الصفحة 20
الصفحة 20
Ecografia in oncologia : Testo-Atlante di ultrasonologia diagnostica e interventistica dei tumori = Ultrasound in oncology : Text-Atlas of diagnostic and interventional ultrasound of tumors
Offers detailed information on the key applications of different ultrasound techniques to the study of tumors. The necessary background on the major problems of clinical oncology is provided: screening, identification, characterization and staging of malignant neoplasms, evaluation of the therapeutic response, follow-up. The examination technique and the interpretative principles of all ultrasound techniques are carefully discussed (grayscale ultrasound, color-Doppler, pulsed Doppler, power-Doppler, echocontrastography), with particular attention to the practical aspects, to the "tricks of the trade. "and the potential methodological and semeiological pitfalls. Particular emphasis is placed on those areas where ultrasound plays a decisive role compared to other diagnostic imaging methods, with a practical and original approach, for "clinical problems". The main eco-interventional, diagnostic and therapeutic procedures are illustrated in detail. The very rich iconography, also including a CD-ROM with original videos, punctually integrates the text. A compact and homogeneous work, necessary for all doctors, both radiologists and non-radiologists, who deal with ultrasound.
Ecografia e procedure interventistiche percutanee: Fegato, vie biliari e pancreas = Ultrasound and percutaneous interventional procedures : Liver, bile ducts and pancreas
The volume presents a concise overview of the most common percutaneous interventional procedures and is intended as a quick guide for the radiologist and sonographer who, more and more frequently, are required to perform interventional procedures on the liver, biliary tract and pancreas for both diagnostic and therapeutic.
Ecocardiografia clinica = Clinical echocardiography
This Atlantean is a candidate for a didactic strategy that is established and intends fornire agli specialisti, co-involves the management of cardiac malattia, strumenti communicates for the understanding of the treatment of the variegated problem of this law in everyday clinical practice. The information is precisely selected and the echocardiography is immersed in the clinical, anatomical, pathophysiological, therapeutic and chirurgical answer when used regularly.
Échographie de contraste : Méthodologie et applications cliniques = Contrast ultrasound : Methodology and clinical applications
The availability of ultrasound contrast agents has introduced a new dimension in ultrasound examination with the possibility of real-time exploration of the kinetics of contrast enhancement of various lesions. The potential indications for these microbubbles affect almost all deep and superficial organs, but also the possibilities of pharmacological studies for neoangiogenesis or therapeutic guidance by physical methods. Finally, new applications are emerging in the field of targeted products and the transport of active ingredients. It seemed opportune to us to attempt to take stock of this changing world through intense collaboration between the various teams involved and recognized in this field, of which unfortunately, only some are represented here. We want this book to be a current reference point for contrast ultrasound, a point that will certainly require development in the coming years. He strongly demonstrates that ultrasound can play a very important role in modern diagnostic and therapeutic imaging because of their diagnostic performance but also because of their non-invasive nature. We hope you enjoy looking for useful information as much as we did discovering real-time functional ultrasound imaging and writing these various chapters.
Earth Observation with CHAMP : Results from Three Years in Orbit
In the summer of 2000 the German geo-research satellite CHAMP was launched into orbit. Its innovative payload arrangement and the low initial orbit allow CHAMP to simultaneously collect and almost continuously analyse precise data relating to gravity and magnetic fields at low altitude. In addition, CHAMP also measures the neutral atmosphere and ionosphere using GPS techniques. Three years after launch, more than 200 CHAMP investigators and co-investigators from all over the world met at the GeoForschungsZentrum in Potsdam to present and discuss the results derived from the extensive data sets of the mission. The main outcome of this expert meeting is summarized in this volume. The book offers a comprehensive insight into the present status of the exploitation of CHAMP data for Earth system research and practical applications in geodesy, geophysics and meteorology.
