experiences from sample projects run by the Cornell University Library and the National Library of the Netherlands. A rated survey list of available systems and tools completes the book.
Julia - Bit by Bit : Programming for Beginners
The main goal of this book is to teach fundamental programming principles to beginners using Julia, one of the fastest growing programming languages today. Julia can be classified as a "modern" language, possessing many features not available in more popular languages like C and Java.
Computational analysis and deep learning for medical care : Principles, methods, and applications
Focuses on the sophisticated methods for improving dye extraction and dyeing properties which will minimize the use of bioresource products. This book also brings out the innovative ways of wet chemical processing to alleviate the environmental impacts arising from this sector.
Compilers : Principles, techniques & tools
This introduction to compilers is the direct descendant of the well-known book by Aho and Ullman, Principles of Compiler Design. The authors present updated coverage of compilers based on research and techniques that have been developed in the field over the past few years. The book provides a thorough introduction to compiler design and covers topics such as context-free grammars, fine state machines, and syntax-directed translation.
Building better interfaces for remote sutonomous systems : An introduction for systems engineers
This book provides foundational knowledge for designing autonomous, asynchronous systems and explains aspects of users relevant to designing for these systems, introduces principles for user-centered design, and prepares readers for more advanced and specific readings.
Blockchains For Network Security : Principles, technologies and applications
Blockchain technology is a powerful, cost-effective method for network security. Essentially, it is a decentralized ledger for storing all committed transactions in trustless environments by integrating several core technologies such as cryptographic hash, digital signature and distributed consensus mechanisms. Over the past few years, blockchain technology has been used in a variety of network interaction systems such as smart contracts, public services, Internet of Things (IoT), social networks, reputation systems and security and financial services. With its widespread adoption, there has been increased focus on utilizing blockchain technologies to address network security concerns and vulnerabilities as well as understanding real-world security implications.
Best practices in software measurement : How to use metrics to improve project and process performance
Not everything that counts can be counted. Not everything that is counted counts. Albert Einstein This is a book about software measurement from the practitioner’s point of view and it is a book for practitioners. Software measurement needs a lot of practical guidance to build upon experiences and to avoid repeating errors. This book t- gets exactly this need, namely to share experiences in a constructive way that can be followed. It tries to summarize experiences and knowledge about software measurement so that it is applicable and repeatable. It extracts experiences and lessons learned from the narrow context of the specific industrial situation, thus facilitating transfer to other contexts. Software measurement is not at a standstill. With the speed software engine- ing is evolving, software measurement has to keep pace. While the underlying theory and basic principles remain invariant in the true sense (after all, they are not specific to software engineering), the application of measurement to specific contexts and situations is continuously extended. The book thus serves as a ref- ence on these invariant principles as well as a practical guidance on how to make software measurement a success.
Beginning Ruby : From novice to professional
Beginning Ruby is a thoroughly contemporary guide for every type of reader who wants to learn Ruby, from novice programmers to web developers to Ruby newcomers. It starts by explaining the principles behind object-oriented programming and within a few chapters builds toward creating a genuine Ruby application.
Beginning Python : From novice to professional
Gain a fundamental understanding of Python's syntax and features with the second edition of Beginning Python, an up–to–date introduction and practical reference. Covering a wide array of Python–related programming topics, including addressing language internals, database integration, network programming, and web services, you'll be guided by sound development principles. Ten accompanying projects will ensure you can get your hands dirty in no time. Updated to reflect the latest in Python programming paradigms and several of the most crucial features found in Python 3.0 (otherwise known as Python 3000), advanced topics, such as extending Python and packaging/distributing Python applications, are also covered
Beginning Java Objects : From concepts to code
Learning to design objects effectively with Java is the goal of Beginning Java Objects: From Concepts to Code, Second Edition. Plenty of titles dig into the Java language in massive detail, but this one takes the unique approach of stepping back and looking at fundamental object concepts first. Mastery of Java—from understanding the basic language features to building complete industrial-strength Java applications—emerges only after a thorough tour of thinking in objects. The first edition of Beginning Java Objects has been a bestseller; this second edition includes material on the key features of J2SE 5, conceptual introductions to JDBC and J2EE, and an in-depth treatment of the critical design principles of model-data layer separation and model-view separation.
Beginning C : From novice to professional
With Beginning C: From Novice to Professional, Fourth Edition, you'll come to understand the fundamentals of the C language and learn how to program. All you need is this book and any one of the widely available free or commercial C or C++ compilers, and you'll soon be writing real C programs. You'll learn C from the first principles.
Beginning ASP.NET 2.0 in VB 2005 : From novice to professional
This book includes best practices and comprehensive discussions about key database and XML principles, which are essential for you to become effective with ASP.NET. The book also emphasizes the invaluable coding techniques of object orientation and code behind, which will enable you to build real-world websites immediately rather than just scraping by with simplified coding practices. By the time you've finished this book, you will have mastered the core techniques and possess the necessary knowledge to begin work as a professional ASP.NET developer.
Beginning ASP.NET 2.0 in C# 2005 : From novice to professional
This book provides thorough coverage of ASP.NET, guiding you from beginning to advanced techniques, such as querying databases from within a web page and performance-tuning your site. You'll find tips for best practices and comprehensive discussions of key database and XML principles. The book also emphasizes the invaluable coding techniques of object orientation and code-behind, which will enable you to build real-world websites instead of just scraping by with simplified coding practices. By the time you finish this book, you will have mastered the core techniques essential to professional ASP.NET developers.
Automated machine learning : Methods, systems, challenges
This book presents the first comprehensive overview of general methods in Automated Machine Learning (AutoML), collects descriptions of existing systems based on these methods, and discusses the first series of international challenges of AutoML systems. The recent success of commercial ML applications and the rapid growth of the field has created a high demand for off-the-shelf ML methods that can be used easily and without expert knowledge. However, many of the recent machine learning successes crucially rely on human experts, who manually select appropriate ML architectures (deep learning architectures or more traditional ML workflows) and their hyperparameters. To overcome this problem, the field of AutoML targets a progressive automation of machine learning, based on principles from optimization and machine learning itself.
