الصفحة 2
الصفحة 2
Netherlands yearbook of international law 2019 : Yearbooks in international law : History, function and future
This volume of the Netherlands Yearbook of International Law (NYIL) is the fiftieth in the Series, which means that the NYIL has now been with us for half a century. The editors decided not to let this moment go by unnoticed, but to devote this year's edition to an analysis of the phenomenon of yearbooks in international law.The Netherlands Yearbook of International Law was first published in 1970. It offers a forum for the publication of scholarly articles in a varying thematic area of public international law.
Negotiations with Asymmetrical Distribution of Power : Conclusions from Dispute Resolution in Network Industries
In many ways, complex negotiations shape the business arena of regulated network markets. In general, negotiating partners are not equal with regard to their various sources and instruments of power. This book unfolds a differentiated and, at the same time, applicable framework for analyzing and managing negotiations. It creatively combines power and negotiations theories. In addition, it illustrates the findings in a very inspiring way by investigating negotiation episodes in network industries such as telecommunications and railways. Thus, this book is highly relevant for all those wanting to better understand the complex political processes and outcomes in regulated industries, but also for those bearing practical responsibility in regulatory and government affairs and wanting to improve their management performance.
Natural Products Targeting Clinically Relevant Enzymes
Covers the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Natural Products : Drug Discovery and Therapeutic Medicine
Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to overcome such problems as antibiotic resistance, the emergence of new diseases, the failure to conquer old diseases, and the toxicity of some contemporary medical products. In Natural Products: Drug Discovery and Therapeutic Medicine, a panel of recognized experts and leaders in the field discuss the past successes of natural products as medicines and review future possibilities arising from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discovery, to accessing microbial diversity, to investigating specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to exploiting specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Natural Product Synthesis II : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural Product Synthesis I : Targets, Methods, Concepts
From its early days, the total synthesis of complex molecules, especially those that are natural products, has been the kings discipline in organic chemistry. The reasons for this are manifold: the challenge lying in a novel and intricate molecular architecture or the difficulty encountered when isolating the substance from its natural sources, or the possibility of finding a wide test ground for established methodology or the incentive to invent new methodology when the old one has failed, or simply the art and elegance which is so typical of a truly efficient synthetic sequence. In any case, everybody will agree that total synthesis is the best way to train young chemists, In these two volumes, the contributions of a number of organic synthetic chemists from the German speaking area have been collected. It is the hope of the authors and the editor that these articles, which highlight all the various aspects of organic synthesis, will provide not only an insight into the basic strategy and tactics but also the purpose of organic syntheses.
Natural Polysaccharides in Drug Delivery and Biomedical Applications
Provides a fundamental overview of natural polysaccharides, their sources, extraction methodologies, and characterizations. It covers specific natural polysaccharides and their effective application in drug delivery and biomedical use. Additionally, chapters in the book discuss key topics including the sources and extraction methodologies of natural polysaccharides, their role in tissue engineering applications, polysaccharide-based nanoparticles in biomedical applications, and their role in the delivery of anticancer drugs. Written by industry leaders and edited by experts, this book emphasizes recent advances made in the field.Natural Polysaccharides in Drug Delivery and Biomedical Applications provides academics, researchers, and pharmaceutical health care professionals with a comprehensive book on polysaccharides in pharmaceutical delivery process.
Natural poisons and venoms: Plant toxins : Polyketides, phenylpropanoids and further compounds
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venoms : Animal toxins
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural poisons and venom : Plant toxins : Terpenes and steroids
Biogenic toxins are fascinating natural products characterized by an enormous diversity of chemical structures and pharmacological activities. They not only pose hazards to humans and animals, but they are important components in the interplay of substances and living beings in nature and, moreover, important sources for new drugs.
Natural occurrence and biological activities of quinoline derivatives
Provides a comprehensive overview of quinoline derivatives, focusing on their chemical structure, biological activities, and therapeutic benefits. It delves into the natural sources of these derivatives, covering their isolation, characterization, and potential therapeutic applications, particularly in areas such as anti-cancer, anti-inflammatory, antimicrobial, and antimalarial activity. With its emphasis on providing valuable reference material, this book is an indispensable resource for researchers, educators, and professionals in the fields of chemistry, biology, pharmacology, and drug discovery.
Natural Language Processing and Information Systems ; Vol. 3513 ; 10th International Conference on Applications of Natural Language to Information Systems, NLDB 2005, Alicante, Spain, June 15-17, Proceedings
The development and convergence of computing, telecommunications and information systems has already led to a revolution in the way that we work, communicate with each other, buy goods and use services, and even in the way that we entertain and educate ourselves.The revolution continues, and one of its results is that large volumes of information will increasingly be held in a form which is more natural for users than the data presentation formats typical of computer systems of the past. Natural language processing (NLP) is crucial in solving these problems, and language technologies will make an indispensable contribution to the success of information systems. We hope that NLDB 2005 was a modest contribution to this goal. NLDB 2005 contributed to advancing the goals and the high international standing of these conferences, largely due to its Program Committee, composed of renowned researchers in the field of natural language processing and inf- mation system engineering. Papers were reviewed by three reviewers from the Program Committee. This clearly contributed to the significant number of - pers submitted (95). Twenty-nine were accepted as regular papers, while 18 were accepted as short papers.
