الصفحة 2
الصفحة 2
Monitors of Organic Chemicals in the Environment : Semipermeable Membrane Devices
Modern, industrialized societies depend on a wide range of chemical substances such as fuels, plastics, biocides, pharmaceuticals and detergents for maintaining the high quality lifestyle to which we aspire. The challenge is to ensure that while we enjoy the benetsof thes esubstances,theirinevitablereleaseintoourbiosphere does not result in unwanted human and ecosystem exposures, and the risk of - verse effects. One response to this challenge has been the extensive effort to detect and analyze or monitor a multitude of chemicals in a variety of environmental media, especially toxic organic compounds in air, water, soils and biota. An extensive literature on these traditional techniques has evolved over the years.
Molecular Sensors for Cardiovascular Homeostasis
This book reveals state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases.It offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
Molecular microbiology of heavy metals
Molecular Microbiology of Heavy Metals includes chapters on allocation of metals in cells, metal transporter, storage and metalloregulatory proteins, cellular responses to metal ion stress, transcription of genes involved in metal ion homeostasis, uptake of essential metals, metal efflux and other detoxification mechanisms. Also discussed are metal bioreporters for the nanomolar range of concentration and tools to address the metallome. Chapters in the second part cover specific metals such as Fe, Mn, Cu, Ni, Co, Zn and Mo as key nutrient elements and Ag, As, Cd, Hg and Cr as toxic elements.
Molecular Chaperones in Health and Disease
Molecular chaperones are involved in a wide variety of essential cellular processes in living cells. A subset of molecular chaperones have been initially described as heat shock proteins protecting cells from stress damage by keeping cellular proteins in a folding competent state and preventing them from irreversible aggregation. Later it became obvious that molecular chaperones are also expressed constitutively in the cell and are involved in complex processes such as protein synthesis, intracellular protein transport, post-translational modification and secretion of proteins as well as receptor signalling. Hence, it is not surprising that molecular chaperones are implicated in the pathogenesis of many relevant diseases and could be regarded as potential pharmacological targets. Starting with the analysis of the mode of action of chaperones at the molecular, cellular and organismic level, this book will then describe specific aspects where modulation of chaperone action could be of pharmacological and therapeutic interest.
Molecular autoimmunity
The autoimmune disease paroxysmal cold hemoglobinuria, a rare hemolytic disorder. After a century of research, the list of autoimmune diseases has become impressive. With a prevalence of approximately 5% of the world-wide population, these chronic, debilitating conditions affect almost every major organ of the body and, for reasons that remain unclear, are much more prevalent in woman than in men. Despite our rapidly expanding knowledge of the cellular and molecular pathways that govern a normal immune response, deciphering the precise etiology of autoimmune diseases remains an important challenge. Over the last few years, our understanding of the pathogenesis of autoimmune diseases has improved rapidly, leading to the emergence of elegant immunointervention strategies. Molecular Autoimmunity illustrates how cutting-edge research is continuing to advance our understanding of autoimmune disease mechanisms and identifies novel therapeutic targets that provide a hope for effective future treatments. This volume contains a selected number of exciting advances in unraveling autoimmune reactions, and the resulting new armory of experimental immunotherapies that may lead to new ways of controlling autoimmune reactions.
Molecular Aspects of the Stress Response
We are extremely happy to present the reader this book containing a summary of a well-known research field, the phenomenon of cellular stress defense from two new angles: networks and membranes.
Modulation of host gene expression and innate immunity by viruses
This book is reference on a relatively young area of research in which virology, cellular biology and molecular pathogenesis govern the principles of coinvestigation. Infection of a naïve (non-immune) host with a virus elicits an immediate response which results in a cascade of changes in the host, including an interferon response (innate immunity). The outcome of this interaction is influenced by the genes of the virus as well as the genes of the host. Interestingly, different viruses do it in different ways. Not only is there a plethora of mechanisms used by the invading organisms, but the host has also evolved a great variety of redundant and robust countermeasures. This interplay of host and virus represents one of the most significant frontiers in biology today. A clearer understanding of the mechanisms involved will arm us with better strategies to deal with viruses, including emerging pathogens and potential bioterrorism agents. This book is sure to benefit students, scientists, and physicians working in the areas of virology, immunology, microbiology, and infectious diseases.
Modern hospice design : The architecture of palliative and social care
Takes cognisance of the new conditions of social care in the 21st century, principally in the UK, Europe and North America. It does so with regard to the development of new building types, but also in response to new philosophies of palliative care and the status of the elderly and the dying. At its core is a public discussion of a philosophy of design for providing care for the elderly and the vulnerable, taking the importance of architectural aesthetics, the use of quality materials, the porousness of design to the wider world, and the integration of indoor and outdoor spaces as part of the overall care environment.
Modern Anesthetics
Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. in this book the very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
Modelling Regional Scenarios for the Enlarged Europe : European Competitiveness and Global Strategies
The aim of this book is to tackle the question of what the European territory will look like over the next fifteen years by providing quali-quantitative territorial scenarios for the enlarged Europe, under different assumptions on future globalisation strategies of BRIC (Brazil, Russia, India and China) and East and West European countries. The approach is as neutral as possible vis-à-vis the results, leaving to a new forecasting model, the MASST model, built by the authors, to produce the tendencies and behavioural paths of regional GDP and population growth in each individual European region under alternative assumptions on the competitiveness strategies of different blocks of countries. The results are accompanied by strong policy messages intended to encourage long-term strategic thinking among a wide range of actors, scientists and policy makers in response to the risks and opportunities that the European territory will face.
