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الصفحة 2
Biomedical applications and toxicity of nanomaterials
Covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
Artrite reumatoide e spondiloentesoartriti : Diagnostica per immagini e imaging follow-up = Rheumatoid Arthritis and Spondyloentesoarthritis : Follow-up imaging and imaging
Recent technological evolutions in diagnostic imaging have allowed him to grasp the anatomical and functional alterations that characterize the onset phase of degenerative and inflammatory arthropathies. In the context of the latter, in particular, imaging is not only fundamental in the diagnosis of the early stage of arthritis but also in defining their evolution and response to modern therapeutic treatment. The evaluation of a new imaging semeiology, which makes considerable use of the use of contrast medium in relation to both power Doppler and magnetic resonance imaging, has made it possible to narrow the gap between histology and imaging in rheumatological diagnostics.
Appropriate Dose Selection - How to Optimize Clinical Drug Development
Optimal dose individualization has become more important in improving clinical efficacy and safety, given the variability in drug response, e.g., due to concurrent illnesses or co-medications. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. The continued use of biomarkers – based on the (known) pharmacology of the drug and/or biology of the underlying disease – along with exposure–response evaluation throughout all phases of drug development can quantitatively integrate clinical pharmacology knowledge, provide early proof of concept, and help in rational dose selection and rational drug product labeling for clinical use.
Anxiety disorders : A pocket guide for primary care
In Anxiety Disorders: A Pocket Guide for Primary Care, distinguished clinicians combine over a century of experience into concise, practical information and techniques for the diagnosis, evaluation, and effective management of psychiatric disorders.
Analisi di Rasch e questionari di misura : Applicazioni in medicina e scienze sociali = Rasch analysis and measurement questionnaires: Applications in medicine and social sciences
Evaluation questionnaires are the most used tools nowadays in the field of medicine and the human sciences to evaluate variables such as disability, altruism or pain. However, clinicians are often unfamiliar with these tools. What do they really measure? How are the results to be interpreted? This book tries to answer these questions.
Agitator Design for Gas-Liquid Fermenters and Bioreactors
Agitator Design for Gas-Liquid Fermenters and Bioreactors delivers a concise treatment and explanation of how to design mechanically sound agitation systems that will perform the agitation process function efficiently and economically. The book covers agitator fundamentals, impeller systems, optimum power and air flow at peak mass transfer calculations, optimizing operation for minimum energy per batch, heat transfer surfaces and calculations, shaft seal considerations, mounting methods, mechanical design, and vendor evaluation.
Advanced Issue Resolution in Safety Pharmacology
Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution topics, thus raising them to the next level of importance by providing scientists with an indispensable resource on solving safety issues.
Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials : Techniques and Applications
This book provides a perspective on the current status of bioimaging technologies developed to assess the quality of musculoskeletal tissue with an emphasis on bone and cartilage. It offers evaluations of scaffold biomaterials developed for enhancing the repair of musculoskeletal tissues. These bioimaging techniques include micro-CT, nano-CT, pQCT/QCT, MRI, and ultrasound, which provide not only 2-D and 3-D images of the related organs or tissues, but also quantifications of the relevant parameters. The advance bioimaging technologies developed for the above applications are also extended by incorporating imaging contrast-enhancement materials.
3D cell culture : Methods and protocols
Expands on the previous edition with discussions about the latest organoid models developed for many more organs; new hydrogels and devices for 3D culture; and the organoid systems that have been improved by incorporating more components of tissue microenvironments in the in vitro culture. The chapters in this book are organized into five parts and cover topics such as biofabrication, organoids, microfluidic systems, bioprinting, and image analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Component-Based Software Development for Embedded Systems : An Overview of Current Research Trends
Embedded systems are ubiquitous. They appear in cell phones, microwave ovens, refrigerators, consumer electronics, cars, and jets. Some of these embedded s- tems are safety- or security-critical such as in medical equipment, nuclear plants, and X-by-wire control systems in naval, ground and aerospace transportation - hicles. With the continuing shift from hardware to software, embedded systems are increasingly dominated by embedded software. Embedded software is complex. Its engineering inherently involves a mul- disciplinary interplay with the physics of the embedding system or environment. Embedded software also comes in ever larger quantity and diversity. The next generation of premium automobiles will carry around one gigabyte of binary code. The proposed US DDX submarine is e?ectively a ?oating embedded so- ware system, comprising 30 billion lines of code written in over 100 programming languages. Embedded software is expensive. Cost estimates are quoted at around US$15– 30 per line (from commencement to shipping). In the defense realm, costs can range up to $100, while for highly critical applications, such as the Space Shuttle, the cost per line approximates $1,000. In view of the exponential increase in complexity, the projected costs of future embedded software are staggering.