Dynamics of Fibre Formation and Processing : Modelling and Application in Fibre and Textile Industry
The book deals with the modelling of steady state and non-steady state basic processes of fibre formation and fibre processing. Focal points are melt spinning processes (polymers and glass, drawing, spunbonded nonwoven), spun yarn spinning processes (drafting, carding) and the description of the dynamics in different process steps during the fibre processing (fibre transport, fibre heating and cooling, false twist texturing). A special chapter deals with dynamics of tensile force (measuring and evaluation possibilities) and its importance for the process stability. All presented examples are based on industrial practice and give the reader a direct imagination of the discussed problems. The results are explained in a userfriendly way and give the practitioner the possibility to optimize his or her own processing.
Drying Technologies for Biotechnology and Pharmaceutical Applications
This book focuses on the application of various drying technologies to the processing of pharmaceuticals and biologicals. It offers a complete overview of innovative as well as standard drying technologies, and addresses the issues of why drying is required and what the critical considerations are for implementing this process operation during drug product development.
Drugs, the brain, and behavior : The pharmacology of therapeutics and drug use disorders
Provides a comprehensive overview of the brain and explores the clinical and pharmacological issues surrounding drug abuse and dependence. Dr Brick provides definitions, historic discoveries about the nervous system, and original, eye-catching illustrations to discuss the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs. Topics include: how psychoactive drugs affect cognition, behavior, and emotion; the brain/behavior relationship; the specific effects of major addictive and psychoactive drug groups; new definitions and thinking about abuse and dependence; and the medical uses of drugs, such as cannabinoids. A new chapter on biobehavioral markers explores how markers can guide the clinician in the diagnosis of some disorders. This book offers a quick reference guide which uses a balance of instruction, illustrations, tables, and formulas, that will give you a broad, lasting introduction to this intriguing subject.
Drugs in palliative care
While palliative care has adopted a holistic approach to treatment / medication-driven symptom management ostensibly forms the critical aspect of care. Prescribing in palliative care can be extremely complex because the patient may often have comorbidity / or occasionally multimorbidity. The associated polypharmacy further complicates the pharmacological management of symptoms being caused by the palliative condition. This can be daunting for healthcare professionals and can negatively impact upon the effectiveness of care provided. Fully revised and updated / the third edition of Drugs in Palliative Care provides a detailed / yet concise overview of topics that are encountered in palliative care clinical practice. The book will appeal to a variety of healthcare professionals involved in the provision of palliative care and medicines information.
Drugs Easily Explained
Provides an overview of the most common diseases and the drugs used to treat them. The book is designed for a general audience. It provides patients with essential information about how medications work and what side effects and interactions to expect. Finally, the book gives patients advice on what they can do themselves to improve drug therapy and safety. Summaries, bullet points, tables and diagrams support the information process.
Drugs Compromising Male Sexual Health
This concise drug guide lists approximately 500 substances, such as pharmaceutical drugs, lifestyle drugs, and environmental toxicants, that show documented untoward effects on the male sexual organs and their functions.
Drugs and nutrients : The interactive effects
Devoted to the effects of food and of nutrient intake on the disposition of foreign compounds, and discusses effects of drugs on nutrition. It is intended for nutritionists and clinical investigators concerned with interpretation of aberrant effects of therapeutic drugs.
Drugs and a methodological compendium : From bench to bedside
Provides a meticulous view on methodological drug discovery and development insights from bench to bedside. Focus on computational modus operandi, pharmacological optimization approaches, modern high-throughput screening methods and in-vitro procedures, role of structural biologists in drug discovery and development, medicinal chemistry approaches for drug design, formulation and drug delivery, in-vivo evaluations of candidate molecules, clinical trial procedures and others. Covers specific case studies, regulatory approval proceedings, and industrial view point alongside the aforementioned conceptual layout. And at the same time, the volume integrates medical, biological, medicinal, pharmacological and computational streams, and it is suggested as an ideal guideline to a wide audience including molecular biologists, biochemist, pharmacologists, medicinal chemist, toxicologists, drug discovery and development researchers, and all other students interested in these disciplines.