Natural Language Processing – IJCNLP 2004 ; 1st International Joint Conference, Hainan Island, China, March 22-24, 2004, Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the First International Joint Conference on Natural Language Processing, IJCNLP 2004, held in Hainan Island, China in March 2004. The 84 revised full papers presented in this volume were carefully selected during two rounds of reviewing and improvement from 211 papers submitted. The papers are organized in topical sections on dialogue and discourse; FSA and parsing algorithms; information extractions and question answering; information retrieval; lexical semantics, ontologies, and linguistic resources; machine translation and multilinguality; NLP software and applications, semantic disambiguities; statistical models and machine learning; taggers, chunkers, and shallow parsers; text and sentence generation; text mining; theories and formalisms for morphology, syntax, and semantics; word segmentation; NLP in mobile information retrieval and user interfaces; and text mining in bioinformatics.
Nanophytomedicine : An emerging platform for drug delivery
Covers recent advances in experimental and theoretical studies on various properties of nanoparticles derived from plant sources. This book assesses the recent advancements and applications of plant-based nanoparticles and also highlights emerging concepts of biomimetics. Contains 24 chapters encompassing various therapeutic applications of phytochemicals derived from plants, ferns, seaweeds, and so on, mediated through nanotechnology and its allied approaches. A fervent attempt has been made to compile every significant advancement in the field of phytonanomedicine so as to accelerate its momentum in the pharmaceutical sector.
Multiwavelength Approach to Unidentified Gamma-Ray Sources : A 2nd Workshop on the Nature of the High-Energy Unidentified Sources
Nearly one half of the point-like gamma-ray sources detected by EGRET instrument of the late Compton satellite are still defeating our attempts at identifying them. To establish the origin and nature of these enigmatic sources has become a major problem of current high-energy astrophysics. The second workshop on Multiwavelength Approach to Unidentified Gamma-ray Sources intends to shed new and fresh light on the problem of the nature of these mysterious sources and the objects behind them. The proceedings contain 46 contributed papers in this subject, which cover theoretical models on gamma-ray sources as well as the best multiwavelength strategies for the identification of the promising candidates. The topics of this conference also include energetic phenomena ocurring both in galactic and extragalactic scenarios, phenomena that might lead to the appearance of what we have called high-energy unidentified sources. The book will be of interest for all active researchers in the high-energy astrophysics and related research areas as well as for scientists and graduate students interested in understanding the recent progress in this field.
Multimodal Texts in Disciplinary Education : A Comprehensive Framework
This book provides an introduction to multimodality and the role of multimodal texts in today’s education. Presenting a comprehensive framework for analysing and working with multimodal texts in disciplinary education, it serves as a tool for researchers and teachers alike. The second part of the book focuses on sample analyses of a variety of educational texts for different age groups and from different disciplines, including games and online resources. The authors also comment on the specific challenges of each text, and how teachers can discuss such texts with their students to enhance both their understanding of the content and their multimodal literacy.
Multifunctional Land Use : Meeting Future Demands for Landscape Goods and Services
The book contributes to the scientific basis for future land development strategies and helps supporting land use decision making on the political, planning and management level. In this publication they (i) analyse general principles of land use multifunctionality, (ii) highlight the specific requirements and approaches of implementing multifunctional land use from different disciplinary viewpoints, (iii) report on success stories of multifunctional land use from different geographic and political settings, and (iv) discuss modelling and monitoring approaches to scientifically assess the impact of mutlifunctional land use implementation.
Multidimensional Poverty Measurement : Concepts and Applications
Conceptualization and measurement of poverty have traditionally relied on purely economic approaches, with income or consumption as the only indicator. Multidimensional approaches have increasingly been used to understand poverty, but have yet to be fully operationalized. This book uses factor analysis and structural equations modeling to develop a multidimensional framework that integrates capability and social inclusion as additional poverty indicators. The empirical relevance of this methodological contribution is demonstrated through its application in the United States and Nepal. The proposed approach not only helps to identify different categories of the poor, but also to more accurately target resources and policies of poverty alleviation. The book will therefore be an important reference for professionals in development agencies as well as for poverty and policy researchers.
MSCs and Innovative Biomaterials in Dentistry
Presents the modern concepts of mesenchymal stem cells (MSCs) and biomaterials as they pertain to the dental field. The book is organized around three main topics: MSCs biology, advanced biomaterials, and clinical applications. The chapters present basic information on stem cell biology and physiology, modern biomaterials that improve bone tissue regeneration, the biomatrices like platelet-rich fibrin (PRF) used to functionalize the biomaterials surface, the strategic and safe intraoral seats of harvesting, the new sources for MSCs, as well as the future perspectives and new challenges in these exciting fields.
Mountains : Sources of Water, Sources of Knowledge
This book addresses the major challenges in assuring globally sustainable water use. Paradoxically, water resources have been identified both as too plentiful, producing major disasters, and increasingly vulnerable to shortages. Addressing both of these aspects requires attention to physical hydrological processes as well as human activities that affect water supply and demand.
