الصفحة 2
الصفحة 2
Natural Products Targeting Clinically Relevant Enzymes
Covers the full spectrum of clinically relevant enzymes that are known to be targeted by natural products. Key enzymes include acetylcholine esterase, angiotensin-I-converting enzyme, cyclooxygenase, dihydrofolate reductase, phospholipase A2, respiratory complexes, and many more. By connecting the diversity of medicinal natural product sources with their potential clinical applications, this volume serves as a companion for the medicinal chemist looking for innovative small molecule compounds as well as for pharmacologist interested in the clinical effects and mode of action of herbal and traditional medicines.
Nanostructured Coatings
Controlling the performance of structures and components of all sizes and shapes through the use of engineered coatings has long been a key strategy in materials processing and technological design. The ever-increasing sophistication of en- neered coatings and the rapid trend toward producing increasingly smaller devices with greater demands on their fabrication, properties and performance have led to signicant progress in the science and technology of coatings, particularly in the last decade or two. Nanostructured coatings constitute a major area of sci- ti?c exploration and technological pursuit in this development.Nanostructured coatings demand study in a highly interdisciplinary research arena which encompasses: surface and interface science study of defects modern characterization methodologies cutting-edge experimental developments to deposit.
Nanoscale Assembly : Chemical Techniques
Recent advances have pushed the limits of lithography firmly into the sub-100 nm domain, with smallest feature sizes around 10 nm. However, compared to living organisms, devices fabricated using nanolithography are not nearly as complex, as they are essentially 2D and contain only a limited number of chemical elements. For centuries, Nature has been a major inspiration for science. First of all to learn how Life functions at cellular level, but increasingly, as a blueprint for designing non-natural devices where the building blocks and their assembly are inspired by biological examples. The key tool in translating these examples into the domain of engineering, has been self-assembly or self-organization. This book gathers a spectrum researchers who have not only furthered our knowledge of self-assembly using small molecules, polymers and colloidal particles as building blocks, but who have also shown it to be a practical tool in the assembly of an astonishing variety of devices, ranging from molecular electronics to biosensors.
Multi-Source National Forest Inventory : Methods and Applications
The book describes in detail the full MS-NFI process, and the input data used – including field data, satellite images, and digital map data, as well as coarse-scale variation of forest variables. It also presents comprehensive information on the types of outputs which can be derived, including maps and statistics, describing, for example, stock volumes and development, dominant tree species, age-class distribution, and large and small-scale variation. The book will provide an invaluable resource for those involved in forest inventory, including government departments and bodies involved in forest policy, management and monitoring, forest managers, and researchers and graduate students interested in forest inventory, modelling and analysis. It will find an additional market among those interested in Earth observation, ecology and broader areas of environmental and natural resource management.
Multiscaling in molecular and continuum mechanics : Interaction of time and size from macro to nano ; Application to biology, physics, material science, mechanics, structural and processing engineering
The manipulation of molecules and atoms has been regarded as a common base for both material and life science. Quantum and continuum mechanics are being applied side by side for exploring the behavior of small and large objects moving at fast and slow speed.
Multiscale processes in the earth’s magnetosphere : From interball to cluster ; Proceedings of the NATO ARW on Multiscale Processes in the Earth's Magnetosphere: From Interball to Cluster, Prague, Czech Republic from 9 to 12 September 2003
The past forty years of space research have seen a substantial improvement in our understanding of the Earth’s magnetosphere and its coupling with the solar wind and interplanetary magnetic ?eld (IMF). The magnetospheric str- ture has been mapped and major processes determining this structure have been de?ned. However, the picture obtained is too often static. We know how the magnetosphere forms via the interaction of the solar wind and IMF with the Earth’s magnetic ?eld. We can describe the steady state for various upstream conditions but do not really understand the dynamic processes leading from one state to another. The main dif?culty is that the magnetosphere is a comp- cated system with many time constants ranging from fractions of a second to days and the system rarely attains a steady state. Two decades ago, it became clear that further progress would require multi-point measurements. Since then, two multi-spacecraft missions have been launched — INTERBALL in 1995/96 and CLUSTER II in 2000. The objectives of these missions d- fered but were complementary: While CLUSTER is adapted to meso-scale processes, INTERBALL observed larger spatial and temporal scales. However, the number of papers taking advantage of both missions simul- neously is rather small.
