الصفحة 23
الصفحة 23
Dendritic Cells in Clinics
Great advances have taken place in basic research and the clinical usefulness of dendritic cells (DCs). It has now been clearly established, for instance, that these cells play a crucial role in immune responses against infectious diseases and cancers. Antigen-presenting DCs are widely distributed in the body and regulate both immunity and immune tolerance. Experimental studies have provided important insights into DCs and how they can be used for treating animal models of various diseases that occur in humans. The role of these cells in pathogenesis and the treatment of human diseases is elaborately set forth in this valuable book. Researchers in the field are optimistic that DCs, already in use for treating patients with cancers, soon can be used therapeutically for patients with chronic infections, autoimmune diseases, and allergic manifestations. This volume provides a working definition of DCs and also explains the phenotypes and functions of DCs so that these can be readily understood not only by clinicians but by immunologists, researchers, and students as well.
Delivery of drugs ; Vol.2 : Expectations and realities of multifunctional drug delivery systems
Examines the formulation of micro-nanosized drug delivery systems and recaps opportunities for using physical methods to improve efficacy via mechano-, electroporation. The book highlights innovative delivery methods like PIPAC, including discussions on the regulatory aspects of complex injectables. Written by a diverse range of international researchers from industry and academia, the chapters examine specific aspects of characterization and manufacturing for pharmaceutical applications as well as regulatory and policy aspects.This book connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stakeholders.
Defects of Secretion in Cystic Fibrosis
This book brings together physicians, physiologists, and other scientists involved in basic research, from molecular biology to drug design and introduces novel investigative and therapeutic aspects of secretion disorders relevant in cystic fibrosis and related diseases. This book will be of interest to Molecular biologists, physiologists, scientists working in pharmaceutical research and drug developement, physicians and researchers in Cystic fibrosis and related diseases.
Deep learning architecture and application
As one of the fastest-growing topics in machine learning, deep learning algorithms have achieved unprecedented success in recent years. Novel paradigms (such as contrastive learning and few-shot learning) in deep learning and rising neural network architectures (e.g., transformer and masked autoencoder) are dramatically changing the field of data-driven algorithms. More importantly, deep learning models are redefining the next generation of industrial applications spanning image recognition, speech processing, language translation, healthcare, and other sciences. For example, recent advances in deep representation learning are allowing us to learn about protein 3D structures, which sheds new light on fundamental medicine and biology along with potentially bringing in billions of dollars (e.g., in the pharmaceutical market).
Deep eutectic polvents : Synthesis, properties, and applications
Deep Eutectic Solvents contains a comprehensive review of the use of deep eutectic solvents (DESs) as an environmentally benign alternative reaction media for chemical transformations and processes. The contributors cover a range of topics including synthesis, structure, properties, toxicity and biodegradability of DESs. The book also explores myriad applications in various disciplines, such as organic synthesis and (bio)catalysis, electrochemistry, extraction, analytical chemistry, polymerizations, (nano)materials preparation, biomass processing, and gas adsorption.
Data Science-Based Full-Lifespan Management of Lithium-Ion Battery : Manufacturing, Operation and Reutilization
This book comprehensively consolidates studies in the rapidly emerging field of battery management. The primary focus is to overview the new and emerging data science technologies for full-lifespan management of Li-ion batteries, which are categorized into three groups, namely (i) battery manufacturing management, (ii) battery operation management, and (iii) battery reutilization management. The key challenges, future trends as well as promising data-science technologies to further improve this research field are discussed.
Data science, AI, and machine learning in drug development
The confluence of big data, AI, and machine learning has led to a paradigm shift in how innovative medicines are developed and healthcare delivered. To fully capitalize on these technological advances, it is essential to systematically harness data from diverse sources and leverage digital technologies and advanced analytics to enable data-driven decisions. Data science stands at a unique moment of opportunity to lead such a transformative change. Intended to be a single source of information, Data Science, AI, and Machine Learning in Drug Research and Development covers a wide range of topics on the changing landscape of drug R&D, emerging applications of big data, AI and machine learning in drug development, and the build of robust data science organizations to drive biopharmaceutical digital transformations
Data Journeys in the Sciences
This groundbreaking, book analyses and compares data practices across several fields through the analysis of specific cases of data journeys. It brings together leading scholars in the philosophy, history and social studies of science to achieve two goals: tracking the travel of data across different spaces, times and domains of research practice; and documenting how such journeys affect the use of data as evidence and the knowledge being produced.
Dark Matter in Astro- and Particle Physics ; Proceedings of the International Conference DARK 2004, College Station, USA, 3-9 October, 2004
The search for dark matter in the universe has established itself as one of the most exciting and central fields of astrophysics, particle physics and cosmology. The lectures and talks in this book emphasize the experimental and theoretical status and future perspectives, stressing in particular the interplay between astro- and particle physics.
