الصفحة 29
الصفحة 29
Computational biology in drug discovery and repurposing
Takes an in-depth look at the emerging and prospective field of computational biology and bioinformatics, which possesses the ability to analyze large accumulated biological data collected from sequence analysis of proteins and genes and cell population with an aim to make new predictions pertaining to drug discovery and new biology. The book explains the basic methodology associated with a bioinformatics and computational approach in drug designing. It then goes on to cover the implementation of computational programming, bioinformatics, pharmacophore modeling, biotechnological techniques, and pharmaceutical chemistry in designing drugs. The major advantage of intervention of computer language or programming is to cut down the number of steps and costs in the field of drug designing, reducing the repeating steps and saving time in screening the potent component for drug or vaccine designin
Complicities : A theory for subjectivity in the psychological humanities
The book examines how we might develop a more socially just psychological theory and practice, which is both systems work and intra-psychological work. In bringing together ways of thinking developed in the humanities with clinical psychotherapeutic practice, this book offers one interdisciplinary take on key questions of social and emotional efficacy in action-oriented psychotherapy work.
Completeness theory for propositional logics
Completeness is one of the most important notions in logic and the foundations of mathematics. Many variants of the notion have been de?ned in literature. We shallconcentrateonthesevariants,andaspects,of completenesswhicharede?ned in propositional logic. Completeness means the possibility of getting all correct and reliable sc- mata of inference by use of logical methods. The word ‘all’, seemingly neutral, is here a crucial point of distinction. Assuming the de?nition as given by E. Post we get, say, a global notion of completeness in which the reliability refers only to syntactic means of logic and outside the correct schemata of inference there are only inconsistent ones. It is impossible, however, to leave aside local aspects of the notion when we want to make it relative to some given or invented notion of truth. Completeness understood in this sense is the adequacy of logic in relation to some semantics, and the change of the logic is accompanied by the change of its semantics.
Complement and Kidney Disease
It is evident that a defective or deregulated complement system results in kidney diseases. An important role of complement effector and regulatory proteins in pathological settings of the kidney has been demonstrated. A large panel of distinct human kidney diseases is caused by defective complement control. Genetic analyses have identified mutations in complement regulators that are associated with these diseases. Mutations have been identified in the fluid phase alternative pathway regulator Factor H and the membrane regulator Membrane Cofactor Protein MCP (CD46). The functional characterization of the mutant proteins allows to define the pathophysiological events on a molecular level. These new concepts and data on disease mechanisms allowed establishing new diagnostic and promising therapeutic approaches for several human kidney diseases. Molecular biology, clinics and therapy are discussed in this volume.
Compact objects in astrophysics : White dwarfs, neutron stars and Black Holes
Camenzind's Compact Objects in Astrophysics gives a comprehensive introduction and up-to-date overview about the physical processes behind these objects, covering the field from the beginning to most recent results, including all relevant observations.
Community-Acquired Pneumonia
Community-acquired pneumonia (CAP) is a disease associated with high morbidity and mortality, with at least one third of cases requiring hospitalization, exceeding the numbers admitted for myocardial infarction and stroke. Despite a broad armamentarium of antimicrobials available, it remains an important cause of death in industrialized countries. CAP is caused by a variety of pathogens with their order of importance dependent on the location and population studied. Despite the importance of CAP, reliable data and a recommended evidence-based therapy are lacking, and basic research must be improved. The goal of this volume is to present state-of-the-art knowledge on epidemiology, clinical presentation, immunology, pathology, and diagnosis including the identification of "new pathogens". Therapeutic approaches, antibiotics resistance, disease management and vaccination strategies are also covered. The volume is of interest to researchers and clinicians in virology, epidemiology and biomedicine.
Common Chinese materia medica ; Vol.7
Describes 247 species of 9 families of medicinal plants, which are commonly used in Chinese medicine. The most important species are Adina rubella, Gardenia jasminoides, Hedyotis diffusa, Morinda officinalis, Rubia cordifolia, Uncaria hirsuta, Uncaria macrophylla, Uncaria rhynchophylla, Uncaria sessilifructus, Uncaria sinensis of Rubiaceae; Lonicera confusa, Lonicera hypoglauca, Lonicera macranthoides, Lonicera japonica of Caprifoliaceae; Patrinia scabiosaefolia, Patrinia villosa, Nardostachys jatamansi of Valerianaceae; Dipsacus asperoides of Dipsacaceae; Arctium lappa, Artemisia annua, Artemisia argyi, Artemisia capillaris, Artemisia scoparia, Atractylodes lancea, Atractylodes macrocephala, Dendranthema indicum, Dendranthema morifolium, Eupatorium chinense, Eupatorium fortunei, Inula helenium, Saussurea costus, Saussurea involucrata, Senecio scandens, Serratula chinensis, Siegesbeckia orientalis, Solidago decurrens, Taraxacum mongolicum, Tussilago farfara、Xanthium sibiricum of Compositae; Gentiana crassicaulis, Gentiana manshurica, Gentiana rigescens, Gentiana scabra, Swertia pseudochinensis of Valerianaceae; Lysimachia christinae of Primulaceae and Plantago asiatica of Plantaginaceae.