Citation Analysis in Research Evaluation
This book is written for members of the scholarly research community, and for persons involved in research evaluation and research policy. More specifically, it is directed towards the following four main groups of readers: – All scientists and scholars who have been or will be subjected to a quantitative assessment of research performance using citation analysis. – Research policy makers and managers who wish to become conversant with the basic features of citation analysis, and about its potentialities and limitations. – Members of peer review committees and other evaluators, who consider the use of citation analysis as a tool in their assessments. – Practitioners and students in the field of quantitative science and technology studies, informetrics, and library and information science. Citation analysis involves the construction and application of a series of indicators of the ‘impact’, ‘influence’ or ‘quality’ of scholarly work, derived from citation data, i.e. data on references cited in footnotes or bibliographies of scholarly research publications. Such indicators are applied both in the study of scholarly communication and in the assessment of research performance. The term ‘scholarly’ comprises all domains of science and scholarship, including not only those fields that are normally denoted as science – the natural and life sciences, mathematical and technical sciences – but also social sciences and humanities.
Brain and Human Body Modeling : Computational Human Modeling at EMBC 2018
This book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner.
Biometric systems : Technology, design and performance evaluation
The use of computers to recognize humans from physical and behavioral traits dates back to the digital computer evolution of the 1960s. But even after decades of research and hundreds of major deployments, the field of biometrics remains fresh and exciting as new technologies are developed andoldtechnologiesareimprovedandfieldedinnewapplications.Wor- wide over the past few years,there has been a marked increase in both g- ernment and private sector interest in large-scale biometric deployments for accelerating human–machine processes, efficiently delivering human services, fighting identity fraud and even combating terrorism. The p- pose of this book is to explore the current state of the art in biometrics- tems and it is the system aspect that we have wished to emphasize. By their nature, biometric technologies sit at the exact boundary of the human–machineinterface.Butlikealltechnologies,bythemselvestheycan provide no value until deployed in a system with support hardware, n- work connections, computers, policies and procedures, all tuned together to work withpeople to improve some real business process within a social structure.
Big data analysis of nanoscience bibliometrics, patent, and funding data (2000-2019)
Presents an evaluation of nanotechnologies outputs (academic outputs and patents) and their impact from 2000-2019. The evaluation uses Elsevier’s Scopus (the largest abstract and citation database of peer-reviewed literature), SciVal (a scientific research analysis platform), Funding Institutional (a funding database), and PatentSight (a patent analysis platform). It covers four key topics regarding nanoscience research, including: 1) An overview of nano-related scholarly output, 2) Nanoscience and its contribution to basic science, 3) Nanoscience and its impact on and collaboration with industry partners, and 4) Key factors that promote the development of nanoscience.
Beginning SQL Server 2005 Express database applications with Visual Basic Express and Visual Web Developer Express : From novice to professional
SQL Server 2005 Express is the database component of Microsoft's Express Suite of products. It is free of charge, inherits many (non-enterprise) features from SQL Server 2005, and comes complete with development and administration tools. As such, it is an ideal database for developers and administrators to use in prototype/evaluation projects. It is also a powerful development platform for database applications on nonprofit websites, e-commerce sites, and in small offices and departments.
Artificial intelligence applied to medical imaging and computational biology
Medical imaging and computational biology continuously pose new fundamental medical and biological questions that often give rise to novel challenges in Artificial Intelligence. These research fields present an increasing need for the application of cutting-edge computational approaches that generally involve machine learning or computational intelligence techniques, which can effectively perform bioimage and biosignal processing in different clinical areas.
Architecting dependable systems IV
As software systems become ubiquitous, the issues of dependability become more and more crucial. Given that solutions to these issues must be considered from the very beginning of the design process, it is reasonable that dependability is addressed at the architectural level. It also contains sections on architectural description languages, architectural components and patterns, architecting distributed systems, and architectural assurances for dependability.
Architecting dependable systems III
As software systems become ubiquitous, the issues of dependability become more and more crucial. Given that solutions to these issues must be considered from the very beginning of the design process, it is reasonable that dependability is addressed at the architectural level. This book comes as a result of an effort to bring together the research communities of software architectures and dependability. The papers are organised in topical sections on architectures for dependable services, monitoring and reconfiguration in software architectures, dependability support for software architectures, architectural evaluation, and architectural abstractions for dependability
Analytical and Stochastic Modeling Techniques and Applications ; 15th International Conference, ASMTA 2008 Nicosia, Cyprus, June 4-6, 2008 Proceedings
This book constitutes the refereed proceedings of the 15th International Conference on Analytical and Stochastic Modeling Techniques and Applications, ASMTA 2008, held in Nicosia, Cyprus, in June 2008.
Analysis and Development of Sustainable Urban Production Systems
Manufacturing of products in urban production sites is connected to unique potentials, yet also to specific challenges. Urban factories can provide functional diversity and contribute positive impacts to a city. The concept of urban production receives rising attention in research and industry and it is recognized in its interdisciplinary nature. With a holistic approach from both the urban perspective and the factory perspective, negative impacts can be minimized, positive effects enabled and mutually beneficial, symbiotic combinations created. The presented framework and methods for the evaluation and implementation of sustainable urban production systems allow the assessment of impacts and provide the means to control and utilize the unique strengths of urban factories for cities and industry. This will allow a structured derivation of methods and measures from the concept of urban production for producing enterprises and the urban stakeholders.