Danno Vascolare E Tromboemostasi : Fisiopatologia e patologia clinica = Vascular injury and thrombohemostasis : Pathophysiology and clinical pathology
Quest’opera descrive alcuni meccanismi chiave dell’angiogenesi e le opportunità riguardanti lo sviluppo di nuove strategie in campo terapeutico. Il volume fornisce un quadro esaustivo della materia spaziando dall’embriologia dei vasi e del sistema emopoietico ai più avanzati approcci terapeutici, primo fra tutti quello che si basa sull'utilizzazione del sangue midollare autologo ad attività staminalica. Grande rilevanza viene inoltre attribuita alla patogenesi dei difetti dell’emostasi e della coagulazione, all’ipertensione arteriosa e ai difetti del quadro lipidico.
Dangerous Pollutants (Xenobiotics) in Urban Water Cycle
The book focused on evaluation of impact of xenobiotics in the whole Urban Water Cycle are an interdisciplinary task which has a rising concern these days. Xenobiotics includes both inorganic elements like heavy metals, metalloids and man-made organic compounds such as pesticides, surfactants, solvents, fragrances, flavours, and pharmaceuticals as well as endocrine dis- pters.
Dangerous of Pharmaceutical Waste From Hospitals and Homes on Human and Environment
The occurrence of pharmaceuticals in environment originating from hospitals and household waste has received increased scientific attention during the last decades because more than 100 different drugs have been detected in the aquatic environment at concentrations from the nanogram (ng) to the μg/l range. This research talk about improper disposal of pharmaceutical waste, impacts of some drugs included in like metals, endocrine disruptors, and various compounds that are dangerous for aquatic and human lives. The safe disposal and management of pharmaceutical waste. The origin of this problem begin due to lack of awareness about this issues beside there is no training or courses for pharmacists and people work in medical departments on pharmaceutical waste management during their academic studies.in addition, this research also talk about how to reduce the amount of pharmaceuticals waste and environmentally friendly and cost-effective ways for handling this waste, beside increase the awareness to overcome this problem.
Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases
Cytokines and cytokine receptors remain an area of great interest for the development of targeted therapies for cutaneous inflammatory diseases.This book summarizes the findings of the 56th International Workshop of the Ernst Schering Research Foundation that focused on "Cytokines as Potential Therapeutic Targets for Inflammatory Skin Diseases".
Cyclized Helical Peptides : Synthesis, Properties and Therapeutic Applications
Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity
Cyclin Dependent Kinase 5 (Cdk5)
Cyclin Dependent Kinase 5 provides a comprehensive and up-to-date collection of reviews on the discovery, signaling mechanisms and functions of Cdk5, as well as the potential implication of Cdk5 in the treatment of neurodegenerative diseases. Since the identification of this unique member of the Cdk family, Cdk5 has emerged as one of the most important signal transduction mediators in the development, maintenance and fine-tuning of neuronal functions and networking. Further studies have revealed that Cdk5 is also associated with the regulation of neuronal survival during development as well as in neurodegenerative diseases. These observations indicate that precise control of Cdk5 is essential for the regulation of neuronal survival. The pivotal role that Cdk5 appears to play in both the regulation of neuronal survival and synaptic functions thus raises the interesting possibility that Cdk5 inhibitors may have therapeutic potential for the treatment of a number of neurodegenerative diseases.
Current Topics in Innate Immunity
This volume represents a collection of topics on natural killer cells, mast cells, phagocytes, toll like receptors, complement, host defense in plants and invertebrates, evasion strategies of microorganisms, pathophysiology, protein structures, design of therapeutics, and experimental approaches discussed during the conference.
Current Topics in Complement
Complement has been regarded as a pivotal effector arm of the innate immune response. Many scientists convened at the Third Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics, to discuss the advances in this field. This volume represents a collection of topics discussed during the conference.
Current Perspectives in microRNAs (miRNA)
In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.
Current medical diagnosis & treatment 2024
Emphasizes the practical features of clinical diagnosis and patient management in all fields of internal medicine and in specialties of interest to primary care practitioners and to subspecialists who provide general care.
Current Drug Synthesis
Delivers an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while capturing the state-of-the-art techniques used to discover some of the most impactful medicines on the market today. Covering six different disease areas – including infectious disease, cancer, cardiovascular and metabolic disease, the central nervous system, anti-inflammatory disease, and a miscellaneous section – the book explores 18 different drugs before concluding with chapters on computational drug discovery and peptide drugs.
