الصفحة 20
الصفحة 20
Metabolome Analyses : Strategies for Systems Biology
Metabolome Analyses is intended as a follow-up to Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Kluwer, 2003). That text offered guidelines to currently available technology, bioinformatics and databases. Evidence was presented showing metabolic profiling as a valuable addition to genomics and proteomics strategies devoted to drug discovery and development. This book focuses on how metabolic profiling is being more comprehensively integrated with the other "omics" technologies. It provides more practical applications of such "panomics" or "Systems Biology" approaches. The expanding use of mass spectrometry as a measurement technology in metabolic profiling is addressed through demonstrated applications. The integration of metabolic profiling and proteomics is probably most developed for plant-based studies, which was not addressed in Volume 1. Other areas related to metabolic profiling continue to show significant development. These include database strategies and an increased acceptance by the pharmaceutical industry of metabolic profiling. Also covered is the use of in silico metabolic networks. Again the focus is primarily on the pharmaceutical industry but the importance of metabolic profiling to studies on human nutrition (a burgeoning area) is discussed.
Messung von Ressourceneffizienz mit der ESSENZ-Methode : Integrierte Methode zur ganzheitlichen Bewertung = Measuring resource efficiency with the ESSENCE method : Integrated method for holistic evaluation
Develops a reliable method for evaluating the use of resources. This is necessary because the strong economic growth of the last decades has led to an intensive use of natural resources. With their increasing use, there are also additional burdens on the environment and restrictions on the availability of resources. For these reasons, efficient use of resources is required as an important contribution to sustainable development.
Messenger RNA therapeutics
Focuses on the fundamentals and applications of messenger RNA (mRNA)-based therapeutics and discusses the strengths and key challenges of this emerging class of drugs. In the past 30 years, extensive research and technological development in many areas have contributed to the emergence of in vitro transcribed mRNA as a therapeutic that has now reached clinical testing. Formulations that protect the mRNA from nucleases and accelerate its cellular uptake, combined with improvements to the mRNA molecules themselves, have been critical advancements for mRNAs to become viable therapeutics. Though once regarded as a serious impediment, the transient nature of mRNA technology is now considered a major advantage in making mRNA therapies safe and, ultimately, a potential game changer in the field of medicine. This new book in the RNA Technologies series provides a state-of-the-art overview on the emerging field of mRNA therapeutics covering essential strategies for formulation, delivery, and application. It also reviews the promising role in cancer immunotherapy, respiratory diseases, and chronic HBV infection and discusses RNA vaccines in light of the current COVID-19 pandemic. mRNA-based approaches have great potential to revolutionize molecular biology, cell biology, biomedical research, and medicine.
Messages security application
The rapid development of communication technology, is bringing many technological conveniences with it and simplifying our lives. On the other hand, it has disadvantages such as hiding the information that is continuously roaming through various communication media resources between senders and receivers and avoid sharing them with third parties. Eliminating these disadvantages via specific security methods and algorithms is related to the discipline called cryptography, which includes information security. Encryption is the process of turning a plaintext to jargon or the method of changing a confidential file to jargon in order to prevent unauthorized persons from gaining access to confidential message. A Message is the transfer of information from the sender to the receiver through a particular medium. Encryption is the most effective process for achieving data security.
MEMS/NEMS : (1) Handbook Techniques and Applications Design Methods, (2) Fabrication Techniques, (3) Manufacturing Methods, (4) Sensors and Actuators, (5) Medical Applications and MOEMS
Micro-Electro Mechanical Systems (MEMS) is the integration of mechanical elements, sensors, actuators, and electronics on a common silicon substrate. While the electronics are fabricated using integrated circuit (IC) process sequences (e.g., CMOS, Bipolar, or BICMOS processes),the micromechanical components are fabricated using compatible micromachining processes that selectively etch away parts of the silicon wafer or add new structural layers to form the mechanical and electromechanical devices. MEMS promises to revolutionize nearly every product category by bringing together silicon-based microelectronics with micromachining technology, thereby, making possible the realization of complete systems-on-a-chip.
MEGAFLOW - Numerical Flow Simulation for Aircraft Design ; Results of the second phase of the German CFD initiative MEGAFLOW, presented during its closing symposium at DLR, Braunschweig, Germany, December 10 and 11, 2002
This volume contains results of the German CFD initiative MEGAFLOW which combines many of the CFD development activities from DLR, universities and aircraft industry. It highlights recent improvements and enhancements of the MEGAFLOW software system.
Mediclica
The main objective of the project here is to show the ability to book online in Syria. And show the interdependence between the patient and follow-up in the correct manner... by entering the data, blood tests, and x-rays required of the patient in shortening his time and effort
Medicinal foods as potential therapies for type-2 diabetes and associated diseases : The chemical and pharmacological basis of their action
Focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. Provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries.
Medicinal compounds in modern healthcare : From tradition to innovation
Reviews the evolution, development, and application of medicinal compounds, beginning with their historical context and advancing to modern innovations. The book describes the therapeutic potential of bioactive compounds from microorganisms, the role of antioxidants and anti-inflammatory agents in managing chronic diseases, and the use of small molecules in pain management and mental healthcare. It further explores immunomodulatory compounds, epigenetic modifiers, and the latest advancements in drug development, including integrative medicine approaches and the applications of nanotechnology in traditional medicine. Additionally, the book addresses the use of immunomodulatory agents like methotrexate and paclitaxel in cancer treatment, regulatory considerations for ensuring safety and efficacy in medicinal compounds, and the growing field of nutraceuticals. Towards the end, the book covers the extraction, profiling, and ADMET evaluation of medicinal compounds, intellectual property challenges, and the significance of traditional medicine in modern healthcare.
