الصفحة 27
الصفحة 27
Magnetic nanoparticles in human health and medicine : Current medical applications and alternative therapy of cancer
Progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery. Focusing on cancer diagnosis and therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine.
Lymphocyte Trafficking in Health and Disease
Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.
Lung biology and pathophysiology
The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells, including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
Longer-Term Psychiatric Inpatient Care for Adolescents : A Multidisciplinary Treatment Approach
Describes the theoretical underpinnings and operational aspects of delivering longer-term inpatient psychiatric care to adolescents experiencing severe, unremitting mental illness. The authorship is drawn from the multidisciplinary team that supports the Walker Adolescent Unit, located in Sydney, Australia. The book begins with an account of the planning and development of the unit, an examination of the physical environment, and the adaptations that have been made to ensure its functionality. There follows a consideration of the therapeutic milieu. The book describes clinical processes such as admission and discharge planning, formulation and case review. There is information about the specific roles of professionals and the therapies that they provide. The book describes the steps taken to maintain and enhance the physical wellbeing of patients. There are chapters dedicated to governance, and to training and education. The final chapter describes how the unit responded to challenges created by the COVID-19 pandemic.
Logos of Phenomenology and Phenomenology of the Logos. Book One : Phenomenology as the Critique of Reason in Contemporary Criticism and Interpretation
During its century-long unfolding, spreading in numerous directions, Husserlian phenomenology while loosening inner articulations, has nevertheless maintained a somewhat consistent profile. As we see in this collection, the numerous conceptions and theories advanced in the various phases of reinterpretations have remained identifiable with phenomenology.
Logos of phenomenology and phenomenology of the logos ; Book Two : The Human Condition in-the-Unity-of-Everything-there-is-alive Individuation, Self, Person, Self-determination, Freedom, Necessity
The Human Condition-in-the-unity-of-everything-there-is-alive, under whose aegis the present selection of essays falls, offers the urgently needed new approach to reinvestigating humanness. While recent advances in the neurosciences, genetics and bio-engineering challenge the traditional abstract conception of "human nature", indicating its transformability, thus putting in question the main tenets of traditional philosophical anthropology, in the new perspective of the Human Creative Condition the human individual is seen in its emergence and unfolding within the dynamic networks of the logos of life, and within the evolution of living types.
Logos of phenomenology and phenomenology of the logos ; Book Three : Logos of history - logos of life, historicity, time, nature, communication, consciousness, Aalterity, Cculture
Situated at the crossroads of nature and culture, physics and consciousness, cosmos and life, history – intimately conjoined with time – continues to puzzle the philosopher as well as the scientist. Does brute nature unfold a history? Does human history have a telos? Does human existence have a purpose, Phenomenology of life projects a new interrogative system for reexamining these questions.We are invited to follow the logos of life as it spins in innumerable ways the interplay of natural factors, human passions, social forces, science and experience – through interruptions and kairic moments of accomplishment .
Logischer empirismus, lebensreform und die deutsche jugendbewegung : Logical empiricism, life reform, and the German Youth Movement
Investigate the roots of Logical Empiricism in the context of the Life Reform and the German Youth Movements. Rudolf Carnap and Hans Reichenbach are the key protagonists; they both belonged to the German Youth Movement and developed their early philosophical views in this setting. By combining scholarly essays with unpublished and hard to access manuscripts, letters, and articles, this volume recasts our understanding of the early years of Logical Empiricism
Liver and Pancreatic Diseases Management
New therapeutical approaches, advances in oncology and in diagnostic imaging, which reduce the need for invasive techniques and reach an improvement in survival and quality of life in cancer, are considered in this book. Modern literature has been reviewed with special reference to articles of general interest. In the clinical management of patients with liver, bile duct and pancreas diseases, it is important to assess the degree of disturbance and to diagnose the causative insult, and therefore clinical and laboratory methods of assessing each of these pathologies are of high interest. This version is an up-to-date account of diseases of the liver, biliary tract and pancreas, including transplantation, which we trust will be of value for surgeons, physicians and pathologists and also a reference book for medical students.
Liposomes as Drug Carriers
Patients have recently suffered from the side effects of a large number of drugs and from the weak pharmacological effect, due to the biokinetics and the difficulty of delivering the drug to the targeted cells, which negatively affected the therapeutic efficacy, creating an opportunity to discover nanometric carriers to load the active drug substances, so we covered in this research the most famous and widely used nanocarriers which are liposomes. We touched in some detail its composition, types, the relationship of structure to influence, methods of preparation, its delivery mechanism for the drug, and at the end of the research, we attached various applications in the field of therapeutic diagnostics and its role in cosmetics, cancers and many other fields.
Lipids in Health and Disease
Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.
Linear Genetic Programming
Linear Genetic Programming examines the evolution of imperative computer programs written as linear sequences of instructions. In contrast to functional expressions or syntax trees used in traditional Genetic Programming (GP), Linear Genetic Programming (LGP) employs a linear program structure as genetic material whose primary characteristics are exploited to achieve acceleration of both execution time and evolutionary progress.
Lindhe's Clinical Periodontology and Implant Dentistry ; 2 Vol. Set ; 7th ed.