Drug utilization research : Methods and applications
Drug Utilization Research (DUR) is a discipline which combines aspects of pharmacotherapy, epidemiology, and health services research into an interdisciplinary set of methods for analyzing and assessing the prescribing, dispensing and consumption of medicines. It combines both qualitative and quantitative approaches to facilitate the safe and effective use of pharmaceuticals. Drug Utilization Research: Methods and Applications provides a comprehensive introduction to this discipline, prepared by an international team of authors with broad experience in numerous fields. Now reorganized and updated to reflect the latest research and global challenges, it is an indispensable resource for understanding the use of pharmaceuticals.
Drug transporters : Molecular characterization and role in drug disposition
Drug Transporters: Molecular Characterization and Role in Drug Disposition provides in-depth analysis of the conceptual evolution and technical development for studying drug transporters. Contributions by an international panel of leading researchers address advances in transporters as drug targets, transporters in pharmacotherapy, the impact of transporters on drug efficacy and safety, the development of sophisticated model systems and sensitive assay methods, and more. Divided into two parts, the book first provides a thorough overview of relevant drug transporters before detailing the principles of drug transport and associated techniques.
Drug Targets in Kinetoplastid Parasites
The book contains 12 chapters contributed by eminent scientists working in this field. The articles deal mainly with two aspects: visual identification of targets and identification of therapeutic agents.Several targets like kDNA replication machinery, purine salvage pathway, purine and pyrimidine biosynthetic pathway, histone deacetylase, DNA topoisomerases, membrane transporter proteins, glycoproteins and glycolipids are discussed in this book. Since current treatments for kinetoplastid parasitic diseases are far from ideal, there is an urgent and genuine need to develop newer compounds as antiparasitic drug candidates. Therefore evelopment of some lead compounds against these parasites as well as drug resistance are also included in this book. Moreover the vast amount of information generated after publication of the "Trytrip" genome sequence now makes possible several new approaches for target identification and discovery of therapeutic agents. This book is an outcome of the contributions of many scientists working in this important area.
Drug target selection and validation
Focuses on the computational aspects of early drug discovery, drug target identification, and validation. It revises current classical paradigms in target and phenotypic-based drug design with still ingrained approximations and concepts and discusses the research in the new network approach concept that include kinetic selectivity and metabolic analysis. Many often-overlooked approximations and concepts in drug discovery are fully covered. Drug Target Selection and Validation includes both introductory sections and research-based sections to be of use to both students and research scientists in drug discovery, design, kinetics and metabolic analysis. Pharmaceutical scientists, pharmaceutics, drug developers, pharmacologists, biomedical researchers in computer science, medicinal chemists, and precision medicine developers benefit from the information provided. The book concludes with a chapter on chemical and structural databases.
Drug Selectivity : An Evolving Concept in Medicinal Chemistry
Provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.
Drug safety evaluation
Presents an all-inclusive practical guide for those who are responsible for developing new drugs and ensuring the safety of an ever-expanding spectrum of therapeutics. This book helps readers understand how the safety of these products are evaluated for use. Extensively revised to reflect up-to-date information, this edition includes changes to the scope of products (vaccines, small synthetic, large protein moieties, cells and tissues), harmonized global and national regulatory requirements, the therapeutic development process, and available technologies to identify and evaluate the relevance of potential patient risks
Drug repurposing and computational drug discovery strategies and advances
Defined as identifying new pharmacological indications from old, existing, failed, investigational, already marketed, or FDA-approved drugs and prodrugs, and applying these new uses in the treatment of diseases other than the drug’s original intended therapeutic use. The application of computational techniques in discovery research not only helps in the development of drugs from leads or existing drug molecules but can also be useful for the repurposing of existing drug candidates.