Medicinal Chemistry for Practitioners
Presenting both a panoramic introduction to the essential disciplines of drug discovery for novice medicinal chemists as well as a useful reference for veteran drug hunters, this book summarizes the state-of-the-art of medicinal chemistry. It covers key drug targets including enzymes, receptors, and ion channels, and hit and lead discovery. The book hen surveys a drug's pharmacokinetics and toxicity, with a solid chapter covering fundamental bioisosteres as a guide to structure-activity relationship investigations.
Medical Treatment of Intoxications and Decontamination of Chemical Agents in the Area of Terrorist Attack
This book includes reports which were presented at a NATO Advanced Research Workshop (ARW) entitled?Medical Treatment of Intoxications and Decontamination of Chemical Agent in the Area of Terrorist Attack?. The focus of this workshop was assessment of scientific concepts and practical means for management of chemical agent casualties in the area of terrorist attack with emphasis on improving the medical treatment and decontamination. These problems were analyzed from an interdisciplinary perspective. The primary objective of the ARW was to provide countries in which chemical-defense systems are currently under development with the experience and expertise of those that are more advanced and/or have already been exposed and responded to a chemical-terrorist attack. . The main areas covered were: 1. new approaches in pre-treatment and prophylaxis of nerve agent intoxication; 2. diagnosis of exposure to chemical agents ; 3. therapy of chemical agent intoxication; 4. development of personal decontamination; 5. decontamination of intoxication with chemical agents.
Medical product regulatory affairs : pharmaceuticals, diagnostics, medical devices
Based on a module prepared by the authors for an MSc course offered by the University of Limerick, Ireland, Medical Product Regulatory Affairs is a comprehensive and practical guide on how pharmaceutical and medical devices are regulated within the major global markets. The Second Edition builds on the success of the first with an even wider scope and full coverage of new EU regulations on the safe use of medical devices. Following a look at drug development, complete sections are devoted to national and EU regulatory issues, manufacturing license application and retention, and regulation in the USA. Other topics dealt with include CDER, CBER and marketing and manufacturing licenses, the ICH process and Good Laboratory/Clinical/ Manufacturing Practices.
Medical genetics and law : An international perspective
Essential resource to understanding the intersection of medical genetics and law. In a unique approach, it provides an overview on the biological principles of DNA basics and genetic inheritance linking the knowledge with the ethical and legal challenges presented by modern developments in genetics.
Medial Representations : Mathematics, Algorithms and Applications
The last half century has seen the development of many biological or physical theories that have explicitly or implicitly involved medial descriptions of objects and other spatial entities in our world. Simultaneously mathematicians have studied the properties of these skeletal descriptions of shape, and, stimulated by the many areas where medial models are useful, computer scientists and engineers have developed numerous algorithms for computing and using these models. We bring this knowledge and experience together into this book in order to make medial technology more widely understood and used.
Mechatronic Systems : Fundamentals
Mechatronic Systems introduces these developments by considering the dynamic modelling of components together with their interactions. The whole range of elements is presented from actuators, through different kinds of processes, to sensors.
Mechanisms, Symbols, and Models Underlying Cognition ; 1st International Work-Conference on the Interplay Between Natural and Artificial Computation, IWINAC 2005, Las Palmas, Canary Islands, Spain, June 15-18, 2005, Proceedings, Part I
Constitute the refereed proceedings of the First International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2005. This two-volume set contains papers that are related with the conceptual developments in the fields of Neurophysiology and cognitive science, and also to bioinspired programming strategies.
Mechanisms of Sepsis-Induced Organ Dysfunction and Recovery
There have been tremendous advances in understanding the cellular mechanisms involved in sepsis and contributing to the development of multiple organ dysfunction and mortality in this setting. The chapters in this book provide up-to-date insights into important pathways that are initiated by sepsis.
Mechanisms of Lymphocyte Activation and Immune Regulation XI ; B Cell Biology
These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Mechanics of Microelectronics
Written by the leading experts with both profound knowledge and rich practical experience in advanced mechanics and microelectronics industry, this book aims to provide the cutting edge knowledge and solutions for various mechanical related problems, in a systematic way. It contains essential and detailed information about the state-of-the-art theories, methodologies, the way of working and real case studies.
Mechanics of Material Forces
The book covers both theoretical and numerical developments. Conceptually speaking, common continuum mechanics in the sense of Newton—which gives rise to the notion of spatial (mechanical) forces—considers the response to variations of spatial placements of "physical particles” with respect to the ambient space, whereas continuum mechanics in the sense of Eshelby—which gives rise to the notion of material (configurational) forces—is concerned with the response to variations of material placements of "physical particles” with respect to the ambient material. Well-known examples of material forces are driving forces on defects like the Peach-Koehler forece, the J-Integral in fracture mechanics, and energy release. The consideration of material forces goes back to the works of Eshelby, who investigated forces on defects; therefore this area of continuum mechanics is sometimes denoted Eshelbian mechanics.