Multiscale Optimization Methods and Applications
One general strategy for dealing with a large or difficult problem is to partition it into smaller ones, which are hopefully much easier to solve, and then work backwards towards the solution of original problem, using a solution from a previous level as a starting guess at the next level.The topics of the chapters selected for this volume are focused on the development of new solution methodologies, including general multilevel solution techniques, for tackling difficult, large-scale optimization problems that arise in science and industry. Applications presented in the book include but are not limited to the circuit placement problem in VLSI design, a wireless sensor location problem, optimal dosages in the treatment of cancer by radiation therapy, and facility location.
Multiscale Methods in Science and Engineering
Multiscale problems naturally pose severe challenges for computational science and engineering. The smaller scales must be well resolved over the range of the larger scales. Challenging multiscale problems are very common This volume is an overview of current mathematical and computational methods for problems with multiple scales with applications in chemistry, physics and engineering.
Multiscale fatigue crack initiation and propagation of engineering materials ; Structural integrity and microstructural worthiness : Fatigue crack growth behaviour of small and large bodies
This book elucidates the correlation of fatigue crack growth data to multiscale cracking, particularly to the understanding of micrographs influenced by mechanical disturbance and thermodynamic variables. Attention is given to the interpretation of test data by fatigue crack growth rate using two empirical parameters in consistence with the fracture control methodology currently used by industry.
Multimodal Concepts for Integration of Cytotoxic Drugs
The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on different forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies, derived from recent advances in molecular oncology. The second part of the book comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented. In addition, the topics of acute and late toxicity, supportive treatment and tolerance in elderly patients are reviewed.
Multimedia Database Retrieval : A Human-Centered Approach
Multimedia Database Retrieval: A Human-Centered Approach presents the latest development in user-centered methods and the state-of-the-art in visual media retrieval. It includes discussion on perceptually inspired non-linear paradigm in user-controlled interactive retrieval (UCIR) systems. It also features a coherent approach which focuses on specific topics within content/concept-based retrievals via audio-visual information modeling of multimedia. Highlights include: * Exploring an adaptive machine that can learn from its environment * Optimizing the learning system by incorporating self-organizing adaptation into the retrieval process * Demonstrating state-of-the-art applications within small, medium, and large databases
Mule 2 : A Developers Guide
Mule 2: A Developer's Guide introduces the Mule 2.0 integration platform for developers of enterprise integration applications who wish to leverage Mule as a lightweight messaging framework that contains a distributable object broker for managing communication between applications. The book is based on insight, knowledge, and experience resulting from working with Mule. The text provides support, consulting, and training to developers implementing Mule in a broad range of scenarios ranging from small projects through to large corporations developing major deployments.
MRI of the Temporomandibular Joint : Correlation Between Imaging and Pathology
This book is the outcome of a fruitful, long-standing cooperation between expert radiologists and clinicians, and explains the most relevant features and technical requirements that are needed to optimally conduct and assess MR examinations for temporomandibular joint (TMJ) pathologies.
MPB : Mall Plus Businies
مشروع تجاري المؤلف من طابقين والبرج الاستثماري بالاضافة إلى العديد من المحلات التجارية المتنوعة وظيفيا وتصميميا ومحاطة بالحدائق وممرات المشاة والعناصر المائية التي تخدم الزوار وتحقق عنصر ترفيهي للمشروع
Molecules in Superfluid Helium Nanodroplets : Spectroscopy, Structure, and Dynamics
This book covers recent advances in experiments using the ultra-cold, very weakly perturbing superfluid environment provided by helium nanodroplets for high resolution spectroscopic, structural and dynamic studies of molecules and synthetic clusters. The recent infra-red, UV-Vis studies of radicals, molecules, clusters, ions and biomolecules, as well as laser dynamical and laser orientational studies, are reviewed. The Coulomb explosion studies of the uniquely quantum structures of small helium clusters, X-ray imaging of large droplets and electron diffraction of embedded molecules are also described. Particular emphasis is given to the synthesis and detection of new species by mass spectrometry and deposition electron microscopy.
