الصفحة 27
الصفحة 27
Biotechnologies for plant mutation breeding : Protocols
This book offers 19 detailed protocols on the use of induced mutations in crop breeding and functional genomics studies, which cover topics including chemical and physical mutagenesis, phenotypic screening methods, traditional TILLING and TILLING by sequencing, doubled haploidy, targeted genome editing, and low-cost methods for the molecular characterization of mutant plants that are suitable for laboratories in developing countries. The collection of protocols equips users with the techniques they need in order to start a program on mutation breeding or functional genomics using both forward and reverse-genetic approaches. Methods are provided for seed and vegetatively propagated crops (e.g. banana, barley, cassava, jatropha, rice) and can be adapted for use in other species.
Biosphere Origin and Evolution
The book covers notions by scientists of various branches on the evolutionary relationship between the biosphere and geosphere, evolution features at various levels of living matter organization, and problems of prebiotic evolution and life origin. The data were collected in the course of the RAS program "Biosphere origin and evolution" (subprogram II) in 2003–2006. The objectives of this subprogram were (1) generalization of data related to problems of biosphere origin and evolution accumulated by geneticists, molecular biologists, zoologists, botanists, paleontologists, microbiologists, geologists, chemists, and archaeologists; (2) search for new interdisciplinary approaches to biosphere origin and evolution; (3) development of a "lingua franca" understandable by experts in various fields, which would allow apprehension of results concerning the topic obtained in allied sciences
Biosaline Agriculture and High Salinity Tolerance
this book reviews the current state of knowledge in biosaline agriculture and high salinity tolerance in plants. It mainly focuses on the biotic approach to economically utilize the stress-prone areas by growing resistant plants.This volume comprises three sections: physiology and biochemistry, ecology, and molecular biology. Thus, a systematic approach has been adopted to uncover plant responses to various ecological factors at physiological and molecular levels.
Bioremediation of Soils Contaminated with Aromatic Compounds
Environmental biotechnology, which was in its infancy in the early 80's, has evolved thanks to the revolution brought about by molecular biology. Multiple successes in the biological cleanup of civil and industrial wastewater and of hydrocarbon soil pollution, demonstrate the vast power of clean technologies. In addition, the buildup of information on the activities of microorganisms as catalysts in all sorts of natural, industrial and animal environments has flourished. There is a continuing realization of the critical role of microbial processes in biological, industrial and geological systems. Since environmental biotechnology has matured, it is ready to tackle bigger challenges: the scaling up of many bioremediation systems still in progress, the search for novel biocatalysts for industrial applications, the continuing effort against common human life-threatening processes such as antibiotic resistance, the accumulation of hormone-mimicking substances (endocrine disrupters), the deposition of air-borne pesticides in the environment and, the degradation of recalcitrant contaminants. These endeavors will help prevent the contamination of food chains, protect human life and allow for human activity and economic development that do not compromise environmental sustainabijity.
Biophysical characterization of functional peptides
Presents reproducible and step-by-step procedures for the peptide synthesis, their characterization and applications. The volume includes an introductory section on in silico modelling of new peptide molecules, Molecular Dynamics Simulations, Docking, Electrostatic fingerprinting of peptides, and other modelling tools for peptide designing and optimization. Further, it covers protocols for the solid phase peptide synthesis, chromatographic and mass spectrometric characterization of peptides. Importantly, it covers methods for biophysical characterizations of peptides for their potential applications as drug delivery vehicles, peptide nano-assembly, bionanocatalysis, protein aggregation diseases, and peptide-based anti-bacterial.
Biophysical Aspects of Transmembrane Signaling
Transmembrane signaling is one of the most significant cell biological events in the life and death of cells in general and lymphocytes in particular. Until recently biochemists and biophysicists were not accustomed to thinking of these processes from the side of a high number of complex biochemical events and an equally high number of physical changes at molecular and cellular levels at the same time. Both types of researchers were convinced that their findings are the most decisive, having higher importance than the findings of the other scientist population. Both casts were wrong. Life, even at cellular level, has a number of interacting physical and biochemical mechanisms, which finally build up the creation of an "excited" cell that will respond to particular signals from the outer or inner world.
Biophotonics ; Optical science and engineering for the 21st century
Biophotonics: Optical Science and Engineering in the 21st Century serves as an ideal aid to the research and development of these areas integrating light, photonics, and biological systems.Key topics include: Fluctuation Correlation Spectroscopy in Cells: Determination of Molecular Aggregation ,Using GFP and FRET Technologies for Studying Signaling Mechanisms of Apoptosis in a Single Living Cell, Study on Protein-Protein Interaction in Single Living Cells, Functional Optical Coherence Tomography: Simultaneous In Vivo Imaging of Tissue Structure and Physiology, Imaging –Photo- and Sonodynamic Diagnosis of Cancer Mediated by Chemiluminescence Probes, Biophotonic Analysis of Spontaneous Self-Organizing Oxidative Processes in Aqueous Systems, Biophoton Emission and Defense Systems in Plants
Biopharmaceutical drug design and development
Biopharmaceutical Drug Design and Development, Second Edition, updates the widely successful first edition, published in 1999. This new, expanded edition investigates the dozens of new biopharmaceutical drugs that have become available since the publication of the first edition. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, such as bioinformatics, DNA microarrays, transgenics, therapeutic gene delivery, stem cells, nucleic acid-based therapeutics, and macromolecular drug delivery. Authors also study pharmacogenetics in the clinic and changes in biologic drug approval at the FDA. Biopharmaceutical Drug Design and Development, Second Edition, is a worthy sequel in the discussion on the dynamic, exciting field of biotechnology.