Modelling Environmental Dynamics : Advances in Geomatic Solutions
Modelling environmental dynamics is critical to understanding and predicting the evolution of the environment in response to the large number of influences including urbanisation, climate change and deforestation. Simulation and modelling provide support for decision making in environmental management.
Modeling and Using Context ; 5th International and Interdisciplinary Conference, CONTEXT 2005, Paris, France, July 5-8, 2005, Proceedings
Context is of crucial importance for research and applications in many disciplines, as evidenced by many workshops, symposia, seminars, and conferences on specific aspects of context. The International and Interdisciplinary Conference on Modeling and Using Context (CONTEXT), the oldest conference series focusing on context, provides a unique interdisciplinary emphasis, bringing together participants from a wide range of disciplines, including artificial intelligence, cognitive science, computer science, linguistics, organizational science, philosophy, psychology, ubiquitous computing, and application areas such as medicine and law, to discuss and report on context-related research and projects. Previous CONTEXT conferences were held in Rio de Janeiro, Brazil (1997), Trento, Italy (1999, LNCS 1688), Dundee, UK (2001, LNCS 2116), and Palo Alto, USA (2003, LNCS 2680). CONTEXT 2005 was held in Paris, France during July 5–8, 2005. There was a strong response to the CONTEXT 2005 Call for Papers, with 120 submissions received. A careful review process assessed all submissions, with each paper first reviewed by the international Program Committee, and then reviewer discussions were initiated as needed to assure that the final decisions carefully considered all aspects of each paper. Reviews of submissions by the Program Chairs were supervised independently and anonymously, to assure fair consideration of all work. Out of the 120 submissions, 23 were selected as full papers for oral presentation, and 20 were selected as full papers for poster presentation. These outstanding papers are presented in this proceedings.
Mobile response ; 1st International Workshop on mobile information technology, for emergency response, mobile response 2007, Sankt Augustin, Germany, February 22-23, 2007. Revised Selected Papers
This book constitutes the thoroughly refereed post-proceedings of the First International Workshop on Mobile Information Technology for Emergency Response, MobileResponse 2007 held in Sankt Augustin, Germany in February 2007.
Mitigation of Natural Hazards and Disasters : International Perspectives
This book examines the aspects of prevention, mitigation, and management of environmental hazards and disasters from an international perspective. In light of the recent debate on climate change and the possible effects of such a change upon increasing frequency and magnitude of extreme environmental events, this publication overviews various policy and response discourse. Several case studies, from various countries and world regions, depicting recent experience in mitigation policy and program development and implementation and establishing interlinks between vulnerability and mitigation are presented to provide further insights.
Migration and Discrimination : IMISCOE Short Reader
This book provides a state of the art overview of the discrimination research field, with particular focus on discrimination against immigrants and their descendants. It covers the ways in which discrimination is defined and conceptualized, how it is measured, how it may be theorized and explained, and how it might be combated by legal and policy means.
Migrants with Irregular Status in Europe : Evolving Conceptual and Policy Challenges
This book explores the conceptual challenges posed by the presence of migrants with irregular immigration status in Europe and the evolving policy responses at European, national and municipal level. It addresses the conceptual and policy issues raised, post-entry, by this particular section of the migrant population.
Microelectronic Circuits
Devices and basic circuits -- Signals, amplifiers and semiconductors -- Operational amplifiers -- Diodes -- Bipolar junction transistors (BJTS) -- Mos field-effect transistors (MOSFETS) -- Transistor amplifiers -- Analog integrated circuits -- Building blocks of integrated-circuit amplifiers -- Differential and multistage amplifiers -- Frequency response -- Feedback -- Output stages and power amplifiers -- Operational-amplifier circuits -- Filters and oscillators -- Digital integrated circuits -- CMOS digital logic circuits -- Digital Design: Power, Speed, and Area -- Memory and Clocking Circuits
Metric Driven Design Verification : An Engineer's and Executive's Guide to First Pass Success
A metric based flow is described that focuses on the four steps of: 1. Planning: Defining what needs to be done and the automatically trackable metrics that will be used to measure progress. 2. Execution: Implementing verification environments and then extensively exercising the device under verification utilizing comprehensive, massively parallel regression strategies. 3. Measurement: Automatically capturing the metrics defined in planning to provide objective data with which to manage the verification project. Custom tailoring those metrics through an automated reporting framework to provide all stakeholders a real-time meaningful view of project status. 4. Response: Utilizing the returned metrics to effectively adapt to changing project conditions. Making use of automated response mechanisms to automate engineering processed and management response to streamline project management processes
Methodological approaches to societies in transformation : How to make sense of change
This book provides methodological devices and analytical frameworks for the study of societies in transformation. It explores a central paradox in the study of change: making sense of change requires long-term perspectives on societal transformations and on the different ways people experience social change, whereas the research carried out to study change is necessarily limited to a relatively short space of time. This volume offers a range of methodological responses to this challenge by paying attention to the complex entanglement of qualitative research and the metanarratives generally used to account for change.
Mercury Pollution in Minamata
It overviews the poisoning which occurred in the 1950s and 1960s among the residents in Minamata who ate seafood contaminated with methylmercury discharged from the chemical factory, Chisso Corporation. It describes the history, symptoms pathogenesis and research on the causal agent, and discusses the responses of Chisso and the national and local governments to the outbreak, the victims, the compensation and environmental restructuring as well as the court ruling on claims. Based on lecture notes from a university course, it includes students’ suggestions for avoiding a repeat of the tragedy. The issue has not been settled yet, and this analysis of the incident provides useful insights into solutions to the current global mercury pollution problem.