Provides an introduction to anatomy, including periodontal tissues, the edentulous ridge, the mucosa at teeth and implants, and osseointegration Discusses the epidemiology of periodontal and peri-implant diseases Explores the microbiology, including dental biofilms and calculus, periodontal infections, peri-implant infections, the pathogenesis of gingivitis and periodontitis, and the genetic susceptibility to periodontal disease Includes the latest perio- and peri-implant disease classifications Contains updated evidence-based preventive and treatment modalities for the treatment of periodontal and peri-implant diseases Features the latest evidence-based therapeutic alternatives on the use of dental implants to rehabilitate the lost dentition
Life in Extreme Environments
Investigating life processes under extreme conditions can also bring clues for understanding and predicting ecosystems' responses to global changes. Furthermore, this area of research has a wide application potential in the fields of (bio)technoloty, chemical industry, pharmaceutics, biomedicine or cosmetics.
Life - As a Matter of Fat : The Emerging Science of Lipidomics
Lipids are as important for life as proteins, sugars, and genes. The present book gives a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. The book is aimed at undergraduate students and young research workers within physics, chemistry, biochemistry, molecular biology, nutrition, as well as pharmaceutical and biomedical sciences. The emphasis is on the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Furthermore, it is shown how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.
Les vérités du cancer : Partager l'information, installer la relation = The truths about cancer : Sharing information, building the relationship
Les médecins et les équipes soignantes perçoivent comme une nouvelle pression la nécessité de transmettre le diagnostic de cancer et de discuter des options thérapeutiques avec un patient qui n’est pas toujours prêt à s y confronter. Bien que l’on puisse saluer le partage de l’information et encourager la transparence, le médecin prend le risque du blocage de dialogue, d’une indifférence, au pire d’un traumatisme. L’idée d’une diminution d’un certain pouvoir médical s’insinue dans le « dispositif » d’annonce qui renvoie la clinique à des apprentissages techniques. Au contraire, certains médecins cherchent à s’inscrire dans un mouvement plus démocratique. Ils constatent que pour le malade, savoir n’est pas choisir, et que dans les cas difficiles, ils restent encore décideurs. Cet ouvrage fait le point sur les changements obtenus par les lois et leurs conséquences sur les pratiques et incite à une réflexion philosophique sur la vérité et les vérités des interlocuteurs de la scène médicale.
Les thérapies ciblées = Targeted therapies
We are at the start of the development of new therapeutic classes, directed against new molecular targets (EGFR, VEGF, IGFR, Rank, etc.) Several diseases such as kidney, colon or breast cancer, GIST, have a natural history now modified thanks to these therapies. This practical book takes stock of the current use of these molecules.
Les infections intra-abdominales aiguës = Acute intra-abdominal infections
Paradoxically, serious intra-abdominal infections are the forgotten ones in the world of infectious diseases. Paradoxical, because they are very common pathologies, affecting all age groups of the population and often life-threatening; paradoxical, because they concern many medical specialties through intensive care, gastroenterology, hepatology, imaging, infectious diseases, emergencies and surgery. Hence the need, thanks to an interdisciplinary collaboration, to publish a book in French bringing together all infectious abdominal pathologies, thus offering a synthesis of recent data from the literature in this field. This document should allow the various specialties concerned to find updates integrating the latest clinical, diagnostic and therapeutic data. Specialty interns and practitioners in the field will find something to establish an effective and up-to-date strategy for the management of patients with these pathologies, the high incidence of which and the severity of which is too often overlooked, it is important to remember.
Les cancers ovariens = Ovarian cancers
Deals with ovarian cancers and their therapeutic management. Besides the epithelial tumors which are the most frequent, the rarer tumors, with attenuated malignancy, germ cells or of the ovarian stroma are also studied. Specialists from multiple backgrounds each deliver in their field the most recent knowledge on the fundamental aspects of the disease, its genetic, epidemiological and prognostic characteristics and its pathological peculiarities. Modern means of diagnosis are presented. The surgical technique, including laparoscopy, is detailed at the different stages of the disease. The therapeutic strategy aims to position the surgery and chemotherapy according to the stage. The current place of radiotherapy and isotopic therapies is indicated. Some more specific aspects are discussed, screening, lymph node dissection, the “second look”, intraperitoneal chemotherapy with or without hyperthermia, treatment of the elderly, monitoring after treatment… as well as the emergence of targeted therapies.
Les cancers digestifs = Digestive cancers
Digestive tumors are among the most common malignant tumors and represent a major public health problem. This is one of the areas that has evolved the most in recent years in oncology due to significant progress in diagnostic strategies and therapeutic management. It seems essential that this progress be implemented in the daily practice of physicians treating these tumors. This book, the result of multidisciplinary work, provides a practical and up-to-date approach to the management of malignant digestive tumors. The first chapters are devoted to general and original subjects such as epidemiology, genetics, the management of elderly subjects. A second part approaches in a pragmatic and practical way the principles of diagnostic and therapeutic management by localization. A third part, devoted to the practical realization of chemotherapy, takes stock of new therapeutic approaches, oral or locoregional chemotherapy. Finally, the last part of the book is dedicated to digestive cancer emergencies and the palliative management of these tumors.