Bionanotechnology : Proteins to Nanodevices
Bionanotechnology is the key integrative technology of the 21st century and aims to use the knowledge, gathered from the natural construction of cellular systems, for the advancement of science and engineering. Investigating the topology and communication processes of cell parts can lead to invention of novel biological devices with exciting applications. Though microscale to nanoscale research offers an excellent space for the development of futuristic technologies, a number of challenges must be overcome. Due to paucity of a dedicated literature on the protein based nanodevices we bring you this monograph that combines collective research works of scientists probing into this fascinating universe of bionanotechnology. The monograph has been written with an aim of surveying engineering design principles of biomolecular nanodevices, prototype nanodevices based on redox proteins, bacteriorhodopsins and natural fibers, and touching upon the future developments in the field.
Biomolecular and bioanalytical techniques : Theory, methodology and applications
Offers an introduction to, and a basic understanding of, a wide range of biophysical techniques. The text takes an interdisciplinary approach with contributions from a panel of distinguished experts. With a focus on research, the text comprehensively covers a broad selection of topics drawn from contemporary research in the fields of chemistry and biology. Each of the internationally reputed authors has contributed a single chapter on a specific technique. The chapters cover the specific technique’s background, theory, principles, technique, methodology, protocol and applications.
Biomineralization : From molecular and nano-structural analyses to environmental science
Over the past 45 years, biomineralization research has unveiled details of the characteristics of the nano-structure of various biominerals; the formation mechanism of this nano-structure, including the initial stage of crystallization; and the function of organic matrices in biominerals, and this knowledge has been applied to dental, medical, pharmaceutical, materials, agricultural and environmental sciences and paleontology. As such, biomineralization is an important interdisciplinary research area, and further advances are expected in both fundamental and applied research.
BioMEMS and biomedical nanotechnology ; Vol. IV : Biomolecular Sensing, Processing and Analysis
This volume contains 18 chapters focused on ‘Biomolecular Sensing, Processing and Analysis’, written by experts in the field of BioMEMS and biomedical nanotechnology. The chapters are groups into three broad categories of Sensors and Materials, Processing and Integrated Systems, and Microfluidics.Prof. Taun Vo-Dinh from Oakridge National Labs begins the Sensors and Materials section by providing a review of biosensors and biochips. This review is followed by an example of mechanical cantilever sensor work described by Prof. Arun Majumdar’s group at UC Berkeley and Prof. Tom Thundat at Oakridge National Laboratory.
BioMEMS and biomedical nanotechnology ; Vol. II : Micro/Nano Technologies for Genomics and Proteomics
Numerous miniaturized DNA microarray, DNA chip, Lab on a Chip and biosensor devices have been developed and commercialized. Such devices are improving the way many impor-tant genomic and proteomic analyses are performed in both research and clinical diagnostic laboratories. The development of these technologies was enabled by a synergistic combina-tion of disciplines that include microfabrication, microfluidics, MEMS, organic chemistry and molecular biology. Some of these new devices and technologies utilize sophisticated mi-crofabrication processes developed by the semiconductor industry.
Biomarkers for alzheimer’s disease drug development
Helping to accelerate Alzheimer’s disease drug development. Addressing the latest advances in preclinical and clinical research, including new insights into the molecular mechanisms and emerging therapeutic strategies, the book continues by exploring digital biomarkers and advanced neuroimaging analysis which will transform how clinical trials in the Alzheimer’s disease field are performed.
Biomarkers for alzheimer’s disease drug development
Aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Biological nitrogen fixation : Towards poverty alleviation through sustainable agriculture ; Proceedings of the 15th International nitrogen fixation congress and the 12th International Conference of the African Association for Biological Nitrogen Fixation
This volume covers recent developments in both fundamental and applied research in biological nitrogen fixation. It emphasizes the application of biological nitrogen fixation for sustainable agriculture, which should lead to poverty alleviation, environmental protection, and good agricultural practices generally. The roles of, and advances in, plant breeding, plant molecular biology, nodule physiology, and symbiotic and associative interactions between plants and microbes in sustaining agricultural productivity and soil fertility are described. The evolution of symbioses and nitrogen fixation are also covered in this volume. To ensure high agricultural productivity, while protecting the environment (both soil and water resources), requires plant cultivars that also respond to beneficial microbes.
Biological Membrane Ion Channels : Dynamics, Structure, and Applications
Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts.
Biological mechanisms of tooth movement ; 3rd ed.
Cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Biological adhesives
Many plants, animals, and microbes use adhesive polymers and structures to attach to inert substrates, to each other, or to other organisms. This is the first major review that brings together research on many of the well-known biological adhesives. Emphasizing the diversity of biological adhesives and associated adhesion processes, it deals with bacteria, fungi, algae, and marine and terrestrial animals. It bridges a variety of disciplines including biochemistry, molecular biology, biomechanics, bioengineering, microbiology, organism structure and function, and ultrastructure. As we learn more about the molecular and mechanical properties of these adhesives, we begin to understand why they adhere so well and how they develop cohesive strength. With this understanding comes the prospect of developing synthetic or semi-synthetic adhesives with broad applications in areas such as medicine, dentistry, and biotechnology. The book is suitable for both industrial and academic researchers.
Bio-informatique moléculaire : Une approche algorithmique = Molecular bioinformatics : An algorithmic approach
Deals with genetic maps, from the problem of sequence comparison and alignment, including DNA chips and genomic rearrangement. It thus covers a wide variety of topics relating to algorithmic and combinatorial processing of questions arising from molecular bioinformatics and biotechnology.