Molecular and Cellular Signaling
A small number of signaling pathways, no more than a dozen or so, form a control layer that is responsible for all signaling in and between cells of the human body. The signaling proteins belonging to the control layer determine what kinds of cells are made during development and how they function during adult life. Malfunctions in the proteins belonging to the control layer are responsible for a host of human diseases ranging from neurological disorders to cancers. Most drugs target components in the control layer, and difficulties in drug design are intimately related to the architecture of the control layer. Molecular and Cellular Signaling provides an introduction to molecular and cellular signaling in biological systems with an emphasis on the underlying physical principles. The text is aimed at upper-level undergraduates, graduate students and individuals in medicine and pharmacology interested in broadening their understanding of how cells regulate and coordinate their core activities and how diseases arise when these regulatory systems malfunction, as well as those in chemistry, physics and computer science interested in pursuing careers in biological and medical physics, bioinformatics and systems biology. To that end, the book includes background information and review sections, and chapters on signaling in the immune, endocrine (hormonal) and nervous systems. It has chapters on cancer, apoptosis and gene regulation, and contains chapters on bacteria and viruses. In those chapters not specifically devoted to pathogens, connections between diseases, drugs and signaling are made. Each chapter also features a problem set to facilitate further discussion and understanding.
Modern Techniques for Characterizing Magnetic Materials
The book includes, but is not limited to the following areas: Magnetic neutron scattering with 3-axis spectrometer * Small-angle neutrons scattering * Polarized neutron magnetic reflectometry * Resonant soft x-ray magneto-optic scattering * Magnetic hard x-ray scattering * Spin resolved photoemission spectroscopy * Lorentz microscopy and electron holography * Scanning electron microscopy with polarization analysis * Spin polarized low energy electron microscopy * Spin-polarized scanning tunneling microscopy * Magnetic force microscopy * Near-field scanning optical microscopy * Time-resolved scanning Kerr microscopy * Brillouin light scattering spectroscopy
Modern parallel programming with C++ and assembly language : X86 SIMD development using AVX, AVX2, and AVX-512
Understand the essential details about x86 SIMD architectures and instruction sets including AVX, AVX2, and AVX-512. / Master x86 SIMD data types, arithmetic instructions, and data management operations using both integer and floating-point operands. / Code performance-enhancing functions and algorithms that fully exploit the SIMD capabilities of a modern x86 processor. Employ C++ intrinsic functions and x86-64 assembly language code to carry out arithmetic calculations using common programming constructs including arrays, matrices, and user-defined data structures. Harness the x86 SIMD instruction sets to significantly accelerate the performance of computationally intense algorithms in applications such as machine learning, image processing, computer graphics, statistics, and matrix arithmetic. / Apply leading-edge coding strategies and techniques to optimally exploit the x86 SIMD instruction sets for maximum possible performance.
Modern Operative Dentistry : Principles for Clinical Practice
Provides the theoretical knowledge required by students when learning how to diagnose oral diseases, plan treatment, and perform various types of dental restoration. It is also useful for clinicians wishing to update their treatment skills and broaden their understanding operative dentistry. Adopting an evidence-based approach, and in accordance with the philosophy of minimally invasive dentistry, it explains in detail the use of both classic and new restorative materials in various clinical situations. It also discusses the principles of smile analysis, as well the technique for esthetic composite restorations on posterior and anterior teeth, including direct and indirect veneers.
Modern Differential Geometry in Gauge Theories : Maxwell Fields ; Vol. I
Differential geometry, in the classical sense, is developed through the theory of smooth manifolds. Modern differential geometry from the author’s perspective is used in this work to describe physical theories of a geometric character without using any notion of calculus (smoothness). Instead, an axiomatic treatment of differential geometry is presented via sheaf theory (geometry) and sheaf cohomology (analysis). Using vector sheaves, in place of bundles, based on arbitrary topological spaces, this unique approach in general furthers new perspectives and calculations that generate unexpected potential applications .Volume 1, the focus is on Maxwell fields. All the basic concepts of this mathematical approach are formulated and used thereafter to describe elementary particles, electromagnetism, and geometric prequantization. Maxwell fields are fully examined and classified in the language of sheaf theory and sheaf cohomology.
