الصفحة 23
الصفحة 23
Drug repurposing : A new fashion for a new hope
The repurposing of drugs is becoming increasingly attractive as it avoids the long process and cost implications associated with bringing a novel drug to market i.e., drug repurposing is cost effective and time saving. This study will discuss the repositioning of several drugs that belong to different pharmaceutical classifications such as antimicrobials (itraconazole and fluoroquinolones), anti-diabetic agents (metformin and sodium glucose co-transporter 2 inhibitors), cardiovascular drugs (β-blockers and digoxin), anticonvulsants (topiramate), immunosuppressants (sirolimus), non-steroidal anti-inflammatory drugs (NSAIDs e.g., COX inhibitors), and cholesterol lowering drugs (statins).
Distributed and parallel computing ; 6th International conference on algorithms and architectures for parallel processing, ICA3PP, Melbourne, Australia, October 2-3, 2005, Proceedings
There are many applications that require parallel and distributed processing to allow complicated engineering, business and research problems to be solved in a reasonable time. Parallel and distributed processing is able to improve company profit, lower costs of design, production, and deployment of new technologies, and create better business environments. The major lesson learned by car and aircraft engineers, drug manufacturers, genome researchers and other specialist is that a computer system is a very powerful tool that is able to help them solving even more complicated problems. That has led computing specialists to new computer system architecture and exploiting parallel computers, clusters of clusters, and distributed systems in the form of grids.
Dissecting the Molecular Anatomy of Tissue
The book provides an updated overview of molecular analysis of human tissues, and the impact this analysis has on diagnosis and prognosis of human diseases. Special emphasis is placed on human cancer and the future directions of the field. Methods of handling clinical tissue samples, including the impact of handling on subsequent molecular analysis, are also discussed. In addition, detailed protocols for molecular analysis of DNA, RNA and protein, with special emphasis on molecular analysis of highly complex human tissue samples containing mixtures of cell populations, are provided.
Disordered Materials : An Introduction
This self-contained text introduces the physics of structurally disordered condensed systems at the level of advanced undergraduate and graduate students. Among the topics are the geometry and symmetries of the structural units used as building blocks of extended structures, the various kinds of disorder, the phenomenology and the main theories of the glass transition, the structure of amorphous systems and the techniques to investigate it, the evolution of system's structure with its size (clusters) and the presence of orientational order in the absence of translational order (quasicrystals). In the second edition, the treatment of the mode coupling theory of the glass transition has been enlarged and connects now to a new section on collective excitations in disordered systems. Special attention has been devoted to nanometer-sized disordered systems, with emphasis on cluster-assembled materials. Questions of what governs the occurrence and stability of quasicrystals, the features of the amorphous to quasicrystal transformation and its reverse transition are discussed. The conditions leading to nano-quasicrystalline phases of technological interest are examined. Throughout the text relevant recent experimental and theoretical results are discussed so as to give readers insight into the currently most vibrant research topics.
Directory of microbicides for the protection of materials : A handbook
This edition is divided into two parts. In Part One 23 contributions of worldwide selected experts present extensively diversified information about: -Microbicides with regard to the relationship between chemical structure and mode of action and activity, -Research and development in consideration of registration procedures,Legislative aspects,The use of microbicides in the major application areas (18) which are described in detail.The Microbicide Data is organized into 21 substance classes (e.g. alcohols, aldehydes, acids, amides, etc.) and collected in Part Two.
Diffusion in solids : Fundamentals, methods, materials, diffusion-controlled processes
This book first gives an account of the central aspects of diffusion in solids, for which the necessary background is a course in solid state physics. It then provides easy access to important information about diffuson in metals, alloys, semiconductors, ion-conducting materials, glasses and nanomaterials.
Diffusion in Condensed Matter : Methods, Materials, Models
Diffusion as the process of particle transport due to stochastic movement is a phenomenon of crucial relevance for a large variety of processes and materials. This comprehensive, handbook-style survey of diffusion in condensed matter gives detailed insight into diffusion as the process of particle transport due to stochastic movement. Leading experts in the field describe in 23 chapters the different aspects of diffusion, covering microscopic and macroscopic experimental techniques and exemplary results for various classes of solids, liquids and interfaces as well as several theoretical concepts and models. Students and scientists in physics, chemistry, materials science, and biology will benefit from this detailed compilation.
Diagrid structures : systems, connections, details
Diagrids are load-bearing structures made of steel diagonal grids. They were first used in the great buildings of the turn of the millennium, such as the Swiss Re Tower in London ("The Gherkin") and the Hearst Magazine Tower in New York City. Dagrids owe their ensuing popularity not only to their stunning aesthetic value, but also to their very tangible benefits: lateral loading capacity, a massive saving of material, a significant gain in open, usable floor area, and increased flexibility. At its opening in 2014, the Leadenhall Building in London will be the first skyscraper without a bearing inner core-thanks to a diagrid structure.
Development, Sexual Cultural Practices and HIV/AIDS in Africa
This book introduces the theoretical frameworks and academic debates concerning sexual cultural practices and HIV/AIDS in Africa. It shows how these frameworks have been applied in a practical sense in Africa to investigate sexual cultural practices and their link with HIV/AIDS. The author provides an overview of both the field of study and the methods used during fieldwork. Finally, it assesses the implications of the findings for the conceptualization and provision of current and future HIV/AIDS policies and programs in Africa. This monograph will appeal to policy makers and practitioners working in the field of HIV/AIDS in the Global South as well as academics and students.