Common Chinese materia medica ; Vol.6
Describes 226 species of 32 families of medicinal plants, which are commonly used in Chinese medicine. The most important species are Aquilaria sinensis and Daphne genkwa of Thymelaeaceae; Benincasa hispida, Siraitia grosvenorii, Trichosanthes kirilowii and Trichosanthes rosthornii of Cucurbitaceae; Camellia sinensis of Theaceae; Cleistocalyx operculatus, Eugenia caryophyllata and Rhodomyrtus tomentosa of Myrtaceae; Osbeckia chinensis of Melastomataceae; Quisqualis indica and Terminalia chebula of Combretaceae; Hypericum japonicum of Hypericaceae; Microcos paniculata of Tiliaceae; Hibiscus mutabilis of Malvaceae; Croton crassifolius, C. lachnocarpus, C. tiglium, Euphorbia humifusa, E. lathyris, E. pekinensis, Phyllanthus emblica and Sauropus spatulifolius of Euphorbiaceae. In each specie, it introduces the scientific names, medicinal names, morphologies, habitats, distributions, acquisition and processing methods of these medicinal plants, the content of medicinal properties, therapeutic effects, usage and dosage of these medicinal plants, and attaches unedited color pictures and pictures of part herbal medicines of each species.
Common Chinese Materia Medica ; Vol.4
Describes 256 species of medicinal plants from 5 families, which are commonly used in Chinese medicine. The most important species are Agrimonia pilosa, Amygdalus persica, Armeniaca mume, Armeniaca vulgaris, Armeniaca sibirica, Chaenomeles sinensis, Eriobotrya japonica of Rosaceae; Chimonanthus praecox of Calycanthaceae；Albizia julibrissin, Archidendron clypearia, Entada phaseoloides, Bauhinia championii of Mimosoideae; Caesalpinia sappan, Cassia tora, Gleditsia sinensis of Caesalpiniaceae; Abrus cantoniensis, Astragalus membranaceus, Astragalus membranaceus, Dalbergia odorifera, Desmodium caudatum, Desmodium styracifolium, Erythrina variegata, Euchresta japonica, Flemingia prostrata, Glycyrrhiza uralensis, Glycyrrhiza inflata, Glycyrrhiza glabra, Lablab purpureus, Sophora japonica and Spatholobus suberectus of Butterflyaceae. In each specie, it introduces the scientific names, medicinal names, morphologies, habitats, distributions, acquisition and processing methods of these medicinal plants, the content of medicinal properties, therapeutic effects, usage and dosage of these medicinal plants, and attaches unedited color pictures and pictures of part herbal medicines of each species. This book series has 10 volumes in total, which covers over 2000 kinds of Chinese medicines that are commonly used. These volumes not only introduce the efficacy function and some prescriptions of the medicines, but also introduce the biological characteristics of them in detail with clear photos of the habitats, so that readers can identify them in the field. Apart from the growing environment, the books expound the distribution areas and other information to facilitate researches and other applications. The volumes are targeted at readers of general interests and it is also of high referential value for scientific researcher and teachers. It can be used as a guide to researchers, clinical doctors, and students in the department of pharmaceutics and traditional Chinese medicine.
Common Chinese materia medica ; Vol.2
Contains 231 species of 40 families of medicinal plants. The most important family of which are Magnoliaceae, such as Magnolia officinalis and Magnolia officinalis subsp. biloba; Schisandra chinensis of Schisandraceae; Cinnamomum aromaticum of Lauraceae, Coptis chinensis Franch., Coptis omeiensis and Coptis teeta of Berberidaceae; Isatis indigotica, Lepidium apetalum and Raphanus sativus of Cruciferae; Rheum palmatum, Rheum officinale and Rheum taguticum of Polygonaceae, etc. In each specie, it introduces the scientific names, herbal medicine names, characteristics, habitats, distributions, Acquisition and processing methods, medicinal traits, tastes, functions, use and dosages, and other information of medicinal plants, and attaches unedited color pictures and pictures of part herbal medicines for each species. This book series has totally 10 volumes, which covers 2000 kinds of Chinese medicines that are commonly seen or used. These volumes not only introduce the efficacy, function and some prescriptions of the medicines, but also introduce the biological characteristics of them in detail with clear photos of the habitats, so that readers can identify them in the field. Apart from the growing environment, the books expound the distribution areas and other information to facilitate researches and other applications. The volumes are targeted at readers of general interests and it is also of high referential value for scientific researcher and teachers. It can be used as a guide to researchers, clinical doctors, and students in the department of pharmaceutics and traditional Chinese medicine.