Development of trans-free lipid systems and their use in food products
Encompasses the work of leading researchers discussing, from a scientific and technological perspective, the latest and most innovative approaches to structure edible oils without the use of trans fats. Additionally, the authors discuss practical uses and technical limitations associated with the use of "structured edible oils" in different food systems. Appealing to researchers and professionals working in lipid science, food chemistry and fat metabolism, it fills the gap in the literature for a book in this fast-changing field.
Designing a programming education system for children to program and simulate robots
JuniorCoders is an innovative educational platform designed to introduce programming and robotics concepts to kids and beginners. It provides an easy-to-use visual programming interface that allows users to create Arduino programs by dragging and dropping blocks of code. The system aims to make programming accessible and shareable, allowing them to create complex programs without having to learn a traditional programming language. Enables users to program and simulate robots using Arduino boards.
Designing & Implementing an IDS in SDN
Solving the problem of the various type of unknown attacks that are hitting not only companies but also high level business individuals, of course we know that there is no way to stop the attacks permanently but this project is attempting to reduce these attacks to the possible minimum where it can detect the attack and declare its type so that the hostile can at least know what is the type of attacks on him and what to do in response and build a higher security. This system is implemented using the SDN environment and IDS technology for monitoring the traffic on the network and for detecting the attack and its type. Also the SDN technology has a built-in OpenFlow protocol. To work in an OF environment, any device that wants to communicate to an SDN controller must support the OpenFlow protocol.
Designers' guide to Eurocode 1 : Actions on buildings : EN1991-1-1 and -1-3 TO -1-7
Provides comprehensive guidance in the form of design aids, indications for the most convenient design procedures and worked examples. The books also include background information to aid the designer in understanding the reasoning behind and the objectives of the codes. All of the individual guides work in conjunction with the Designers' Guide to EN 1990 Eurocode: Basis of Structural Design.
Designers' guide to Eurocode 1 : Actions on Bridges : EN 1991-2, EN 1991-1-1, -1-3 TO -1-7 and EN 1990 Annex A2
Provides comprehensive guidance in the form of design aids, indications for the most convenient design procedures and worked examples. The books also include background information to aid the designer in understanding the reasoning behind and the objectives of the codes. All of the individual guides work in conjunction with the Designers' Guide to EN 1990 Eurocode: Basis of Structural Design. The parts of Eurocode 1 covered by this guide, EN 1991-1 and EN 1991-2, address the general actions and traffic loads on civil engineering structures. This Designers' Guide looks specifically at these actions as they apply to bridges, including full explanation, commentary, examples, and direction to the National Annex documents on each of the following parts and sub-parts of the code. EN1990 Annex 2: Basis of structural design.
Designers' guide to EN 1998-1 and 1998-5. Eurocode 8 : Design provisions for earthquake resistant structures
Provides comprehensive guidance in the form of design aids, indications for the most convenient design procedures and worked examples. The books also include background information to aid the designer in understanding the reasoning behind and the objectives of the codes. All of the individual guides work in conjunction with the Designers' Guide to EN1990 Eurocode: Basis of Structural Design.
Design of Hybrid Structures : Where Steel Profiles Meet Concrete
Focuses on design approaches for concrete structures reinforced in an unconventional way by steel profiles. It explains force transfer mechanisms of steel profiles and oncrete interfaces, and an analysis of the characteristics of hybrid structures, including slendercomponents. Several types of hybrid designs are addressed: walls and columns with several embedded steel profiles, connections strengthened by steel profiles between steel and composite or reinforced concrete components, including the specific case of shear keys connecting deep beams or flat slabs to columns. The transition zones in partly reinforced concrete and partly composite columns are also covered.
Davidson's principles and practice of medicine
Describes the pathophysiology and clinical features of the most frequently encountered conditions in the major specialties of adult medicine, and explains how to recognise, investigate, diagnose and manage them. Taking its origins from Sir Stanley Davidson’s much-admired lecture notes, Davidson’s has endured because it keeps pace with how modern medicine is taught and provides a wealth of trusted information in an easy-to-read, concise and beautifully illustrated format.
Data Management in Grids ; 1st VLDB Workshop, DMG 2005, Trondheim, Norway, September 2-3, 2005, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Data Management in Grids, DMG 2005, held in Trondheim, Norway in September 2005 in conjunction with VLDB 2005. papers address all current research activities in relation to data management in dynamic, heterogeneous and cross-organizational environments, i.e. grids. They show unique expertise in the management of very large, widely distributed databases.
Dangerous Pollutants (Xenobiotics) in Urban Water Cycle
The book focused on evaluation of impact of xenobiotics in the whole Urban Water Cycle are an interdisciplinary task which has a rising concern these days. Xenobiotics includes both inorganic elements like heavy metals, metalloids and man-made organic compounds such as pesticides, surfactants, solvents, fragrances, flavours, and pharmaceuticals as well as endocrine dis- pters.
Current Developments in Solid-state Fermentation
Over the period of last two decades, there has been significant resurgence in solid-state fermentation due to the numerous benefits it offers, especially in the engineering and environmental aspects. SSF has shown much promise in the development of several bioprocesses and products. This resurgence gained further momentum during the last 5-6 years with the developments in fundamental and applied aspects. A good deal of information has been generated in published literature and patented information. Several commercial ventures have come up based on SSF in different parts of the world. The contents are organized into four parts: Part 1 deals with the General and Fundamentals aspects of SSF; Part 2 deals with the production of bulk chemicals and products such as enzymes, organic acids, spores and mushrooms in SSF; Part 3 is on the use of SSF for specialty chemicals such as gibberellic acid, antibiotics and other pharmaceutically valuable secondary metabolites, pigments, and aroma compounds; Part 4 deals with the use of SSF miscellaneous application such as SSF for food and feed applications, agro-industrial residues as substrates in SSF and the production of silage and vermicompost.