Common Chinese materia medica ; Vol.10
Records 5 species of resin, 74 species of animals, 41 species of minerals and fossils. There are resins such as Liquidambar orientalis, Commiphore myrrha, Boswellia carterii, Garcinia hanburyi; animals such as Solenognathus hardwickii, , Cervus nippon, Scolopendra subspinipes, Cryptotympana pustulata, Agkistrodon acutus, Bombyx mori, Collocalia esculenta, Moschus moschiferus, Hippocampus kelloggi, Gekko gekko; minerals and fossils such as mercury, gypsum, alum, mirabilite, cinnabar, actinolite, calomel, keel, dens draconis, lithodes, fossilia spiriferis.
Clinical oral anatomy : A comprehensive review for dental practitioners and researchers
Presents the most current and comprehensive review of oral anatomy for clinicians and researchers alike. In 26 chapters, the reader is taken on a unique anatomical journey, starting with the oral fissure, continuing via the maxilla and mandible to the tongue and floor of the mouth, and concluding with the temporomandibular joint and masticatory muscles. Each chapter offers a detailed description of the relevant anatomical structures and their spatial relationships, provides quantitative morphological assessments, and explains the relevance of the region for clinical dentistry. All dental health care professionals require a sound knowledge of anatomy for the purposes of diagnostics, treatment planning, and therapeutic intervention. A full understanding of the relationship between anatomy and clinical practice is the ultimate objective, and this book will enable the reader to achieve such understanding as the basis for provision of the best possible treatment for each individual patient as well as recognition and comprehension of unexpected clinical findings.
Clinical nuclear medicine
Clinical Nuclear Medicine … focuses on the universal state of the art in both diagnostic and therapeutic radionuclide methodology. … This book is easily readable, with presentation of essential points and plentiful references, and the quality of the figures and tables is excellent. … is a useful guide to students, technologists, and practitioners in nuclear medicine and radiology, as well as to general physicians who request nuclear diagnosis or treatment. … will be a welcome contribution to the bookshelf of nuclear medicine or radiology clinics.
Clinical microbiology made ridiculously simple
Is a brief, clear, thorough, and updated approach to clinical microbiology, brimming with mnemonics, humor, summary charts, and illustrations. Topics include Ebola, AIDS, flesh-eating bacteria, mad cow disease, hantavirus, anthrax, smallpox, and tuberculosis; the latest antibiotics; pandemic flu, including H7N9; SARS-like coronavirus; hepatitis C treatment options; HIV diagnostics and approved HIV meds; Zika virus; measles; and a new chapter on the latest emerging infectious diseases and drug-resistant bacteria. The major update to this book is the addition of a new chapter on the SARS-COV-2 virus and COVID-19 disease, which delves into the nature of the virus such as infectivity within the body, transmission between individuals, timeline of infectivity, symptoms, risk factors, therapeutics, and vaccines approved for use.
Clinical dental pharmacology
Quick reference for drugs relevant to clinical dentistry. It delivers an essential reference for dental practitioners seeking quick, easy access to current and accurate information about drugs used by dentists in clinical practice. The book covers common drugs prescribed by dental practitioners as well as systemic medications which may impact on provision of clinical dental care. A separate section on recognition and management common medical emergencies in dental practice is also included.
Clinical biochemistry and drug development : From fundamentals to output
Focuses on clinical biochemistry fundamentals, cell culture techniques, and drug discovery and development concepts. It deals with three different fields of clinical research: cell culture, clinical biochemistry, and drug discovery and development.
Clinical Approaches in Endodontic Regeneration : Current and Emerging Therapeutic Perspectives
This book combines explanation of the scientific base underpinning vital pulp treatment with description of current and emerging trends in clinical practice. It guides the reader through modern views on pulp diagnostics, deep caries, and pulp exposure management, leading to an analysis of the biological aspects of regenerative techniques such as angiogenesis, neurogenesis, inflammation, and epigenetics.
Clinical applications of mass spectrometry in drug analysis : Methods and protocols
This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls.
Click chemistry
In chemical synthesis, click chemistry is a class of simple atomic economy reactions commonly used to join two selected molecular entities. Click chemistry is not one specific reaction, but describes a method for generating products that follow examples in nature, which also generates substances by joining small modular units. In many applications, click interactions that join a biomolecule and a reporter molecule. Click chemistry is not limited to biological conditions: the concept of a 'click' reaction has been used in protein chemistry, pharmacokinetics, and many biomimetic applications. However, they have been made remarkably useful in the discovery, localization and qualification of biomolecules.
Cleaning validation : Practical compliance approaches for pharmaceutical manufacturing
Timely coverage of cleaning validation for the pharmaceutical industry, a dynamic area in terms of health-based limits. Encourages pharmaceutical manufacturers, and particularly upper management, to meet the challenges of the science-based and riskbased approaches to cleaning validation. Draws on the author’s vast experience in the field of cleaning validation and hazardous materials. Discusses EMA vs. ISPE on Cleaning Limits and revised Risk-MaPP for highly hazardous products in shared facilities. A diverse list of topics from protocol limits for yeasts and molds to cleaning validation for homeopathic drug products.
